Clinical trials: Management
Healthy
A Clinical Study to Explore Biomarkers for Drug-induced Liver Injury (DILI)
This study has an open-label, one-sequence, multiple drug administration design. The purpose of this study is as follows; To evaluate the change of liver function according to glutathione s-transferase (GST) genotype after the…
- Trial name
- NCT02143323
- Testing
- Augmentin tablet
- Where
- 2 sites in South Korea
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Pain, Postoperative
A Phase I Study to Evaluate the Safety and PK of ND-340 in Healthy Volunteers
This study focuses on ND-340 extended release injection suspension for healthy volunteers with a one-time nerve blockade to determine the safety, tolerability, and pharmacokinetic profile.
- Trial name
- NCT05588557
- Testing
- Marcaine® 100mg/20mL (0.5%) bupivacaine solution for Injection, ND-340 (Bupivacaine Microsphere), 300 mg/vial bupivacaine for extended-release injectable suspension
- Where
- Taiwan
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Nang Kuang Pharmaceutical Co., Ltd.
Chronic Idiopathic Constipation
This Study Aims to Evaluate the Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Properties and Food Effect of IN-114199 in Healthy Participants
This study aims to evaluate the safety, tolerability, pharmacokinetic and pharmacodynamic properties and food effect of IN-114199 in healthy participants
- Trial name
- NCT06736912
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- HK inno.N Corporation
Type 1 Diabetes Mellitus
The Effect of a Web-Based Education Program on Eating Habits, Metabolic Control, and Self-Management in Adolescents With Type 1 Diabetes Mellitus and Their Mothers With Irregular Eating Behavior
The study was planned as a randomized controlled experimental study to investigate the effects of a web-based educational program given to adolescents with diabetes mellitus and their mothers on eating habits, metabolic control…
- Trial name
- NCT07355660
- Testing
- Eating habits, Diabetes self-management, Metabolic control
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Airway Morbidity
What is the Gold Standard of Airway Management in the Anticipated Difficult Airway
A prospective Observationalstudie to analyze the current significance of the awake flexible endoscopy in German hospitals.
- Trial name
- FOI (NCT04158323)
- Testing
- Airway Management in patients with a anticipated difficult airway
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Johannes Gutenberg University Mainz
Neuropathic Pain
Efficacy and Safety of Pregabalin/Tramadol Combination Versus Pregabalin in Acute Pain of Neuropathic Origin
Phase IIIb confirmatory study of efficacy and safety, longitudinal, multicenter, randomized, double-blind study of the combination Pregabalin/Tramadol versus Pregabalin in the management of acute pain of neuropathic origin.
- Trial name
- LOBUXALIII (NCT05324059)
- Testing
- Pregabalin 75mg/ Tramadol 50 mg, Pregabalin 75mg
- Where
- Mexico
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Laboratorios Silanes S.A. de C.V.
Infertility, Female
Clinical Efficacy of Virtual Reality During Office Hysteroscopy and Endometrial Biopsy in Subfertility
This study is a comparison between the current standard practice of performing a diagnostic hysteroscopy and a relatively recently developed technology that is added to the standard diagnostic hysteroscopy.
- Trial name
- HYSVIR (NCT04438759)
- Testing
- Oncomfort, commercially available Virtual Reality headset
- Where
- Belgium
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Therapeutic Equivalency
Bioequivalence Study of Vigabatrin ORPHELIA Pharma 500mg Soluble Tablets and SabrilTM 500mg Granules for Oral Administration
Methodology: The study was an open label, randomized, crossover, 2 periods study in 20 healthy male/female volunteers. Subjects received 500 mg of the new formulation of soluble tablets vigabatrin or Sabril, as single oral…
- Trial name
- NCT04468282
- Testing
- VGB-ST
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Orphelia Pharma
Healthy Volunteer
A Study to Investigate the Pharmacokinetics, Tolerability and Safety of Two Different Dupilumab Drug Products in Healthy Participants
This is a phase 1, single subcutaneous dose study to evaluate safety and pharmacokinetics of 2 different dupilumab drug product in healthy volunteers. The duration per participant is up to 11 weeks.
- Trial name
- NCT05976360
- Testing
- Dupilumab (SAR231893)
- Where
- 2 sites in United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Sanofi
Mildly Hypercholesterolemic Subjects
Effects of Fermented Milk Product Enriched With Plant Sterols and Policosanols in Mild Hypercholesterolaemic Adults
The objective of this study is to investigate the effect of consumption of a low-fat, no added sugar, dairy fermented product enriched with plant sterols and policosanols at two doses, on LDL-cholesterol concentration in…
- Trial name
- NCT01571882
- Testing
- 1- Low fat drinkable fermented dairy product enriched with 1.6g of plant sterol (as free equivalent) + 10 mg of policosanols per unit, 2- Low fat drinkable fermented dairy product enriched with 1.6g of plant sterol (as free equivalent) + 20 mg of policosanols per unit, 3- Low fat drinkable fermented dairy product with 1.6g of plant sterol (as free equivalent) but without policosanols (Active control)
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Danone Global Research & Innovation Center
Healthy Aging
Adopting a Health-social Partnership Program to Promote Health and Self-care Management Among Older Adults in the Community
Hong Kong has notably the longest life expectancy in the world. Ever-increasing demand and challenges are posing to the healthcare, social welfare, and elderly care service system.
- Trial name
- NCT05621720
- Testing
- Case management, Social control call and usual are
- Where
- Hong Kong
- Volunteers
- 788 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Diabetes, Diabetes Mellitus
Phase 1 Study in Diabetes Mellitus(Fasting)
An open-label, randomized, fasting, single-dose, 2-sequence, 2-period, crossover phase 1 study in healthy volunteers.
- Trial name
- NCT06552182
- Testing
- HUC2-344, HUC2-344-R1, HUC2-344-R2
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Huons Co., Ltd.
Childhood Obesity, Family
FamCe-HLP- Family-centered Obesity Management Program in Primary Care Settings
This clinical trial aims to compare the adiposity and weight status among mother-child dyads with overweight or obesity who receive the Fam-Ce-HLP intervention with the mother-child dyads with overweight or obesity who did not…
- Conditions
- Childhood Obesity, Family, Behavior, Health, Lifestyle, Healthy
- Trial name
- NCT06394882
- Testing
- Family-Centered Healthy Lifestyle Program (FamCe-HLP)
- Where
- 4 sites in Oman
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Oman Ministry of Health
Healthy Male Volunteers
Drug Interaction Between CKD-501 and Metformin
The purpose of this study is to evaluate safety, tolerance by comparing availability and the pharmacokinetic drug interaction between the CKD-501 and metformin when administered alone and combination to healthy male volunteers.
- Trial name
- CKD-19HPS09H (NCT01005160)
- Testing
- Metformin, CKD-501
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Pediatric ALL, Cardiac Arrest
Effect of IAM With an I-gel® on Ventilation Parameters in Simulated Pediatric OHCA
Pediatric cardiac arrest occurs most in the prehospital setting. Most of them are due to respiratory failure (e.g., trauma, drowning, respiratory distress), where hypoxia leads to cardiac arrest.
- Conditions
- Pediatric ALL, Cardiac Arrest, Cardiopulmonary Arrest, Resuscitation
- Trial name
- NCT05498402
- Testing
- i-gel ® device, bag-valve-mask ventilation
- Where
- 4 sites in Switzerland
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Geneve TEAM Ambulances
Growth Failure, Adiposity
Optimal Growth of Preterm Infants With Growth Restriction
In this prospective randomized controlled multi center trial the investigators stratify "Very Low Birthweight " (VLBW)-infants with growth retardation in small for gestational age (SGA) or intrauterine growth restricted (IUGR) …
- Conditions
- Growth Failure, Adiposity, Diabetes, Neurologic Deficits
- Trial name
- OPTIGROW (NCT02999945)
- Testing
- SGA-enhanced nutrients, IUGR-enhanced nutrients, SGA-standard nutrients
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Healthy
Plasm Gastrin Concentrations in Response to Nexium Administration in Healthy Volunteers
This dose response study is proposed to explore the extent to which Nexium increases endogenous gastrin concentrations and to assess whether Nexium treatment may be useful in the setting of islet cell transplantation for type 1…
- Trial name
- NCT01135472
- Testing
- Esomeprazole Magnesium
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Neuropathic Pain
BreEStim Pre-trial
The overall goal is to evaluate the effectiveness of different stimulation protocol of a novel intervention - Breathing-controlled electrical stimulation (BreEStim) in managing neuropathic pain after spinal cord injury (SCI).
- Trial name
- NCT07878429
- Testing
- Single-pulse BreEStim Treatment, Multiple-pulse BreEStim Treatment
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Healthy Volunteers
A Study Evaluating the Effect of a Single-dose Oral Administration of Nemonoxacin Capsule on QTc Intervals and Heart Rhythms of Healthy Subjects and the Influence of Food Intake on QTc Intervals and Pharmacokinetic Characteristics
A randomized, single-center, placebo and positive control, 4-period and 4-crossover clinical study with the following main purposes: (1) To evaluate the effect of a single-dose oral administration of nemonoxacin malate capsule on…
- Trial name
- NCT03362853
- Testing
- Nemonoxacin 500Mg Capsule, Moxifloxacin 400Mg Tablet, Nemonoxacin 750Mg Capsule
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- TaiGen Biotechnology Co., Ltd.
Postoperative Blood Loss
Effect of Early Administration of TXA in Adult Hip Fractures
This is a prospective clinical study designed to assess blood loss in intracapsular and extracapsular hip fractures undergoing operative fixation at a Level II trauma center.
- Trial name
- NCT05047133
- Testing
- Tranexamic acid
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Ascension Health
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