Clinical trials: Management
Coronavirus Disease 2019, Coronavirus Disease 2019 (COVID-19)
A Study of How Ibuzatrelvir is Taken up Into the Blood of Healthy Adults After Taking Different Tablets of Ibuzatrelvir
Healthy adults will be enrolled into this open-label, Phase 1 research study. Participants will spend about 9 nights and 10 days in the clinical research unit (CRU) and the total time in the study will be about 11 weeks.
- Conditions
- Coronavirus Disease 2019, Coronavirus Disease 2019 (COVID-19), COVID-19 (Coronavirus Disease 2019), Upper Respiratory Tract Infections
- Trial name
- NCT07552779
- Testing
- Ibuzatrelvir co-process API film coated tablet, Ibuzatrelvir filmcoated tablet
- Where
- Belgium
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Pfizer
Hypersensitivity
Efficacy of Fluoride Varnish Containing Xylitol Coated Calcium Phosphate Versus Conventional Fluoride Varnish in Management of Hypersensitivity of Exposed Root Surfaces in Adult Patients
This clinical trial will be conducted to compare the efficacy of fluoride varnish containing xylitol coated calcium and phosphate or potassium nitrate gel versus conventional fluoride varnish in the management of hypersensitivity…
- Trial name
- NCT04472182
- Testing
- Fluoride varnish with xylitol coated calcium and phosphate
- Where
- Egypt
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Cairo University
Post-operative Nausea and Vomiting, Laparoscopic Sleeve Gastrectomy
Designing Optimal Prevention and Management of Postoperative Nausea and Emesis for Patients Undergoing Laparoscopic Sleeve Gastrectomy
Bariatric surgery remains the most effective therapy for obesity. Postoperative nausea and vomiting (PONV) are commonly reported following bariatric surgery.
- Trial name
- NCT03435003
- Testing
- Aprepitant 80 mg Oral Capsule, scopolamine transdermal, Total intravenous anesthesia
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Education, Medical, Airway Management
Virtual Reality: a Teaching-learning Strategy for Cognitive Mastery in Airway Trauma Management
Airway injury in patients is a high risk and complex medical crisis. Unfortunately, training for airway management in injured patients is challenging. The most effective way of practicing airway management is using mannequins.
- Conditions
- Education, Medical, Airway Management, Students, Medical, Virtual Reality
- Trial name
- AW&VR (NCT04451590)
- Testing
- VR-based simulation, Mannequin-based simulation
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
COVID-19, Influenza
Immunogenicity of Concomitant Administration of COVID-19 Vaccines With Influenza Vaccines
The goal is to evaluate the in-depth immunogenicity analysis (including B-cell and T-cell response) of coadministration of a omicron-containing COVID-19 vaccine and influenza vaccine among healthy adults during 2023-24 season.
- Conditions
- COVID-19, Influenza, Vaccine Reaction, Contaminant Injected
- Trial name
- NCT06091410
- Testing
- Omicron-containing COVID-19 vaccine, influenza vaccine
- Where
- 2 sites in South Korea
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Catholic Kwandong University
Osteoarthritis of Hip
Management of Postoperative Pain After Total Hip Arthroplasty
Orthopedic surgery is reportedly among the most painful surgical procedures. Surgical damage following major orthopedic surgery often involves a large, deep incision with considerable tissue dissection and muscle, bone, and…
- Trial name
- NCT01040273
- Testing
- Bupivacaine
- Where
- Taiwan
- Volunteers
- healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Anesthesia, Airway Management
Review of the Follow-up of Difficult Airway Guidelines
This questionnaire study aimed to ask the participants selected questions from the recommendations of the main guidelines on airway management.
- Trial name
- NCT06524141
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Kocaeli City Hospital
Acute Pain
Efficacy of Co-administration of an NSAID With a Dopamine Agonist In Healthy Subjects
Findings from the investigator's lab and others' show the involvement of the brain's mesolimbic circuitry in pain perception and evaluation, as well as during the transition from acute to chronic pain states in both humans and…
- Trial name
- NCT02116790
- Testing
- Naproxen, Sinemet
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northwestern University
Apnea, Ventilation Therapy; Complications
THRIVE Apneic Ventilation With Standardized Airway Management During General Anesthesia.
Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) denotes the use of high-flow humidified nasal oxygen system (for example Optiflow®) as an alternative ventilation modality for an anesthetized patient without…
- Conditions
- Apnea, Ventilation Therapy; Complications, Respiratory Acidosis
- Trial name
- NCT03797859
- Testing
- Apneic ventilation
- Where
- 2 sites in Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Low Back Pain
Active Management for Low Back Pain for 6 to 8 Year Old Schoolchildren
The objective is to assess the effectiveness of a prevention campaign promoting active management in shifting beliefs in 6 to 8 year old schoolchildren.
