Clinical trials: Marijuana Abuse
Renal Insufficiency, Kidney Disease
A Study to Evaluate the Pharmacokinetics Of Sativex® in Subjects With Severe Renal Impairment or End Stage Renal Disease, Compared to Matched Subjects With Normal Renal Function.
The study aims to determine the pharmacokinetic (PK) profile of a single oromucosal dose of Sativex® (i.e. how the body absorbs, distributes, metabolises and excretes the drug) when subjects have severe renal impairment or end…
- Trial name
- NCT02325024
- Testing
- Sativex
- Volunteers
- healthy volunteers welcome
- Sponsor
- GW Pharmaceuticals Ltd
Drug Addiction
The Role of Sleep in the Treatment of Cannabis Use Disorders
The number of people seeking treatment for marijuana-related problems is on the rise, yet there is no currently accepted medication proven to help them quit.
- Trial name
- NCT01685073
- Testing
- Zolpidem extended-release, MET/CBT
- Where
- United States
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Marijuana Dependence
Ph1 Marinol Interaction Study - Part 2 - 1
This study will examine the effects of oral dronabinol tetrahydrocannabinol (THC) on withdrawal symptoms in marijuana dependent volunteers, and evaluate the safety, pharmacokinetics (PK), and cardiovascular effects of the…
- Trial name
- NCT00490269
- Testing
- Dronabinol
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Marijuana Impairment, Alcohol Impairment
Examine the Feasibility of a Standardized Field Test for Marijuana and Alcohol Impairment: Laboratory Evaluations
Alcohol and Cannabis (CNB) are two of the most widely used intoxicants. The effects of driving while intoxicated on alcohol are well documented, resulting in numerous drunken driving laws and regulations.
- Trial name
- Alc-NHTSA (NCT04856566)
- Testing
- Low Marijuana, Hash, THC, or Grass, High Marijuana, Hash, THC, or Grass, 0.05 BAC Alcohol
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Yale University
Cannabis
Transcranial Magnetic Brain Stimulation to Reduce Cannabis Use in Heavy Cannabis Users
The growing legalization of cannabis across the U.S. is associated with increases in cannabis use, and accordingly, an increase in the number of individuals with cannabis use problems, including cannabis use disorder (CUD).
- Trial name
- iCURE (NCT05401929)
- Testing
- iTBS
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Duke University
Pain Threshold, Mood
Comparison of the Analgesic Effects of Dronabinol and Smoked Marijuana in Daily Marijuana Smokers
The following study is designed to determine the analgesic efficacy of smoked marijuana (0, 1.98, and 3.56% THC) and oral THC (0, 10, and 20 mg) in the Cold-Pressor Test (CPT), a laboratory model of pain which has predictive…
- Trial name
- NCT00743119
- Testing
- Inactive marijuana (0% THC), Low dose Dronabinol, High dose Dronabinol
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Drug Abuse, Intoxication by Drug
Evaluation of Smoked THC and CBD in Men and Women
The purpose of this study is to determine the pharmacokinetics and pharmacodynamics of inhaled cannabis with varying amounts of delta-9-tetrahydrocannabinol (THC), and cannabidiol (CBD) and to evaluate detection of recently…
- Conditions
- Drug Abuse, Intoxication by Drug, Impairment
- Trial name
- S-TACOFS (NCT05037487)
- Testing
- 20 mg CBD Cannabis, 20 mg CBD + 20 mg THC Cannabis, 20 mg THC Cannabis
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Opioid Use Disorder
Cannabis and Opioid Use Disorder
This study plans to enroll participants with opioid use disorder who are not currently seeking treatment to assess the effects of cannabis on opioid withdrawal and other related outcomes.
- Trial name
- NCT05729932
- Testing
- Inhaled vaporized cannabis, Intransal opioid
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Shanna Babalonis, PhD
Marijuana Abuse and Dependence
Development and Efficacy Test of Computerized Treatment for Marijuana Dependence
More US residents are dependent on marijuana than on any other illicit drug, and the number enrolled in treatment for marijuana continues to increase such that it is now comparable to that for cocaine and heroin.
- Trial name
- NCT00594659
- Testing
- Psychotherapy, Computerized Psychotherapy, Motivational enhancement therapy
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Cannabis Use Disorder
Understanding Effects of Cannabis Use and Abstinence on Neural Glutamate Homeostasis
This study will be the first in vivo human multimodal neuroimaging study exploring the relationship between mGluR5 availability (PET), neural oscillations (EEG), and cognitive function in people with CUD.
- Trial name
- NCT05664763
- Testing
- [18F]FPEB with PET, Cannabis abstinence
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Yale University
Marijuana, THC
THC Memory & Reward Learning Pilot
Tetrahydrocannabidiol (THC) is the psychoactive chemical in cannabis that makes people high. This study aims to dissect acute impairment of various forms of memory and learning by THC in cannabis compared to placebo.
- Conditions
- Marijuana, THC, Cannabis
- Trial name
- NCT05116527
- Testing
- Marijuana, Hash, THC, or Grass
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hartford Hospital
Marijuana Dependence
Marijuana Treatment Project 4
Marijuana is the most commonly used illicit drug in the US, but treatment for marijuana dependence is not fully effective. In the current proposal we are exploring the idea that more tailored teaching of coping skills may result…
- Trial name
- MTP4 (NCT02030665)
- Testing
- Contingency Management, Individualized Assessment & Treatment, Cognitive-Behavioral Treatment
- Where
- United States
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- UConn Health
Marijuana Use
Computer-Mediated Versus Face-to-Face Motivational-Type Interviews
This study looks at whether in-person and computer-based motivational type interviews lead to the same kind of language and behavior change in young adults when they talk about their marijuana use.
- Trial name
- NCT06945471
- Testing
- 1) Face-to-face, and 2) Computer-mediated motivational type interviews
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Texas, El Paso
Smoking
Development of a Videogame Prototype Targeting Cigarette and Marijuana Smoking, and Tobacco Product Prevention Among Young Adolescents
To study feasibility and implementation of a education videogame and the effects on adolescents knowledge and beliefs around tobacco products.
- Trial name
- smokeSCREEN (NCT03107936)
- Testing
- smokeSCREEN game
- Where
- 4 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Yale University
HIV, Cannabis
Effects of Cannabidiol and Tetrahydrocannabinol on Microbiome and Neuroinflammation in HIV
This study has the potential to contribute to a more complete understanding of the independent and combined effects of cannabis use and HIV on the brain and on inflammation.
- Conditions
- HIV, Cannabis, THC, Neuroinflammatory Disease
- Trial name
- CAMI (NCT05514899)
- Testing
- THC, CBD
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Cannabis, Nicotine
Behavioral Pharmacology of Cannabis and Nicotine
This study will evaluate the individual and interactive pharmacokinetic and pharmacodynamic effects of smoked cannabis and nicotine.
- Trial name
- NCT04124432
- Testing
- Cannabis, Nicotine
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Healthy
Cannabis Cigarettes Used for Doping: Delta-9-Tetrahydrocannabinol (THC) Urine Detection
The purpose of this study on volunteers is whether THC and short-living metabolites are suited to detect recent Cannabis smoking within urine doping control.
- Trial name
- NCT00534716
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Federal Office of Sports, Switzerland
Marijuana Abuse
Evaluating Responses to Drug-Related Cues Versus Neutral Cues to Understand the Effects of Marijuana Craving - 1
The majority of past research on marijuana treatment has specifically targeted the alleviation of withdrawal symptoms. Minimal focus has been placed on how altering craving effects may play a role in treating marijuana addiction.
- Trial name
- NCT00218478
- Testing
- Cue Desensitization
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Behavioral Economics, Cannabis Smoking
Using Novel Behavioral Economic Measures to Characterize Dual Marijuana and Tobacco Use in Young Adults
The multi session experimental study aims to determine dual use patterns of marijuana and tobacco by assessing the impact of price and availability of marijuana and tobacco using a cross price elasticity of demand task.
- Conditions
- Behavioral Economics, Cannabis Smoking, Tobacco Smoking
- Trial name
- MATEY (NCT07398443)
- Testing
- Cue Reactivity
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Brown University
Insomnia, Alcohol Use, Unspecified
Research Evaluating Sleep & Trends for Universal Prevention
This study is designed to develop an integrated intervention to reduce alcohol and marijuana use and consequences and improve sleep among young adults with comorbid heavy episodic drinking, marijuana use, and sleep impairment.
- Conditions
- Insomnia, Alcohol Use, Unspecified, Marijuana Use
- Trial name
- REST-UP (NCT04783519)
- Testing
- Brief Behavioral Therapy for Insomnia (BBTI), Brief Alcohol Screening and Intervention for College Students (BASICS)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Washington