Clinical trials: Mandibular Deficiency
Mandibular Hypoplasia, Relapse
Evaluation of Early Relapse After Mandibular Lengthening Surgery
The goal of this study is to evaluate whether the use of a bone graft substitute at the osteotomy site will result in better stability and diminish early relapse after mandibular lengthening surgery.
- Trial name
- NCT03710512
- Testing
- Bilateral sagittal split osteotomy
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Universitair Ziekenhuis Brussel
Class III Malocclusion in Growing Patients
Changes Following the Treatment of Lower Jaw Protrusion Using Two Appliances
An in vivo study evaluating the efficacy of the Tandem appliance in the treatment of maxillary deficiency in growing patients compared to the conventional facemask appliance treatment.
- Trial name
- NCT02144324
- Testing
- Tandem Appliance
- Where
- Syria
- Volunteers
- 30 people
- Sponsor
- Damascus University
Mandible Small
Augmentation of Atrophic Mandibule Using Poly Ether Ether Ketone Mesh
Comparative study between custom-made polyether ether ketone and titanium mesh for augmentation of atrophic posterior mandible.
- Trial name
- RCT (NCT04017117)
- Testing
- under local anasthesia,Ridge Augmention of posterior atrophic mandible by using mix of autogenous bone graft and bone substitutes is used under PEEK mesh
- Where
- Egypt
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Cairo University
Palatal Expansion Technique, Cleft Lip and Palate
MARPE in Patients With Cleft Lip and Palate
The objective of this randomized controlled study will be to evaluate the dental and skeletal effects of maxillary protraction with a facemask, associated with MARPE and Class III elastics in patients with unilateral cleft lip…
- Conditions
- Palatal Expansion Technique, Cleft Lip and Palate, Class III Malocclusion, Skeletal Malocclusion
- Trial name
- NCT04354116
- Testing
- Rapid maxillary expansion, Maxillary Protraction
- Where
- Brazil
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Pontifícia Universidade Católica de Minas Gerais
Dental Malocclusion, Maxillary Deficiency
Effect on Periodontal Phenotype of Flapless Piezoincission During Orthodontic Treatment
Research Question While the reduction in treatment times and the patient satisfaction after periodontally accelerated osteogenic orthodontics (PAOO) are well sustained in the scientific literature, there is still controversy…
- Trial name
- Piezo_Ortho (NCT06315348)
- Testing
- flapless alveolar decortication with augmentation
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Universidad Complutense de Madrid
Malocclusion, Angle Class II
Effect of Skeletally Anchored Herbst Appliance in Treatment of Skeletal Class 2 Due to Mandibular Retrusion
Ten adolescent female patients with Class 2 mandibular deficiency with a mean age of 16.5 ±1.71 years treated with type IV Herbst appliance.
- Trial name
- NCT04388046
- Testing
- Herbst fixed functional appliance
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Khaled ELHabbak
Orofacial Myofunctional Disorders, Myo Munchee
Trial to Compare the Effects of Myo Munchee Therapy and Oral Motor Therapy (OMT) in Pediatric Patients to Treat Maxillary Deficiency and Orofacial Myofunctional Dysfunction (OMD).
Multi-center, 6-month, randomized, and controlled trial to compare the effects of Myo Munchee therapy and Oral Motor Therapy (OMT) in pediatric patients (aged 3-5 years) to treat maxillary deficiency and orofacial myofunctional…
- Conditions
- Orofacial Myofunctional Disorders, Myo Munchee, Oral Motor Therapy, Maxillary Deficiency
- Trial name
- NCT07088055
- Testing
- Chewing device only, Myo Munchee and Oral Motor Therapy Treatment, Oral Motor Therapy Treatment Arm
- Where
- 2 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Myo Munchee (Operations) Pty Ltd
Mandibular Retrognathia
The Effect of Mandibular Advancement With Clear Aligners on Maxillary and Mandibular Volumes
The aim of this study is to compare the effectiveness of two different orthodontic treatment methods used in patients with skeletal Class II malocclusion, a condition in which the lower jaw is positioned backward.
- Trial name
- NCT07056829
- Testing
- Mandibular Advancement Appliance (Invisalign MA), Activator Appliance
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people
- Sponsor
- Batman University
Angle Class II, Division 1
Skeletally Versus Dentally Anchored Herbst Appliance
The treatment of skeletal Class II malocclusion can be carried out through different approaches. One of these is the using of Fixed Functional Appliances (FFA), one of main drawbacks of these appliances is the proclination of the…
- Trial name
- NCT04402164
- Testing
- Herbst appliance
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Malocclusion, Anxiety
Patient Education Before Orthognathic Surgery
To evaluate the effectiveness in the use of an educational material through: Assessment of knowledge about post-operative orthognathic surgery; assessing levels of anxiety with the survey of Anxiety Inventory-STATE-TRAIT…
- Conditions
- Malocclusion, Anxiety, Micrognathism, Prognathism
- Trial name
- NCT01803204
- Testing
- Booklet - Preoperative Educational
- Where
- Brazil
- Volunteers
- 48 people
- Sponsor
- University of Sao Paulo
Class III Malocclusion, Skeletal Malocclusion
Comparison of Skeletal Anchorage Versus Conventional Tooth-Borne Face Mask Therapy Following the Alt-RAMEC Protocol
This study investigated two different methods of maxillary protraction in growing patients with skeletal Class III malocclusion characterized by maxillary deficiency.
- Conditions
- Class III Malocclusion, Skeletal Malocclusion, Maxillary Deficiency
- Trial name
- MiniFM (NCT07279662)
- Testing
- Skeletal Anchorage Supported Maxillary Protraction, Tooth-Borne Maxillary Protraction Appliance
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Murat Kaan Erdem
Benign Thoroid Disease Requiring Total Thyroidectomy
Clinical Trial on Harmonic Focus Shears Versus Ligasure Small Jaw and Clamp-and-tie Technique for Total Thyroidectomy
The Harmonic Focus and Ligasure small-Jaw are the last device designed for thyroid surgery. The aim is to assess: 1. decrease of operative time (minutes); 2. decrease of post-operative blood loss (milliliters); 3.
- Trial name
- NCT01649154
- Testing
- Total Thyroidectomy with cut and tie technique vs Total Thyroidectomy with Ligasure Small-JAW vs Total Thyroidectomy with Harmonic Focus
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Ospedale Regina Apostolorum
Deficiency of Alveolar Ridge (Disorder), Alveolar Bone Grafting
Safety and Efficacy Evaluation of the Ivory Dentin Graft Device
Ivory Dentin Graft is at least as good as the competitor treatment group (OsteoBiol Gen Os) for alveolar ridge preservation following tooth extraction.
- Conditions
- Deficiency of Alveolar Ridge (Disorder), Alveolar Bone Grafting, Mandibular Prosthesis User
- Trial name
- IvoryGraft (NCT03150472)
- Testing
- Graft Matrix
- Where
- Israel
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Ivory Graft Ltd.
Peri-implant Soft Tissue Deficiency, Partial Edentulism
Soft Tissue Augmentation Around Dental Implants Using Connective Tissue Graft, Submerged Tenting Abutment, or Sub-crestal Implant Placement
Peri-implant soft tissue thickness is an important determinant of the long-term stability and success of dental implants. Patients with a thin peri-implant soft tissue phenotype are at increased risk of soft tissue recession…
- Conditions
- Peri-implant Soft Tissue Deficiency, Partial Edentulism, Tooth Loss
- Trial name
- NCT07714265
- Testing
- subepithelial connective tissue graft, Submerged Tenting Abutment, Sub-crestal Implant Placement
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Misr International University
Micrognathia of Lower Jaw, Retrognathism
Comparison Between Internal and External Distractors in Osteogenesis
Distraction osteogenesis is a powerful technique for creating new bone during significant lengthening of the mandible without the need for bone grafting and associated donor site morbidity.
- Conditions
- Micrognathia of Lower Jaw, Retrognathism, Facial Asymmetry
- Trial name
- NCT03540329
- Testing
- Internal Osteogenesis distractor, External Osteogenesis distractor
- Volunteers
- 30 people
- Sponsor
- Assiut University
Cleft Palate, Cleft Lip
Perioperative Respiratory Adverse Events in Cleft Lip and Palate Surgery: Incidence, Risk Factors, and Clinical Scoring
Cleft lip and palate surgeries present unique anesthetic challenges due to shared airway access with the surgical field, frequent anatomical abnormalities, and a predominantly infant and toddler population.
- Conditions
- Cleft Palate, Cleft Lip, Laryngospasm, Bronchospasm
- Trial name
- NCT07651904
- Testing
- Standard General Anesthesia per Institutional Protocol
- Volunteers
- 150 people
- Sponsor
- Marmara University Pendik Training and Research Hospital
Malocclusion, Maxillar Hypoplasia
Comparison of 2 Techniques of Surgically Assisted Rapid Maxillary Expansion
This study evaluates 2 Techniques of Surgically Assisted Rapid Maxillary Expansion (SARME) in the treatment of maxillary transverse deficiency.
- Conditions
- Malocclusion, Maxillar Hypoplasia, Transverse Maxillary Deficiency
- Trial name
- SARME (NCT03503448)
- Testing
- Osteotomy between the maxillary central incisors, Osteotomy between the maxillary lateral incisors and canines
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario Pedro Ernesto
Opiate Addiction, Pregnancy
Pharmacologically-based Strategies for Opioid Substitution Therapy During Pregnancy
This study is a pharmacodynamic study in pregnant women evaluating the relationship between buprenorphine concentration and outcome such as opioid withdrawal symptoms , NAS scores, neurodevelopmental and neuroanatomic outcomes.
- Trial name
- NCT03831113
- Testing
- Magnitude Group, Frequency Group
- Where
- 2 sites in United States
- Volunteers
- 13 people
- Sponsor
- Steve N. Caritis, MD
Bilateral Complete Cleft Lip And/or Alveolus and Acrylic Splint, and, Maxillary Deficiency
Evaluating the Impact of Prefabricated Acrylic Splints on Premaxillary Stability in Alveolar Cleft Bone Graft Repairs: a Randomized Controlled Trial
Rationale for conducting the research: Bilateral alveolar clefts pose significant management challenges, with current treatments like autogenous bone grafting showing instability in up to 40% of cases within a year, risking graft…
- Conditions
- Bilateral Complete Cleft Lip And/or Alveolus and Acrylic Splint, and, Maxillary Deficiency, Stability
- Trial name
- RCT (NCT06807645)
- Testing
- Clinical Trial Intervention Description General Study Setup Objective: To compare the efficacy of using a custom-made prefabricated acrylic splint versus no splint in maintaining premaxillary stabilit
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Cairo University
Craniofacial Abnormalities, Mandibular Hypoplasia
Dexmedetomidine Versus Sevoflurane in Children With Anticipated Difficult Intubation
difficult problem in the paediatric age group because of their small mouth opening and un-cooperativeness.Currently used methods of sedation for fibreoptic intubation such as benzodiazepines, propofol or opioids may cause…
- Trial name
- NCT04426552
- Testing
- dexmedetomidine, sevoflurane
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Alexandria University