Clinical trials: Marijuana Dependence
Alcohol-Related Disorders, Marijuana Abuse
Substance Dependent Teens - Impact of Treating Depression Study 1 - 1
The purpose of this study is to evaluate the impact of treating depression on substance dependent teens.
- Conditions
- Alcohol-Related Disorders, Marijuana Abuse, Substance-Related Disorders
- Trial name
- NCT00061113
- Testing
- Fluoxetine + outpatient cognitive behavioral therapy, fluoxetine
- Where
- 2 sites in United States
- Volunteers
- 126 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cannabis, Cannabis Intoxication
Do Adolescents and Adults Differ in Their Acute Response to Cannabis?
The acute effects of cannabis may differ between adolescents and adults. Furthermore, these effects may be tempered by the presence of cannabidiol.
- Conditions
- Cannabis, Cannabis Intoxication, Cannabis Use, Cannabis Dependence
- Trial name
- CannTeenA (NCT04851392)
- Testing
- Cannabis with delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), Cannabis with THC without CBD
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University College, London
Cannabis Use Disorder
Trial of Tirzepatide for the Treatment of Cannabis Use Disorder
The purpose of this randomized, double-blind, placebo-controlled, multi-site clinical trial is to evaluate the safety and efficacy of tirzepatide in a sample of 100 patients diagnosed with moderate or severe CUD by DSM-5 criteria.
- Trial name
- NCT07468552
- Testing
- Tirzepatide
- Volunteers
- 100 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cannabis Dependence
Open-Label Pilot Study of Guanfacine-Extended Release for the Treatment of Cannabis Dependence
The purpose of this study is to determine whether guanfacine represents a tolerable, potentially effective pharmacotherapy option for cannabis dependence.
- Trial name
- GUAN (NCT01467999)
- Testing
- Guanfacine
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- New York State Psychiatric Institute
Marijuana Abuse
Dronabinol Treatment for Marijuana Addiction
The purpose of this study is to determine if dronabinol decreases the symptoms of marijuana addiction and withdrawal.
- Trial name
- MARINOL (NCT00217971)
- Testing
- Dronabinol
- Where
- United States
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Marijuana Dependence
Vilazodone Treatment for Marijuana Dependence
Marijuana is the most commonly used illicit drug, yet few clinical trials have evaluated pharmacotherapy treatments for marijuana dependence.
- Trial name
- NCT01574183
- Testing
- Vilazodone
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Medical University of South Carolina
Smoking Cessation
Benefit of Systematic Proposition of Nicotine Substitution for Patients Undergoing Surgery
Smoking is associated with a higher rate of surgical complications. For example, in orthopedics, the risk of complications is 31% in smokers against 5% in non-smokers.
- Trial name
- PATCHIR (NCT04572646)
- Testing
- NRT proposition and exhaled CO measurement
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Groupe Hospitalier Mutualiste de Grenoble
Cannabis Dependence, Cannabis Withdrawal
Clinical and Neurobiological Effects of Cannabis Dependence in Young Adults
The purpose of this study is to find out more about cognitive functioning in people who are cannabis dependent, relative to people who do not use cannabis, and how their brains process information after one month of not using…
- Trial name
- SCCAN (NCT00656487)
- Testing
- rimonabant
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- The Scripps Research Institute
Marijuana Dependence
Pregnenolone and Marijuana Dependence
The cannabinoid delta 9-tetrahydrocannabinol (THC) is the primary psychoactive component of marijuana. THC is believed to be a significant factor in the addictive potential associated with marijuana use.
- Trial name
- NCT02439814
- Testing
- Pregnenolone
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Medical University of South Carolina
Cannabis Use Disorder, Psychosis
rTMS Treatment for Cannabis Use Disorders in Psychosis
Cannabis use during adolescence represents a significant risk factor for the development of psychosis including schizophrenia. Moreover, cannabis is the most commonly used drug among patients with an existing psychotic disorder.
- Trial name
- NCT03069612
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- Centre for Addiction and Mental Health
Marijuana Dependence
Comparison Between Marijuana Smoked in Cigarette Paper Versus Cigar Paper
The purpose of this study is to investigate whether or not marijuana blunts will produce comparable plasma THC levels as marijuana joints and if blunts will produce larger cardiovascular and subjective effects.
- Trial name
- NCT00374127
- Testing
- Marijuana blunt, marijuana cigarette
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Marijuana Dependence
Ph1 Marinol Interaction Study - Part 1 - 1
The purpose of this study is to examine the effects of oral dronabinol tetrahydrocannabinol (THC) on withdrawal symptoms in marijuana dependent volunteers, and evaluate the safety, pharmacokinetics (PK), and cardiovascular…
- Trial name
- NCT00438139
- Testing
- Dronabinol
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence, Cocaine Use Disorder
Neurobehavioral Measurement of Substance Users in Outpatient Treatment Setting
This study was an internal program effectiveness evaluation of the effects of a four-session weekly individualized cognitive therapy program (called the "Mind Freedom Plan" (MFP)) on substance use outcomes and substance abuse…
- Conditions
- Cocaine Dependence, Cocaine Use Disorder, Opiate Dependence, Opioid-use Disorder
- Trial name
- NCT03662529
- Testing
- Four-Session Mind Freedom Plan, Treatment as usual therapy
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Hunter Holmes Mcguire Veteran Affairs Medical Center
Marijuana Dependence
Ph1 Marinol Interaction Study - Part 2 - 1
This study will examine the effects of oral dronabinol tetrahydrocannabinol (THC) on withdrawal symptoms in marijuana dependent volunteers, and evaluate the safety, pharmacokinetics (PK), and cardiovascular effects of the…
- Trial name
- NCT00490269
- Testing
- Dronabinol
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
First Episode Psychosis (FEP), Psychosis
Mobile Application-Based Interventions for Cannabis Use in Young Adults With First Episode Psychosis
Psychotic disorders affect approximately 4% of Canadians and have a significant impact on individuals' well-being, their families and social networks, and healthcare systems.
- Conditions
- First Episode Psychosis (FEP), Psychosis, Schizophreni-form Disorder, Dependence Addictive
- Trial name
- Mobile Health (NCT07811466)
- Testing
- CHAMPS, I Can Change
- Volunteers
- 550 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Cannabis Dependence, Alcohol Dependence
Pharmacological Treatment of Comorbid Alcohol and Marijuana Withdrawal and Dependence
The primary aim of the supplemental study is to provide POC testing of aprepitant as a treatment for comorbid alcohol and cannabis dependence.
- Conditions
- Cannabis Dependence, Alcohol Dependence, Cannabis Use Disorder, Alcohol Use Disorder
- Trial name
- NCT02210195
- Testing
- aprepitant, Manual-guided behavioral counseling
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The Scripps Research Institute
Cannabis Dependence
Study of Long-Acting Injectable Naltrexone to Treat Cannabis Dependence
This is an 8 week, outpatient research study testing the use of long-acting naltrexone (Vivitrol) as a treatment for marijuana dependence.
- Trial name
- NCT02088177
- Testing
- Long-acting injectable naltrexone
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- New York State Psychiatric Institute
Cannabis, Marijuana Abuse
Dronabinol Interactions With Cognitive Enhancing Drug in Humans
Marijuana use is a major problem among veterans and non-veterans. A patient's use of marijuana while engaged in psychotherapy treatment may affect their memory and, therefore, limit their ability to benefit from treatment.
- Trial name
- NCT00842985
- Testing
- drug condition
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Yale University
Cannabis Dependence, Tobacco Dependence
Varenicline for Co-occurring Cannabis and Tobacco Use
Pilot, eight week, open-label, within-subject cross over trial of four weeks of standard clinical care (SCC) in an outpatient substance use disorder treatment program and four weeks of SCC and varenicline among current and former…
- Trial name
- NCT04595318
- Testing
- Standard clinical care first, followed by standard clinical care and varenicline, Standard clinical care and varenicline first, followed by standard clinical care
- Volunteers
- 7 people
- Sponsor
- Albert Einstein College of Medicine
Marijuana Dependence
The Effects of Marijuana on Orientation and Motor Coordination and Brain Metabolism in Regular Smokers of Marijuana
This study investigates the effects of 17mg and 13mg Delta THC on orientation and motor coordination and brain metabolic activity in regular users of marijuana.
- Trial name
- NCT00270803
- Testing
- Tetra Hydro Cannabinol (THC)
- Where
- Israel
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center