Clinical trials: Maternity Care
Spinal Anesthesia Induced Hypotension
COMPARISON BETWEEN EFFICACY OF NOREPINEPHRINE AND PHENYLEPHRINE BOLUSES for PREVENTION OF SPINAL ANAESTHESIA INDUCED HYPOTENSION IN OBSTETRICAL PATIENTS UNDERGOING EMERGENCY CESAREAN SECTION-A Double Blind Randomized Controlled Trial
The goal of this clinical trial is to learn if norepinephrine is more effective than phenylephrine for prevention of spinal anesthesia induced hypotension.
- Trial name
- NCT06836986
- Testing
- Norepinephrine Bolus, Phenylephrine bolus
- Where
- Pakistan
- Volunteers
- 124 people
- Sponsor
- Dow University of Health Sciences
Pregnancy
Clinical Data Collection for Obstetric Ultrasound Algorithms
The goal of this clinical trial is to Collect ultrasound data from pregnant and non-pregnant individuals presenting to multiple study sites.
- Trial name
- MOBUS (NCT06742229)
- Testing
- Research Ultrasound scan
- Where
- 3 sites in United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Caption Health, Inc.
Newborns
Intervention of Psychological and Ethical Professionals of Human Science in Obstetrical Morbidity and Mortality Conferences (OPERA)
This cluster-randomised controlled trial will test the hypothesis that a multifaceted program with psychological intervention in morbidity mortality conferences (MMC) improve care quality and reduce the rate of morbidity…
- Trial name
- OPERA (NCT02584166)
- Testing
- multifaceted program
- Volunteers
- 4,929 people
- Sponsor
- Hospices Civils de Lyon
Neonatal Complication, Labor (Obstetrics)--Complications
Can the Use of a Next Generation Partograph Improve Neonatal Outcomes? (PICRINO)
The overall aim is to evaluate the impact of the use of two different guidelines for monitoring labor progress, the WHOs LCG versus standard care, on neonatal and maternal outcomes.
- Trial name
- NCT05560802
- Testing
- WHOs Labour care guide
- Where
- 24 sites in Sweden
- Volunteers
- 120,000 people
- Sponsor
- Linkoeping University
Cardiac Arrythmias
Carbetocin on Myocardial Repolarization Dynamics in Obstetrics Study
Relationship between carbetocin dose on transmural dispersion of repolarization (TDR).
- Trial name
- CaRDIO (NCT03716076)
- Testing
- Carbetocin
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Postpartum Fatigue, Maternity Blues
Back Massage for Postpartum Fatigue and Maternity Blues After Cesarean Birth
This randomized controlled trial evaluated the effects of back massage applied after elective cesarean birth on postpartum fatigue and maternity blues.
- Trial name
- BAM-CB (NCT07867561)
- Testing
- Back Massage
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Kocaeli University
Stress, Psychological, Maternal Health
Caring for Providers to Improve Patient Experience (CPIPE) Trial
The activities described in this proposal are aimed at addressing health care provider stress and unconscious bias to improve quality of maternal health care, particularly related to the person-centered dimensions of care-i.e.
- Conditions
- Stress, Psychological, Maternal Health, Healthcare Provider, Adverse Outcomes
- Trial name
- CPIPE (NCT06085105)
- Testing
- CPIPE Training, Peer support groups, Mentorship
- Where
- 2 sites in Ghana, Kenya
- Volunteers
- 6,379 people
- Sponsor
- University of California, San Francisco
Pregnancy Complications
Impact of Age at Conization on Obstetrical Outcome: A Case-Control Study
The maternity ward attached to the colposcopy clinic was also the obstetrical referral center for the region and carried out approximately 2500 deliveries per year.
- Trial name
- OBSTETRICON (NCT05765188)
- Testing
- loop electrosurgical excision procedure
- Where
- France
- Volunteers
- 115 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Analgesia, Analgesics, Opioid
Dexmedetomine as Adjuvant for Spinal Anesthesia in Elective Cesarian Sections : a Pilot Study
The proposed pilot study is a prospective, randomized, controlled, double-blind, single-center pilot study.The aim of this pilot project is to evaluate the feasibility of a phase III study on the use of dexmedetomidine in…
- Conditions
- Analgesia, Analgesics, Opioid, Anesthesia, Obstetrical, Anesthesia, Spinal
- Trial name
- NCT05099055
- Testing
- Dexmedetomidine 0.004 MG/ML [Precedex], Opioids
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- St. Justine's Hospital
Telemedicine, Digital Health
Development of an International Remote Digital Care System for Accessible, Inclusive and Sustainable Pregnancy Care
Pregnancy care is under increasing pressure due to a rising number of women needing medical care, a shortage of obstetric healthcare professionals, and growing healthcare costs.
- Conditions
- Telemedicine, Digital Health, Pregnancy Complications
- Trial name
- PregnaDigit EU (NCT07191236)
- Where
- 4 sites in Netherlands, Spain and 1 more
- Volunteers
- 450 people
- Sponsor
- UMC Utrecht
Emergency Maternity Care, Health Inequalities in Maternity Care Access
Disparities In Access to the Northwest Ambulance Service During Pregnancy, Birth and Postpartum Period and Its Association With Neonatal and Maternal Outcomes
This study is the first in the United Kingdom (UK) to look at how women and families from different backgrounds use ambulance services during the 'perinatal period' - through pregnancy, birth, and shortly after having a baby.
- Conditions
- Emergency Maternity Care, Health Inequalities in Maternity Care Access, Disparities in Access to Maternity Care, Deprivation
- Trial name
- DIAAS (NCT07049263)
- Where
- United Kingdom
- Volunteers
- 18,000 people
- Sponsor
- Manchester University NHS Foundation Trust
Preeclampsia
Preeclampsia Ratio (sFlt-1/PlGF)
The aim of the PRECOG study is to determine in a prospective interventional randomized study whether the implementation of a predictive test based on the sFLT-1/PlGF ratio improves perinatal care and reduces costs, in patients…
- Trial name
- PRECOG (NCT03289611)
- Testing
- sFlt-1 / PlGF ratio
- Where
- France
- Volunteers
- 84 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Obstetrics, Surgery
Early Oral Intake Following Cesarean Surgery
In this study we are trying to compare the safety and financial benefit of starting the realimentation early versus conventional oral intake following the Cesarean surgery in Iran.
- Trial name
- NCT00370708
- Testing
- Oral Intake following admittance to the postpartum ward
- Where
- Iran
- Volunteers
- healthy volunteers welcome
- Sponsor
- Tehran University of Medical Sciences
Preeclampsia
China Obstetrics Alliance Cohort Study
Preeclampsia (PE) is one of a common type of hypertensive disorder complicating pregnancy (HDCP). It is a class of clinical syndromes which shows relevant symptoms, hypertension and proteinuria after 20 weeks pregnant as main…
- Trial name
- COACS (NCT03038555)
- Where
- 5 sites in China
- Volunteers
- 900 people
- Sponsor
- The Third Affiliated Hospital of Guangzhou Medical University
Inflammatory Response, Abortion, Habitual
Explore the Role of NLRP7 in the Regulation of Progestereone Induced Decidualization of Human Endometrial Stroma Cells
The investigators have found that NLRP7 was upregulated and nuclear translocated in an in vitro model of decidualization. Knock-down or overexpression of NLRP7 reduced or enhanced the expression of decidual marker IGFBP-1.
- Trial name
- NCT04148638
- Where
- Taiwan
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Hemorrhage, Postpartum, Placenta Previa
Tranexamic Acid for the Prevention of Postpartum Hemorrhage in Pregnant Women With Placenta Previa
Many RCT(randomized controlled trial) studies reported that tranexamic acid reduced blood loss in women who had elective cesareans.
- Trial name
- TRAPP (NCT05811676)
- Testing
- Tranexamic acid, 0.9% sodium chloride
- Where
- 27 sites in China
- Volunteers
- 1,732 people, healthy volunteers welcome
- Sponsor
- Guangzhou Medical University
Pregnancy, Preterm Labor
Biomarkers in Obstetrical Complications
Objective: To study the natural history of normal pregnancy and the most frequent pregnancy complications responsible for the excessive rate of perinatal morbidity and mortality, in order to develop models to predict the…
- Conditions
- Pregnancy, Preterm Labor, Maternal Fetal Factors, Preterm Birth
- Trial name
- NCT03480139
- Where
- United States
- Volunteers
- 746 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Antiphospholipid Syndrome, Factor V Leiden Thrombophilia
Assessment of the Prevalence of Major Psychiatric Disorders in a Cohort of Women With Clinical Criteria Corresponding to Pure, Abortive-form, Obstetrical, Antiphospholipid Syndrome
The primary objective of this study was to evaluate and compare the prevalence of the following psychiatric pathologies (based on the MINI5.0.0 questionnaire) among 3 groups of women (Leiden versus aP1Ab-positive versus…
- Trial name
- NOHA-PSY (NCT02833194)
- Where
- France
- Volunteers
- 1,592 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Analgesia Obstetrical, Analgesia
Intrathecal Versus Epidural Morphine for Post-Cesarean Analgesia
Cesarean section is one of the most commonly performed surgical procedures worldwide, making effective management of acute postoperative pain a key issue in obstetric anesthesiology.
- Conditions
- Analgesia Obstetrical, Analgesia, Post Operative Pain, Patient Satisfaction
- Trial name
- NCT07386353
- Testing
- Intrathecal Morphine, Epidural Morphine
- Where
- Portugal
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hospital Central do Funchal
Hepatitis B
Cameroon HepB Birth Dose Feasibility Pilot
This feasibility assessment is to provide quantitative findings of an intervention integrating immunizations into maternity and newborn care across 15 health facilities in Cameroon.
- Trial name
- NCT04893616
- Testing
- Integration of vaccination services into delivery services
- Where
- 13 sites in Cameroon
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Clinton Health Access Initiative Inc.