Clinical trials: Maternal and Neonatal Outcomes
Meconium Stained, Azithromycin
Efficacy of Azithromycin in MSAF Cases to Improve Maternal and Neonatal Outcomes
Meconium stained amniotic fluid increases the risk of maternal complications (e.g., dystocia, operative delivery, and postpartum endometritis) and neonatal complications (e.g., sepsis, admission to the neonatal intensive care…
- Conditions
- Meconium Stained, Azithromycin, Postpartum Endometritis
- Trial name
- NCT05118984
- Testing
- Azithromycin capsule (Zithromax, Pfizer) (250 mg)
- Where
- 2 sites in Egypt
- Volunteers
- 324 people, healthy volunteers welcome
- Sponsor
- Cairo University
Fetal Growth Retardation, Stillbirth and Fetal Death
Antenatal Melatonin Supplementation for Neuroprotection in Fetal Growth Restriction
Fetal growth restriction (FGR) is a significant health care issue, affecting 20,000 Australian pregnancies every year. Undetected FGR is one of the key risk factors for stillbirth, but FGR can also cause significant impairments…
- Conditions
- Fetal Growth Retardation, Stillbirth and Fetal Death, Pregnancy Preterm
- Trial name
- PROTECTMe (NCT05651347)
- Testing
- Melatonin 10 MG
- Where
- 12 sites in Australia, New Zealand
- Volunteers
- 336 people, healthy volunteers welcome
- Sponsor
- Monash University
Pregnancy Related, Umbilical Cord Issue
Association Between Blood Volume, the Interval From Delivery to Cord Clamping, and Number of Umbilical Cord Milking
Delayed umbilical cord clamping (DCC), usually 1-3 minutes, is reported to be beneficial for term and preterm infants. Nevertheless, there are reasons that urge us to reevaluate the effect of DCC.
- Conditions
- Pregnancy Related, Umbilical Cord Issue, Placental Transfusion
- Trial name
- NCT04898868
- Testing
- cord blood spontaneous drainage, Umbilical cord miking
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Overweight or Obesity
NDPP-NextGen: A Clinical Trial to Reduce Intergenerational Obesity and Diabetes Risks
The goal of this clinical trial is to test an enhanced version of the National Diabetes Prevention Program (NDPP-NextGen) that is tailored to young women in childbearing years.
- Trial name
- NCT05674799
- Testing
- NDPP-NextGen
- Where
- United States
- Volunteers
- 403 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Intact Cord Placental Delivery, Delayed Cord Clamping
Intact Cord Placental Delivery vs Delayed Cord Clamping
The management of the third stage of labour plays a critical role in neonatal transition. Uninterrupted Intact Cord Clamping (UICC), is a clinical approach where the umbilical cord remains unclamped until the placenta is…
- Conditions
- Intact Cord Placental Delivery, Delayed Cord Clamping, Standard Delayed Cord Clamping, Timing of Cord Clamping
- Trial name
- TTC (NCT07713277)
- Where
- Italy
- Volunteers
- 1,979 people, healthy volunteers welcome
- Sponsor
- Azienda ULSS 8 Berica
Maternal Anemia, Micronutrient Deficiency
MMS, IFA, and MMS+IFA Supplementation in Pregnant Women
This study aims to compare the effectiveness of Multiple Micronutrient Supplementation (MMS), Iron-Folic Acid (IFA) supplementation, and combined MMS+IFA supplementation among pregnant women.
- Conditions
- Maternal Anemia, Micronutrient Deficiency, Pregnancy Outcomes, Maternal Nutrition
- Trial name
- NCT07665957
- Testing
- Multiple Micronutrient Supplementation (MMS), Iron-Folic Acid (IFA)
- Volunteers
- 402 people, healthy volunteers welcome
- Sponsor
- Sindh Institute of Child Health and Neonatology
Advanced Maternal Age Pregnancy, Early Pregnancy
Very Advanced Maternal Aged Pregnants and Early Adolescent Pregnant Women
Maternal age is an important factor affecting the pregnancy process and its results. Adverse obstetric outcomes such as preterm birth, stillbirth, and infant mortality are more common in women older than 35 years and younger than…
- Trial name
- NCT05484869
- Volunteers
- 297 people, healthy volunteers welcome
- Sponsor
- Siirt University
Gestational Diabetes Mellitus in Pregnancy, Diet- Controlled
Maternal Glucose, Cortisol, and Neonatal Outcomes With and Without GDM
This study will compare maternal blood glucose and cortisol responses and neonatal outcomes between women with gestational diabetes mellitus and women without gestational diabetes mellitus who receive epidural analgesia during…
- Trial name
- NCT07870629
- Where
- 3 sites in Vietnam
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Hanoi Medical University
Obesity, Pregnancy Related
The Role of Physical Activity During Pregnancy on Metabolic Function, Inflammation, and Maternal and Neonatal Outcomes
Maternal obesity during pregnancy is a serious public health concern as it contributes to inflammation, insulin resistance, and excessive gestational weight gain- all of which negatively impact maternal and neonatal health.
- Trial name
- NCT03504319
- Testing
- Exposure to high-fat smoothie
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Western Kentucky University
Premature Neonate
Effect of "Kangaroo Mother Care" on Premature Infants Physiological Outcomes
This project aims at testing the effect of applying the KMC on the premature infants' physiological outcomes. The findings of this project are expected to contribute to the discipline of preterm infants' care by providing…
- Trial name
- NCT02919540
- Testing
- Kangaroo care approach
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Respiratory Syncytial Virus Infections
A Study of Outcomes and Events of Interest in Pregnant Women, Neonates and Infants and of RSV Surveillance
The purpose of this study is to assess pregnancy outcomes, and maternal, as well as neonatal events of interest in healthy pregnant women and their new-borns.
- Trial name
- PEPNI (NCT03614676)
- Testing
- Blood sample collection, Cord blood sample collection, Maternal Diary Card
- Where
- 40 sites in Argentina, Bangladesh and 8 more
- Volunteers
- 4,493 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Labor Pain
Effectiveness of Using the Swiss Ball in Birth
A randomized clinical trial will be conducted to evaluate the effectiveness of using the Swiss Ball as a resource that reduces the length of labor time.
- Trial name
- BIRTHBALL (NCT04124835)
- Testing
- Swiss Ball, Control Grup
- Where
- Brazil
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Instituto Materno Infantil Prof. Fernando Figueira
Effects of a Cord Clamping Bundle on Maternal and Neonatal Outcomes
"The Effect of the Cord Clamping Bundle at Birth Developed With the Delphi Method on Maternal and Newborn Outcomes"
This clinical trial aims to evaluate the effects of a cord clamping bundle developed through the Delphi method on maternal and neonatal outcomes.
- Trial name
- Cord Clamping (NCT07701434)
- Testing
- Cord Clamping Bundle, Routine Cord Clamping Care
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Elif MARANGOZ
Obesity, Maternal, Weight Gain, Maternal
The Difference of Weight Gain Tendencies and Obesity During Pregnancy
Background: Excess weight and obesity are a global pandemic, particularly among women of childbearing age. Pre-pregnancy obesity is linked to adverse maternal and neonatal outcomes, including preterm birth, macrosomia…
- Conditions
- Obesity, Maternal, Weight Gain, Maternal, Birth Weight, Birth Outcome, Adverse
- Trial name
- NCT06540014
- Testing
- No intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 323 people, healthy volunteers welcome
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
Group B Streptococcus Carrier in Childbirth, Group B Streptococcal Infection, Late-Onset
Maternal, Neonatal and Infant Outcomes at Kawempe National Referral Hospital
Maternal immunisation is an evolving field that deserves special attention given its potential to have a significant positive impact on the health of women and children globally, and the potential safety and risk considerations…
- Conditions
- Group B Streptococcus Carrier in Childbirth, Group B Streptococcal Infection, Late-Onset, Group B Streptococcal Infection, Early-Onset, Group B Streptococcus Neonatal Sepsis
- Trial name
- PREPARE (NCT04653948)
- Where
- Uganda
- Volunteers
- 3,423 people, healthy volunteers welcome
- Sponsor
- St George's, University of London
Labor Delivery, Maternal and Neonatal Outcomes
Effect of Social Support During Labor
Problem Statement: In the governmental hospitals it is not allow to presence one of family with woman during child birth in labor room that affects negatively in pregnant emotion and feel more anxious especially primigravida…
- Trial name
- SSP (NCT07539376)
- Testing
- Supportive person during labor
- Where
- Jordan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- The Hashemite University
Oligohydramnios
Fetal Renal Artery Doppler Indices in Borderline Isolated Oligohydramnios
The purpose of the study is to investigate third trimester fetal renal artery doppler indices in borderline idiopathic isolated oligohydramnios and relationship between neonatal outcomes.
- Trial name
- NCT02901340
- Testing
- one to two liters of water daily
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Kayseri Education and Research Hospital
Hypovitaminosis D, Pregnancy Complications
Effect of Vitamin D Replacement on Maternal and Neonatal Outcomes
The optimal vitamin D replacement dose during pregnancy remains undefined. Therefore, the aim of this study is to test the hypothesis that a daily equivalent dose of vitamin D of 3,000 IU/day is needed for Middle Eastern women…
- Conditions
- Hypovitaminosis D, Pregnancy Complications, Infant, Newborn, Diseases
- Trial name
- NCT02434380
- Testing
- Euro D
- Where
- Lebanon
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Cesarean Birth
The Cesarean Study: Optimizing Cesarean Sections and Improving Patient-Healthcare Provider Trust Using Evidence Informed Recommendations
Cesarean section (CS) rates have rapidly increased worldwide, with projections suggesting that by 2030, one in every three births will be by CS (1).
- Trial name
- CS (NCT07759622)
- Testing
- Cesarean Bundle
- Where
- Sweden
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Lund University
Pregnancy Related, Benzodiazepines Causing Adverse Effects in Therapeutic Use
Maternal and Neonatal Outcomes Following Exposure to Benzodiazepines During Pregnancy
This is a nationwide cohort study to assess maternal and neonatal outcomes following exposure to benzodiazepines during pregnancy.
- Conditions
- Pregnancy Related, Benzodiazepines Causing Adverse Effects in Therapeutic Use, Congenital Anomaly
- Trial name
- NCT04856436
- Testing
- Benzodiazepine
- Where
- South Korea
- Volunteers
- 3,094,227 people, healthy volunteers welcome
- Sponsor
- Sungkyunkwan University