Clinical trials: Margin, Tumor-Free
Cardiovascular Diseases, NSTEMI
Cholesterol Lowering Via Bempedoic Acid/Ezetimibe, an ACL-Inhibiting Regimen in Acute Coronary Syndrome Study
The overall objective of the Cholesterol Lowering via Bempedoic Acid/Ezetimibe, an ACL-Inhibiting Regimen in Acute Coronary Syndrome ACS (CLEAR ACS) study is to determine the efficacy, safety, and tolerability of bempedoic…
- Conditions
- Cardiovascular Diseases, NSTEMI, STEMI
- Trial name
- NCT05263778
- Testing
- Bempedoic Acid / Ezetimibe Oral Tablet
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Kaiser Permanente
Preoperative Fasting, Perioperative Patient Comfort / Quality of Care
Quality Improvement Project to Reduce Preoperative Fasting Times Before Elective Procedures
This single-center quality improvement project evaluates preoperative fasting times before elective procedures requiring anesthesiology care.
- Conditions
- Preoperative Fasting, Perioperative Patient Comfort / Quality of Care, Postoperative Nausea and Vomiting (PONV), Postoperative Pulmonary Complications
- Trial name
- NCT07488468
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- University of Giessen
Type 1 Diabetes
Closing the Loop in Adults With Type 1 Diabetes (CLEAR)
The main objective of this study is to determine whether home use of fully closed-loop glucose control applying ultra-rapid Lispro insulin is superior to standard insulin pump therapy with continuous glucose monitoring (CGM) in…
- Trial name
- NCT04977908
- Testing
- CamAPS HX, Standard insulin pump therapy with CGM
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- University of Cambridge
Clear Cell Renal Cell Carcinoma
Combination of Toripalimab and JS004 Therapy for ccRCC
This study is a single center, prospective, randomized controlled phase II clinical trial aimed at examining the efficacy and safety of the combination of toripalimab and JS004 versus standard therapy for second-line treatment of…
- Trial name
- NCT06690697
- Testing
- JS004, Toripalimab, Axitinib
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Fudan University
Nausea/Vomiting
Prospective Controlled Trial On Clear Feeds Versus Low Residue Diet After Surgery In Elective Colorectal Surgery Patients
Prospective randomized controlled trial investigating commencement of low residue diet versus clear feeds on postoperative day one following elective colorectal surgery, with regards to patient tolerability, incidence of nausea…
- Trial name
- NCT01890499
- Testing
- Low Residue diet arm.
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Cedars-Sinai Medical Center
White Spot Lesions
The Effect of Nano Chitosan Surface Coating on White Spot Lesions Development in Clear Aligner Therapy Patients
In this study, it was intended to investigate the effect of nano Chitosan (antimicrobial agent) coating on clear aligner orthodontic appliance if it reduces the incidence of white spot lesions (demineralization) of enamel…
- Trial name
- NCT07715552
- Testing
- chitosan nanoparticles, No Treatment Added
- Where
- Jordan
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Immunotherapy, Cancer
Observational Basket Trial to Collect Tissue to Develop and Train a Live Tumor Diagnostic Platform (ELEPHAS-02)
The primary objective of this study is to develop and train the Elephas live tumor diagnostic platform and determine the ex-vivo accuracy of the Elephas Score using in-vivo RECIST 1.1 as the reference method
- Conditions
- Immunotherapy, Cancer, Bladder Cancer, Urothelial Carcinoma Bladder
- Trial name
- ELEPHAS-02 (NCT05520099)
- Testing
- Core Needle Biopsy, Forceps Biopsy, Punch Biopsy
- Where
- 12 sites in United States
- Volunteers
- 416 people
- Sponsor
- Elephas
Corneal Astigmatism
Limbal Relaxing Incisions Versus Paired 4 mm Clear Corneal Incisions on Steep Meridian During Phacoemulsification
The goal of this is prospective, computer based randomized clinical trial is to compare the efficacy of reduction of the pre-existing corneal astigmatism at the time of cataract surgery in patients admitted in sohag university…
- Trial name
- LRI-CCI (NCT05593263)
- Testing
- surgical correction of astigmatism with cataract
- Volunteers
- 120 people
- Sponsor
- Sohag University
Kidney Cancer
Everolimus and Imatinib Mesylate in Treating Patients With Metastatic or Unresectable Kidney Cancer
RATIONALE: Everolimus and imatinib mesylate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Everolimus may also block blood flow to the tumor.
- Trial name
- NCT00331409
- Testing
- Everolimus, imatinib mesylate
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- OHSU Knight Cancer Institute
Pediatric Solid Tumor, Osteosarcoma
B7-H3-Specific Chimeric Antigen Receptor Autologous T-Cell Therapy for Pediatric Patients With Solid Tumors (3CAR)
3CAR is being done to investigate an immunotherapy for patients with solid tumors. It is a Phase I clinical trial evaluating the use of autologous T cells genetically engineered to express B7-H3-CARs for patients ≤ 21 years old…
- Conditions
- Pediatric Solid Tumor, Osteosarcoma, Rhabdomyosarcoma, Neuroblastoma
- Trial name
- NCT04897321
- Testing
- Fludarabine, Cyclophosphamide, MESNA
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- St. Jude Children's Research Hospital
Anterior Crossbite
Evaluation of the Effect of Labio-Lingual Spring Hawley and Clear Aligners on Periodontal Health and Salivary Parameters
Objective: The aim of our study was to determine the effect of two different types of removable appliances on periodontal health, dental plaque colonization, as well as saliva, pH, flow rate, and buffering capacity of the…
- Trial name
- NCT06858033
- Testing
- Clear aligner, Labiolingual spring hawley
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Ozge Gungor
Supraglottic Airway Devices, Laryseal Clear Laryngeal Mask
Clinical Performance of Laryseal Clear Versus Ambu Aura 40 Laryngeal Mask Airway for Preschool Children
Preschool children have specific anatomical and physiological characteristics which necessitates careful selection of an appropriate airway management device.
- Trial name
- NCT07553247
- Testing
- LarySeal clear Group, Ambu Aura40 Group
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Zagazig University
Endometrial Cancer, Endometrial Adenocarcinoma
Safety, Efficacy and Quality of Life After Adjuvant Hypofractionated Radiotherapy for Endometrial Cancer
Clinical experience with hypo fractionated radiotherapy to date has shown that it is a safe and effective way to treat many types of cancer.
- Trial name
- HEROS (NCT07871838)
- Testing
- Hypo fractionated RT
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Clear Cell Renal Cell Carcinoma, Recurrent Renal Cell Carcinoma
Sorafenib Tosylate With or Without Recombinant Interferon Alfa-2b in Treating Patients With Metastatic Kidney Cancer
This randomized phase II trial is studying sorafenib and interferon alfa-2b to see how well they work compared to sorafenib alone in treating patients with metastatic kidney cancer.
- Conditions
- Clear Cell Renal Cell Carcinoma, Recurrent Renal Cell Carcinoma, Stage IV Renal Cell Cancer
- Trial name
- NCT00126594
- Testing
- Sorafenib Tosylate, Recombinant Interferon Alfa-2b, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- National Cancer Institute (NCI)
Narrow Palate
Comparison of the Predictability of Dentoalveolar Expansion With Two Clear Aligner Systems
To analyze the clinical predictability of transverse arch expansion achieved with two clear aligner systems (Invisalign, Angel Aligner-Angel Aligner Pro) by comparing planned and achieved dental movements through digital model…
- Trial name
- NCT07608302
- Testing
- Invisalign expansion, Angel Aligner, Angel Aligner Pro
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- University of Salamanca
Metastatic Renal Cell Carcinoma
Biological, Pathological and Imagery Markers in the First-line Treatment of Metastatic Clear-cell Renal Cell Carcinoma
The aim of this study is to identify and/or validate biomarkers and imaging markers to predict and monitor the activity of a new class of therapeutic agents called antiangiogenics for the treatment of metastatic renal cell…
- Trial name
- PREINSUT (NCT00930345)
- Testing
- Sunitinib (SUTENT)
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Renal Cell Carcinoma, Clear Cell
A Multimodal Predictive Recurrence Score for Patients With Clear Cell Renal Cell Carcinoma
The main goal of this observational study is to construct a predictive recurrence model for renal clear cell carcinoma through an artificial intelligence multimodal algorithm, which will improve the prognosis and survival time of…
- Trial name
- NCT06656039
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- RenJi Hospital
Select Advanced Malignancies, Kidney Cancer
A Phase 1/2, Open-label Study to Evaluate the Safety and Antitumor Activity of MEDI0680 (AMP-514) in Combination With Durvalumab Versus Nivolumab Monotherapy in Participants With Select Advanced Malignancies
To evaluate the Safety and Antitumor Activity of MEDI0680 (AMP-514) in Combination with Durvalumab versus Nivolumab Monotherapy in Participants with Select Advanced Malignancies.
- Conditions
- Select Advanced Malignancies, Kidney Cancer, Clear Cell Renal Cell Carcinoma
- Trial name
- NCT02118337
- Testing
- MEDI0680, Durvalumab, Nivolumab
- Where
- 27 sites in United States, Australia and 4 more
- Volunteers
- 97 people
- Sponsor
- MedImmune LLC
Non-clear Renal Cell Carcinoma
Postoperative Adjuvant Therapy for Non-clear Renal Cell Carcinoma With High-risk Recurrence Factors
The goal of this prospective, multicenter, single-arm clinical study is to evaluate the efficacy and safety of toripalimab in combination with axitinib for postoperative adjuvant therapy for non-clear renal cell carcinoma with…
- Trial name
- IUNU-RC (NCT05768464)
- Testing
- Toripalimab, Axitinib
- Where
- 2 sites in China
- Volunteers
- 30 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Hypercholesterolemia, Atherosclerotic Cardiovascular Diseases
Evaluation of Long-Term Safety and Tolerability of ETC-1002 in High-Risk Patients With Hyperlipidemia and High CV Risk (CLEAR Harmony)
The purpose of this study is to see if ETC-1002 (bempedoic acid) is safe and well-tolerated versus placebo in patients with high cardiovascular risk and elevated LDL cholesterol that is not adequately controlled by their current…
- Trial name
- NCT02666664
- Testing
- ETC-1002
- Where
- 104 sites in United States, Canada and 4 more
- Volunteers
- 2,230 people
- Sponsor
- Esperion Therapeutics, Inc.
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