Clinical trials: Marijuana
Marijuana Abuse
Treatment for Adolescent Marijuana Abuse
Marijuana remains the most prevalent illicit substance used by adolescents and the number of adolescents receiving treatment for marijuana abuse more than tripled during the last decade.
- Trial name
- NCT00580671
- Testing
- MET/CBT, CM, BPT
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Cannabis Dependence
Fixed or Self-Titrated Dosages of Sativex on Cannabis Users
The purpose of this study is to to demonstrate the feasibility and tolerability of the use of Sativex in cannabis dependent individuals and to assess the effects of fixed or self titrated dosages of SATIVEX®…
- Trial name
- NCT01748799
- Testing
- Sativex
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- Centre for Addiction and Mental Health
Schizophrenia, Dual Diagnosis
Cannabis, Schizophrenia and Reward: Self-Medication and Agonist Treatment?
In this translational research proposal, based on our formulation, we seek to confirm and expand upon data obtained in our pilot study suggesting that cannabis and the cannabinoid agonist dronabinol, given in low dose to patients…
- Conditions
- Schizophrenia, Dual Diagnosis, Psychotic Disorder, Cannabis Use Disorder
- Trial name
- NCT01964404
- Testing
- Marijuana, Dronabinol
- Where
- 2 sites in United States
- Volunteers
- 263 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Cannabis Abuse, Cannabis Dependence
Biobehavioral Effects of Topiramate on Cannabis-Related Outcomes in Adolescents
Cannabis use is a significant public health concern that disproportionately affect youth. Although promising psychosocial interventions are being developed, most youth do not benefit from these interventions alone.
- Trial name
- NCT01110434
- Testing
- Topiramate
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Brown University
Cannabis Use
CanCope: Digital Intervention for Coping With Cannabis Craving
The CanCope Study is a micro-randomized trial conducted to gather evidence about and compare the effectiveness of a momentary intervention to help young adults cope with cannabis cravings as they attempt to reduce their use.
- Trial name
- NCT05328362
- Testing
- CanCope
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Trustees of Dartmouth College
Cannabis Intoxication, Alcohol Intoxication
The Impact of Oral Cannabis Administration and Co-Administration of Alcohol on Impairment
This study will evaluate the individual and interactive effects of oral cannabis and alcohol on subjective and behavioral measures of impairment.
- Trial name
- NCT04931095
- Testing
- Cannabis, Alcohol
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Depression, Marijuana Abuse
Free Venlafaxine Treatment for Marijuana Addiction and Depression - 1
The purpose of this study is to determine if Venlafaxine Extended Release (Ven-XR) is effective in treating individuals with marijuana addiction and depression.
- Trial name
- VEN (NCT00131456)
- Testing
- Venlafaxine
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- New York State Psychiatric Institute
Health Risk Behaviors, Risk Reduction Behavior
Enhancing Quality in Protective Strategies
The most successful young adult alcohol or marijuana interventions involve the provision of accurate, nonjudgmental personalized feedback, but notably the inclusion and effectiveness of protective behavioral strategies (PBS)…
- Trial name
- EQUIP (NCT04978129)
- Testing
- Online and Text Messaging Intervention
- Where
- United States
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- University of North Texas Health Science Center
Schizophrenia, Dual Diagnosis
Treatment of Schizophrenia and Comorbid Cannabis Use Disorder: Comparing Clozapine to Treatment-as-Usual
Many individuals with schizophrenia also suffer from marijuana addiction. Clozapine, an atypical antipsychotic medication, may prove useful at preventing drug relapse in schizophrenic individuals who are seeking treatment for…
- Conditions
- Schizophrenia, Dual Diagnosis, Schizoaffective Disorder, Psychotic Disorder
- Trial name
- NCT00498550
- Testing
- Clozapine, Treatment as usual
- Where
- 4 sites in United States
- Volunteers
- 31 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Cannabis Use, Tobacco Use Disorder
N-Acetylcysteine for Smoking Cessation in Tobacco and Cannabis Co-Use
Tobacco and cannabis co-use is a common and growing public health problem, especially in states that have legalized cannabis. There are no pharmacologic treatments for co-occurring tobacco and cannabis use.
