Clinical trials: Mandibular Advancement
Obstructive Sleep Apnea
Determinants of Tooth Movement in Oral Appliance Treatment of OSA.
Obstructive sleep apnea (OSA) is a sleep related breathing disorder, affecting approximately 10% of adults. Mandibular advancement oral appliances (OAM) are an effective treatment for OSA, however, long term use has shown to lead…
- Trial name
- TACO (NCT03341130)
- Testing
- Mandibular Repositioning Splint, Mandibular Advancement Oral Appliance
- Where
- Canada
- Volunteers
- 105 people
- Sponsor
- University of British Columbia
Obstructive Sleep Apnea
Safety Monitoring for a Novel 3D Printed Mandibular Advancement Device
The purpose of this study is to evaluate the safety profile of the novel oral appliance (OA )device and to assess patient comfort of the novel OA device.
- Trial name
- NCT05018234
- Testing
- Noval Oral Appliance
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Obstructive Sleep Apnea Syndrome
Predictive Factors for Occlusal Changes in Obstructive Sleep Apnea Treatment With Mandibular Advancement Appliance
This research addresses obstructive sleep apnea syndrome (OSAS), affecting 6-12% of French adults, often treated with mandibular advancement devices (MADs).
- Trial name
- APNEAMOUVE (NCT06576310)
- Testing
- Mandibular Advancement Device
- Where
- France
- Volunteers
- 118 people
- Sponsor
- University Hospital, Toulouse
Sleep Apnea Syndromes, Atherosclerosis
The Influence of Mandibular Advancement Device Treating OSAHS on Primary Prevention of Ischemic Stroke
1. The purpose of this study is to detect the differences of carotid atherosclerosis severity between patients with or without OSAHS(Obstructive Sleep Apnea and Hypopnea Syndrome) in a cross-sectional study in a large sample. 2.
- Conditions
- Sleep Apnea Syndromes, Atherosclerosis, Carotid Plaque
- Trial name
- NCT03665818
- Testing
- oral appliance treatment
- Volunteers
- 100 people
- Sponsor
- Xuanwu Hospital, Beijing
Sleep Apnea, Obstructive, Apnea, Obstructive
Efficacy of a Novel MAD in OSA
Oral appliances (OA) have emerged as an alternative to continuous positive airway pressure (CPAP) for obstructive sleep apnea (OSA) treatment.
- Conditions
- Sleep Apnea, Obstructive, Apnea, Obstructive, OSA, OSAH
- Trial name
- BVL Project (NCT03196583)
- Testing
- Velo-Lingual Bite (BVL)
- Where
- Switzerland
- Volunteers
- 21 people
- Sponsor
- Mauro Manconi
Class II Malocclusion, Mandibular Retrognathism
Comparison Of The Effects Of Clear Aligners And Twinblock Appliances In Functional Treatment Of Class II Malocclusion
This prospective clinical study aimed to compare the skeletal and dentofacial effects of Twin Block (TWB) and clear aligners with mandibular advancement, and to evaluate mandibular trabecular bone changes through fractal analysis…
- Trial name
- NCT07454694
- Testing
- Invisalign Clear Aligners, Twinblock Functional Appliance
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Bezmialem Vakif University
Sleep Apnea, Obstructive
Mandibular Advancement Device on Sleep Quality in Obstructive Sleep Apnea Patients
Sleep is an important factor that influences long-term quality of life with known health consequences. Obstructive sleep apnea, the most prevalent disease that disturbs sleep, is considered a public health problem.
- Trial name
- DAMOSA (NCT06169228)
- Testing
- mandibular advancement
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Obstructive Sleep Apnea (OSA), Mandibular Advancement Device
Clinial Study of Treatment With Mandibular Advancement Device in Patients With Obstructive Sleep Apnea Across 6 General Hospitals
Study Objectives: To retrospectively study mandibular advancement treatment efficacy using apnea-hypopnea index (AHI) and oxygen desaturation index (ODI), in a large cohort of patients, in 'real world' settings across 6 general…
- Trial name
- RACEMADT (NCT06837285)
- Testing
- mandibular advancement device
- Where
- 6 sites in Belgium
- Volunteers
- 182 people
- Sponsor
- University Hospital, Antwerp
Mandibular Advancement
Sensory Re-Training Following Facial Surgery for Correction of Facial Skeletal Disharmony
The purpose of this study is to determine whether facial exercises in conjunction with opening exercises routinely provided after facial surgery to correct a facial skeletal disharmony will shorten the time until a patient…
- Trial name
- NCT00078507
- Testing
- Sensory Re-training, Sensory Retraining, Opening Exercises
- Where
- 2 sites in United States
- Volunteers
- 186 people
- Sponsor
- University of North Carolina, Chapel Hill
Obstructive Sleep Apnea
Severe Label Expansion for EVO Products Trial
Title: Severe Label Expansion for EVO Positioner (SLEEP) Study Description: Single-arm study to determine the safety and effectiveness of treating severe obstructive sleep apnea using the EVO Sleep and Snore Device (ProSomnus…
- Trial name
- SLEEP (NCT07090395)
- Testing
- EVO Sleep and Snore Device
- Where
- 2 sites in United States
- Volunteers
- 49 people
- Sponsor
- ProSomnus Sleep Technologies
Obstructive Sleep Apnea
Implant Supported Oral Appliance Treatment of OSA
Mandibular advancing oral appliances (OAm) are an effective and increasingly common treatment modality for the management of obstructive sleep apnea (OSA) in adults.
- Trial name
- BIMA (NCT03362671)
- Testing
- Implant Supported Mandibular Advancement Oral Appliance, Orthodontic Mini Implant
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- University of British Columbia
Sleep Apnea, Snoring
Substantial Equivalence of iSlpr™ and SomnoDent® Classic in the Treatment of Snoring and Mild to Moderate Sleep Apnoea.
The study is a thirty three week, prospective, open-label, randomized, parallel-group non-inferiority study. The study aims to investigate the Substantial Equivalence of a novel mandibular device called iSlpr™, produced by…
- Trial name
- NCT04250584
- Testing
- iSlpr™, SomnoDent® Classic
- Volunteers
- 66 people
- Sponsor
- BioAnalytics Holdings Pty Ltd
Obstructive Sleep Apnea Syndrome
Fast Titration of Oral Appliance at Obstructive Sleep Apnea Syndrome (OSAS) Treatment
The literature does not discuss if the fast oral appliance titration (30 days period) in Obstructive Sleep Apnea Syndrome (OSAS) treatment, may improve subjects quality of life in such brief period.
- Trial name
- NCT01315535
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- Associacao Fundo de Incentivo a Psicofarmcologia
Skeletal Malocclusion
Comparison Between Aesthetic Functional Appliances and Twin Block in Correction of Skeletal Class II
The goal of this is to evaluate the skeletal, dental and soft tissue effects between aesthetic functional appliance and Twin block appliance in treatment of skeletal class II in ( growing male/female patients)
- Trial name
- NCT06631235
- Testing
- orthopedic appliance, aesthetic orthopedic appliance
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Mansoura University
Obstructive Sleep Apnea (OSAS), Obstructive Sleep Apnea (SAOS)
Home-based Under Mattress Monitor for OSA
The aim of the study is to evaluate the effectiveness of the under-mattress monitoring device to aid in the titration process of a mandibular advancement device (MAD) for the management of obstructive sleep apnea (OSA).
- Trial name
- NCT07186725
- Testing
- Under-mattress monitor, level 3 Home Sleep Apnea Test, Mandibular Advancement Device (MAD)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Isabel Moreno Hay
Obstructive Sleep Apnea
Reducing Obstructive Sleep Apnea After Hypoglossal Nerve Stimulation Through Mandibular Advancement
The purpose of this study is to evaluate the effectiveness, feasibility, and safety of mandibular advancement devices (MAD) for treating severe obstructive sleep apnea (OSA) in patients who are CPAP intolerant and have failed…
- Trial name
- ROHMA (NCT07132307)
- Testing
- Mandibular advancement device (MAD)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Washington University School of Medicine
Malocclusion Class II
Comparison Between Mandibular Advancement With Aligners and Twin Block in Class II Malocclusion in Growing Patients
To analyze mandibular advancement between the traditional Twin Block and the Angel Aligner A6 mandibular advancement clear aligners using cephalometric analysis in growing patients and a repeatable and reproducible digital…
- Trial name
- NCT07591025
- Testing
- AngelAligner A6 Mandibular Advancer, Twin Block, Clear aligners
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- University of Salamanca
Sleep Apnea
Phenotypic Characteristics of Responders to Obstructive Sleep Apnea Treatment Using Mandibular Advancement Devices
Currently, mandibular advancement devices (MAD) are recommended by the American Academy of Sleep Medicine (AASM) as the first treatment a line in cases of mild and moderate OSAS in patients without severe cardiovascular…
- Trial name
- NCT05596825
- Testing
- Mandibular Advancement Device
- Volunteers
- 75 people
- Sponsor
- University of Valencia
Obstructive Sleep Apnea
Effectiveness of NOA OATMAD
This study is looking at how well the OrthoApnea NOA appliance, a special custom-made mouthpiece, helps treat people with obstructive sleep apnea (OSA).
- Trial name
- NCT07111962
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- University of Alberta
Obstructive Sleep Apnea
The Effect of Mandibular Advancement Devices on Markers of Cardiovascular Health in Obstructive Sleep Apnea Patients
Obstructive sleep apnea (OSA) is a type of disordered breathing defined by the repetitive obstruction of airflow during sleep due to upper airway collapse. Each obstructive event contributes to decreased blood oxygen, or hypoxia.
- Trial name
- NCT05387122
- Testing
- mandibular advancement device (MAD)
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- University of Alberta