Clinical trials: Management
Type 2 Diabetes
Clinical Study to Evaluate the Pharmacokinetics and Safety of CKD-383 0.25/12.5/1000mg in Healthy Volunteers
This study is a randomized, open-label, single dose, crossover study to evaluate the pharmacokinetics and safety of CKD-383 in healthy volunteers
- Trial name
- NCT07304726
- Testing
- CKD-383 0.25/12.5/1000mg, CKD-501, D745, D150
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Obesity
A Study of JNJ-64565111 After Single Subcutaneous Administration at Different Injection Sites in Otherwise Healthy Overweight/Obese Adult Participants and a Study of JNJ-6456511 in Otherwise Healthy Obese Adult Participants After Multiple Dose
The purpose of this study is to compare the relative bioavailability of JNJ-64565111 between subcutaneous (SC) administrations in the upper arm versus the abdomen, and between SC administrations in the thigh versus the abdomen in…
- Trial name
- NCT03586843
- Testing
- JNJ-64565111
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Healthy Male Volunteers
Safety, Tolerability, Pharmacokinetics and Effects on Transcranial Magnetic Stimulation of Oral Doses of XEN1101
The XEN1101 Phase 1 clinical trial is a randomized, double-blind, placebo-controlled study that will eventuate the safety, tolerability, pharmacokinetics (PK) and effects on transcranial magnetic stimulation (TMS) of oral doses…
- Trial name
- NCT03468725
- Testing
- XPF-008, Microcrystalline Cellulose
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Xenon Pharmaceuticals Inc.
Diabetes Mellitus
Comparison of PK After Administration of HCP1201 and Co-administration of Metformin SR 750mg and Rosuvastatin 10mg
To compare the pharmacokinetic characteristics between HCP1201 tablet 750/10 mg and co-administration of metformin 750 mg plus rosuvastatin 10 mg under fed state condition.
- Trial name
- NCT02026817
- Testing
- HCP1201 750/10mg, Metformin SR 750mg, Rosuvastatin 10mg
- Where
- South Korea
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Hanmi Pharmaceutical Company Limited
Intrauterine Insemination
GnRH Agonist and Intrauterine Insemination
The aim of this study is to assess whether GnRH agonist administration in the luteal phase improves pregnancy outcome in intrauterine insemination (IUI) cycles.
- Trial name
- NCT00503217
- Testing
- Tryptorelin
- Where
- Spain
- Volunteers
- healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Measles, Rubella
Non-interference Study of MR and Yellow Fever Vaccines Among Bangladeshi Infants Aged 9-12 Months
This study will be conducted among 1530 healthy infants of 9 to 12 months of age residing in the Dakshinkhan and Uttarkhan area which is located in Dhaka North City Corporation (DNCC) to enroll the required number of…
- Conditions
- Measles, Rubella, Yellow Fever
- Trial name
- NCT06815835
- Testing
- Measles-Rubella vaccine (Live) I.P. (Freeze Dried) of M/s. Zydus Lifesciences Ltd, Yellow fever Vaccine (WHO prequalified)
- Where
- Bangladesh
- Volunteers
- 1,530 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Brain Injury Traumatic Mild
Spotting and Managing Adult Repeated Traumas in the Brain
Emerging evidence suggests that concussions (a type of mild traumatic brain injury; mTBIs) may cause chronic neurological disturbances with effects lasting beyond 20 years, changing brain structure and nearly doubling the risks…
- Trial name
- SMARTBRAIN (NCT07025317)
- Testing
- Perceptual-cognitive
- Where
- 3 sites in Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Université de Montréal
Anesthesia Effectiveness
Pain Perception During Inferior Alveolar Nerve Block Administration in Children Using Vibraject and Dental Vibe Versus Conventional Syringe
This RCT study aims to establish evidence based decision comparing between Vibraject (MiltexInc LLC.,York,PA,USA).and Dental vibe(BING Innovations LLC,Crystal Lake,IL,USA versus Conventional Syringe on pain perception during…
- Trial name
- NCT07571278
- Testing
- Vibraject, Dental vibe, Conventional syringe
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Cairo University
Gastroesophageal Reflux Disease (GERD)
Study to Assess Management Strategies for the Use of Esomeprazole (Nexium) in Helicobacter Pylori Infected Patients
The primary objective of this study is to investigate whether eradication treatment of Helicobacter pylori followed by therapy with esomeprazole for a total of 8 weeks extends the time to relapse in patients with gastroesophageal…
- Trial name
- NCT00574925
- Testing
- Esomeprazole
- Where
- Switzerland
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Zurich
Temporomandibular Disorders (TMD), Internal Derangement of the Tempromandibular Joint
Liquid Phase Concentrated Growth Factor Versus Conventional Arthrocentesis in Temporomandibular Disc Displacement
This study aims to rigorously assess the effectiveness of LPCGF in the management of internal disc displacement in patients with TMD through a randomized clinical trial.
- Conditions
- Temporomandibular Disorders (TMD), Internal Derangement of the Tempromandibular Joint, Anterior Disc Displacement
- Trial name
- LPCGF in TMDs (NCT07075276)
- Testing
- Liquid Phase Concentrated Growth Factor, Conventional arthrocentesis
- Where
- Egypt
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Horus University
Stress, Fatigue
A Clinical Trial to Evaluate the Effects of a Herbal Tincture on Energy Levels, Weight Management, and Markers of Metabolic Health
This study will evaluate the effects of the Blue Burn Tincture on energy levels, weight management, and markers of metabolic health. It is a single-arm, hybrid trial involving 40 participants over a 12-week period.
- Trial name
- NCT06949540
- Testing
- Blue Burn Tincture
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Apothekary
Melatonin, Pharmacokinetics
Pharmacokinetics of Intravenous, Rectal, Intravesical, Vaginal, and Transdermal Melatonin in Healthy Female Volunteers
We will investigate the safety and pharmacokinetics of melatonin, when administered rectally, intravesically, vaginally and transdermally. We will recruit 10 healthy female volunteers.
- Conditions
- Melatonin, Pharmacokinetics, Safety
- Trial name
- NCT03519750
- Testing
- Melatonin 25 mg
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Dennis Bregner Zetner
Atypical Hemolytic Uremic Syndrome
Complement Inhibition in aHUS Dialysis Patients
This study evaluates the effect of CCX168, a C5aR Antagonist, Oral Administration on Ex Vivo Thrombus Formation and Disease Activity in ten patients with diagnosis of Atypical Hemolytic Uremic Syndrome with or without genetic…
- Trial name
- ACCESS (NCT02464891)
- Testing
- CCX168
- Where
- Italy
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Mario Negri Institute for Pharmacological Research
Contraception
Investigation of Three Contraceptive Hormone Patches in Regard to Inhibition of Ovulation Following Application Over 3 Treatment Cycles in Healthy, Young Women.
The primary objective of this trial is to examine whether ovulation is suppressed after use of hormone patches containing different dosages of ethinyl estradiol (EE) and gestodene (GSD) for 3 treatment cycles.
- Trial name
- NCT01204190
- Testing
- Gestodene/EE Patch (BAY86-5016)
- Where
- 2 sites in Germany, Netherlands
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- Bayer
Transitions of Care, Patient Portals
Interactive Digital Health Tools to Improve Patient Safety in Acute Care
Study 1: The goal of this study is to implement and evaluate an interactive patient-centered discharge toolkit (PDTK) to engage patients and care partners in discharge preparation and communication with providers after discharge.
- Conditions
- Transitions of Care, Patient Portals, General Medicine, Discharge Checklist
- Trial name
- NCT03116074
- Testing
- Interactive Digital Health Tools
- Where
- United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Healthy Volunteers
Effect of Intragastric Administration of Fatty Acids on Generalized Reward Sensitivity
This study aim to investigate the influence of intragastrically infused fatty acid on the generalization of responses to reward within the food domain and between financial and sexual domains.
- Trial name
- NCT02984150
- Testing
- dodecanoic acid, saline
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Dry Eye Disease
Self-care Management Program for Dry Eye Disease Patients Using the heiQ
Dry Eye Disease (DED)is a chronic disease without a cure. Empowering patients to engage in better self-care requires knowledge of their disease and skills in self-management, which can lead to improved well-being and quality of…
- Trial name
- heiQ (NCT03467490)
- Testing
- DED self-management
- Where
- Canada
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Influenza
Assessment of CR8020, a Monoclonal Antibody Against Influenza A Viruses
The purpose of this study is to assess in healthy subjects the safety, tolerability, pharmacokinetics and immunogenicity of single escalating doses of CR8020, a monoclonal antibody against influenza A viruses.
- Trial name
- NCT01756950
- Testing
- 2 mg/kg CR8020, 5 mg/kg CR8020, 15 mg/kg CR8020
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Crucell Holland BV
Gestational Diabetes
Gestational Diabetes in Uganda and India Improving Screening and Self-management
This trial will evaluate a package of three interconnected educational/behavioural interventions aimed at: a) improving knowledge and skills of GDM guidelines and skills of health providers; b) raising awareness of importance of…
- Trial name
- GUIDES (NCT03937050)
- Testing
- Intervention
- Where
- 2 sites in India, Uganda
- Volunteers
- 16,500 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Idiopathic Scoliosis, Transfusion Reaction
Changes in Cerebral Oxygenation During the Administration of Cell Saver Blood and Allogeneic Blood
A prospective study designed to evaluate changes in tissue and cerebral oxygenation before and following administration of blood for patients undergoing spinal surgery.
- Trial name
- NCT02607150
- Testing
- Cerebral Oxygenation Changes
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital
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