- Conditions
- Cannabis Use, Tobacco Use Disorder, Drug Use Disorder
- Trial name
- NAC_CUD-TUD (NCT04627922)
- Testing
- N-Acetyl cysteine, Cognitive behavioral therapy (CBT)
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Ellen Herbst
Pain, Cannabis
Enhancing Medication-based Analgesia in Humans- STUDY 2
This is a single-group, within-subject, double-blind, double-dummy, placebo and active-controlled study evaluated whether the FDA-approved cannabinoid cannabidiol (CBD; Epidiolex) would enhance analgesia, subjective reports, and…
- Conditions
- Pain, Cannabis, Opioid Use
- Trial name
- NCT04036968
- Testing
- Within-subject test of blinded study medications
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Marijuana Dependence
Effect of Oxytocin on Stress in Marijuana Users
The purpose of this study is to evaluate how people who frequently use marijuana respond to a stressful task, and if a medication (oxytocin) affects this response.
- Trial name
- NCT01335789
- Testing
- Oxytocin, Saline
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Medical University of South Carolina
Multiple Sclerosis
Sativex Versus Placebo When Added to Existing Treatment for Central Neuropathic Pain in MS
The purpose of this study is to find out if cannabis-based medicine compared to a dummy medicine (placebo that contains no active ingredient) can help the central neuropathic pain patients experience as a result of multiple…
- Trial name
- NCT00391079
- Testing
- Sativex
- Where
- 6 sites in Canada
- Volunteers
- 339 people
- Sponsor
- GW Pharmaceuticals Ltd
Schizophrenia, Schizoaffective Disorder
Controlled Trial of Brexpiprazole For The Treatment of Co-occurring Schizophrenia and Substance Use Disorder
The proposed study is a 4-site, 12-week, novel, feasibility, investigation of patients who have co-occurring diagnoses of schizophrenia and current substance use disorder (alcohol, cocaine, heroin, or cannabis).
- Conditions
- Schizophrenia, Schizoaffective Disorder, Substance Use Disorders
- Trial name
- NCT03526354
- Testing
- Brexpiprazole, Treatment as Usual
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Massachusetts, Worcester
Marijuana Dependence
Comparison Between Marijuana Smoked in Cigarette Paper Versus Cigar Paper
The purpose of this study is to investigate whether or not marijuana blunts will produce comparable plasma THC levels as marijuana joints and if blunts will produce larger cardiovascular and subjective effects.
- Trial name
- NCT00374127
- Testing
- Marijuana blunt, marijuana cigarette
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Marijuana Dependence
Baclofen Effects on Marijuana Dependence
Studies show that certain reminders of drug use such as the sight of someone using marijuana, pictures of blunts, particular moments throughout the day, prompt marijuana users to smoke marijuana.
- Trial name
- NCT02011516
- Testing
- Baclofen, Psychosocial
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Marijuana Use Disorder
Effects of Smoked Marijuana on Risk Taking and Decision Making Tasks
The purpose of this study is to investigate the effects of smoked marijuana on both risk taking and decision making tasks.
- Trial name
- NCT00373399
- Testing
- Inactive Marijuana (0% THC), Low THC marijuana (1.8 %THC), High THC marijuana (3.9% THC)
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Cannabis Dependence
Treatment for Cannabis Withdrawal and Dependence
Cannabis is the most widely used illicit drug in the United States, and worldwide, with 1 in 10 users estimated to meet diagnostic criteria for cannabis dependence.
- Trial name
- NCT01611948
- Testing
- Aprepitant, Manual-guided behavioral counseling
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- The Scripps Research Institute
Pain, Diabetic Neuropathy
A Study of Sativex® for Pain Relief Due to Diabetic Neuropathy
The purpose of this study is to evaluate the efficacy of Sativex® compared with placebo in relieving pain due to Diabetic Neuropathy.
- Trial name
- NCT00710424
- Testing
- Sativex
- Where
- United Kingdom
- Volunteers
- 297 people
- Sponsor
- Jazz Pharmaceuticals
Cannabis Use
Cannabis Edibles Packaging Imagery Experiment
The purpose of this study is to assess differences in perceptions of product appeal, harm, and subsequent willingness to try cannabis edibles products with/without packaging imagery.
- Trial name
- NCT06358144
- Testing
- Packaging imagery, No Imagery (Control)
- Where
- United States
- Volunteers
- 1,260 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences