Clinical trials: Mastectomy
Fascial Plane Block, Pain, Postoperative
Transverse vs. Longitudinal Serratus Anterior Plane Block in Breast Surgery
The aim of this prospective, randomized controlled trial is to compare the analgesic efficacy of transverse versus longitudinal ultrasound probe orientations during Serratus Anterior Plane (SAP) block in patients undergoing…
- Conditions
- Fascial Plane Block, Pain, Postoperative, Breast Surgery, Acute Pain
- Trial name
- NCT07739277
- Testing
- Transverse SAP Block, Longitudinal SAP Block
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Ankara Etlik City Hospital
Breast Cancer Surgery
Long-term Safety of Nipple Sparing Mastectomy in Women With High Penetrance Breast Cancer Susceptibility Genes in Breast Cancer
Patients with a germline pathogenic variant (GPV) in high-penetrance breast cancer susceptibility genes who are considering risk reducing mastectomy (RRM) often strongly desire to keep their nipple areola complex but inquire as…
- Trial name
- NSM (NCT06888388)
- Testing
- Nipple Sparing Mastectomy (NSM), Skin-Sparing Mastectomy (SSM), Total (Simple) Mastectomy
- Where
- 16 sites in United States, Australia and 6 more
- Volunteers
- 4,700 people
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Breast Cancer, Breast Neoplasms
Study of the Safety of MRI Scans in People Who Have Breast Tissue Expanders After Mastectomy
The purpose of this study is to find out whether it is safe to perform MRI scans in people who have breast tissue expanders in place.
- Conditions
- Breast Cancer, Breast Neoplasms, Breast Adenocarcinoma
- Trial name
- NCT04769960
- Testing
- MRI Studies, Patient Reported Outcomes
- Where
- 3 sites in United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Upper Limb Edema
Scapular PNF and Activity Oriented Antiedema Proprioceptive Therapy on Shoulder Dysfunction Post Mastectomy Lymphedema
Eighty -four female patients suffering from shoulder dysfunction after breast cancer-related arm lymphedema, will Cairo University hospitals be randomly distributed into three groups equal in number.
- Trial name
- NCT06602180
- Testing
- Scapular PNF technique, (TAPA) technique for the affected shoulder region plus conventional physiotherapy program in a form of (Complex decongestive therapy (CDT)., Activity-Oriented Antiedema Proprioceptive Therapy (TAPA) technique for the affected shoulder region plus conventional physiotherapy program in a form of (Complex decongestive therapy (CDT), Scapular proprioceptive neuromuscular facilitation PNF technique for the affected shoulder region plus conventional physiotherapy program in a form of (Complex decongestive therapy (CDT)
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Cairo University
Breast Cancer, Node-positive Breast Cancer
Hypofractionated Regional Nodal Irradiation Clinical Trial for Women With Breast Cancer
Single-arm, phase 2 study evaluating hypofractionated irradiation of breast and regional nodes in women with breast cancer. Patients will be grouped in 3 surgery-related treatment groups: 1) An intact breast following lumpectomy…
- Conditions
- Breast Cancer, Node-positive Breast Cancer, Breast Adenocarcinoma, Invasive Breast Carcinoma
- Trial name
- NCT02515110
- Testing
- External Beam Radiation Therapy
- Where
- 2 sites in United States
- Volunteers
- 137 people
- Sponsor
- Virginia Commonwealth University
Ductal Breast Carcinoma, Invasive Breast Carcinoma
Hypofractionated Radiation Therapy After Mastectomy in Preventing Recurrence in Patients With Stage IIa-IIIa Breast Cancer
This randomized phase III trial studies how well hypofractionated radiation therapy works in preventing recurrence in patients with stage IIa-IIIa cancer who have undergone mastectomy.
- Conditions
- Ductal Breast Carcinoma, Invasive Breast Carcinoma, Lobular Breast Carcinoma, Medullary Breast Carcinoma
- Trial name
- NCT03414970
- Testing
- Radiation Therapy, Questionnaire Administration, Quality-of-Life Assessment
- Where
- 859 sites in United States, Canada
- Volunteers
- 898 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Breast Cancer Surgery, Postoperative Pain, Acute
Chronic Pain in Post-Mastectomy Patients; The Difference Between Pectoral Nerve (PECS I-II) and Erector Spinal Plane (ESP) Blocks
This study looks at two types of injections (called PECS and ESP blocks) to see which one works better for reducing pain after breast cancer surgery (mastectomy).
- Conditions
- Breast Cancer Surgery, Postoperative Pain, Acute, Postoperative Pain, Chronic, Post-mastectomy Pain Syndrome
- Trial name
- NCT06900842
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Hacettepe University
Immune Deficiency, Diet, Healthy
Aerobic Training and Diet on the Immune System in Postmastectomy Patients Receiving Chemotherapy
The purpose of the study was to investigate the impact of aerobic exercise combined with diet protocol on the immune system in post-mastectomy patients receiving chemotherapy.
- Conditions
- Immune Deficiency, Diet, Healthy, Breast Cancer
- Trial name
- NCT05605808
- Testing
- Aerobic exercises, Diet protocol
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Esketamine and the Quality of Recovery
Esketamine Administration on Recovery Quality After Radical Mastectomy
Some studies have reported that intravenous esketamine reduce postoperative pain intensity. The investigators investigated whether esketamine could improve the the quality of recovery after modified radical mastectomy.
- Trial name
- NCT05289440
- Testing
- Low-dose esketamine infusion, High-dose esketamine infusion, Saline infusion
- Where
- China
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Anqing Municipal Hospital
Breast Cancer
Multidisciplinary Care Pathway With Electronic Patient Reported Outcomes (ePRO) Post-operative Follow-up of Breast Cancer Surgery Complications to Optimize Patient Quality of Life
This project is a follow-on study of the BEAUTIFY-2 study (NCT04957186). The "BEAUTIFY" (BrEast cAncer qUaliTy of lIfe aFter surgerY) program was built by a committee of experts on the basis of reflections carried out within 2…
- Trial name
- BEAUTIFY-3 (NCT05449340)
- Testing
- BEAUTIFY application
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Mastectomy Related Lymphedema, Breast Reconstruction
A Comparison of Dermal Autograft to AlloDerm in Breast Reconstruction
Breast Cancer affects about 1 out of 8 American women. Twenty percent of breast cancer patients undergo some form of breast reconstruction. Several types of reconstructive procedures are available for appropriate patients.
- Conditions
- Mastectomy Related Lymphedema, Breast Reconstruction, Breast Cancer
- Trial name
- NCT01561287
- Testing
- Dermal Autograft, AlloDerm
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Kentucky
Breast Neoplasms
Women Underwent TRAM Surgery: Its Influence on Abdominal Muscle Function and the Effects of Therapeutic Exercises
The unilateral transverse rectus abdominis musculocutaneous (TRAM) flap is a major operation widely used for breast reconstruction.
- Trial name
- NCT04886921
- Testing
- Abdominal muscle training
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Breast Cancer, Post-Mastectomy
Incentive Spirometry With and Without Transcutaneous Electric Diaphragmatic Stimulation in Post-mastectomy Patients
This randomized clinical trial will compare the effects of incentive spirometer therapy with and without transcutaneous electrical diaphragmatic stimulation (TEDS) in females who have undergone mastectomy.
- Trial name
- NCT07862426
- Testing
- Transcutaneous Electrical Diaphragmatic Stimulation, Incentive Spirometer, Conventional Physiotherapy
- Where
- Pakistan
- Volunteers
- 58 people
- Sponsor
- University of Lahore
Breast Cancer, Pain, Postoperative
IV Dexmedetomidine vs Oral Gabapentin and Their Combination for Postoperative Analgesia in Cancer Patients Undergoing Modified Radical Mastectomy
Breast cancer is the most common malignant tumour among females with an incidence of about 2.1 million women every year.Nearly about 40-60% of breast surgery patients develop severe acute postoperative pain.⁴ Opioids are the…
- Conditions
- Breast Cancer, Pain, Postoperative, Pain, Acute
- Trial name
- NCT06354478
- Testing
- Dexmedetomidine Hydrochloride 0.5 MG/ML, Gabapentin
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- National Cancer Institute, Egypt
Breast Cancer Surgery, Reconstruction Breast Surgery
Improvement in Breast Skin Sensibility After Breast Reconstruction: a Comparison of 3 Surgical Techniques
The goal of this clinical trial is to learn if nerve sutures in free flap breast reconstruction can optimize sensibility in the reconstructed breast in patients opting for DIEP flap breast reconstruction due to breast cancer or…
- Conditions
- Breast Cancer Surgery, Reconstruction Breast Surgery, Sensitization, DIEP Flap Breast Reconstruction
- Trial name
- S-DIEP (NCT06930378)
- Testing
- Nerve Suture
- Where
- Switzerland
- Volunteers
- 63 people
- Sponsor
- Patricia Esther Engels
Breast Reconstruction, Mastectomy; Lymphedema
New Era of DIEP With Minimally Invasive Mastectomy
The free deep inferior epigastric artery perforator (DIEP) flap is the gold standard in autologous breast reconstruction. Asian patients often present with a smaller body mass index with relatively insufficient tissue.
- Trial name
- NCT06321549
- Testing
- The reference point of minimally invasive mastectomy procedure conducted
- Where
- Taiwan
- Volunteers
- 278 people
- Sponsor
- Chang Gung Memorial Hospital
Lymphoedema
A Clinical Trial About the Contribution of Manual Lymph Drainage in Complex Physical Therapy for Patients With Lymphoedema Secondary to Mastectomy
Hypothesis: To know the utility of manual lymph drainage (MLD) as part of the Physical Complex Therapy has turn out relevant because of the exclusive dedication that it supposes to the therapist.
- Trial name
- NCT01152099
- Testing
- Compression Bandaging, Manual Lymph Drainage (MLD) and Compression Bandaging
- Where
- Spain
- Volunteers
- 39 people
- Sponsor
- Fundación de Investigación Biomédica - Hospital Universitario de La Princesa
Breast Cancer, BRCA Mutation
Tranexamic Acid Usage in Bilateral Mastectomy to Reduce Post-surgical Drainage
Tranexamic acid (TxA) is a drug that was approved by the FDA in 1986. It is an antifibrinolytic drug - this means that it is used to promote blood clotting by preventing the breakdown of blood clots that the participant's body…
- Trial name
- NCT05554211
- Testing
- Tranexamic acid, Normal saline
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northwestern University
Post Mastectomy Lymphedema
Educational Program on Self-Management for Women With Post-Mastectomy Lymphedema
Post mastectomy lymphedema is a chronic disease that negatively affect physical, social, psychological and emotional well-being, so Patient education regarding self-management is crucial to enhance women's self -care and quality…
- Trial name
- NCT06591871
- Testing
- Self-management educational program for post mastectomy lymphedema women
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Assiut University
Post Operative Pain
Comparing Between Ultrasound Guided Pectoral Nerve Block Versus Ultrasound Guided Mid-point Transverse Process Block for Postoperative Analgesia in Patients Undergoing Modified Radical Mastectomy
The aim of the study is to compare the effectiveness of ultrasound guided pectoral nerve block versus mid-point transverse process block for postoperative analgesia in patients undergoing modified radical mastectomy
- Trial name
- NCT06873893
- Testing
- Midpoint transverse process block, Pectoral Nerve Block
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University