Clinical trials: Massive Transfusion
Wounds and Injuries, Shock, Hemorrhagic
Trauma Resuscitation With Low-Titer Group O Whole Blood or Products
The goal of this clinical trial is to compare the effectiveness of unseparated whole blood (referred to as Low-Titer Group O Whole Blood) and the separate components of whole blood (including red cells, plasma, platelets, and…
- Trial name
- TROOP (NCT05638581)
- Testing
- LTOWB, Components
- Where
- 13 sites in United States
- Volunteers
- 1,100 people
- Sponsor
- University of Alabama at Birmingham
Post Partum Hemorrhage, Fibrinogenolysis; Hemorrhage
Patient Blood Management for Massive Obstetric Hemorrhage
Obstetric Hemorrhage continues to be the first cause of maternal morbidity and mortality around the world especially in middle to low income countriesThe blood components are high value resources; however, its use has been shown…
- Conditions
- Post Partum Hemorrhage, Fibrinogenolysis; Hemorrhage, Fibrinogen; Deficiency, Acquired, Massive Hemorrhage
- Trial name
- NCT03784794
- Testing
- Thromboelastometry, Standard Coagulation Test, Fibrinogen Concentrate Human
- Where
- Mexico
- Volunteers
- 100 people
- Sponsor
- Angel Augusto Perez Calatayud
Trauma, Blood Transfusion Complication
UltraMTP in Adult Trauma Patients Undergoing Surgery Within 24 Hours: Effects on Mortality and Clinical Outcomes
The purpose of this study is to determine the effects of ultraMTP (>/=30 units pRBC within 24 hours) in trauma patients on mortality and secondary outcomes.
- Conditions
- Trauma, Blood Transfusion Complication, Death
- Trial name
- NCT04866953
- Testing
- Blood transfusion
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- University of Southern California
Cardiac Surgery, Cardiopulmonary Bypass
AProtinin Versus Tranexamic Acid in Cardiac Surgery Patients With High-risk for Excessive Bleeding
In this before-after multicenter study the authors tested the hypothesis that the prophylactic use of aprotinin compared to tranexamic acid could reduce the proportion of patients presenting severe perioperative bleeding.
- Conditions
- Cardiac Surgery, Cardiopulmonary Bypass, High Risk Bleeding
- Trial name
- APACHE (NCT04804345)
- Testing
- standard of care
- Where
- 7 sites in France
- Volunteers
- 693 people
- Sponsor
- University Hospital, Bordeaux
Massive Transfusion, Bleeding During/Following Surgery
"ADE Fibrinogen/RBC" Ratio on Mortality and Outcome in Massive Transfusion Patients
Our study focuses on the transfusion of blood and blood products in cases of major bleeding, including massive transfusion scenarios where repeated doses of packed red blood cells (PRBC), fresh frozen plasma (FFP)…
- Trial name
- ADEFES (NCT06021184)
- Where
- Turkey (Türkiye)
- Volunteers
- 1,679 people
- Sponsor
- Ankara City Hospital Bilkent
Thromboembolus, Massive Blood Transfusion; Thrombocytopenia
Comparative Outcomes of PCC and Recombinant Activated Factor VIIa in Trauma-Associated Massive Transfusion
This study aims to compare the incidence of thromboembolic complications among trauma patients receiving PCC, rFVIIa, both agents, or neither during massive transfusion.
- Conditions
- Thromboembolus, Massive Blood Transfusion; Thrombocytopenia, Trauma
- Trial name
- NCT07290634
- Testing
- Number of Participants with massive blood transfusion
- Where
- 2 sites in United States
- Volunteers
- 75 people
- Sponsor
- Zeliha Alicikus
Trauma
Massive Transfusion in Trauma Patient Registry
The early use of blood products as a part of Massive Transfusion Protocol (MTP) during trauma resuscitation has been increasingly supported by providers and backed by the literature.
- Trial name
- NCT06136715
- Testing
- blood products as a part of Massive Transfusion Protocol
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Methodist Health System
Abdominal Injuries, Wounds and Injuries
Predictors of In-Hospital Mortality in Severe Abdominal Trauma
Severe abdominal trauma is a leading cause of early death from bleeding and of later death from sepsis and organ failure. Clinicians use scoring systems to estimate the risk of dying, but most of these scores were developed and…
- Conditions
- Abdominal Injuries, Wounds and Injuries, Wounds, Nonpenetrating, Wounds, Penetrating
- Trial name
- NCT07843628
- Where
- Egypt
- Volunteers
- 430 people
- Sponsor
- Minia University
Trauma Associated Hemorrhage
Prehospital Transfusion Outcomes in Traumatic Hemorrhage: a Prospective Cohort Study
Traumatic injuries can cause severe bleeding, which causes a lot of deaths worldwide that could be prevented. Starting treatment as early as possible has been shown to improve survival, which makes fast care very important.
- Trial name
- PRONTO (NCT07883252)
- Where
- Netherlands
- Volunteers
- 750 people
- Sponsor
- Erasmus Medical Center
Trauma Patients Received Blood Transfusion ≥ 10 U, Trauma Patients Had Not Received Blood Transfusion ≥ 10 U
Delta Shock Index in Predicting Massive Transfusion
Background: To determine the performance of delta shock index (ΔSI), a change in shock index (SI) upon arrival at the emergency room (ER) from that in the field in predicting the need for massive transfusion (MT) among adult…
- Trial name
- NCT03786705
- Testing
- Massive transfusion, Non-Massive Transfusion
- Where
- Taiwan
- Volunteers
- 7,957 people
- Sponsor
- Chang Gung Memorial Hospital
Blood Transfusion Complication
To Establish a Blood Transfusion Prediction Model for Liver Transplantation Patients Based on PBM
Based on the principle of patient blood management, this study aims to reduce the risk of blood transfusion in allogeneic liver transplantation patients, to ensure the safety of blood transfusion, and to provide new methods and…
- Trial name
- NCT03814772
- Testing
- Liver transplant
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Adverse Effects in the Therapeutic Use of Other and Unspecified Agents Affecting Blood Constituents
Antibiotic Concentrations After MassivE Transfusion Study
Combat and civilian trauma frequently result in open wounds that are at risk for infection. Data from the Department of Defense Trauma Registry demonstrate that 74% of combat trauma casualties have an open wound.
- Trial name
- ACME (NCT06699901)
- Testing
- Massive Transfusion Group, Control Group
- Where
- 2 sites in United States
- Volunteers
- 417 people
- Sponsor
- Brooke Army Medical Center
Transfusion Related Complications
Clinical Trial of West-China Perioperative Transfusion Score (WCPTS）for Massive Hemorrhagic Surgery
Guidelines for blood transfusion have been issued for years. According to these guidelines, red blood cells (RBCs) transfusion should be given when the hemoglobin level is less than 6g/dL or 7g/dL and is unnecessary when the…
- Trial name
- WCPTS (NCT01345643)
- Testing
- Maintenance of hemoglobin level not less than 10g/dL, Transfusion trigger based on WCPTS
- Where
- China
- Volunteers
- 190 people
- Sponsor
- Ren Liao
Blood Coagulation Disorders, Trauma
Evaluating URMC's Massive Transfusion Protocol
The purpose of the study is to evaluate the efficacy of the University of Rochester Medical Center's current Massive Transfusion Protocol.
- Conditions
- Blood Coagulation Disorders, Trauma, Acute Coagulopathy
- Trial name
- MTP-TEG (NCT02083549)
- Testing
- Blood collection
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Rochester
Trauma
Unmet Need for Massive Transfusion in Indian Trauma Patients
This study aims to estimate the difference between predicted and provided massive transfusion in adult trauma patients admitted to university hospitals in urban India.
- Trial name
- NCT03068104
- Testing
- No intervention
- Volunteers
- 16,047 people
- Sponsor
- Karolinska Institutet
Bleeding, Massive Hemorrhage
Initial Resuscitation With Albumin in Hemorrhagic Shock to Reduce Positive Fluid Balance
This study is designed to evaluate the effect of early albumin transfusion within massive transfusion protocol on fluid balance and reduced requirement of transfusion.
- Conditions
- Bleeding, Massive Hemorrhage, Massive Transfusion Protocol
- Trial name
- ABSOLUTE (NCT06111261)
- Testing
- Albumin solution, Balanced crystalloid solution
- Volunteers
- 36 people
- Sponsor
- Seoul National University Hospital
Massive Transfusion, Nomogram Model
A Nomogram Predicting the Risk of High-dose Transfusion in Non-cardiac Surgery
This retrospective study was designed to develop a preoperative nomogram, validated both internally and externally, to supply an individual and precise tool for predicting the probability that patients will require perioperative…
- Trial name
- NCT06701747
- Where
- China
- Volunteers
- 11,197 people
- Sponsor
- West China Hospital
Trauma
Pragmatic, Randomized Optimal Platelet and Plasma Ratios
Pragmatic, Randomized, Optimal Platelet and Plasma Ratios (PROPPR)is a Phase III trial designed to evaluate the difference in 24-hour and 30-day mortality among subjects predicted to receive massive transfusion ([MT] (defined as…
- Trial name
- PROPPR (NCT01545232)
- Testing
- 1:1:1 Blood Transfusion Ratio, 1:1:2 Blood Transfusion Ratio
- Where
- 12 sites in United States, Canada
- Volunteers
- 680 people
- Sponsor
- The University of Texas Health Science Center, Houston
Hemorrhage, Trauma
Empiric Calcium in Massive Transfusion
Calcium helps blood to clot and thereby stop bleeding. Trauma patients who experience large volume blood loss often require blood transfusions and bleeding is the most common cause of death.
- Conditions
- Hemorrhage, Trauma, Hypocalcemia, Shock, Hemorrhagic
- Trial name
- NCT05953376
- Testing
- Calcium Gluconate
- Sponsor
- University of California, Irvine
Surgical Blood Loss, Surgical Hemorrhage
TEG Use in Children Undergoing Procedures With High Anticipated Blood Loss
The research team proposes a prospective, observational study to better understand how TEG can be useful in guiding clinical practice in the Main OR for subject's undergoing high transfusion risk surgeries.
- Conditions
- Surgical Blood Loss, Surgical Hemorrhage, Post Operative Hemorrhage
- Trial name
- NCT05379530
- Testing
- Thromboelastography (TEG), Anesthesia Provider Survey
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital