Clinical trials: Marijuana Impairment
Cannabis Use, Impaired Driving
Examining the Role of Tolerance on Dose-dependent Effects of Acute THC on Oculomotor and Cognitive Performance
The purpose of this research is to determine the extent to which oculomotor function accurately detects THC-impairment, if cannabis use experience impacts this detection threshold, and to examine how the oculomotor index…
- Conditions
- Cannabis Use, Impaired Driving, Cognitive Impairment
- Trial name
- NCT06351540
- Testing
- Cannabis
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Psychotic Disorders, Cannabis Use Disorder
Investigating the Neural Correlates of Cognitive Function in Psychosis Patients and Non-Psychiatric Controls With Cannabis Use
Cognitive impairment is well established in people with psychosis and is associated with cannabis use. The current study will investigate the neurobiological basis of cognitive change associated with 28-days of cannabis…
- Conditions
- Psychotic Disorders, Cannabis Use Disorder, Cannabis Dependence, Cannabis Use
- Trial name
- NCT05445180
- Testing
- Contingency management
- Where
- Canada
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Douglas Mental Health University Institute
Mild Cognitive Impairment
CBD for Individuals at Risk for Alzheimer's Disease
This is a double-blind, randomized controlled trial designed to test the effects of cannabidiol (CBD) on validated biomarkers of Alzheimer's disease (AD) progression, and behavioral, neurocognitive, and clinical measures, with…
- Trial name
- NCT05822362
- Testing
- Cannabidiol
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- University of Colorado, Denver
Cannabis Use, THC
Cannabis THC Potency, Metabolism, and Cognitive Impairment in Young Adults
The goal of this interventional study is to determine the impact of high potency THC product use on cognitive function of young adults aged 21-25.
- Conditions
- Cannabis Use, THC, Marijuana Use, Cognitive Impairment
- Trial name
- THC-YA (NCT06077292)
- Testing
- 15% THC Potency Reduction, 35% THC Potency Reduction
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Drug Abuse, Intoxication by Drug
Evaluation of Smoked THC and CBD in Men and Women
The purpose of this study is to determine the pharmacokinetics and pharmacodynamics of inhaled cannabis with varying amounts of delta-9-tetrahydrocannabinol (THC), and cannabidiol (CBD) and to evaluate detection of recently…
- Conditions
- Drug Abuse, Intoxication by Drug, Impairment
- Trial name
- S-TACOFS (NCT05037487)
- Testing
- 20 mg CBD Cannabis, 20 mg CBD + 20 mg THC Cannabis, 20 mg THC Cannabis
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Impairment, Cognitive, Impairment of Attention
High Confusion: Cannabis & Driving
This study is being done to assess the feasibility of administrating Δ9-THC and Δ8-THC isolates and simultaneously adopting several data harmonization measures to generate uniquely translatable data.
- Conditions
- Impairment, Cognitive, Impairment of Attention, Impairment, Psychomotor
- Trial name
- NCT06236815
- Testing
- Delta-9-THC, Delta-8-THC
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Marijuana Impairment
Standardized Field Test for Marijuana Impairment II
This research responds to NHTSA's request with a proposal to increase our understanding of smoked cannabis' (CNB's) acute effects on driving-relevant cognition and simulated driving performance, the persistence of these deficits…
- Trial name
- NHTSA-II (NCT05115513)
- Testing
- Medium THC
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Yale University
Marijuana Impairment, Alcohol Impairment
Examine the Feasibility of a Standardized Field Test for Marijuana and Alcohol Impairment: Laboratory Evaluations
Alcohol and Cannabis (CNB) are two of the most widely used intoxicants. The effects of driving while intoxicated on alcohol are well documented, resulting in numerous drunken driving laws and regulations.
- Trial name
- Alc-NHTSA (NCT04856566)
- Testing
- Low Marijuana, Hash, THC, or Grass, High Marijuana, Hash, THC, or Grass, 0.05 BAC Alcohol
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Yale University
Cannabis Use, Major Depressive Disorder
Extended Effects of Cannabis Abstinence on Clinical Symptoms and Cognition in Depression
The prevalence of major depressive disorder (MDD) is ~5.0%, and rates of co-occurring SUDs in these patients approach 40-50%. Specifically, rates of co-morbid cannabis use disorder (CUD) in patients with MDD are elevated 2-3 fold…
- Conditions
- Cannabis Use, Major Depressive Disorder, Cognitive Impairment
- Trial name
- NCT04935619
- Testing
- Contingency Reinforcement, Non-Contingency Reinforcement
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- Centre for Addiction and Mental Health
Marijuana Impairment
Neuroscience of Marijuana Impaired Driving
Marijuana is one of the most widely used substances. However, marijuana intoxication is not fully understood in relation to driving.
- Trial name
- MJDriving (NCT02757313)
- Testing
- Low dose THC marijuana, High dose THC marijuana
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Yale University
Marijuana Impairment
Examine the Feasibility of a Standardized Field Test for Marijuana Impairment: Laboratory Evaluations
Marijuana is one of the most widely used substances. This study will characterize the persistence of cannabis' (CNB's) acute effects on cognitive test performance and simulated driving over a several hour time period.
- Trial name
- NCT03191084
- Testing
- Low Dose THC Marijuana, High Dose THC Marijuana
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Yale University
Driving Impaired, Cognitive Impairment
Dose-response of Cannabis and Driving
Epidemiological studies have established a link between collisions while driving and cannabis use. With the changing legal landscape around cannabis, there is much interest in determining per se limits of cannabis while driving.
- Conditions
- Driving Impaired, Cognitive Impairment, Abuse Cannabis
- Trial name
- NCT03656029
- Testing
- Cannabis
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health