Clinical trials: Maternal Substance Use, open to volunteers
Pregnancy
Prenatal Exposure Effects Psychophysiology Study
The purpose of the study is to understand the biology and behavior of early mother-infant attachment, and to investigate how it may be affected by prenatal substance exposures.
- Trial name
- PEEPS (NCT01134770)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Substance Use Disorders (SUD), Pregnancy
Culturally Engaged REcovery: MOms Connected Through Native communitY
Pregnant and postpartum American Indian and Alaska Native people (Native mothers) face a more than two-fold higher risk of maternal mortality compared to non-Hispanic White mothers.
- Conditions
- Substance Use Disorders (SUD), Pregnancy, Maternal Morbidity and Mortality, Cultural Adaptation
- Trial name
- CEREMONY (NCT06747442)
- Testing
- Cradleboard Journey
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- University of Utah
Substance Use Disorders, Pregnancy Related
The Oklahoma Parent-Child Assistance Program
The Parent-Child Assistance Program (PCAP) helps mothers who have used alcohol, opioids, or other drugs during pregnancy and their children through the work of highly trained, closely supervised case managers.
- Conditions
- Substance Use Disorders, Pregnancy Related, Alcohol Use Disorder (AUD), Alcohol Use Complicating Pregnancy, First Trimester
- Trial name
- NCT05534568
- Testing
- Parent-Child Assistance Program
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of Oklahoma
Opioid Use Disorder, Neonatal Abstinence Syndrome
An Intervention Mapping Approach to Closing the Gap in Maternal OUD and Infant NAS Care (SUPPORT)
The purpose of this study is to address the gap in maternal OUD treatment and infant neonatal opioid withdrawal syndrome care. The research team will develop a treatment model and a set of strategies to provide evidence-based OUD…
- Trial name
- SUPPORT (NCT06576323)
- Testing
- An implementation model for co-located Medications for Opioid Use Disorder (MOUD) prescription in the NICU
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Opioid-use Disorder, Opioid Use, Unspecified
Opioid Use Disorder in Pregnancy in Long-Term Maternal/Infant Outcomes
The objective of this study is to better understand the comprehensive integration of both clinical and genetic factors that will help to identify mothers who could be at an increased risk of poor response to opioid substitution…
- Conditions
- Opioid-use Disorder, Opioid Use, Unspecified, Buprenorphine Dependence
- Trial name
- Mother/BabyOUD (NCT03923374)
- Testing
- Subutex / Buprenorphine, Fetal & Neonatal MRI, DNA/Genetic/Pharmacokenetic Blood Draws
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Senthil Sadhasivam
Substance Use Treatment, Perinatal Substance Use
Improving Outcomes for Early Postpartum Mothers in Outpatient MOUD Treatment
Drug overdose is a leading cause of death among postpartum women and opioid-related mortality is 4 times higher in the postpartum period when compared to the third trimester of pregnancy.
- Conditions
- Substance Use Treatment, Perinatal Substance Use, Parenting
- Trial name
- NCT07071766
- Testing
- Proud of Baby and Me
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Arkansas
Opioid Use Disorder, Pregnancy Related
Predicting and Preventing Adverse Maternal and Child Outcomes of Opioid Use Disorder in Pregnancy
This study will be a 12-month prospective, genotype-blinded longitudinal observational study with current standard of clinical care. This study will enroll 100 pregnant women with OUD at UPMC Hospitals with its high volumes.
- Trial name
- NCT05942313
- Testing
- Buprenorphine/ Methadone exposure
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Ilana Hull
Mother-Child Relations, Substance Use
Optimizing Mental Health for Infants Exposed to Early Adversity: A Comparison of Breaking the Cycle and Maxxine Wright
The goal of this clinical trial is to compare the effectiveness of the Breaking the Cycle (BTC) and Maxxine Wright (MW) programs in substance-involved mothers and their children.
- Trial name
- NCT05768815
- Testing
- Breaking the Cycle Program, Maxxine Wright Program
- Where
- 2 sites in Canada
- Volunteers
- 100 people
- Sponsor
- University of Ottawa
Opioid Use Disorder, Parent-Child Relations
Postpartum Intervention for Mothers With Opioid Use Disorders (R33)
Having met the milestones of the R61, this R33 is a 2-site, 2-group, pre/post RCT of mothers with OUD (n=~80/group). We will test whether the beneficial pre-post changes in OUD mothers randomized to vMP exceed those of mothers…
- Trial name
- PIMO (NCT07632053)
- Testing
- Mom Power
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Stony Brook University
Substance Use Disorders, Parent-Child Relations
MIO-CPP to Improve the Well-being, Permanency, and Safety Outcomes for Young Children at Risk of or in Out-of-home Placement in Philadelphia and Bucks Counties, and Affected by Maternal Substance Use
The goal of the project is to improve child well-being, permanency, and safety, and reduce the risk for involvement in the child welfare system for families with children pre-birth to five years who are affected by parental…
- Conditions
- Substance Use Disorders, Parent-Child Relations, Parent Child Abuse
- Trial name
- NCT04294134
- Testing
- MIO-CPP
- Where
- United States
- Volunteers
- 320 people
- Sponsor
- Children's Hospital of Philadelphia
Stress Disorders, Post-Traumatic, Opioid Use Disorder
MDMA for Co-occurring PTSD and OUD After Childbirth
This is an open-label study of the use of MDMA Assisted Therapy for postpartum people with co-occurring Post Traumatic Stress Disorder (PTSD) and Opioid Use Disorder (OUD).
- Trial name
- NCT05219175
- Testing
- MDMA Assisted Therapy
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of New Mexico
Alcohol-Related Disorders, Substance-Related Disorders
Improving Alcohol and Substance Use Care Access, Outcome, Equity During the Reproductive Years
The goal of this clinical trial is to test the effectiveness of evidence-based Screening, Brief Intervention, and Referral to Treatment (SBIRT) among adult patients who screen positive to one or more risky alcohol or substance…
- Conditions
- Alcohol-Related Disorders, Substance-Related Disorders, Mental Health, Reproductive Health
- Trial name
- NCT05910580
- Testing
- Screening, Brief Intervention, and Referral to Treatment (SBIRT)
- Where
- 4 sites in United States
- Volunteers
- 400 people
- Sponsor
- Emory University
Substance Use Disorder
A Type I Hybrid Effectiveness-Implementation Trial of MIO
Mothers with substance use disorders face unprecedented stress in their roles as parents working to care for their children while maintaining healthy recovery.
- Trial name
- NCT07168642
- Testing
- Mothering from the Inside Out
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Baystate Medical Center
Opioid Use Disorder
Postpartum Intervention for Mothers With Opioid Use Disorders
Opioid use disorder (OUD) is a fast-growing and devastating epidemic in the US with many mothers suffering cravings, depression, impaired interpersonal interactions and maladaptive parenting behaviors that may lead to child…
- Trial name
- PIMO (NCT05614661)
- Testing
- Mom Power
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Methamphetamine Use Disorder, Pregnancy
Transcranial Magnetic Stimulation for Methamphetamine Use Disorder During Pregnancy
The goal of this clinical trial is to learn whether transcranial magnetic stimulation, also called TMS, is a practical and acceptable treatment option for methamphetamine use disorder during pregnancy.
- Trial name
- NCT07849530
- Testing
- 4- Week Dual-Target Transcranial Magnetic Stimulation (TMS), Accelerated Dual-Target Transcranial Magnetic Stimulation (aTMS), Treatment as Usual (TAU)
- Volunteers
- 45 people
- Sponsor
- University of Utah
Perinatal Opioid Use Disorder, Opioid Use Disorder
Adapting the Penny Chatbot for Perinatal OUD Patients: COPILOT
To address both loneliness and engagement in perinatal and OUD care among perinatal women, the investigators plan to adapt an existing texting support chatbot, Penny, to make it appropriate for use by women who are pregnant and…
- Trial name
- PENNY-COPILOT (NCT06969261)
- Testing
- Penny COPILOT
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Pennsylvania