Clinical trials: Marfan Syndrome
Marfan Syndrome
Marfan Syndrome Moderate Exercise Trial II
Marfan syndrome (MFS) is a distinctive connective tissue disorder that affects multiple organ systems including the heart, bones, ligaments, and eyes, and is associated with significant risk of aortic dissection.
- Trial name
- NCT05809323
- Testing
- Exercise Intervention Group, Control Group
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Baylor College of Medicine
Marfan Syndrome
Adapted Physical Activity Program (APA) for Effort Rehabilitation of Children and Teenagers With Marfan Syndrome
This research study aims to evaluate the effect of a 6-month adapted physical activity program (APA) on the endurance capacities (evaluated as the maximum oxygen consumption [VO2 peak] on a cardiopulmonary exercise test) of…
- Trial name
- M&M's (NCT05838235)
- Testing
- Adapted Physical Activity program
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Toulouse
Chronic Pain, Marfan Syndrome
Single-Session "Empowered Relief" Class for Marfan Syndrome and Related Conditions
Empowered Relief (ER) is a 1-session pain relief skills intervention that is delivered in-person or online by certified clinicians to groups of patients with acute or chronic pain.
- Conditions
- Chronic Pain, Marfan Syndrome, Vascular Ehlers-Danlos Syndrome, Loeys-Dietz Syndrome
- Trial name
- NCT05980104
- Testing
- Empowered Relief
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Stanford University
PCOS, Insulin Resistance
Myoinositol Treatment and Asprosin Levels in PCOS
Policystic ovary syndrome is the most common endocrinopthy during reproductive period. One of the factors implicated in the pathogenesis is insulin resistance.
- Trial name
- NCT05951309
- Testing
- inofolic combi, Glucophage 500Mg Tablet
- Where
- Cyprus
- Volunteers
- 30 people
- Sponsor
- Near East University, Turkey
Marfan Syndrome
Effects of Losartan Versus Atenolol on Aortic and Cardiac Muscle Stiffness in Adults With Marfan Syndrome
Marfan syndrome is an inherited connective tissue disorder with morbidity and mortality from aortic dilation and dissection. The degree of aortic dilation and response to beta-blockade (standard of care) vary in adults with…
- Trial name
- NCT00723801
- Testing
- Atenolol, Losartan
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Brigham and Women's Hospital
Marfan Syndrome, Marfan Syndrome Cardiovascular Manifestations
Mortality and Morbidity Outcomes in Marfans
Marfan Syndrome (MFS) is a genetic disease affecting the eyes, skeleton, heart and arteries. Despite MFS affecting multiple organ systems, cardiovascular manifestations are the most serious and life threatening.
- Trial name
- NCT04774172
- Where
- United Kingdom
- Volunteers
- 6,700 people
- Sponsor
- Barts & The London NHS Trust
Aortic Diseases, Aortic Dissection
Proximal Aortopathy in Scotland - Epidemiology and Surgical Outcomes
The aorta is the principal arterial vessel arising from the left heart that transfers blood to the body. Certain genetic and familial disease processes are known to weaken the aortic wall resulting in dilation and potential…
- Conditions
- Aortic Diseases, Aortic Dissection, Aortic Aneurysm, Thoracic, Aortic Ectasia
- Trial name
- NCT05389865
- Testing
- Surgery on the proximal aorta (aortic root +/- ascending aorta), Patients diagnosed with thoracic aortopathy but not operated upon
- Where
- United Kingdom
- Volunteers
- 1,662 people
- Sponsor
- Golden Jubilee National Hospital
Marfan Syndrome
Children and Adolescents With Marfan Syndrome: 10,000 Healthy Steps and Beyond
Marfan patients are at risk of sudden death due to weakening of the wall of the large blood vessel leading from the heart (aorta).
- Trial name
- NCT03567460
- Testing
- Exercise
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Stanford University
Rare Diseases, Fatigue
Fatigue, Depressive Disorders and Insomnia in Adult Patients with Marfan Syndrome and Ehlers-Danlos Syndrome: Survey
The goal of this observational study is to describe and assess the presence of perceived fatigue in subjects with MFS and EDS. the main question it aims to answer through the FSS instrument is: The relationship of fatigue with…
- Conditions
- Rare Diseases, Fatigue, Insomnia, Depression
- Trial name
- FAMED (NCT05712564)
- Testing
- Questionnaire
- Where
- Italy
- Volunteers
- 282 people
- Sponsor
- IRCCS Policlinico S. Donato
Periodontitis, Periodontal Health
Asprosin Level in Individuals With Periodontal Disease
The aim of this study was to investigate the levels of asprosin hormone and tumour necrosis factor alpha (TNF-α) in gingival crevicular fluids and to compare its level with those in saliva and serum in patients with gingivitis…
- Conditions
- Periodontitis, Periodontal Health, Gingivitis
- Trial name
- ALIGCF (NCT06627972)
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Mustafa Kemal University
Marfan Syndrome
APPLICATION OF THERAPEUTIC PHOTOGRAPHY AND EXPRESSIVE WRITING IN THE MANAGEMENT OF PATIENTS WITH MARFAN SYNDROME
This study explores the efficacy of therapeutic photography and expressive writing as interventions in routine practice for patients with Marfan syndrome.
- Trial name
- FOTOTEMA (NCT06872268)
- Testing
- Therapeutic photography and expressive writing, Expressive writing
- Where
- Italy
- Volunteers
- 8 people
- Sponsor
- IRCCS Policlinico S. Donato
Marfan Syndrome, Marfan's Syndrome With Cardiovascular Manifestations
Transcriptomic Study of Adult Population With Marfan Syndrome
This project is designed to discover circulating biomarkers for aortic aneurysms in adults affected by Marfan Syndrome (MFS). The first aim is to identify circulating transcripts, protein-coding (mRNA) and not (ncRNAs), which…
- Trial name
- MaRfaNomicA (NCT05700175)
- Testing
- Transcriptomic, epigenetic and proteomic analysis
- Where
- Italy
- Volunteers
- 99 people
- Sponsor
- IRCCS Policlinico S. Donato
Behcet Disease
Asprosin in Behect Patients
This study aims to investigate serum Asprosin concentrations in patients with BD and their relationship with disease activity and major clinical manifestations.
- Trial name
- NCT07803198
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Assiut University
Ehlers-Danlos Syndrome, Stickler Syndrome
Studies of Heritable Disorders of Connective Tissue
Background: Heritable disorders of connective tissue are genetic conditions that can affect the skin and other parts of the body. They are related to mutations in genes that are responsible for building tissues.
- Conditions
- Ehlers-Danlos Syndrome, Stickler Syndrome, Marfan Syndrome
- Trial name
- NCT00270686
- Where
- United States
- Volunteers
- 929 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Marfan Syndrome, Marfan Related Disorders
Development of a Blood Test for Marfan Syndrome
The objective of this study is to determine whether a simple blood test can be a useful clinical tool for monitoring aortic disease in Marfan syndrome and Marfan-related disorders.
- Conditions
- Marfan Syndrome, Marfan Related Disorders, Control Subjects
- Trial name
- NCT02148900
- Where
- 5 sites in United States
- Volunteers
- 336 people, healthy volunteers welcome
- Sponsor
- Shriners Hospitals for Children
Sleep-disordered Breathing, Snoring
Hemodynamics Response to Upper Airway Obstruction in Marfan Syndrome
Upper airway obstruction (UAO) is an unrecognized source of hemodynamic stress that may contribute to aortic adverse events in persons with Marfan Syndrome (MFS).
- Trial name
- MSB (NCT03985657)
- Testing
- CPAP
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Marfan Syndrome
Angiotensin Converting Enzyme Inhibitors in Marfan Syndrome
The purpose of this research is to assess the effects of a drug called perindopril on the aorta in people known to have Marfan Syndrome.
- Trial name
- NCT00485368
- Testing
- Coversyl (perindopril)
- Volunteers
- 17 people
- Sponsor
- Bayside Health
Marfan Syndrome
Nebivolol Versus Losartan Versus Nebivolol+Losartan Against Aortic Root Dilation in Genotyped Marfan Patients
The major clinical problems in patients with Marfan Syndrome (MFS) are aortic root dilation (ARD), dissection and rupture. Although the available treatments (beta-blockers, BBs) improve the evolution of the disease, they do not…
- Trial name
- MaNeLo (NCT00683124)
- Testing
- Losartan and nebivolol, Losartan, Nebivolol
- Where
- Italy
- Volunteers
- 291 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Pregnancy Related
Myoinositol Effect on Asprosin Levels
Asprosin is aa adipokine associated with glucose and insulin metabolism. Insulin and glucose metabolism change during pregnancy and studies examining asprosin levels during pregnancy are increasing rapidly.
- Trial name
- NCT05943158
- Testing
- myoinositol and folic acid, folic acid
- Where
- Cyprus
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Near East University, Turkey
Marfan Syndrome
Clinical Variability in Marfan Syndrome
Marfan syndrome is an autosomal dominant connective tissue disorder caused by mutations in the fibrillin-1 gene (FBN1). Penetrance of FBN1 mutations is complete but intra and inter familial clinical expressivity is extremely…
- Trial name
- Variarfan (NCT01707563)
- Testing
- skin punch biopsy and molecular biology, fibroblast culture and molecular biology
- Where
- France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris