Clinical trials: Management
Adrenal Incidentaloma, Subclinical Hypercortisolism
Evaluation of New Diagnostic Indicator of Subclinical Hypercortisolism
The purpose of this study is to evaluate the serum dehydroepiandrosterone sulfate in subclinical hypercortisolism
- Trial name
- NCT04833192
- Testing
- experimental group
- Where
- China
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Diabetes Mellitus, Type 2
A Research Study to See How Much Semaglutide and SNAC is in the Milk of Healthy, Breastfeeding Women Taking Semaglutide Tablets
Participants in the study, will receive the study drug once daily for 10 days in tablet form for oral (by mouth) intake. On day 1 to 5 the tablet will contain 3 mg semaglutide, and on day 6-10 the tablet will contain 7 mg…
- Trial name
- NCT04817644
- Testing
- Oral semaglutide
- Where
- 2 sites in United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Chronic Conditions, Multiple
Pharmacist and Family Medicine Physician Collaboration for Pre-Visit Planning and Team Huddles for CCM Patients
This is a novel project which incorporates clinic and community pharmacists in three aspects of the Patient-Centered Medical Home: pre-visit planning, pre-visit care team huddles, and chronic care management (CCM).
- Trial name
- NCT04342338
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Northeast Iowa Medical Education Foundation
Speech Sound Disorder
Beatboxing and Residual Speech Errors
This project will study the effect of practicing speech sounds via beatboxing on speech accuracy, engagement in therapy, and functional outcomes for older children and adolescents with speech sound disorders (SSDs).
- Trial name
- NCT03972449
- Testing
- BEAT-Speech, Traditional Articulation Approach
- Volunteers
- healthy volunteers welcome
- Sponsor
- Duquesne University
Mobility Limitation
Stepping-Up: Partnering With the Community to Prevent Early Mobility Decline
Preclinical mobility limitations (PCML) manifest early in the process of declining mobility, and are not typically identified or acted upon by clinicians.
- Trial name
- Stepping-Up (NCT04368949)
- Testing
- Stepping-Up, Telephone-Based Coaching Walking Program, Chair-Based Yoga Program
- Where
- Canada
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- McMaster University
Alcohol Use Disorder
Effect of Endotoxin on Alcohol Consumption
For this protocol, the investigators plan to collect pilot data to examine the effect of endotoxin on drinking behavior in the human laboratory.
- Trial name
- NCT04527185
- Testing
- Endotoxin
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Yale University
Abortion, Induced
Oral Mifepristone and Buccal Misoprostol Administered Simultaneously for Abortion Through 63 Days Gestation
HYPOTHESIS: For women with pregnancies at <49, 50-56, and 57-63 days gestation who receive mifepristone 200 mg orally and misoprostol 800 mcg buccally at the same time, the complete abortion rate 24 hours after misoprostol…
- Trial name
- NCT00330993
- Testing
- mifepristone, misoprostol
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
COVID-19
Ivermectin for Severe COVID-19 Management
In this multicenter study; it was aimed to investigate the effectiveness and safety of ivermectin use in the treatment of patients with severe COVID-19 pneumonia that have no mutations which alter ivermectin metabolism and cause…
- Trial name
- NCT04646109
- Testing
- Ivermectin
- Where
- 4 sites in Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Afyonkarahisar Health Sciences University
HIV-1-infection, Hepatic Impairment
Study to Evaluate the Safety and PK of Elpida® in Healthy Subjects and Patients With Hepatic Impairment and to Assess the Impact of Food Intake and Drug-Drug Interactions With Other Antiviral Drugs
This is open label, phase 1 clinical study to evaluate the safety, tolerability and pharmacokinetics of Elpida® in healthy subjects and patients with hepatic impairment (Child - Pugh Class А and B), as well as to assess the…
- Trial name
- NCT03706898
- Testing
- Elpida®, Dolutegravir, Sofosbuvir
- Where
- Russia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Viriom
Anger, Stress Disorders, Post-Traumatic
Remote Exercise for Learning Anger and Excitation Management
The immediate objective of this project was to demonstrate the feasibility of Remote Exercises for Learning Anger and Excitation Management (RELAX).
- Trial name
- RELAX (NCT02132793)
- Testing
- Anger Management Therapy, Anger Management Therapy & RELAX app
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- VA Pacific Islands Health Care System
Pharmacokinetics, Hormone Deficiency
Pharmacokinetics of a Novel Vaginal Delivery System for Testosterone and Dehydroepiandrosterone (DHEA)
This study was performed to determine the pharmacokinetic parameters of vaginal rings that contain DHEA, testosterone, or combinations of both androgens, in comparison to the oral administration of DHEA and the transdermal…
- Trial name
- NCT03967964
- Testing
- Dehydroepiandrosterone 2.2 g, Dehydroepiandrosterone 1.5 g/Testosterone 25 mg, Testosterone
- Where
- Chile
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Laboratorios Andromaco S.A.
Musculoskeletal Pain, Ankle Injuries
Video Aided Mindful Deep Breathing for Pain Management
Chronic ankle instability (CAI) is the most common musculoskeletal injury in sports and the rate of CAI accounts for 85% of ankle injuries.
- Conditions
- Musculoskeletal Pain, Ankle Injuries, Joint Instability
- Trial name
- NCT04812158
- Testing
- standard ankle physiotherapy or rehabilitation for chronic ankle instability
- Where
- Malaysia
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Universiti Tunku Abdul Rahman
Airway Management
Ultrasound Guided Versus Palpation Guided Cricothyrotomy With Poorly Defined Anatomical Landmarks
Inability to provide oxygen to the patient remains the most fearful anesthesia-related mishap. Cricothyrotomy (CT) is an infrequently performed but life saving procedure for an anesthesiologist, who is encountered with this…
- Trial name
- NCT01475487
- Testing
- Utrasound guided cricothyrotomy
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Type 2 Diabetes Mellitus (T2DM)
A Phase I Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Subcutaneous UBT38006 Injection in Healthy Adult Males
This study is a single-center, randomized, double-blind, placebo- and active-controlled, parallel-group, single-ascending dose (SAD) design.
- Trial name
- NCT07630233
- Testing
- UBT38006, Insulin Degludec Injection, Insulin Icodec Injection
- Where
- China
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- The United Bio-Technology (Hengqin) Co., Ltd.
HIV, Intravenous Substance Abuse
Implementing PrEP for Women Who Inject Drugs
Women who inject drugs are among the most vulnerable to acquiring HIV, but very few women who inject drugs are prescribed pre-exposure prophylaxis (PrEP) for HIV prevention largely due to barriers within our healthcare system.
- Conditions
- HIV, Intravenous Substance Abuse, Women's Health, Organization and Administration
- Trial name
- NCT05360849
- Testing
- Practice Facilitation
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Liver Diseases
Effect of Perioperative Sivelstat Administration for Liver Resection
It is reported that sivelstat improved and preserved the postoperative renal function in the orthopedic management. Moreover because sivelstat reduced the migration of neutrophil, it improved acute lung injury.
- Trial name
- KMS (NCT00738348)
- Testing
- sivelstat, glucose
- Where
- Japan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Kochi University
Brain Injuries, Stroke
Financial Coaching for Adults Living With Acquired Brain Injury
This pilot study will utilize a longitudinal concurrent mixed-methods research design that gathers and analyzes qualitative and quantitative data overtime about a new 10-session financial coaching program the investigators have…
- Trial name
- NCT06401655
- Testing
- Financial Coaching for People living with Acquired Brain Injury (FC-ABI)
- Where
- Canada
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Overdose Antidote
Naloxone Auto-injection in Healthy Volunteers
This study continues the work to develop a mobile breathing monitoring system to detect slowed breathing and overdose events caused by opioid use.
- Trial name
- NCT05099614
- Testing
- Naloxone hydrochloride injection solution, SmartDose wearable auto injector and mobile respiratory sensing system
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Washington
Renal Impairment, Renal Insufficiency
Elafibranor Pharmacokinetic Parameters in Renal Impaired Patients
This study is being conducted in order to assess the need for dose adjustment for elafibranor in participants with renal impairment.
- Conditions
- Renal Impairment, Renal Insufficiency, Kidney Diseases, Pharmacokinetics
- Trial name
- NCT03844555
- Testing
- Elafibranor
- Where
- 2 sites in France, Romania
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Genfit
Gingivitis
Efficacy Of Lotus Leaves In Management Of Plaque Induced Gingivitis
Due to difficulties in maintenance of an effective mechanical oral hygiene regime, effective chemical adjunctive measures will likely significantly contribute to overall oral health, the function of which should be to augment…
- Trial name
- NCT01956656
- Testing
- lotus leaf mouthwash
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sri Hasanamba Dental College and Hospital
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