Clinical trials: Mathematics Disorder
Bronchiectasis, Quality of Life
Evaluating the Effects of Traditional Chinese Medicine by N-of-1 Trials
Treatment based on syndrome differentiation is the essence of traditional Chinese Medicine(TCM) and forms the individualized treatment.
- Conditions
- Bronchiectasis, Quality of Life, Traditional Chinese Medicine, Sputum
- Trial name
- NCT03147443
- Testing
- Individualized Decoction, Tested drug minus heat-clearing herbs
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Shanghai University of Traditional Chinese Medicine
Multimorbidity, Health Knowledge, Attitudes, Practice
Clinical Complexity in Internal Medicine Wards. San MAtteo Complexity Study
The progressive rising of multimorbidity, which has been always considered the hallmark of clinical complexity (CC), has made management of the "complex" patient one of the most topical and challenging issues in medicine.
- Trial name
- SMAC (NCT03439410)
- Testing
- Clinical Complexity Index
- Where
- Italy
- Volunteers
- 2,000 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Coronary Artery Disease
One-Dimensional Mathematical Model-Based Automated Assessment of Fractional Flow Reserve
This study evaluates the diagnostic efficiency of an automated method of noninvasive assessment of the fractional reserve of coronary blood flow.
- Trial name
- NCT03797118
- Testing
- FFR
- Where
- Russia
- Volunteers
- 31 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
COVID-19
Advanced Modeling of the Evolution of the Epidemiological Outbreak of SARS-CoV-2 Pandemic
The various epidemics that health systems periodically suffers require having valid and detailed information on its evolution and predictions in the short, medium and long term in real time to allow the health system to organize…
- Trial name
- NCT06070896
- Where
- Spain
- Volunteers
- 715,206 people
- Sponsor
- Hospital Galdakao-Usansolo
Cataract
Non-genetic Risk Factors of Congenital Cataracts
Prevention and treatment of the reversible childhood blindness, including congenital cataracts (CC), has been listed as a significant component of the international programme "VISION 2020 - the Right to Sight" launched by WHO in…
- Trial name
- NCT03215186
- Testing
- observational study
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Obesity, Hypertension
Methods for Measuring Insulin Sensitivity
Patients with high blood pressure, diabetes, and who are overweight are known to have defects in the way their body responds to insulin.
- Conditions
- Obesity, Hypertension, Diabetes-Mellitus, Non-Insulin Dependent
- Trial name
- NCT00001625
- Where
- United States
- Volunteers
- 480 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Acute Respiratory Distress Syndrome, Mechanical Ventilation, Respiratory Mechanics, Ventilator-induced Lung Injury
A Modified Mathematical Model to Calculate Power Received by Mechanically Ventilated Patients With Different Etiologies
Ventilator-induced lung injury is a common complication. The latest and most noticeable theory of its pathogenesis is called 'ergotrauma' by Gattinoni in 2016.
- Trial name
- NCT04046380
- Testing
- work of breath measurement and calculation
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Changhua Christian Hospital
Breast Cancer
Novel Capecitabine Dosing Schedule in Combination With Lapatinib, Based on the Norton-Simon Mathematical Method in Patients With HER2 Overexpressed/Amplified, Trastuzumab (Herceptin) -Refractory, Metastatic Breast Cancer
HER2 is a protein that sits on the surface of breast cancer cells in some people. Because you are one of these people, your breast cancer is called "HER2-positive." The HER2 protein is involved in the growth of your breast…
- Trial name
- NCT00721630
- Testing
- capecitabine, lapatinib
- Where
- 5 sites in United States
- Volunteers
- 24 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Cancer, Colo-rectal Cancer
Gut Microbiota and Color-rectal Cancer.
This clinical trial is focused in the development of a screening test for the people at risk of colo-rectal cancer (aged more than 50 years old), valid and safe, improving the screening prognosis increasing the sensitivity and…
- Conditions
- Cancer, Colo-rectal Cancer, Diagnoses Disease, Microbiota-related Disease
- Trial name
- CCR-microbiota (NCT04662853)
- Testing
- Gut microbiota determination from feces samples.
- Where
- Spain
- Volunteers
- 153 people
- Sponsor
- Maimónides Biomedical Research Institute of Córdoba
Breast Cancer
Mathematical Modeling to Predict Response to Neoadjuvant Chemotherapy in Breast Cancer
This is a feasibility study evaluating the use of a mathematical model to predict response to standard neoadjuvant anthracycline / taxane based chemotherapy in patients with breast cancer.
