Clinical trials: Maternal Blood Loss
Premature Birth, Neonatal Hypoglycemia
Higher-Dose Dexamethasone Improves Breathing and Shortens NICU Stay in Preterm Babies
The goal of this observational study was to compare two doses of dexamethasone given to pregnant women at risk of preterm birth. Dexamethasone is a medicine used before birth to help a baby's lungs mature.
- Conditions
- Premature Birth, Neonatal Hypoglycemia, Maternal Infection During Pregnancy, Neurodevelopmental Disorder of Foetus
- Trial name
- NCT07765329
- Testing
- Dexamethasone 12 mg Every 12 Hours, Dexamethasone 6 mg Every 12 Hours
- Where
- Indonesia
- Volunteers
- 200 people
- Sponsor
- Stella Maris Women and Children Hospital
Post-partum Hemorrhage
REBOA in Life-threatening Postpartum Hemorrhage (PPH) in Uganda
Background Maternal mortality rates in many low-income countries (LMICs) remain high. The most prominent cause is bleeding after birth, called postpartum haemorrhage (PPH).
- Trial name
- REBOA-PPH (NCT05598502)
- Testing
- REBOA, Resuscitative Endovascular Occlusion of the Aorta, National guidelines
- Where
- Uganda
- Volunteers
- 95 people
- Sponsor
- Centre For International Health
Hypovolemic Shock, Hemorrhage
Efficacy Study of the Non-Pneumatic Anti-Shock Garment (NASG) in Egypt
This study will test the efficacy of the NASG on women suffering from obstetric hemorrhage as compared to hemorrhaging women who do not receive the NASG.
- Trial name
- NCT00305253
- Testing
- Non-pneumatic Anti-shock Garment (NASG)
- Where
- 2 sites in Egypt
- Volunteers
- 990 people
- Sponsor
- University of California, San Francisco
Postpartum Hemorrhage
Study of Predictors of Failure of Sulprostone Treatment in Postpartum Hemorrhage
The investigators wish to identify potential factors predicting failure of second-line drug treatment (sulproston (Nalador®)): risk factors and factors linked to a failure to take initial care for PPH.
- Trial name
- NALAPOST (NCT06164236)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Strasbourg, France
Post Partum Hemorrhage
Combating Maternal Mortality in Uganda: An Assessment of the Role of Misoprostol in Prevention of Post-Partum Hemorrhage
Null hypothesis: 10 IU Oxytocin is better than sublingual misoprostol 600µg in management of third stage of labor Alternative hypothesis: Sublingual misoprostol 600µg is non- inferior to 10 IU oxytocin and will not be more than…
- Trial name
- NCT01866241
- Testing
- Misoprostol
- Where
- Uganda
- Volunteers
- 1,140 people
- Sponsor
- Mbarara University of Science and Technology
Pregnancy Complications, Maternal Death
Nutrition Optimalization Among Pregnant Women to Improve Maternal and Neonatal Outcome in DKI Jakarta
The goal of this MONAS Study is to learn about comprehensive monitoring and nutritional intervention among pregnant women in order to improve maternal and neonatal outcomes. The main questions it aims to answer are: 1.
- Conditions
- Pregnancy Complications, Maternal Death, Preeclampsia, Intrauterine Infection
- Trial name
- MONAS (NCT06268509)
- Testing
- Nutritional panel laboratory examination, Pregnancy supplements (other than provided by Ministry of Health), Fetomaternal ultrasound
- Where
- Indonesia
- Volunteers
- 245 people
- Sponsor
- Dr Cipto Mangunkusumo General Hospital
Gestational Diabetes, Pregnancy Complications
Gestational Diabetes Monitoring and Management
The primary goal is to predict the clinical outcomes of mother and baby using blood glucose and other routinely collected clinical data in pregnancy to predict adverse outcomes at birth in women with GDM.
- Conditions
- Gestational Diabetes, Pregnancy Complications, Pregnancy in Diabetic, Pregnancy, High Risk
- Trial name
- NCT06963528
- Where
- United Kingdom
- Volunteers
- 1,800 people
- Sponsor
- University of Oxford
Hypovolemic Shock, Hemorrhage
Non-Pneumatic Anti-Shock Garment for Obstetrical Hemorrhage: Zambia and Zimbabwe
This trial will address the question of whether early application of the Non-pneumatic Anti-Shock Garment (NASG) at the Satellite Health Facility (SHF) level before transport to a Referral Hospital (RH) will decrease maternal…
- Trial name
- NASG (NCT00488462)
- Testing
- non-pneumatic anti-shock garment
- Where
- 5 sites in Zambia, Zimbabwe
- Volunteers
- 887 people
- Sponsor
- University of California, San Francisco
Postpartum Hemorrhage
The Influence of Prenatal Factors on Maternal Hemorrhage
This research evaluates the effects of prenatal factors on adverse pregnancy outcomes, the general demographic information, the level of maternal exposure to air pollution, the environmental condition, pregnancy-related…
- Trial name
- TIOPFOMH (NCT04517617)
- Testing
- The level of air pollution
- Where
- China
- Volunteers
- 500 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Obstetric Labor Complications, Post-partum Hemorrhage
Improving Maternal and Child Health in India: Evaluating Demand and Supply Side Strategies (IMATCHINE)
The study evaluates the impact of a new conditional cash transfer (CCT) program (Thayi Bhagya Yojana) to promote child birth in obstetric facilities in the state of Karnataka, India in order to determine its policy value and to…
- Conditions
- Obstetric Labor Complications, Post-partum Hemorrhage, Sepsis, Pre-eclampsia
- Trial name
- IMATCHINE (NCT01480544)
- Testing
- Experimental: Treatment 1, Experimental: Treatment 2
- Where
- India
- Volunteers
- 14,990 people
- Sponsor
- Duke University
Postpartum Hemorrhage, Cesarean Section Complications
Comparison of the Efficacy of Misoprostol and Tranexamic Acid for Postpartum Hemorrhage Prophylaxis in Cesarean Delivery
Postpartum hemorrhage (PPH) is an obstetric emergency, with an estimated incidence ranging from 2.8% to 7.9%. Recent studies indicate an increasing trend in the frequency of PPH.Although it is more commonly seen in developing…
- Conditions
- Postpartum Hemorrhage, Cesarean Section Complications, Delivery Complication
- Trial name
- NCT06970483
- Testing
- Tranexamic acid, Misoprostol 200mcg Tab
- Where
- Turkey (Türkiye)
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Ankara Etlik City Hospital
Blood Loss
Maternal-fetal Outcomes of Genital Blood Loss Beyond 18 Weeks of Pregnancy
The primary objective is to assess in terms of frequency the adverse outcomes (premature birth, maternal-fetal haemorrhage, maternal fetal-neonatal death) of pregnancies of women attending the obstetric-gynaecological emergency…
- Trial name
- PEG18 (NCT06802874)
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Post Partum Hemorrhage
Effect of Delayed vs Immediate Umbilical Cord Clamping on Maternal Blood Loss in Term Spontaneous Vaginal Delivery
Policies for timing of cord clamping vary, with early cord clamping generally carried out in the first 60 seconds aLer birth, whereas latercord clamping usually involves clamping the umbilical cord greater than one minute after…
- Trial name
- NCT04353544
- Testing
- delayed cord clamping
- Where
- Italy
- Volunteers
- 122 people
- Sponsor
- Federico II University
Third Stage of Delivery
Maternal Outcomes Following Manual Lysis of the Placenta.
Comparison of maternal outcomes following manual lysis of placenta 15 vs 30 minutes after delivery. A primary outcome of the drop in hemoglobin will be compared between the two groups.
- Trial name
- NCT03626844
- Testing
- Manual Lysis of Placenta after 15 minutes (Intervention), Manual Lysis of Placenta after 30 minutes (Control)
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Holy Family Hospital, Nazareth, Israel
Postpartum Hemorrhage
Oral Misoprostol Versus Intravenous Oxytocin in Preventing Blood Loss After Non-scheduled Cesarean Section
Postpartum hemorrhage (PPH) ranks among the leading causes of maternal morbidity and mortality, both in developed and developing countries.
- Trial name
- NCT00107874
- Testing
- misoprostol
- Where
- Switzerland
- Volunteers
- 56 people
- Sponsor
- University Hospital, Basel, Switzerland
Early Pregnancy Bleeding, Recurrent Pregnancy Loss
Maternal and Newborn Safety Profile of Progestogens in EARLY Pregnancy
This multinational, prospective, active surveillance, registry study following two cohorts will include study participants who are pregnant and seeking any type of medical treatment, including dydrogesterone and other…
- Trial name
- PEARLY (NCT05186779)
- Testing
- Progestagen
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Center for Epidemiology and Health Research, Germany
Obesity, Maternal, Post Partum Hemorrhage
Efficacy of Carbetocin in Prevention of Postpartum Hemorrhage in Obese Versus Non Obese Women
Postpartum hemorrhage [PPH] can have serious consequences and is the leading cause of maternal mortality globally. Uterine contractility plays an important role in post-delivery uterine involution; impaired contractility can…
- Trial name
- NCT06217354
- Testing
- Carbetocin 100 Microgram/mL Solution for Injection
- Where
- Egypt
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Cairo University
Maternal Blood Loss, Cesarean Delivery
Delayed Cord Clamping at Term Cesarean
The purpose of this research study is to find out how delaying cutting the umbilical cord until one minute after delivery of the baby during a cesarean impacts the amount of blood the mother loses during surgery.
- Conditions
- Maternal Blood Loss, Cesarean Delivery, Delayed Cord Clamping, Neonatal Health
- Trial name
- NCT03150641
- Testing
- Umbilical cord clamping
- Where
- United States
- Volunteers
- 113 people
- Sponsor
- Columbia University
Post Partum Hemorrhage, Asphyxia; Fetal
Evaluation of Maternal & Newborn Health Simulation Lab Centers of Excellence in Nepal
Postpartum hemorrhage and birth asphyxia are the leading causes of maternal and neonatal mortalities worldwide. Prevention and adequate treatment are, therefore crucial.
- Conditions
- Post Partum Hemorrhage, Asphyxia; Fetal, Maternal-Fetal Relations
- Trial name
- SLAB (NCT06577922)
- Testing
- Establishment of a simulation lab and provision of simulation based trainings
- Where
- Nepal
- Volunteers
- 1,464 people, healthy volunteers welcome
- Sponsor
- One Heart Worldwide
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health