Clinical trials: Marijuana
Driving Behavior, Driving Under the Influence
Validation of the Drug Impaired Driving Scenario (DIDS) on the CRCDS-miniSim
Subjects will participate in a 4-visit study protocol at the National Advanced Driving Simulator, part of the University of Iowa, in which they will be asked to complete assorted questionnaires, computerized cognitive tasks, and…
- Trial name
- PDID (NCT04970342)
- Testing
- 0.75 mg Alprazolam Capsule, Cannabis (6.18% THC / <0.025% CBD), Cannabis (0%/ THC / 0% CBD)
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Timothy L. Brown
Posttraumatic Stress Disorder
Pilot Study of the Safety and Efficacy of Four Different Potencies of Smoked Marijuana in 76 Veterans With PTSD
This pilot study gathered preliminary evidence of the safety and efficacy of four potencies of smoked cannabis to manage chronic, treatment-resistant PTSD among veterans: (1) High THC/ Low CBD (High THC), (2) Low THC/High CBD…
- Trial name
- NCT02759185
- Testing
- High THC cannabis, High CBD cannabis, THC/CBD cannabis
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Multidisciplinary Association for Psychedelic Studies
Marijuana Dependence
Vaping THC From Electronic Cigarettes
This study aims to understand THC pharmacology and the safety of cannabis vaping, including the pharmacology and safety of co-administration of nicotine and THC.
- Trial name
- V-PAX (NCT02955329)
- Testing
- Nicotine, Cannabis, PAX Loose Leaf Vaporizer
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Cannabis Use Disorder, Cannabis Dependence, Continuous
Brain Imaging of Cannabinoid Receptors
All participants will be healthy volunteers and all procedures will be completed for research purposes only. Two groups will be recruited, females who use cannabis (marijuana, MJ), and female who do not use cannabis (controls).
- Trial name
- NCT03204305
- Testing
- 11C-OMAR, Cannabis
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Cannabis Dependence
Safety and Efficacy of a FAAH-Inhibitor to Treat Cannabis Withdrawal
Cannabis dependence is associated with changes in the brain's cannabinoid system. When cannabis dependent individuals try to quit using cannabis, some of them experience problems that make it difficult for them to achieve and…
- Trial name
- NCT01618656
- Testing
- PF-04457845
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Yale University
Psychosis, Substance Use
Families With Substance Use and Psychosis: A Pilot Study
The purpose of this study is to develop and evaluate an intervention that adapts Community Reinforcement and Family Training (CRAFT) for families experiencing first episode psychosis and substance use delivered via telemedicine…
- Conditions
- Psychosis, Substance Use, Substance Use Disorders, Family
- Trial name
- NCT04284813
- Testing
- CRAFT-FT
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Cannabis, Post Traumatic Stress Disorder
Nabilone in Cannabis Users With PTSD
Despite the prevalence of cannabis use among the PTSD population and self-reports that it is used to help cope with PTSD symptoms, the direct effects of cannabis on PTSD symptomology are unknown.
- Trial name
- NCT03251326
- Testing
- Nabilone, Cannabis, Propranolol
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- New York State Psychiatric Institute
Cannabis Intoxication
The Impact and Detection of Driving Impairments Associated With Acute Cannabis Smoking
This study was authorized by the California Legislature (Assembly Bill 266, the Medical Marijuana Regulation and Safety Act to help with detection of driving under the influence of cannabis.
- Trial name
- NCT02849587
- Testing
- Cannabis
- Where
- United States
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Cannabis-use Disorders
Behavioral Effects of Pregabalin and Cannabis
Cannabis is the most commonly used illicit drug in the United States, and its use is associated with rates of development of abuse and dependence, treatment admission and relapse that are comparable to other illicit drugs.
- Trial name
- NCT01511640
- Testing
- Pregabalin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Joshua A. Lile, Ph.D.
Cannabis Use Disorder
Effect of Clonazepam on Cannabis Withdrawal and Relapse in Treatment-seeking Patients
The proposed protocol is a double-blind, placebo-controlled inpatient and outpatient study,looking at the clinical treatment of cannabis use disorder. The treatment study is a total of 12 weeks.
- Trial name
- NCT02913924
- Testing
- Clonazepam
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- New York State Psychiatric Institute
Opioid-use Disorder, Cocaine Use Disorder
Feasibility and Validation of a Standard Phenotyping Assessment Battery
The overall goal of this project is to collect preliminary data on psychosocial measures and behavioral performance comparing individuals with Opioid Use Disorder, Cocaine Use Disorder, dual diagnosis of Opioid and Cocaine Use…
- Conditions
- Opioid-use Disorder, Cocaine Use Disorder, Marijuana Use Disorder, Healthy Controls
- Trial name
- PhAB (NCT03495869)
- Where
- United States
- Volunteers
- 368 people
- Sponsor
- Virginia Commonwealth University
Cannabis, Cannabis Use
Impact of Reduced Cannabis Use on Functional Outcomes
Nearly 20 million Americans report use of cannabis in the past month, and heavy cannabis use has increased by nearly 60% in the U.S. since 2007.
- Trial name
- NCT03681353
- Testing
- Mobile Contingency Management, active
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Duke University
Cannabis Use Disorder
Lorcaserin for Cannabis Use Disorder
The primary purpose of this study is to investigate the effect of lorcaserin on reductions in cannabis use and multiple constructs of impulsivity in outpatient treatment-seeking individuals with cannabis use disorder (CUD).
- Trial name
- NCT03637842
- Testing
- Lorcaserin
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- New York State Psychiatric Institute
Obsessive-Compulsive Disorder
Effects of Marijuana on Symptoms of OCD
The purpose of this pilot research study is to test whether certain components of the marijuana plant, known as "cannabinoids", may help to reduce symptoms in patients with OCD.
- Trial name
- ECOS (NCT03274440)
- Testing
- Cannabis
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- New York State Psychiatric Institute
Cannabis Abuse, Cannabis Dependence
Biobehavioral Effects of Topiramate on Cannabis-Related Outcomes in Adolescents
Cannabis use is a significant public health concern that disproportionately affect youth. Although promising psychosocial interventions are being developed, most youth do not benefit from these interventions alone.
- Trial name
- NCT01110434
- Testing
- Topiramate
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Brown University
Marijuana Dependence
Hormones and Reduction in Co-users of Marijuana and Nicotine
The purpose of this study is to examine the role of progesterone (a naturally occurring hormone found in both men and women) on reducing marijuana use.
- Trial name
- NCT02579421
- Testing
- Progesterone
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Schizophrenia, Cannabis Abuse
Clozapine for Cannabis Use in Schizophrenia
Many individuals with schizophrenia also suffer from marijuana addiction that worsens their problems related to schizophrenia. Most of the medications prescribed for schizophrenia have no effect on reducing marijuana use.
- Conditions
- Schizophrenia, Cannabis Abuse, Cannabis Dependence, Dual Diagnosis
- Trial name
- CLOCS (NCT01639872)
- Testing
- Clozapine, Risperidone
- Where
- 9 sites in United States
- Volunteers
- 49 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Alcohol Abuse, Cocaine Abuse
Therapeutic Substance Abuse Treatment in Pregnancy - 1
The purpose of this study is... To assess whether a behavioral treatment that combines motivational enhancement and cognitive skills training therapy (MET-CBT) is more effective than brief advice in: 1) decreasing use of a full…
- Conditions
- Alcohol Abuse, Cocaine Abuse, Marijuana Abuse
- Trial name
- PRIDE-P (NCT00227903)
- Testing
- MI-CBT, Brief Advice
- Where
- 2 sites in United States
- Volunteers
- 168 people
- Sponsor
- Yale University
Medical Abortion, Pain
Cannabinoids for Pain Control During Medical Abortion
The objective of this study is to determine if a synthetic cannabis derivative, dronabinol, in addition to ibuprofen, decreases maximum pain scores compared to ibuprofen and placebo in women undergoing medical abortion.
- Trial name
- NCT03604341
- Testing
- Dronabinol 5mg Cap
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Oregon Health and Science University
Cannabis Dependence
Facilitating the Behavioral Treatment of Cannabis Use Disorder
Cannabis use disorders remain a significant public health problem. The pharmacological facilitation of behavioral treatment represents a promising strategy for addressing disordered cannabis use.
- Trial name
- NCT02946489
- Testing
- CI-581a
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- New York State Psychiatric Institute