Clinical trials: Mask
Diabetic Macular Edema (DME)
A Phase 3 Trial for Intravitreal Injection of 4D-150 in Adults With Diabetic Macular Edema (DME).
A Phase 3, Randomized, Double-Masked, Active-Controlled Trial to Evaluate the Safety, Efficacy, and Durability of a Single Intravitreal Injection of 4D-150 versus Aflibercept in Adults with Diabetic Macular Edema (4SIGHT)
- Trial name
- 4SIGHT (NCT07867080)
- Testing
- 4D-150 IVT (3x10^10 vg), EYELEA ® (aflibercept) Injection 2 mg (0.05mL)
- Where
- 87 sites in United States, China and 1 more
- Volunteers
- 514 people
- Sponsor
- 4D Molecular Therapeutics
Osa Syndrome
Nasal Versus Oronasal Mask in Continuous Positive Airway Pressure (CPAP) Treatment of Patients Affected by Obstructive Sleep Apnea Syndrome (OSAS).
Continuous positive airway pressure (CPAP) is considered the gold standard treatment for patients with moderate to severe obstructive sleep apnea (OSA).
- Trial name
- NCT04681196
- Testing
- patients shifted to nasal mask after persistent OSA with oronasal mask
- Where
- Italy
- Volunteers
- 61 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Face Mask Squeeze
Use of the Mask and Current Pandemic
Due to the continued use of the mask in order to prevent the spread of COVID-19, an impact on people is observed in different areas.
- Trial name
- Mask (NCT04727762)
- Where
- Spain
- Volunteers
- 542 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Virtual Reality, Catheterization, Peripheral Venous
Virtual Reality and Peripheral Intravenous Catheter Insertion to Children (R3VP)
Main objective : Evaluate the effect of using a virtual reality mask during the peripheral intravenous catheter insertion in a pediatric day hospital on the pain and anxiety in children from 6 to 11 years old.
- Conditions
- Virtual Reality, Catheterization, Peripheral Venous, Children, Only, Pain, Procedural
- Trial name
- R3VP (NCT05066061)
- Testing
- control arm, anxiolytic and analgesic gas, Virtual reality mask
- Where
- France
- Volunteers
- 34 people
- Sponsor
- University Hospital, Clermont-Ferrand
Age Related Macular Degeneration (ARMD)
ReNEW:Phase 3 Study of Efficacy, Safety & Pharmacokinetics of Subcutaneous Injections of Elamipretide in Subjects With Dry Age-Related Macular Degeneration (Dry AMD)
The goal of this clinical trial is to evaluate the efficacy, safety and pharmacokinetics of elamipretide in subjects with dry age-related macular degeneration (AMD).
- Trial name
- ReNEW (NCT06373731)
- Testing
- Elamipretide
- Where
- 53 sites in United States, Czechia and 6 more
- Volunteers
- 313 people
- Sponsor
- Stealth BioTherapeutics Inc.
Surgery
OPTiMASK: Comparison of Pre-oxygenation With Standard Face Mask Combined With High Flow Nasal Oxygen With Pre-oxygenation With Standard Face Mask Alone
This is an observational, prospective study of patients undergoing a surgical procedure. Three parallel studies are taking place with collaborators in other countries.
- Trial name
- NCT05495841
- Testing
- Pre-oxygenation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Beth Israel Deaconess Medical Center
Anesthesia, Deep Sedation
Comparison of Two Electroencephalograms (EEG) Monitors in Patients Undergoing General Anesthesia
Hypothesis: There is a statistically measurable correlation between qNOX and rough clinical signs of insufficient anti-nociception such as movements during Laryngeal Mask Airway (LMA) insertion, skin Incision, LMA removal.
- Trial name
- NCT02928172
- Testing
- qCON-qNOX, BIS
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Cedars-Sinai Medical Center
Apnea, Bradycardia
MRSOPA-Drills to Improve Mask Ventilation in the Delivery Room
Establishing breathing after birth is vital for survival and long-term health of premature babies. 10% of all preterm babies fail to breathe after birth and require help with breathing.
- Trial name
- MRSOPA (NCT02375230)
- Testing
- Control group, MR SOPA
- Where
- Canada
- Volunteers
- 56 people
- Sponsor
- University of Alberta
Covid19, Tuberculosis
New Reusable Mask Design With Superior Filtration and Fit
This study will test the filtration, air leak, and breathability of a newly designed fully washable mask developed by Dr. Nordell with the Mayo Clinic.
- Conditions
- Covid19, Tuberculosis, Respiratory Viral Infection
- Trial name
- NCT04826809
- Testing
- N95 mask, Nordell single E-100 layer mask, Nordell double E-100 layer mask
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Sleep Apnea, Obstructive
Humidity Under Continuous Positive Airway Pressure
Heated humidification in CPAP therapy is often not enough to prevent side effects like dryness of nasal mucosa and xerostomia, especially in cases of mouth breathing or mask leakage.
- Trial name
- NCT01462409
- Testing
- RESMed S9 with humidifier H5i and heated tube Climate Line, CPAP without humidification, CPAP with heated humidification
- Where
- Germany
- Volunteers
- 19 people
- Sponsor
- Institut für Pneumologie Hagen Ambrock eV
Laryngeal Mask, Throat Pain
The Effect of Preoperative Chewing Gum on Anxiety and Sore Throat in Patients With Laryngeal Mask Airway
This study was planned to investigate the effect of chewing gum in the preoperative period on patients' sore throat and anxiety levels.
- Conditions
- Laryngeal Mask, Throat Pain, Anxiety
- Trial name
- NCT06168981
- Testing
- Chewing Gum
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Ankara Medipol University
Dry Eye
LME636 in the Relief of Persistent Ocular Discomfort in Subjects With Severe Dry Eye Disease
The purpose of this study is to evaluate the efficacy of LME636 compared to vehicle in the reduction of ocular symptoms and to evaluate the safety and tolerability of LME636, when administered topically for up to 42 days, in…
- Trial name
- NCT02365519
- Testing
- LME636 ophthalmic solution, LME636 Vehicle
- Volunteers
- 514 people
- Sponsor
- Alcon, a Novartis Company
Second Degree Perineal Tear During Delivery - Delivered, Episiotomy; Complications
Perineal Local Infiltration Study
The prevalence of birth canal lacerations is more than 70% of all deliveries in Canada. The repair of such lacerations is usually done using a pre-existing epidural analgesia.
- Conditions
- Second Degree Perineal Tear During Delivery - Delivered, Episiotomy; Complications, Anesthesia, Local
- Trial name
- PLIS (NCT03672500)
- Testing
- Bupivacaine 0.5%+Epinephrine 50mc
- Where
- Canada
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Dry Eye Disease (DED)
Evaluation of the Efficacy and Safety of OC-01 Nasal Spray on Signs and Symptoms of Dry Eye Disease
The objective of this study is to evaluate the safety and effectiveness of OC-01 Nasal Spray as compared to placebo on signs and symptoms of dry eye disease.
- Trial name
- NCT04036292
- Testing
- OC-01 (varenicline) nasal spray
- Where
- 22 sites in United States
- Volunteers
- 758 people
- Sponsor
- Oyster Point Pharma, Inc.
Thyroid Eye Disease
Study to Assess Batoclimab in Participants With Active Thyroid Eye Disease
To evaluate the efficacy of batoclimab 680 milligrams (mg) subcutaneous (SC) once a week (QW) for 12 weeks followed by 340 mg SC QW for 12 weeks versus placebo on proptosis responder rate at Week 24.
- Trial name
- NCT05524571
- Testing
- Batoclimab
- Where
- 45 sites in United States, Australia and 9 more
- Volunteers
- 86 people
- Sponsor
- Immunovant Sciences GmbH
Prevention of COVID-19
Effects of Surgical Mask Use on Peak Torque, Total Work and Interset Fatigability During Isokinetic Strength Testing
The coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly transmittable person-to-person when an infected individual coughs, sneezes or talks while within at least 6…
- Trial name
- NCT04706299
- Testing
- Resistance Exercise
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Airway Management
Artificial Intelligence-Assisted Ultrasound Assessment of Laryngeal Mask Airway Placement
This prospective observational study aims to develop and evaluate artificial intelligence-based models for the assessment of laryngeal mask airway (LMA) placement in adult patients undergoing elective surgery under general…
- Trial name
- NCT07766382
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Duzce University
Dry Eye Syndromes
Evaluation of the Safety and Effectiveness of the Oculeve Intranasal Lacrimal Neurostimulator in Patients With Dry Eye
The purpose of this study was to evaluate the safety and effectiveness of the Intranasal Tear Neurostimulator applied intranasally compared with the same device applied extranasally (control) in treating the symptoms of dry eye…
- Trial name
- NCT02313454
- Testing
- Intranasal Tear Neurostimulator
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Allergan
COPD, Walking, Difficulty
Effect of Face Masks on Pulmonary Function in Patients With COPD
Given the heightened vulnerability of COPD patients to severe illness upon SARS-CoV-2 infection, precautions like mask-wearing are deemed crucial.
- Trial name
- NCT05742880
- Testing
- 6 Minute Walking Test, Blood gas analysis, Wearing a Surgical Facemask
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Medical University of Vienna
Neovascular Age-Related Macular Degeneration (nAMD)
A Clinical Study of QL1207H Injection Versus Aflibercept for Neovascular Age-related Macular Degeneration
The goal of this clinical trial is to evaluate the efficacy and safety of QL1207H injection versus aflibercept 8 mg in patients with neovascular age-related macular degeneration.
- Trial name
- NCT07489586
- Testing
- QL1207H injection, Aflibercept 8 mg
- Volunteers
- 356 people
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
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