Clinical trials: Masses
Adnexal Mass
Accuracy of the Characterization of Adnexal Masses, Indeterminate at Ultrasonography, Using a MRI Protocol Without Contrast: Validation of the Cambridge Score
The aim of this prospective observational study is to evaluate the accuracy and to validate the Cambridge Score,a Test Index to predict the malignancy of the ovarian lesions on the basis of an MRI examination without contrast
- Trial name
- CAMBRIDGE (NCT05815992)
- Where
- Italy
- Volunteers
- 370 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Ovarian Cancer
Prospective Evaluation of the Role of MRI in Ovarian Masses During Pregnancy
Ovarian cancer represents 7% of all cancers in pregnant women. Characterizing an ovarian mass during pregnancy is essential to avoid unnecessary treatment and if treatment is required, to plan it accordingly.
- Trial name
- PROM-P (NCT06635837)
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Kidney Cancer
Investigation of Differential Biology of Benign and Malignant Renal Masses Using Advanced Magnetic Resonance Imaging Techniques
The aim of this study is to develop techniques for non-invasive imaging of biology in participants with benign or malignant renal masses based on the novel scanning MRI techniques, including recently invented Hyperpolarised MRI…
- Trial name
- IBM-Renal (NCT06016075)
- Testing
- Hyperpolarised MRI, Sodium MRI, Deuterium metabolic imaging (DMI) MRI
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Cambridge
Gastric Subepitelial Mass
Endoscopic Resection of Gastric Subepithelial Masses, EndoResect Study
Gastric subepithelial masses might harbour gastrointestinal stromal tumors, which should get resected because of their malignant potential. To minimize the associated surgical trauma endoscopic endoluminal resection is favorable.
- Trial name
- EndoResect (NCT01105728)
- Testing
- Endoscopic resection
- Where
- Germany
- Volunteers
- 38 people
- Sponsor
- Technical University of Munich
Breast Masses
Breast Masses MRI Volumetry Compared to Post-operative Pathological Volume
Breast cancer is one of the most common malignancies afflicting women worldwide 1. Tumor size is important prognostic factor, its accurate measurement is essential for formulating surgery and chemotherapy plans.
- Trial name
- NCT07268300
- Volunteers
- 59 people
- Sponsor
- Assiut University
Renal Cell Carcinoma
European Active Surveillance of Renal Cell Carcinoma Study (EASE RCC Study)
The goal of this observational, prospective, multi-national clinical study is to assess overall survival of patients who are diagnosed with incidental, histologically (biopsy) confirmed, <4 cm Renal Cell Carcinoma (RCC) and are…
- Trial name
- EASE (NCT06336187)
- Testing
- active surveillance, molecular investigation
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Meningioma, Glioblastoma
Pilot Study Evaluating Panitumumab-IRDye800 as an Optical Imaging Agent to Detect Intracranial Lesions During Neurosurgical Procedures
This pilot clinical study evaluates the safety and imaging performance of panitumumab-IRDye800 (pan800), a fluorescent, EGFR-targeted imaging agent - in patients undergoing neurosurgical resection of intracranial lesions.
- Conditions
- Meningioma, Glioblastoma, Acoustic Neuroma, Brain Cancer
- Trial name
- NCT07493447
- Testing
- Panitumumab-IRDye800
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Eben Rosenthal
Hodgkin Lymphoma, B-Cell Lymphoma
Detection and Characterization of Residual Masses in Lymphomas
The present study aims to further optimize a whole-body Diffusion-Weighted Magnetic Resonance Imagery (DW-MRI or DWI) protocol on 3 Tesla MR and/or new system combining 3Tesla MR and Positron Emission Tomography (PET), to develop…
- Trial name
- ADAMANTIUS (NCT02300402)
- Where
- France
- Volunteers
- 120 people
- Sponsor
- The Lymphoma Academic Research Organisation
Architectural Distortions, Breast Tomosynthesis
Comparison of Conspicuity of Masses and Architectural Distortions Between Wide- and Narrow-angle Digital Breast Tomosynthesis Systems
To compare narrow-angle digital breast tomosynthesis (DBT) and wide-angle DBT.
- Trial name
- NCT06373354
- Testing
- Digital Breast Tomosynthesis (DBT)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- M.D. Anderson Cancer Center
Submucosal Tumor, Pancreas Tumor
25G and 22G Puncture Needles
The screened patients were randomly assigned 25G puncture needles and 22G puncture needles in a 1;1 ratio, based on the computer-generated random order, before receiving an ultrasound endoscope puncture.
- Trial name
- NCT05101772
- Where
- China
- Volunteers
- 73 people
- Sponsor
- Peking Union Medical College Hospital
Patients With Adnexal Mass Prior to Surgery
Prospective Validation and Comparison of Different Ultrasound Methods for Discrimination Between Benign and Malignant Ovarian/Tubal Masses Prior to Surgery
The ability of different methods to discriminate between benign and malignant adnexal masses has been compared in a meta-analysis showing that the IOTA Simple Rules and the IOTA logistic regression model LR2 were superior to RMI…
- Trial name
- IOTA7 (NCT02847832)
- Testing
- Standardized transvaginal ultrasound examination
- Where
- Belgium
- Volunteers
- 1,700 people
- Sponsor
- KU Leuven
Contrast Media, Computed Tomography
Multiple Arterial Phase Computed Tomography Examination to Improve Detection of Tumors in the Liver and Pancreas
To examine inter-subject variations of optimal late arterial phase contrast-enhancement defined as the greatest difference in contrast attenuation of hepatocellular carcinoma (HCC) compared to background liver parenchyma resp.
- Conditions
- Contrast Media, Computed Tomography, Imaging, Pancreatic Cancer
- Trial name
- NCT04813432
- Testing
- Computed Tomography of the Abdomen
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Karolinska Institutet
Pancreas Cancer, Pancreas Neoplasm, Benign
Endoscopic Ultrasound Guided Tissue Sampling (The SharkBITE Study)
This study compares the diagnostic performance of Endoscopic ultrasound (EUS) guided fine needle aspiration and EUS guided core biopsy (SharkCore) in patients with a solid pancreatic mass.
- Conditions
- Pancreas Cancer, Pancreas Neoplasm, Benign, Chronic Pancreatitis, Pancreas Adenocarcinoma
- Trial name
- SharkBITE (NCT03532347)
- Testing
- EUS-FNA needle (Beacon)
- Where
- United Kingdom
- Volunteers
- 108 people
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Complex Adnexal Masses
MRI Perfusion in Adnexal Masses
As ovarian cancer is characterized by an anarchic neovascularization resulting in a wide number of immature microvessels. These vessels are characterized by a lack of coverage by pericytes and the higher expression of one of the…
- Trial name
- MRI-CAM (NCT02694406)
- Testing
- MRI perfusion
- Where
- 2 sites in Egypt
- Volunteers
- 40 people
- Sponsor
- Assiut University
Breast Carcinoma
Contrast Enhanced Ultrasound Medical Imaging for Identifying Breast Masses
This clinical trial investigates the role of contrast enhanced ultrasound (CEUS) in identifying cystic breast masses as benign or malignant.
- Trial name
- NCT06171607
- Testing
- Contrast-Enhanced Ultrasound, Perflutren Lipid Microspheres, Sulfur Hexafluoride Lipid Microspheres
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Southern California
Cystic Renal Disease, Kidney Cancer
Comparison of Surgery and Active Surveillance in the Treatment of Bosniak III Renal Cysts
The incidence of renal cysts is rising due to increased abdominal imaging. Renal complicated cysts have been traditionally classified according to the Bosniak classification, which distinguishes cystic masses by specific features…
- Conditions
- Cystic Renal Disease, Kidney Cancer, Surgery
- Trial name
- NCT04670887
- Testing
- Delayed surgery, Immediate surgery
- Volunteers
- 200 people
- Sponsor
- Helsinki University Central Hospital
Pancreatic Tumor
Efficiency Study of the EUS-FNA Needles With and Without a Side Port in Pancreatic Masses
For diagnosis of pancreatic tumors, endoscopic ultrasound (EUS) and EUS-guided fine needle aspiration (EUS-FNA) are well established techniques in clinical practice.
- Trial name
- NCT01978808
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Ovarian Mass
Concordance Between Radiologic Laparoscopic and Laparotomic Evaluation for Complete Cytoreduction of Ovarian Masses
Ovarian mass occur in women of all ages, and their etiology and frequency range age accordingly. The ovarian mass may come from functional or physiological changes, inflammatory processes, endometriosis, benign and malignant…
- Trial name
- NCT07416435
- Volunteers
- 28 people
- Sponsor
- Assiut University
Osteosarcoma
Single High-dose Brachytherapy for Giant Osteosarcoma Masses
This study is a prospective, single-arm, phase II, single-center study. Patients with locally unresectable giant osteosarcoma masses who meet the criteria are enrolled in the experimental group, and all patients receive a single…
- Trial name
- NCT06524778
- Testing
- brachytherapy
- Volunteers
- 16 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Pancreatic Masses
Optimal Number of To-and-fro Motion in EUS-guided Fine Needle Aspiration for Pancreatic Masses
EUS-FNA is the standard of care for diagnosing pancreatic masses. According to the operator's preference, EUS-FNA with suction or without suction technique has been used.
- Trial name
- NCT01576497
- Testing
- EUS-FNA, EUS-FNA with suction, EUS-FNA without suction
- Where
- South Korea
- Volunteers
- 193 people
- Sponsor
- Asan Medical Center