Clinical trials: Mandible; Deformity
Orthognathic Surgical Procedures, Three Dimensional (3D) Orthodontic Device
Accuracy of Three-Dimensional Soft Tissue Prediction Using Dolphin 3D Software in Patients With Mandibular Deformities Undergoing Orthognathic Surgery
This study aims to evaluate the accuracy of "Dolphin 3D" software for prediction of soft tissue changes in management of patients seeking orthognathic surgery to treat their mandibular deformities and collecting their feedback…
- Trial name
- NCT07557758
- Testing
- Dolphin 3D Software
- Where
- Egypt
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Missing Teeth
A Full-Arch Implant- Supported Prosthesis in the Upper and/or Lower Jaw-USA
This study follows subjects who have agreed with their dentist that their failing teeth or missing teeth all need replacing. This study follows their standard routine care with some additional assessments.
- Trial name
- NCT03655990
- Testing
- Treatment with the JUVORA™ Dental Disc
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Juvora Ltd.
Bilateral Complete Cleft Lip And/or Alveolus and Acrylic Splint, and, Maxillary Deficiency
Evaluating the Impact of Prefabricated Acrylic Splints on Premaxillary Stability in Alveolar Cleft Bone Graft Repairs: a Randomized Controlled Trial
Rationale for conducting the research: Bilateral alveolar clefts pose significant management challenges, with current treatments like autogenous bone grafting showing instability in up to 40% of cases within a year, risking graft…
- Conditions
- Bilateral Complete Cleft Lip And/or Alveolus and Acrylic Splint, and, Maxillary Deficiency, Stability
- Trial name
- RCT (NCT06807645)
- Testing
- Clinical Trial Intervention Description General Study Setup Objective: To compare the efficacy of using a custom-made prefabricated acrylic splint versus no splint in maintaining premaxillary stabilit
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Cairo University
Cherubism
Genetic and Functional Analysis of Cherubism
The goal of this research study is to identify genes and regulatory elements on chromosomes that cause cherubism. Together with the investigators collaborators the investigators also study blood samples and tissue samples from…
- Trial name
- CBM (NCT01630447)
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- UConn Health
Class III Malocclusion, Skeletal Malocclusion
Comparison of Skeletal Anchorage Versus Conventional Tooth-Borne Face Mask Therapy Following the Alt-RAMEC Protocol
This study investigated two different methods of maxillary protraction in growing patients with skeletal Class III malocclusion characterized by maxillary deficiency.
- Conditions
- Class III Malocclusion, Skeletal Malocclusion, Maxillary Deficiency
- Trial name
- MiniFM (NCT07279662)
- Testing
- Skeletal Anchorage Supported Maxillary Protraction, Tooth-Borne Maxillary Protraction Appliance
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Murat Kaan Erdem
Retrognathism, Prognathism
Pharmacological Treatment on the Recovery of Neurosensory Disturbance After Bilateral Sagittal Split Osteotomy
The bilateral sagittal split osteotomy (BSSO) of the mandible is one of the most used surgical techniques to achieve a harmonious jaw relation in the context of orthognathic surgery.
- Conditions
- Retrognathism, Prognathism, Orthognathic Surgery, Neurosensory Disorder
- Trial name
- NCT05536596
- Testing
- Orthognathic Surgery, Melatonin 10 MG Oral Tablet, Hydroxycobalamin
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Expansion of Maxillary Arch, Maxillary Hypoplasia
Dentoskeletal Changes Expansion Using Invisalign Versus Conventional Expander
Cbct evaluation of dentoskeletal changes after expansion using Invisalign versus conventional expander
- Trial name
- NCT05899530
- Testing
- Invisalign, Conventional expander
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Anterior Crossbite, Class III Malocclusion
Evaluation of the Treatment Effects of Tooth Borne Versus Bone-anchored Protraction Procedures in Class III Patients With Maxillary Deficiency
The aim of this prospective randomized controlled clinical study is to compare the effects of bone-anchored and tooth borne maxillary protraction on dentofacial structures in skeletal Class III patients.
- Conditions
- Anterior Crossbite, Class III Malocclusion, Maxillary Deficiency
- Trial name
- NCT04863404
- Testing
- Face mask with hybrid-hyrax, Face mask with conventional bonded RME
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Skin Laxity, Facial Aging
RESTRUCTURING THE MANDIBULAR ANGLE IN FACIAL AGING: A NOVEL TECNIQUE USING POLY-L-LACTIC ACID
Skin laxity is a common complaint among patients seeking aesthetic dermatological interventions, affecting the facial contour, especially in the mandibular angle, due to bone aging and the loss of tissue support in the lower…
- Trial name
- NCT06948045
- Testing
- PLLA application to the mandibular angle
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Doris Hexsel
Gingival Recession, Mucogingival Deformity - Insufficient Keratinized Tissue
Modified Coronally Advanced Tunnel for Mandibular Lingual Root Coverage
This study will follow adults who have gum recession on the tongue side of the lower teeth. Participants will receive a gum surgery called the Modified Coronally Advanced Tunnel technique with a connective tissue graft taken from…
- Trial name
- NCT07590960
- Testing
- Modified Coronally Advanced Tunnel with Connective Tissue Graft
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pittsburgh
Facial Asymmetry, Retrognathism
Efficacy of Intravenous Iron Therapy in Maintaining Hemoglobin Concentration on Patients Undergoing Bimaxillary Orthognathic Surgery
The aim of this study is to evaluate the effect of Intravenous iron isomaltoside on maintaining hemoglobin concentration in patients undergoing bimaxillary orthognathic surgery.
- Conditions
- Facial Asymmetry, Retrognathism, Prognathism
- Trial name
- NCT03094182
- Testing
- Iron Isomaltoside 1000, Normal saline
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Yonsei University
Prognathism, Retrognathism
Natural History of Craniofacial Anomalies and Developmental Growth Variants
Background: Some head and facial abnormalities are rare and present at birth. Others are more common, and may not show up until puberty. These conditions have different causes and characteristics.
- Conditions
- Prognathism, Retrognathism, Dentofacial Deformities
- Trial name
- NCT02639312
- Where
- United States
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Posterior Crossbite, Maxilla; Hypoplasia
Leaf Expander Versus Hyrax Expander in Mixed Dentition Patients With Posterior Crossbite.
Design: Two-arm parallel randomized clinical trial in mixed dentition (6-12 years). Arms: (1) 9 mm, 900 g leaf expander; (2) 9 mm Hyrax expander.
- Trial name
- NCT07301918
- Testing
- The Leaf expander, Hyrax expander
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Maxillary Hypoplasia, Cleft Lip Palate
Time and Type Dependent Evaluation of Different Techniques for Correction of Cleft Maxillary Hypoplasia
Maxillary hypoplasia in CLP deformities results from congenital reduction in midfacial growth and the effects of the surgical scar from CLP repair.Turvey et al.
- Conditions
- Maxillary Hypoplasia, Cleft Lip Palate, Orthognathic Surgery
- Trial name
- NCT06852196
- Testing
- orthognathic surgery ,lefort 1,bsso ,DO, distraction osteogenesis
- Volunteers
- 22 people
- Sponsor
- Assiut University
Opiate Addiction, Pregnancy
Pharmacologically-based Strategies for Opioid Substitution Therapy During Pregnancy
This study is a pharmacodynamic study in pregnant women evaluating the relationship between buprenorphine concentration and outcome such as opioid withdrawal symptoms , NAS scores, neurodevelopmental and neuroanatomic outcomes.
- Trial name
- NCT03831113
- Testing
- Magnitude Group, Frequency Group
- Where
- 2 sites in United States
- Volunteers
- 13 people
- Sponsor
- Steve N. Caritis, MD
Mandible Tumor, Mandibular Injuries
Evaluation of EpiBone-CMF for Mandibular Ramus Reconstruction
EpiBone-Craniomaxillofacial (EB-CMF) is an autologous, anatomically shaped bone graft created specifically for the patient's defect, using the patients own adipose-derived mesenchymal stem cells.
- Conditions
- Mandible Tumor, Mandibular Injuries, Mandible; Deformity
- Trial name
- EB-CMF (NCT03678467)
- Testing
- EB-CMF
- Where
- 3 sites in United States
- Volunteers
- 6 people
- Sponsor
- Epibone, Inc.
Maxillary Retrusion, Nasal Airway Obstruction
Evaluation of the Effect of Three Types of Rapid Maxillary Expanders (Conventional, Hybrid and MSE)
Aim of the study: To compare radiographically the morphometric changes in the nasal airway after using three types of rapid maxillary expansion (RME) conventional hyrax (CH), hybrid hyrax (HH) and maxillary skeletal expander…
- Trial name
- NCT05446714
- Testing
- CH 4 band, HH 2 bands, MSE 2 bands and 4
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Al-Azhar University
Mandibular Hypoplasia
Juvederm Voluma® XC for the Treatment of Hypoplastic Chin
This is a single center study of the safety and efficacy of Juvedérm Voluma for the treatment of hypognathism. Each qualified subject will undergo treatment with Juvedérm Voluma in the anterior and lateral chin for volume…
- Trial name
- VolumaChin (NCT02330016)
- Testing
- Voluma XC
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Kenneth Beer
Maxillary Deficiency
Maxillary Sinus Augmentation Via the "Bone Lid Technique"
Maxillary sinus augmentation is one of the most performed procedures to increase the bone quantity of the atrophic maxilla in order to allow implant placement.
- Trial name
- SINUSLID_2023 (NCT06222970)
- Testing
- Bone lid repositioning in course of sinus lift
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Pisa
Apnea, Airway Obstruction, Nasal
Upper Airway's Pressure Drop Analyses After Mandibular Advancement and Maxillary Expansion
Breathing is a crucial function for everyone. Breathing impairment in children could lead to behavioral and cognitive problems at least.
- Conditions
- Apnea, Airway Obstruction, Nasal, Mandible Small, Maxillary Hypoplasia
- Trial name
- NCT04190953
- Testing
- Twin block then Hyrax, Hyrax then Twin block
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Alberta