Clinical trials: Marijuana Use, open to volunteers
Breast Carcinoma, Colorectal Carcinoma
Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics
This is a multi-site clinical study enrolling 2000 newly diagnosed patients with breast, colorectal, melanoma, non-Hodgkin lymphoma, or non-small cell lung cancer, who are planning to receive one or more systemic cancer directed…
- Conditions
- Breast Carcinoma, Colorectal Carcinoma, Lung Non-Small Cell Carcinoma, Melanoma
- Trial name
- COSMIC (NCT06418204)
- Testing
- Non-interventional Study
- Where
- 491 sites in United States, Puerto Rico
- Volunteers
- 2,000 people
- Sponsor
- Wake Forest University Health Sciences
Cannabis Use Disorder
Trial of Tirzepatide for the Treatment of Cannabis Use Disorder
The purpose of this randomized, double-blind, placebo-controlled, multi-site clinical trial is to evaluate the safety and efficacy of tirzepatide in a sample of 100 patients diagnosed with moderate or severe CUD by DSM-5 criteria.
- Trial name
- NCT07468552
- Testing
- Tirzepatide
- Volunteers
- 100 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Alcohol Use Disorder, Cannabis Use Disorder
Phenotyping Patients With Alcohol and Cannabis Use Disorders Using the Addictions Neuroclinical Assessment
This 2-arm study will recruit participants with 1) alcohol use disorder and 2) cannabis use disorder for a 12-week cognitive behavioral therapy, following a thorough baseline assessments on executive function, incentive salience…
- Trial name
- NCT05855668
- Testing
- CBT
- Where
- Canada
- Volunteers
- 400 people
- Sponsor
- Centre for Addiction and Mental Health
Opioid Use Disorder, Methadone
Evaluating Tetrahydrocannabinol as an Adjunct to Opioid Agonist Therapy
This pilot study will evaluate the feasibility and safety of using 1:1 tetrahydrocannabinol (THC):Cannabidiol (CBD) cannabis oil as an adjunct therapy to methadone-based Opioid Agonist Therapy (OAT) for individuals with opioid…
- Conditions
- Opioid Use Disorder, Methadone, Cannabis, Fentanyl
- Trial name
- THC-MMT (NCT05985850)
- Testing
- Aurora 1:1 Drops (Indica)
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- BC Centre on Substance Use
Opioid Use Disorders, Cannabis Use
Cannabis and Opioid Use Disorder, Study 2
This inpatient study enrolls healthy individuals who have opioid use disorder. Participants live at the University of Kentucky Hospital for approx. 6 weeks.
- Trial name
- NCT07661446
- Testing
- Inhaled Cannabis, Intranasal Opioid
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Kentucky
Cannabis Use Disorder
Repetitive Transcranial Magnetic Stimulation for Cannabis Use Disorder
There has been a considerable rise in cannabis consumption in recent years, with estimates of 200 million individual users globally.
- Trial name
- NCT05859347
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- Centre for Addiction and Mental Health
Stress Disorders, Post-Traumatic, Marijuana Abuse
Applying Mixed Methods to Identify Links Between PTSD Symptoms, Cannabis Use, and Functional Behaviors With Personalized Feedback Intervention Development
Many Veterans live with posttraumatic stress disorder (PTSD) and use cannabis to manage distress, despite limited supportive evidence.
- Trial name
- NCT07721285
- Testing
- Personalized Feedback Session (PFS)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- VA Office of Research and Development
Cannabis Use, Tobacco Use
Effect of Cannabis on Cigarette Use Behavior
The purpose of this study is to determine the impact of tetrahydrocannabinol (THC) administration on motivational, subjective, and physiological effects of cigarettes.
- Conditions
- Cannabis Use, Tobacco Use, Cigarette Smoking
- Trial name
- NCT06609083
- Testing
- THC 30mg, THC 5mg, THC 0mg
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Cannabis Use Disorder
A Study of Cannabidiol in Young Adult Cannabis Users
The investigators will study the harm-reducing effect of hemp-derived CBD in non-treatment-seeking emerging adults who use cannabis regularly.
- Trial name
- NCT06569394
- Testing
- Broad Spectrum Cannabidiol (bsCBD) 400 mg
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Colorado, Denver
Post Traumatic Stress Disorder, Cannabis Use
Warrior CARE: Cannabis Behavioral Health
This study is a randomized, controlled clinical trial to examine the therapeutic potential of cannabinoids for treating veterans with PTSD and suicidal ideation.
- Conditions
- Post Traumatic Stress Disorder, Cannabis Use, Suicide, Veterans
- Trial name
- CBH (NCT06381180)
- Testing
- Tetrahydrocannabinol, Cannabidiol
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Wayne State University
Cannabis Use, Tobacco Use
Effect of Cannabis on E-Cigarette Use Behavior
The purpose of this study is to determine the impact of tetrahydrocannabinol (THC) administration on motivational, subjective, and physiological effects of electronic cigarettes.
- Conditions
- Cannabis Use, Tobacco Use, Electronic Cigarette Use
- Trial name
- NCT06609109
- Testing
- THC High Dose, THC Low Dose, THC 0mg
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Cannabis Use
Activity-Based Intervention to Address Cannabis Use
This study is being completed to test a method to promote patient-centered outcomes among people who use cannabis behaviors.
- Trial name
- NCT07813442
- Testing
- Motivational and Behavioral Economics Informed Intervention, Enhanced Usual Care
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Michigan
THC, Cannabis
Understanding the Clinical Pharmacology of Marijuana-Tobacco Co-administration
This is a crossover, randomized, double-blinded clinical pharmacology study enrolling dual cannabis-tobacco smokers to better understand the combined effects of co-administering cannabis and tobacco.
- Conditions
- THC, Cannabis, Cannabis Use, Cannabis Smoking
- Trial name
- CANNIC (NCT05999383)
- Testing
- Cannabis, Nicotine, Pax Loose Leaf Vaporizer
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Cannabis Use
Investigating Cannabis Use Parameters on Anesthesia and Inflammation in Lumbar Spinal Surgeries
Cannabis is the most commonly used illicit drug in the United States with reported rates of use increasing from approximately 50 million in 2020 to 61.8 million in 2023 among individuals aged 12 or older.
- Trial name
- NCT07354412
- Where
- 2 sites in United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Cannabis Use Disorder
Determining the Effect of Six Weeks of Cannabis Abstinence on Fronto- Striatal fMRI Markers in Adolescents With Cannabis Use Disorder (ABSCAN)
The goal of this study is to understand the changes in neural correlates of reward in adolescents with and without Cannabis Use Disorder (CUD).
- Trial name
- NCT06124846
- Testing
- CB-Abst, CB-Mon
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Cannabis, HIV
Modeling the Effects of Chronic Marijuana Use on Neuroinflammation and HIV-related Neuronal Injury
This study applies a hypothesis-driven approach to examine the effects of chronic marijuana use on HIV-associated inflammation and its subsequent impacts on central nervous system function, with the goal of identifying the…
- Conditions
- Cannabis, HIV, Inflammation, Cognition
- Trial name
- CHI (NCT04810858)
- Testing
- Multimodal, multi-parametric MRI, Immune and cytokine profiling, Neuropsychological testing
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Alcohol Use, Cannabis Use
MATAspire: Mental Health Awareness Tailored App for Substance Prevention and Integrated Resilience Education
The MATAspire intervention is a web-app designed to promote substance misuse prevention education and bolster protective coping skills whereby students complete six weekly interactive modules using a smart device or computer.
- Conditions
- Alcohol Use, Cannabis Use, Nicotine Use, Illicit Drug Use
- Trial name
- MATAspire (NCT06553196)
- Testing
- MATAspire Web-app
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- California State University, Northridge
Alcohol Use Disorder
Alcohol Use Disorder and Cannabidiol
This is a double-blind, placebo-controlled, parallel group study designed to assess the efficacy of full spectrum CBD and broad spectrum CBD, compared to a placebo control (PC), to reduce drinking in participants with alcohol use…
- Trial name
- NCT05613608
- Testing
- Cannabidiol
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of Colorado, Denver
Cannabis Abuse, Cannabis Dependence
Exercise Intervention as Treatment for People Using Cannabis (ExIT-C)
In Hong Kong, although the total number of drug abusers is trending down in recent years, the number of cannabis users continues to surge.
- Conditions
- Cannabis Abuse, Cannabis Dependence, Cannabis Use Disorder
- Trial name
- ExIT-C (NCT07091292)
- Testing
- Indoor Cycling
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- The University of Hong Kong
Cannabis Withdrawal
Efficacy of PP-01 in Mitigating Cannabis Withdrawal Symptoms in Adults With Cannabis Use Disorder
This study is a randomized, double-blind, placebo and active-controlled, multicenter trial conducted to evaluate whether PP-01 mitigates the withdrawal symptoms associated with discontinuing cannabis in participants with moderate…
- Trial name
- NCT07644052
- Testing
- PP-01, Nabilone
- Where
- 22 sites in United States
- Volunteers
- 420 people
- Sponsor
- PleoPharma, Inc.