Clinical trials: Management of Anticoagulation
Healthy
Evaluation of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamic Effects of PER977 Following Heparin
Normal subjects will receive unfractionated heparin followed by a single dose of PER977 with dose escalation by cohort. Ten subjects enrolled in Cohort 4 will receive a single dose of PER977 followed by a one-week washout and…
- Trial name
- NCT02206087
- Testing
- PER977, Heparin Sodium
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Perosphere Pharmaceuticals Inc, a wholly owned subsidiary of AMAG Pharmaceuticals, Inc.
Atrial Fibrillation, Anticoagulants
Application of "I-Anticoagulation"in Patients With Atrial Fibrillation
The goal of this prospective, multicenter, cluster randomized controlled trial is to assess the effectiveness of a shared decision-making tool, "I-Anticoagulation", for anticoagulation management in AF patients.
- Trial name
- NCT06137794
- Testing
- Use of "I-Anticoagulation" to make the decision and manage patients
- Volunteers
- 440 people
- Sponsor
- RenJi Hospital
Venous Thromboembolism
Remote Home Prothrombin Time (PT)/International Normalized Ratio (INR) Monitoring and Patient Management System
Long-term anticoagulation is indicated in patients for the prophylaxis and/or treatment of the thromboembolic complications associated with atrial fibrillation and/or mechanical cardiac valve replacement, prevention or treatment…
- Trial name
- vMetrics-AMS (NCT00978445)
- Testing
- vMetrics protocol
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- ZIN Technologies, Inc.
Atrial Fibrillation, Oral Anticoagulation
Management of Patients With Atrial Fibrillation Undergoing Coronary Artery Stenting
Treatment of patients suffering from atrial fibrillation pose problems when percutaneous coronary intervention with stent implantation (PCI-S) is performed.
- Conditions
- Atrial Fibrillation, Oral Anticoagulation, Percutaneous Coronary Intervention
- Trial name
- AFCAS (NCT00596570)
- Testing
- PCI
- Where
- Finland
- Volunteers
- 996 people
- Sponsor
- University of Turku
Thrombosis, Cancer
Safety of Perioperative Anticoagulation Management in People With Active Cancer Undergoing Cancer-Related Surgery or Procedures (ACE-HIGH Study)
The purpose of this study is to help find how safe current practices are when managing blood thinners in people with cancer who are having surgery or medical procedures.
- Conditions
- Thrombosis, Cancer, Thrombosis, Deep Vein, Atrial Fibrillation (AF)
- Trial name
- ACE-HIGH (NCT07372716)
- Testing
- standardized perioperative anticoagulation management Guideline
- Where
- Canada
- Volunteers
- 700 people
- Sponsor
- Ottawa Hospital Research Institute
Thromboembolism, Anticoagulant-induced Bleeding
Optimization of Management in Patients With Cardiovascular Disease After Lower Limb Joint Replacement
The goal of the study is to evaluate the frequency of cardiovascular and thromboembolic complications in patients with cardiovascular disease after lower limb joint replacement, the influence of known risk factors and strategies…
- Trial name
- NCT06627933
- Testing
- No intervention
- Where
- Russia
- Volunteers
- 1,733 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Acute Ischemic Stroke
Second Enhanced Control of Hypertension and Thrombectomy Stroke Study (ENCHANTED2)
ENCHANTED2 is an international, multicenter, prospective, randomised, open, blinded end-point assessed (PROBE) trial, to assess different approaches to manage blood pressure (BP) in acute ischemic stroke (AIS) patients who have…
- Trial name
- ENCHANTED2 (NCT04140110)
- Testing
- Intensive BP lowering
- Where
- China
- Volunteers
- 816 people
- Sponsor
- The George Institute for Global Health, China
Periprocedural Complication
Periprocedural Direct Oral Anticoagulant Management
Direct oral anticoagulants (DOAC) are a new drug group that has been approved for chronic anticoagulation of patients in atrial fibrillation or suffering acute thrombosis, between others.
- Trial name
- RA-ACOD (NCT03182218)
- Testing
- Direct oral anticoagulant
- Where
- 30 sites in Spain
- Volunteers
- 1,100 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Lung Transplantation, Extracorporeal Membrane Oxygenation (ECMO)
Prospective Observational Pilot Study of LMWH Versus UFH as ECMO Anticoagulation in Lung Transplantation
The aim of this observational pilot study is to evaluate the effectiveness and safety of low-molecular-weight heparin (LMWH) compared to unfractionated heparin (UFH) as anticoagulation in perioperative ECMO during bilateral lung…
- Conditions
- Lung Transplantation, Extracorporeal Membrane Oxygenation (ECMO), Anticoagulants and Bleeding Disorders
- Trial name
- LUX-ET-LT (NCT06868823)
- Where
- Czechia
- Volunteers
- 40 people
- Sponsor
- University Hospital, Motol
Anticoagulation, Mechanical Heart Valve Replacement
Choice of Valve Substitute in the Era of Oral Anticoagulation Self-Management
The optimal valve substitute for patients between 60-70 years is controversial. We compared anticoagulation-related adverse events (ARAE) in patients receiving mechanical heart valve replacement (MHVR) on INR self-management vs.
- Trial name
- NCT01269905
- Sponsor
- Johann Wolfgang Goethe University Hospital
Atrial Fibrillation, Venous Thromboembolism
Self-management of Anticoagulation Treatment
The aim of the study was to compare self-management of anticoagulant treatment with conventional anticoagulant treatment in Norway.
- Conditions
- Atrial Fibrillation, Venous Thromboembolism, Artificial Heart Valve
- Trial name
- NCT02864537
- Testing
- Training
- Volunteers
- 130 people
- Sponsor
- University of Bergen
Atrial Fibrillation
A Study to Quantify Use of Anticoagulation to Improve Management of Atrial Fibrillation
The purpose of this study is to evaluate the impact of a hospital quality improvement (QI) program on the use of guideline-recommended oral anticoagulants (OAC) in hospitalized patients with atrial fibrillation (AF) at risk for…
- Trial name
- QUANTUM AF (NCT03382613)
- Where
- 62 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- Janssen Scientific Affairs, LLC
Anticoagulation, Blood Thinners , Atrial Fibrillation, Bleeding, Stroke
Profile and Antithrombotic Management of Patients With NVAF Attending Internal Medicine Departments in Spain (PERFILAR Study)
This is a national, multicenter, cross-sectional, observational study within a convenience sample of Internal Medicine departments from 100 hospitals in Spain which agree to participate in the study.
- Trial name
- NCT02447341
- Where
- Spain
- Volunteers
- 987 people
- Sponsor
- Bristol-Myers Squibb
Hypoprothrombinemia
Randomized Controlled Feasibility Trial of the Fearon Algorithm to Improve Management of Unstable Warfarin
Patients on warfarin but with unstable international normalized ratio (INR) will be recruited to a randomized trial comparing dosing based on an algorithm (Fearon algorithm, named after the mathematician Michael Fearon), which…
- Trial name
- NCT02267408
- Testing
- Warfarin adjustment using the Fearon algorithm, Warfarin adjustment using standard dosing
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- McMaster University
Aortic Valve Disease
DIrect Oral Anticoagulation and Bioprothesis Aortic Valve
DIAMOND study is a national, multicentre, randomized, parallel-group, open label study in patients (aged ≥18 years) with aortic bioprosthesis (excluding TAVI) at least 7 days after cardiac surgery.
- Trial name
- DIAMOND (NCT05687448)
- Testing
- Apixaban 5 MG Oral Tablet, Aspirin 75 to 100mg once a day
- Where
- France
- Volunteers
- 1,500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Atrial Fibrillation, Venous Thromboembolism
Verification of XAPPORT: a Decision Support App for Physicians Used for Patients Anticoagulated With Rivaroxaban in Terms of Anticoagulation Management in Elective Surgery: Verification Process of Medical Decision Algorithm
This study shall determine whether XAPPORT - a mobile device app based on different guidelines, the summary of product characteristics of rivaroxaban, and clinical facts and practice - provides adequate guidance to physicians…
- Conditions
- Atrial Fibrillation, Venous Thromboembolism, Pulmonary Embolism
- Trial name
- VeriXAPPORT (NCT02900404)
- Testing
- XAPPORT, Expert Panel ("gold standard")
- Sponsor
- Bayer
Implantation of a Veno-arterial or Veno-venous ECMO
Thrombin Generation as a New Test for Anticoagulation Management in Patients With ECMO
ECMO (Extracorporeal Membrane Oxygenation) is a circulatory assistance device aiming at maintaining or restoring cardiopulmonary circulation.
- Trial name
- ECMOstase (NCT03832842)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Strasbourg, France
Renal Failure, Hemodialysis
OPG and RANKL Plasma Level After Administration of Unfractionated Heparin (UFH) and Low-Molecular-Weight Heparin (LMWH) in Hemodialysis
A randomised, prospective, cross over study will be done to determine whether the anticoagulation therapy with UFH or LMWH used for hemodialysis sessions modifies osteoprotegerin and RANKL plasma levels.
- Trial name
- NCT00669721
- Testing
- law molecular weigth heparin, unfractioned heparin
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Acute Necrotizing Pancreatitis, Portosplenomesenteric Venous Thrombosis
Acute Pancreatitis and Thrombosis (PATHRO)
Severe acute pancreatitis (AP) is a pathology with high morbidity and mortality. Portosplenomesenteric vein thrombosis is a well-known local complication of AP with a variable incidence, which can reach up to 50% in case of…
- Trial name
- PATHRO (NCT04642794)
- Testing
- observational study
- Where
- France
- Volunteers
- 51 people
- Sponsor
- Nantes University Hospital
Self Management of Oral Anticoagulation With VKA Therapy
Clinical Outcomes From Patient Self-management of Antivitamin K Treatment
ORION is a retrospective, observational, one center study to evaluate the incidence of complications (both thromboembolic and bleedings) in a cohort of patients receiving Vitamin K antagonists (VKA) under a self-management…
- Trial name
- ORION (NCT03532724)
- Testing
- Patient Self-Management of VKA therapy
- Where
- Spain
- Volunteers
- 927 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau