Clinical trials: Maternal Substance Use
Substance-Related Disorders
Growing Together: Women in Opioid Treatment and Their Infants
This study evaluates the effectiveness of the home-based therapeutic parenting intervention BRIGHT with pregnant women and postpartum mothers with opioid use disorders (OUDs) and their infants.
- Trial name
- NCT03866694
- Testing
- BRIGHT, STAR/TAU+
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Boston University Charles River Campus
Substance Abuse Problem, Pregnancy
Prenatal Cocaine, Nasal Oxytocin, and Maternal Psychophysiology
The purpose of this research is to study the effects of nasal oxytocin administration on maternal behaviors that may be influenced by cocaine use during pregnancy.
- Trial name
- NOX (NCT02872467)
- Testing
- Syntocinon treatment
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Pregnancy
Prenatal Exposure Effects Psychophysiology Study
The purpose of the study is to understand the biology and behavior of early mother-infant attachment, and to investigate how it may be affected by prenatal substance exposures.
- Trial name
- PEEPS (NCT01134770)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Substance Use
Evaluation of EBT With Young, Substance Abusing Homeless Mothers
A dearth of information is available regarding how best to intervene with substance use disordered homeless mothers and their young children.
- Trial name
- NCT02577666
- Testing
- Ecologically Based Therapy, Housing Only, Treatment as Usual
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Substance Use Disorders (SUD), Pregnancy
Culturally Engaged REcovery: MOms Connected Through Native communitY
Pregnant and postpartum American Indian and Alaska Native people (Native mothers) face a more than two-fold higher risk of maternal mortality compared to non-Hispanic White mothers.
- Conditions
- Substance Use Disorders (SUD), Pregnancy, Maternal Morbidity and Mortality, Cultural Adaptation
- Trial name
- CEREMONY (NCT06747442)
- Testing
- Cradleboard Journey
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- University of Utah
Family Relations, Mental Health
Mothers Living With HIV and Their Adolescent Children
Context: Mothers living with HIV (MLH) and their children face predictable challenges: maintaining physical and mental health, parenting while ill, and addressing HIV-related stressors.
- Conditions
- Family Relations, Mental Health, Physical Health, Risky Sexual Behavior
- Trial name
- TALK LA (NCT00988390)
- Testing
- Cognitive-behavioral, small-group format sessions
- Volunteers
- 543 people
- Sponsor
- University of California, Los Angeles
Tobacco Smoking in Mother Complicating Pregnancy, Tobacco Use Disorder
Smoking Reduction In Gravid Substance Use Disorders
The aim of this study is to encourage smoking cessation in women with substance use disorders by providing knowledge of expired carbon monoxide.
- Conditions
- Tobacco Smoking in Mother Complicating Pregnancy, Tobacco Use Disorder, Tobacco Smoking
- Trial name
- SIGS (NCT04132232)
- Testing
- knowledge of expired maternal carbon monoxide and fetal carboxyhemoglobin levels
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Substance Use Disorders, Pregnancy Related
The Oklahoma Parent-Child Assistance Program
The Parent-Child Assistance Program (PCAP) helps mothers who have used alcohol, opioids, or other drugs during pregnancy and their children through the work of highly trained, closely supervised case managers.
- Conditions
- Substance Use Disorders, Pregnancy Related, Alcohol Use Disorder (AUD), Alcohol Use Complicating Pregnancy, First Trimester
- Trial name
- NCT05534568
- Testing
- Parent-Child Assistance Program
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of Oklahoma
Opioid Use Disorder
Neuroplasticity in Maternal Opioid Use Disorder (OUD)
Opioid use disorder (OUD) remains a major public health problem particularly for mothers in the perinatal period, for whom stress, relapse rates, and risk for overdose are elevated.
- Trial name
- NCT05495984
- Testing
- ERPs with electroencephalography (EEG), MIO
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Yale University
Substance Use Disorders, Pregnancy
Study of Ultrasound To Increase Parental Bonding in Women With Substance Use Disorders
1. A randomized trial of 3-dimensional vs. 2-dimensional ultrasound, comparing scores on the Maternal Antenatal Attachment Scale (MAAS), a validated instrument measuring maternal attachment as a marker of maternal bonding.
- Trial name
- NCT02158429
- Testing
- 2 dimensional vs. 3 dimensional ultrasound
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Hawaii
Opioid Use Disorder
Child Healthcare at MATER - Pediatric Study
The objective of this project is to implement and evaluate a group model of well child care for mothers in treatment for opioid use disorder and their children that addresses the specific health needs and concerns of…
- Trial name
- CHAMPS (NCT05488379)
- Testing
- Group well child care
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Thomas Jefferson University
Substance Use Disorders, Children of Mothers With Substance Use Disorders
Parenting Intervention for Mothers With Substance Use Disorder
Children of mothers with substance use disorder (SUD) constitute a growing and highly vulnerable population. Evidence-based parenting interventions have the potential to both support parents' recovery and mental health by helping…
- Trial name
- NCT06489522
- Testing
- THRIVE
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Boston Medical Center
Opioid Use Disorder, Substance-Related Disorders
Maternal Brain Imaging in Opioid Use Disorder
This research study aims to learn more about opioid use disorder (OUD) during pregnancy and how outcomes for pregnant women and their newborns can be improved.
- Conditions
- Opioid Use Disorder, Substance-Related Disorders, Substance Use, Pregnancy Related
- Trial name
- NCT06008990
- Testing
- Buprenorphine, Maternal Brain MRI, Blood Samples
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Indiana University
Opioid Use Disorder, Neonatal Abstinence Syndrome
An Intervention Mapping Approach to Closing the Gap in Maternal OUD and Infant NAS Care (SUPPORT)
The purpose of this study is to address the gap in maternal OUD treatment and infant neonatal opioid withdrawal syndrome care. The research team will develop a treatment model and a set of strategies to provide evidence-based OUD…
- Trial name
- SUPPORT (NCT06576323)
- Testing
- An implementation model for co-located Medications for Opioid Use Disorder (MOUD) prescription in the NICU
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Opioid Use Disorder, Maternal Drugs Affecting Fetus
Night Respite for Postpartum Mothers With SUD
This single arm pilot feasibility study will evaluate the implementation of overnight infant respite care and parenting skills to mothers with substance use disorders in the early postpartum period residing in residential…
- Conditions
- Opioid Use Disorder, Maternal Drugs Affecting Fetus, Postpartum Mood Disturbance, Sleep Disorder
- Trial name
- NCT05746507
- Testing
- Night Respite Care
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- Massachusetts General Hospital
Opioid-use Disorder, Opioid Use, Unspecified
Opioid Use Disorder in Pregnancy in Long-Term Maternal/Infant Outcomes
The objective of this study is to better understand the comprehensive integration of both clinical and genetic factors that will help to identify mothers who could be at an increased risk of poor response to opioid substitution…
- Conditions
- Opioid-use Disorder, Opioid Use, Unspecified, Buprenorphine Dependence
- Trial name
- Mother/BabyOUD (NCT03923374)
- Testing
- Subutex / Buprenorphine, Fetal & Neonatal MRI, DNA/Genetic/Pharmacokenetic Blood Draws
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Senthil Sadhasivam
Opioid-use Disorder
Buprenorphine vs Buprenorphine/Naloxone on the Effects of Maternal Symptomatology
This study will assesses the efficacy of buprenorphine/naloxone vs buprenorphine on maternal withdrawal symptoms and drug cravings.
- Trial name
- NCT03740243
- Testing
- Buprenorphine/naloxone, Buprenorphine
- Volunteers
- healthy volunteers welcome
- Sponsor
- Stony Brook University
Maternal Substance Use, Child Abuse and Neglect
Stage I Randomized Trial of Mentalization-Based Therapy for Substance Using Mothers of Infants and Toddlers
The primary goal of this Stage I therapy development study will be to manualize and test the preliminary efficacy of a parenting intervention for drug dependent mothers that aims to foster their ability to recognize children's…
- Trial name
- NCT00319436
- Testing
- Mentalizing Therapy for Substance Using Mothers, Standard Parent Education for Substance Using Mothers
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Yale University
Substance Use Treatment, Perinatal Substance Use
Improving Outcomes for Early Postpartum Mothers in Outpatient MOUD Treatment
Drug overdose is a leading cause of death among postpartum women and opioid-related mortality is 4 times higher in the postpartum period when compared to the third trimester of pregnancy.
- Conditions
- Substance Use Treatment, Perinatal Substance Use, Parenting
- Trial name
- NCT07071766
- Testing
- Proud of Baby and Me
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Arkansas
Substance Use Disorders
Interventions for HIV+ Mothers With Problem Drinking
The purpose of this study is to evaluate the efficacy of a 14-session behavioral intervention for HIV-infected and uninfected mothers with problem drinking.
- Trial name
- NCT00183209
- Testing
- Family First
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- New York University