- Trial name
- NCT03983538
- Testing
- Mathematical modeling to predict response to chemotherapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- New Mexico Cancer Research Alliance
Heart Diseases, Cardiac Conduction Defect
Developing Methods for Reconstructing Electrical Heart Activity
Non-invasive reconstruction of electrical heart activity can yield important scientific and clinical insights in cardiac rhythm disorders.
- Trial name
- NCT03947021
- Testing
- Computed tomography (CT) scan, Body-surface potential mapping
- Where
- Netherlands
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Urolithiasis
Comparison of Morphological and Radiological Data in Patients With Urolithiasis
The aim of the study was to compare the ultrastructural changes in the renal parenchyma with the results of postprocessing CT analysis with contrast enhancement in patients with urolithiasis.
- Trial name
- NCT04506723
- Testing
- Percutaneous Nephrolithotomy, Partial nephrectomy, Radical nephrectomy
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Prostate Cancer
Mathematical Modeling Analysis of Serum Prostate Specific Antigen After Radiotherapy
Clinical data are being used to build a mathematical model to describe the clinical results of radiotherapy for prostate cancer.
- Trial name
- NCT00126815
- Where
- Canada
- Volunteers
- 1,000 people
- Sponsor
- AHS Cancer Control Alberta
Prostate Cancer, Head and Neck Cancer
Predictors of Normal Tissue Response From the Microenvironment in Radiotherapy for Prostate and Head-and-neck Cancer
The main idea behind MICRO-LEARNER is to provide new insights about the response of healthy tissues to radiation by using information from the micro-environment obtained by biological measurements and imaging.
- Trial name
- MICROLEARNER (NCT03294122)
- Testing
- External beam radiotherapy for prostate cancer, External beam radiotherapy for head and neck cancer
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Liver Transplant Disorder, Liver Cancer
Deep Learning Model for the Prediction of Post-LT HCC Recurrence
Identifying patients at high risk for recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) represents a challenging issue.
- Conditions
- Liver Transplant Disorder, Liver Cancer, Recurrent Cancer
- Trial name
- TRAIN-AI (NCT05200195)
- Testing
- Liver transplantation
- Where
- Italy
- Volunteers
- 4,026 people
- Sponsor
- European Hepatocellular Cancer Liver Transplant Group
Metastatic Breast Cancer
A Pilot Dose Escalation Trial of a Densified Chemotherapy Association of Docetaxel and Epirubicin Driven by Mathematical Modeling in Metastatic Breast Cancer Patients: The MODEL1 Study
To determine the maximum tolerated dose of a densified regimen of the association of docetaxel (DTX) and epirubicin (EPI), supported by the concomitant administration of hematopoietic growth factors in patients with metastatic…
- Trial name
- MODEL1 (NCT02392845)
- Testing
- Combination of Docetaxel (DTX) and Epirubicin (EPI)
- Where
- France
- Volunteers
- 17 people
- Sponsor
- Hospices Civils de Lyon
Hearing Disorder
Brain Imaging of Tinnitus
This study will use magnetic resonance imaging (MRI) to compare brain function in three groups of people: hearing-impaired people with tinnitus; hearing-impaired people without tinnitus; and people with normal hearing and without…
- Trial name
- NCT00359931
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Breast Cancer
Study of Biweekly Capecitabine Dosing With Bevacizumab for the Treatment of Metastatic Breast Cancer Based Upon the Norton-Simon Mathematical Model
The purpose of this study is to find out what effects (both good and bad) that capecitabine has on you and your breast cancer when given in a novel schedule in combination with the antibody therapy, bevacizumab.
- Trial name
- NCT00468585
- Testing
- Capecitabine, Bevacizumab
- Where
- 5 sites in United States
- Volunteers
- 62 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Atrial Fibrillation
Reverse Prediction of Ion Channel Remodeling in Patients With Atrial Fibrillation Utilizing Monophasic Action Potential and Mathematical Modeling
Atrial fibrillation(AF) is the most common sustained arrhythmia in humans. The loss of rate-dependent action potential duration(APD) adaptation is one of the characteristics of atrial fibrillation, but detailed understanding of…
- Trial name
- NCT02414815
- Testing
- Monophasic action potential(MAP) catheter
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Yonsei University
Diabetes Mellitus, Type 1
Carbohydrate Count Aided by a Simulation in People With Type 1 Diabetes Mellitus. A Protocol for a Clinical Trial
Insulin remains the only approved treatment for type 1 diabetes mellitus patients and is used by many with type 2 diabetes. Carbohydrate counting is the most recommended way to prescribe prandial insulin dose because it is safe…
- Trial name
- NCT05181917
- Testing
- STUDIA app
- Where
- Colombia
- Volunteers
- 28 people
- Sponsor
- Hospital Pablo Tobón Uribe