Clinical trials: Maturity Onset Diabetes of the Young
Maturity-Onset Diabetes of the Young (MODY), Type 2 Diabetes
Optimized Diagnosis and Precision Medicine of MODY
The goal of this observation is to establish a complete registry for the clinical manifestations, environment, genetic, and other related gene variation information of young-onset diabetic patients.
- Conditions
- Maturity-Onset Diabetes of the Young (MODY), Type 2 Diabetes, Diabetes Complications
- Trial name
- NCT06111833
- Where
- Taiwan
- Volunteers
- 1,500 people
- Sponsor
- Taichung Veterans General Hospital
Obesity, Type 2 Diabetes Mellitus
Effect of Pre-meal Serving of Dairy and Dairy Alternatives on Post-meal Satiety and Glycaemia in Healthy Young Adults
Regular consumption of dairy products is found to negatively associated with metabolic diseases and improve body composition in long term studies and has positive effect on acute glycemia control and satiety.
- Trial name
- NCT04600128
- Testing
- Dairy-based greek yogurt, Dairy-based cheddar cheese, Plant-based yogurt
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Type 2 Diabetes, Obesity
The Impact of the Glycaemic Index (GI) on Daily Blood Glucose Profiles and Food Intake in Young Chinese Adult Males
This study is carried out to find out the inclusion of high and low glycaemic Index (GI) foods to daily meals impact on 24 hour blood glucose fluctuations and food intake.
- Conditions
- Type 2 Diabetes, Obesity, Prediabetes
- Trial name
- NCT02340507
- Testing
- Rice and bread (high GI), Rice and bread (low GI)
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Obesity, Diabetes Mellitus, Type 2
Dairy and Non-Dairy Alternatives Comparative on Metabolic Outcomes
The purpose of this study is to compare the acute effects of a single serving of dairy and non-dairy alternatives on post-treatment and post-meal glycemia, appetite, plasma amino acid concentrations, and gastrointestinal hormones…
- Trial name
- NCT05919667
- Testing
- Dairy and plant-based dairy beverages and solids
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Diabetes Mellitus Type 1, Diabetes Mellitus Type 2
MoCa Test for the Early Detection of Mild Cognitive Impairment During Annual Assessment of Young Adults With Diabetes and in a Control Group Without Diabetes
T2D and cognitive impairment are two of the most common chronic condition found in persons 60 years and older. Diabetes type 2 increases with age and studies suggest that the diabetes is one of the risk factor for cognitive…
- Conditions
- Diabetes Mellitus Type 1, Diabetes Mellitus Type 2, Mild Cognitive Impairment
- Trial name
- NCT02545062
- Testing
- MoCa test
- Where
- Israel
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Clalit Health Services
Type 1 Diabetes, MODY
Usefulness of Continuous Glucose Monitoring in MODY Diagnosis
Observational study about usefulness of intermittently scanned continuous glucose monitoring (isCGM) in the diagnosis of maturity-onset of the young (MODY) patients.
- Trial name
- UCMODY (NCT05918484)
- Testing
- Intermittenly scanned continuous glucose monitoring, MODY genetic diagnostic test
- Where
- 9 sites in Spain
- Volunteers
- 500 people
- Sponsor
- Castilla-La Mancha Health Service
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Application of UCPCR as a Testing Tool for Identification of MODY Patients in the UAE
The study aims to investigate the validity of 2 hour post-prandial UCPCR test in paediatric and adult patients with diabetes duration greater than 2 and 5 years, respectively, for the purposes of distinguishing between patients…
- Conditions
- Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Maturity-onset Diabetes of the Young
- Trial name
- NCT03607604
- Testing
- Next generation sequencing (NGS)
- Where
- United Arab Emirates
- Volunteers
- 778 people, healthy volunteers welcome
- Sponsor
- Imperial College London Diabetes Centre
Maturity-Onset Diabetes of the Young, Type 3, Type 2 Diabetes
Impact of SGLT2 on Glucosuria in HNF1A-MODY
Maturity onset diabetes of the young (MODY) is a subtype of diabetes which is caused by mutations in specific genes leading to diabetes.
- Trial name
- MOD3ST-CLAMP (NCT05417646)
- Testing
- Hyperglycaemic clamp, Empagliflozin
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- Steno Diabetes Center Copenhagen
Diabetes, Maturity Onset Diabetes of the Young
MODY in Young-onset Diabetes in Different Ethnicities
The purpose of this study is to describe and compare the different types of diabetes that exist in people from white European and south Asian origin in the UK (United Kingdom) who are diagnosed with diabetes before they turn 30…
- Conditions
- Diabetes, Maturity Onset Diabetes of the Young, Type 1 Diabetes, Type 2 Diabetes
- Trial name
- MYDIABETES (NCT02082132)
- Where
- United Kingdom
- Volunteers
- 916 people
- Sponsor
- Imperial College London
Diabetes Mellitus, Type 2
Phenotypic and Genetic Correlates of Diabetes (Non-Type 1) in Young Non-Obese Asian Indians in North India and A Study to Evaluate the Efficacy of Sitagliptin (DPP-4 Inhibitor) in a Sub-group of the Study Population
This is a phase IV study of 3.5 years duration to evaluate the phenotypic and genetic correlates of diabetes (non-Type 1 in young non-obese Asian Indians in North India and pilot case control study to evaluate the efficacy of…
- Trial name
- NCT00964184
- Testing
- Metformin, Lifestyle modification
- Where
- India
- Volunteers
- 133 people
- Sponsor
- Diabetes Foundation, India
Type 2 Diabetes
Determining the Minimal Amount of Exercise to Improve Glycaemic Control
In 2015, there were 415 million adults worldwide with type II diabetes and by 2040, typeII diabetes will affect one in ten adults worldwide.
- Trial name
- MiniEx (NCT04129268)
- Testing
- Cycle ergometry exercise at 60% VO2max
- Where
- United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Lancaster University
Maturity-Onset Diabetes of the Young, Type 3, Maturity Onset Diabetes of the Young, Type 1
Switching From Insulin to Sulfonylurea in Diabetes Associated With Variants in MODY Genes
The purpose of this study is to switch from insulin to oral sulfonylurea in patients with apparent type 1 diabetes or maturity onset diabetes in the young that are insulin treated.
- Conditions
- Maturity-Onset Diabetes of the Young, Type 3, Maturity Onset Diabetes of the Young, Type 1, Childhood Diabetes Mellitus, Insulin-dependent Diabetes Mellitus
- Trial name
- SUtoChildT1D (NCT04239586)
- Testing
- Sulfonylurea
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- Haukeland University Hospital
Obesity
Mirabegron and Brown Adipose Tissue
Obesity and type 2 diabetes (T2D) are emerging problems worldwide. In particular South Asian individuals (representing 20% of the world population) have an increased risk of obesity and related disorders.
- Trial name
- Mirab (NCT03012113)
- Testing
- Mirabegron, Short term mild cooling
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ingrid Jazet
Obesity, Type II Diabetes Mellitus
Yellow Pea Protein and Fibre and Short Term Food Intake
It is hypothesized that yellow pea protein and fiber will reduce short-term food intake, subjective appetite and glycemic response.
- Conditions
- Obesity, Type II Diabetes Mellitus, Metabolic Syndrome
- Trial name
- NCT01255085
- Testing
- yellow pea protein, yellow pea fiber, Control Tomato Soup
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Type 2 Diabetes Mellitus, Obesity
Form of Dairy Products on Satiety, Food Intake and Post-meal Glycaemia in Young and Older Adults
The proposed study is planned to determine the potential role for regular fat dairy products in short-term metabolic control in younger and older adults and the metabolic flexibility in response to food components, which are…
- Trial name
- NCT02491801
- Testing
- Dietary intervention
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Type 2 Diabetes, Diabetes Mellitus, Type 2
Comparative Bioavailability - Gender Effect - Single and Multiple Ascending Dose Safety and Pharmacokinetic Study of GFT505
The Sponsor, Genfit, has developed a new formulation of GFT505 (60 mg). The objective is to compare the relative bioavailability between the new GFT505 formulation (capsule dosed at 60 mg GFT505) and the old GFT505 formulation…
- Conditions
- Type 2 Diabetes, Diabetes Mellitus, Type 2, Metabolic Diseases, Cardiovascular Diseases
- Trial name
- NCT01474161
- Testing
- GFT505 120mg - old formulation, GFT505 120mg - new formulation, GFT505 180mg - new formulation
- Where
- France
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Genfit
Healthy
A Study in Healthy People to Test How Empagliflozin is Taken up in the Body When Taken as a Whole Tablet or Dissolved in Water and Mixed With Food
This trial is conducted to test how empagliflozin is taken up in the body when taken as a whole tablet or dissolved in water and mixed with food.
- Trial name
- NCT06962826
- Testing
- Empagliflozin
- Where
- Germany
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Maturity-onset Diabetes of the Young, Monogenic Diabetes
Identifying Maturity-onset Diabetes of the Young in Emirati Patients
Diabetes Mellitus is a disease that affects nearly 1 in 5 people in United Arab Emirates and is one of leading causes of death and disability.
- Conditions
- Maturity-onset Diabetes of the Young, Monogenic Diabetes, MODY
- Trial name
- NCT05586594
- Testing
- Genetic testing for 4 MODY genes (GCK, HNF1A, HNF4A, HNF1B)
- Volunteers
- 150 people
- Sponsor
- United Arab Emirates University
Maturity-onset Diabetes of the Young
The Effects of GLP-1 in Maturity-Onset Diabetes of The Young (MODY)
The purpose of this study is to evaluate the treatment potential of GLP-1-analogues in patients with Maturity Onset Diabetes of the Young (MODY) compared to common treatment.
- Trial name
- NCT01610934
- Testing
- liraglutide, Glimepiride
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- University Hospital, Gentofte, Copenhagen