- Trial name
- NCT00809640
- Testing
- Education (Back Comic-Book)
- Where
- Spain
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Kovacs Foundation
Healthy
A Study to Evaluate the Effect of Itraconazole on the Pharmacokinetics of PF-04958242 in Healthy Subjects
The purpose of the current study is to characterize the pharmacokinetic (PK) profile of PF 04958242 when co administered with a strong cytochrome P450 3A4 (CYP3A4) inhibitor.
- Trial name
- NCT02341482
- Testing
- PF-04958242, Itraconazole
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Biogen
Rhino Sinusitis
Herbal Tea Extract for Management of Rhinosinusitis
The objective of this phase I controlled clinical trial is to determine the safety and efficacy of Berry leaves \& Mango leaves mixture in symptomatic treatments on disease-related quality of life in adults with clinically…
- Trial name
- NCT07534280
- Testing
- mango leaves extract, local steroids, nasal saline
- Where
- 2 sites in Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Deraya University
Emotional Dysregulation
Effectiveness and Security Testing of a Mobile App for Self-Managing Emotion Dysregulation
To assess the effectiveness and security of a mobile App (beta version) for people with borderline traits recruited from a non-clinical population of college students in Barcelona (Spain).
- Trial name
- NCT04210648
- Testing
- Mobile app
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Consorci Sanitari del Maresme
Apetite Stimulants
Clinical Trial to Evaluate the Pharmacokinetic Characteristics of DW5221 and DW5221-R
A bioequivalence study to compare and evaluate the pharmacokinetic characteristics and the safety after administration of DW5221 and DW5221-R in healthy adult m ale volunteers
- Trial name
- NCT06147908
- Testing
- DW5221, DW5221-R
- Where
- South Korea
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Daewon Pharmaceutical Co., Ltd.
Cannabis Intoxication, Alcohol Intoxication
Vaporized Cannabis Administration and Co-Administration of Alcohol on Impairment
This human laboratory study will use cognitive, behavioral, and subjective measures to characterize impairment associated with co-use of alcohol and vaporized cannabis.
- Trial name
- NCT06293040
- Testing
- Cannabis, Alcohol
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Hemorrhage, Postpartum
Haemorrhagia Postpartum: an Implementation Study on the NVOG Guidelines and MOET Instructions
The objectives of this study is first to asses to what extent the guidelines of the Dutch Society of Obstetrics and Gynaecology (NVOG) and the MOET (Management of Obstetric and Emergencies and Trauma) instructions for…
- Trial name
- Fluxim (NCT00928863)
- Testing
- implementation aids
- Where
- Netherlands
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- ZonMw: The Netherlands Organisation for Health Research and Development
Fasting
Bioequivalence Study of Sulfadoxine/Pyrimethamine 500/25 mg Dispersible Tablet
The primary objective of this study is to assess the bioequivalence between the test product and the reference product based on Cmax and AUC0->72 for sulfadoxine and pyrimethamine in healthy adults under fasting conditions.
- Trial name
- NCT06522763
- Testing
- Sulfadoxine 500 MG / Pyrimethamine 25 MG dispersible tablets., Sulfadoxine 500 MG / Pyrimethamine 25 MG dispersible tablets in SPAQ
- Where
- Jordan
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Swiss Pharma Nigeria Limited
Healthy
A Study of LY3871801 in Healthy Participants
The main purpose of this study is to compare the amount of LY3871801 that gets into the blood stream and how long it takes the body to get rid of it, when given as crystalline freebase tablet (test) and as a solid dispersion oral…
- Trial name
- NCT05222399
- Testing
- LY3871801
- Where
- Singapore
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Bioavailability, Dexmedetomidine
Pharmacokinetics of Different Mode Administration of Intranasal Dexmedetomidine
Intranasal dexmedetomidine has been studied and used in children for premedication before anaesthesia or fro sedation. It can be administered by simple dripping or by Mucosal Atomization Device (MAD®).
- Trial name
- NCT03323593
- Testing
- Dexmedetomidine
- Where
- Hong Kong
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Mass Balance Recovery
Study in Healthy Adult Female Subjects
An Open Label Phase 1 Study in Healthy Adult Female Subjects to Determine the Mass Balance Recovery, Absorption, Metabolism, and Excretion of [14C] D-0502 Following Single Oral Dose Administration
- Trial name
- NCT05339633
- Testing
- [14C]-D-0502
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- InventisBio Co., Ltd
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