Clinical trials: Marker Screening
Severe Pneumonia, Biomarkers
Rapid Diagnosis of Severe Respiratory Tract Infectious Diseases and Screening of Biomarkers for Stratified Diagnosis
The purpose of this study is to clarify the biomarkers for rapid diagnosis and stratified diagnosis of severe respiratory tract infectious diseases through clinical experiments.
- Trial name
- NCT06533514
- Volunteers
- 100 people
- Sponsor
- Chinese PLA General Hospital
Precancerous Conditions, Neoplasms
Cervical Cancer Prevention: From DNA to mRNA? - New Technologies for Cervical Cancer Screening 2
In industrialized countries, cervical cancer is a well controlled disease thanks to the diffusion of Pap test and, in particular, to organized screening programs, which are able to detect and treat pre-invasive lesions (cervical…
- Trial name
- NTCC2 (NCT01837693)
- Testing
- Experimental: immediate colposcopy
- Where
- 5 sites in Italy
- Volunteers
- 41,127 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Diabetes Mellitus, Diabetes
The Occurence of Pancreatic Cancer Studied in Association With Newly Diagnosed Diabetes in the Elderly
The aim of this study is to accomplish the early diagnosis of pancreatic cancer, in patients over 60 years of age with newly diagnosed diabetes. Only patients with type 2 diabetes are meant to be included.
- Conditions
- Diabetes Mellitus, Diabetes, Diabetes Mellitus, Type 2, Diabetes type2
- Trial name
- NODES (NCT04164602)
- Where
- Hungary
- Volunteers
- 2,522 people
- Sponsor
- University of Pecs
Lung Cancer, Pulmonary Nodule
Improving Detection of Early Lung Cancer in a Diverse Population (IDEAL) Study
The goal of this trial is to (a) identify people at high risk of lung cancer who would benefit from LDCT screening but are currently ineligible based on current lung cancer screening criteria (b) provide the framework to manage…
- Trial name
- IDEAL (NCT06628102)
- Testing
- Chest CT Scan
- Where
- Canada
- Volunteers
- 3,600 people, healthy volunteers welcome
- Sponsor
- British Columbia Cancer Agency
Lung Cancer
Manchester Lung Health Study
The Manchester Lung Health Study (qUEST) will assess the uptake of a community-based lung cancer screening service and its impact across a deprived area of North and East Manchester, which has high rates of lung cancer.
- Trial name
- qUEST (NCT04409444)
- Testing
- Lung Cancer Screening, Biomarkers
- Where
- United Kingdom
- Volunteers
- 9,730 people
- Sponsor
- Manchester University NHS Foundation Trust
Lung Cancer
Early Lung Cancer Detection in High Risk Individuals
The MILD project is a randomized lung cancer screening trial whose primary aim is to evaluate the impact on mortality of early lung cancer detection through LDCT (low-dose computed tomography) in 2 groups: a control group…
- Trial name
- MILD (NCT02837809)
- Testing
- Low dose CT
- Where
- Italy
- Volunteers
- 4,099 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Intracerebral Hemorrhage
Biomarkers and Imaging Markers for ICH
Intracerebral hemorrhage (ICH) is a subtype of stroke associated with high mortality and disability. Basic and clinical research has contributed to our understanding of the complex pathophysiology in ICH.
- Trial name
- NCT06462274
- Testing
- body sample collection and imaging scan
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Southwest Hospital, China
Down Syndrome (Trisomy 21), Edwards Syndrome (Trisomy 18)
Non-Invasive Screening for Fetal Aneuploidy: A New Maternal Plasma Marker
Validate that circulating cell free fetal nucleic acid can be used to identify a direct marker for fetal aneuploidy, particularly fetal Down Syndrome (DS), that is better than surrogate markers.
- Conditions
- Down Syndrome (Trisomy 21), Edwards Syndrome (Trisomy 18), Patau Syndrome (Trisomy 13), Turner Syndrome
- Trial name
- NCT00770458
- Where
- 7 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Sequenom, Inc.
Periodontitis, Diagnosis
Self-detection and Professional Screening Strategies for Early Detection of Periodontal Disease
The majority of the burden of periodontal diseases in the population remain undetected. Self-detection and confirmation with simple, non-clinical tests may improve early case detection and access to the needed level of care.
- Conditions
- Periodontitis, Diagnosis, Self-Assessment
- Trial name
- NCT05513599
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Chronic Atrophic Gastritis, Depressive Symptoms
Objective Vascular Biomarkers as Triage for Depression in Chronic Atrophic Gastritis
Depressive symptoms are highly prevalent in patients with chronic atrophic gastritis (CAG) but are frequently under-detected due to stigma and reliance on subjective questionnaires.
- Conditions
- Chronic Atrophic Gastritis, Depressive Symptoms, Depression, Gastrointestinal Diseases
- Trial name
- NCT07319338
- Testing
- Vascular-Psychological Triage Workflow
- Where
- 4 sites in China
- Volunteers
- 520 people
- Sponsor
- China Academy of Chinese Medical Sciences
Motor Neuron Disease, Amyotrophic Lateral Sclerosis
Clinical Characteristics, Natural History, Health Care Measures, and Genetic Screening in Patients With ALS
Patients with sporadic ALS (sALS), which refers to those without a family history of ALS, are typically not subjected to genetic investigations as part of their standard care. Therefore, their mutation status is often unknown.
- Trial name
- ID-ALS (NCT05852405)
- Where
- Germany
- Volunteers
- 2,000 people
- Sponsor
- Ambulanzpartner Soziotechnologie APST GmbH
Pre-Eclampsia
Study for Improving Maternal, Pregnancy and Child Outcomes
The overall aims of this proposal are to improve, facilitate, optimize and equalize the existing screening system for adverse pregnancy outcomes in early pregnancy in order to limit adverse consequences for both the mother and…
- Trial name
- IMPACT (NCT03831490)
- Testing
- history
- Where
- 9 sites in Sweden
- Volunteers
- 13,000 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Sarcopenia, Coxarthrosis
Sarcopenia Screening in Advanced Coxarthrosis: The SARCO-COX Study
The SARCO-COX study evaluates whether screening for sarcopenia (loss of muscle strength and mass) in adults aged 65 years or older with advanced hip osteoarthritis, followed by a structured postoperative exercise program…
- Trial name
- SARCO-COX (NCT07734129)
- Testing
- Intensive Physical Rehabilitation, Preoperative Sarcopenia Screening
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Preeclampsia
CercaTest™ Red Urine Test for Predicting Preeclampsia
The goal of this observational study is to predict preeclampsia in pregnant women aged 18 years or older with a singleton pregnancy at 20 or more weeks of gestation who present with suspected signs or symptoms of preeclampsia.
- Trial name
- PRE-CERCA (NCT07625501)
- Where
- Hong Kong
- Volunteers
- 1,000 people
- Sponsor
- Chinese University of Hong Kong
Lung Cancer
Circulating and Imaging Biomarkers to Improve Lung Cancer Management and Early Detection
Validation of biomolecular markers in the circulation and radiomic features are the focus of this project.The aim is to assess the role of molecular and cellular biomarkers (exosomes antigens, Circulating tumor cells - CTCs…
- Trial name
- SMAC-2 (NCT04315753)
- Testing
- LDCT (Low Dose CT)
- Where
- Italy
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
HER2-positive Gastric Cancer
ctDNA Screening in Advanced HER2 Positive Gastric Cancer
To identify molecular biomarker panel correlating with efficacy of trastuzuamb in advanced HER2 positive gastric cancer patients.
- Trial name
- NCT04520295
- Testing
- ctDNA screening
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Ruijin Hospital
Nasopharyngeal Carcinoma
Screening Nasopharyngeal Carcinoma With EBV Associated Biomarkers in Zhongshan City
The study includes two cohorts: (1) a serological screening cohort; (2) a serological and EBV DNA screening cohort. All participants will be tested for EBNA1-IgA, VCA-IgA, BNLF2b total antibodies (P85-Ab), with additional plasma…
- Trial name
- NCT04085900
- Testing
- Blood and saliva, P85-Ab, EBNA1-IgA, VCA-IgA, Consecutive EBV DNA testing
- Where
- 2 sites in China
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- Zhongshan People's Hospital, Guangdong, China
Gestatiaonl Diabetes Mellitus, Early Pregnancy
Biomarkers for Early Screening of Gestational Diabetes Mellitus
Gestational Diabetes Mellitus (GDM) refers to the abnormal glucose metabolism first detected during pregnancy. It is estimated that approximately 7% of pregnant women worldwide and their offspring are affected by GDM.
- Trial name
- NCT05142020
- Where
- China
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Colorectal Cancer
PRESEPT Study: Evaluation of SEPT9 Biomarker Performance for Colorectal Cancer Screening
The purpose of this study is to collect blood specimens and clinical data from screening guideline eligible individuals designated by their physician to receive a screening colonoscopy, and to evaluate the performance of a…
- Trial name
- PRESEPT (NCT00855348)
- Testing
- All eligible subjects will provide blood for SEPT9 biomarker testing
- Where
- 23 sites in United States, Germany
- Volunteers
- 7,929 people, healthy volunteers welcome
- Sponsor
- Epigenomics, Inc
Cervical Dysplasia, Uterine, Vaginal Dysplasia
Clinical, Translational and Biomarker-Based Female Genital HPV Induced Dysplasia and Cancer Screening Study Using Cf-HPV-DNA Blood Tests
Uterine cervical dysplasia and other female genital dysplasia continue to be significant health problems despite Cervical Screening Programs and HPV vaccinations being available.
- Conditions
- Cervical Dysplasia, Uterine, Vaginal Dysplasia, Vulvar Dysplasia
- Trial name
- TTMV HPV DNA (NCT05536843)
- Volunteers
- 500 people
- Sponsor
- University of Mississippi Medical Center