Clinical trials: Marker Screening
Bladder Cancer
UroX Biomarker Bladder Cancer Study
This is a prospective observational study looking at urine samples from participants under referral for a standard of care investigative cystoscopy and biopsy.
- Trial name
- NCT03973307
- Testing
- UroX bladder cancer biomarker test
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- East and North Hertfordshire NHS Trust
Lung Cancer
Lung EpiCheck Biomarkers Development Study
This study is part of the development of a non-invasive lung cancer screening test which aim to identify early-stage lung cancer in patients at high risk for lung cancer.
- Trial name
- NCT06245876
- Testing
- Blood collection
- Where
- 10 sites in United States, Hungary and 2 more
- Volunteers
- 2,132 people, healthy volunteers welcome
- Sponsor
- Nucleix Ltd.
Lung Cancer, Tobacco Use Disorder
Biomarkers for Early Detection of Lung Cancer in Patients With Lung Cancer, Participants at High-Risk for Developing Lung Cancer, or Healthy Volunteers
RATIONALE: Collecting and storing samples of sputum and tissue to study in the laboratory may help doctors identify biomarkers related to cancer.
- Trial name
- NCT00899262
- Testing
- immunohistochemistry staining method, laboratory biomarker analysis, sputum cytology
- Where
- 2 sites in United Kingdom
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- South West Wales Cancer Institute
Alzheimer's Disease(AD), Mild Cognitive Impairment (MCI)
Community-based Screening for Alzheimer's Disease
The goal of this prospective, multicenter, observational cohort study is to evaluate the screening performance of blood-based biomarkers for Alzheimer's disease (AD) in a real-world community screening setting, and to establish…
- Conditions
- Alzheimer's Disease(AD), Mild Cognitive Impairment (MCI), Cognitive Impairment
- Trial name
- CSAD (NCT07570719)
- Testing
- No study-specific intervention
- Where
- 4 sites in China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Kuang XiaoJun
Lung Cancer
Plasma microRNA Profiling as First Line Screening Test for Lung Cancer Detection: a Prospective Study
In the present project we propose a large prospective study in heavy smokers volunteers based on plasma miRNA profiling to assess its efficacy as a first line screening test for lung cancer detection.
- Trial name
- BIOMILD (NCT02247453)
- Testing
- screening
- Where
- Italy
- Volunteers
- 4,119 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Mechanism, Marker Screening
Proteomics/Modifier Based on Mass Spectrometry Reveals the Pathogenesis of Eclampsia During Pregnancy and the Screening of Disease Markers
Pregnancy-induced hypertension is a unique abnormal blood pressure disease in women during pregnancy, including eclampsia, preeclampsia, pregnancy-induced hypertension, chronic hypertension and so on.
- Trial name
- NCT04833881
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Heilongjiang University of Chinese Medicine
Diabetic Nephropathy Type 2, Biomarker
Screening and Application Research of Early Diabetic Nephropathy Markers Based on Lipidomics.
Diabetic nephropathy (DN) is one of the major microvascular complications associated with diabetic patients, and also the major global cause of chronic kidney disease and end-stage renal disease (ESRD).
- Trial name
- NCT04931537
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Neoplasms
Development of a Pan-Cancer Screening Model Based on Blood Biomarkers
This study aims to develop a pan-cancer screening model using routine blood biomarkers (including complete blood count, biochemical tests, coagulation panel, and tumor markers).
- Trial name
- PanCanBlood (NCT07554157)
- Testing
- No intervention
- Where
- China
- Volunteers
- 10,000,000 people, healthy volunteers welcome
- Sponsor
- Zhejiang Cancer Hospital
Colorectal Cancer Screening
Validation of Advanced Colorectal Neoplasm Risk Categories in a Prospective Cohort in Mexico
Worldwide, there are 1,361,000 new cases of colorectal cancers (CRC) annually, with 694,000 deaths. However, the incidence varies by up to a factor of 10x between high and low incidence countries (eg.
- Trial name
- COLOFIT (NCT05661292)
- Testing
- Fecal inmunochemical test, Colonoscopy, Optional collection of tissue, blood and urine for future biomedical research
- Where
- Mexico
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
High Myopia
Screening and Identification of Biomarkers for High Myopia by a Rapid Method
To screen and identify sensitive biomarkers for high myopia via a robust, convenient, and cost-effective approach according to the association between high myopia and concentration of biomarkers in tear fluid, saliva and blood…
- Trial name
- NCT05803174
- Testing
- blood sample
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Beijing Tongren Hospital
Oropharyngeal Cancer, HPV-Related Carcinoma
Biomarker Approach to Screening for the Early Detection of HPV-related Oropharyngeal Cancer (BASH OPC)
Investigators seek to determine the sensitivity and specificity of a combined HPV 16 DNA and host gene methylation oral biomarker panel to distinguish early Oropharyngeal Cancer (OPC) cases from controls among 100 early and 100…
- Trial name
- BASH OPC (NCT06305676)
- Testing
- combined HPV 16 DNA and host gene methylation oral biomarker panel
- Where
- 3 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Stomach Neoplasms
Screening of Small Non-coding RNAs as an Auxiliary Diagnostic Biomarker for Gastric Cancer
Gastric cancer is one of the most common malignancies of the gastrointestinal system, especially in East Asia. A host of patients are diagnosed with GC at the late stage, leading to poor patient prognosis.
- Trial name
- NCT06776835
- Testing
- Analysis of relative quantitative of small non-coding RNAs
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital of Nantong University
Lung Cancer Screening
LUNG-07: Advancing Precision-Based Lung Cancer Screening: Implementation, AI-Guided Risk Stratification, and Biomarker Integration (CREST AI)
This research study aims to investigate methods for enhancing lung cancer screening. The study will investigate whether an artificial intelligence (AI) tool, known as Sybil, can aid in predicting the risk of lung cancer.
- Trial name
- NCT07408531
- Testing
- Sybil Artificial Intelligence (AI) screening
- Where
- 2 sites in United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Barrett Esophagus
Clinical Utility of a Non Endoscopic Device EsoCheck and Biomarker EsoGuard as Alternative to Endoscopy for Screening for Barrett's Esophagus in At Risk Population
This will be a prospective randomized, controlled, virtual, patient study to measure the impact of EsoCheck/EsoGuard on health care provider's decision for upper endoscopy referral.
- Trial name
- ASBE (NCT05778851)
- Testing
- EsoGuard result
- Where
- United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Lucid Diagnostics, Inc.
Periodontal Diseases, Inflammatory Response
SCREENING OF EPIGENETIC BIOMARKERS (miRNAs) IN THE GINGIVAL SULCUS
Epigenetics has produced a high impact in biomedical research and is providing new biomarkers for the diagnosis and prognosis of diseases.
- Trial name
- NCT03510702
- Testing
- Levels of epigenetic biomarkers present in the gingival fluid and its possible relationship with bone metabolism.
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Tobacco Use Disorder, Lung Cancer
Assessing the Link Between Smoke Carcinogen Biomarkers and Lung Cancer Risk - 1
Lung cancer is the leading cause of cancer death in the United States. Currently it remains impossible to predict which smokers will get cancer. Each puff of a cigarette delivers a mixture of over 60 known carcinogens.
- Trial name
- NCT00218179
- Testing
- Non-intervention
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
COVID 19, Inflammatory Status
FOUND - Ancillary Study to Smile Protocol NCT03654105
During the current pandemic, in Italy the majority of asymptomatic or pauci-symptomatic COVID-19 cases were not identified nor diagnosed and this fact caused a decrease in the effectiveness of the various containment measures…
- Trial name
- FOUND (NCT04441814)
- Where
- Italy
- Volunteers
- 960 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Cardiomyopathies
Magnetocardiography as a Diagnostic Screening Tool for Myocarditis and Other Types of Cardiomyopathy
Accurate and rapid screening is an unmet medical need to address the increasing demand for advanced diagnostic workup in patients with suspected cardiomyopathy.
- Trial name
- MagMa (NCT06689098)
- Testing
- Magnetocardiography scan
- Where
- Germany
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- German Heart Institute
Cervical Cancer, Cervical Intraepithelial Neoplasia
Dry Run of the ScreenUrSelf Trial
The proposed study is the Dry Run preceding the ScreenUrSelf trial.
- Conditions
- Cervical Cancer, Cervical Intraepithelial Neoplasia, Human Papilloma Virus, HPV-Related Cervical Carcinoma
- Trial name
- NCT05996796
- Testing
- Colli-Pee Small Volumes, Evalyn Brush
- Where
- Belgium
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen