Clinical trials: Maximal Oxygen Uptake
Single Ventricle Heart Disease
Fontan Udenafil Exercise Longitudinal Assessment Trial - 2
This study will evaluate the clinical efficacy and safety of udenafil, an orally administered, potent and selective inhibitor of PDE5, versus placebo for the treatment of adolescent who have had the Fontan procedure.
- Trial name
- FUEL-2 (NCT05918211)
- Testing
- Udenafil
- Where
- 40 sites in United States, South Korea
- Volunteers
- 436 people
- Sponsor
- Mezzion Pharma Co. Ltd
VO2max, Lactate Threshold
Evaluating Non-Invasive Haptics During Extreme Exercise
This study aims to compare determinants of endurance performance between participants wearing an active patch with haptic vibrotactile trigger technology (VTT) versus a placebo patch without VTT among recreational to competitive…
- Conditions
- VO2max, Lactate Threshold, Lactate
- Trial name
- ENDURE (NCT07285252)
- Testing
- Victory Patch with Haptic Vibrotactile Trigger Technology
- Where
- United Kingdom
- Volunteers
- 75 people
- Sponsor
- SuperPatch Limited LLC
Healthy Adult, Fitness Testing
Molecular Indicators of Systematic Fitness
The goal of this study is to characterize associations between cardiorespiratory fitness, as measured by VO₂max/VO₂peak, and blood-based molecular measurements in adults.
- Conditions
- Healthy Adult, Fitness Testing, Athlete, Aging
- Trial name
- MISFIT (NCT07393841)
- Testing
- There is no intervention.
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- VO Health, Inc.
Healthy Subjects With Low Energy Levels
A Trial to Study the Effects of Ginseng and Cordyceps on Aerobic Capacity, Lactate Kinetics, and Nitric Oxide
This study is a double-blind, randomized, parallel group, three-arm, placebo-controlled trial of seventy-five (75) apparently healthy male and female participants to be recruited at a single investigational center in Northeast…
- Trial name
- NCT07729943
- Testing
- Panax ginseng, Cordycep Militaris
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Applied Food Sciences Inc.
Single Ventricle Heart Disease After Fontan Surgery
Pharmacokinetic/Pharmacodynamic Study of Udenafil in Adolescents
To determine the pharmacokinetic profile and safety of udenafil in adolescents with Fontan physiology and to assess the short-term pharmacodynamic effect of udenafil on pharmacodynamic measures of exercise capacity, ventricular…
- Trial name
- NCT02201342
- Testing
- Udenafil
- Where
- 6 sites in United States, Canada
- Volunteers
- 36 people
- Sponsor
- Mezzion Pharma Co. Ltd
Healthy
The Effects of Ashwagandha in Endurance Exercise Performance
Ashwagandha (Withania Somnifera) is a widely used herb in Ayurvedic medicine for vitality and rejuvenation. This study investigates the effects of both acute and short-term oral supplementation of Shoden (Ashwagandha extract)…
- Trial name
- NCT03596307
- Testing
- Ashwagandha extract
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Arjuna Natural Limited
Reduced Maximum Oxygen Uptake Due to Poor Systemic Oxygen Extraction
A Study to Evaluate ASP0367 in Participants With Reduced Maximum Oxygen Uptake Due to Poor Systemic Oxygen Extraction
The purpose of this study is to to evaluate the effect of ASP0367 on improvement of aerobic capacity relative to placebo, as well as evaluate the safety and tolerability of ASP0367 relative to placebo.
- Trial name
- NCT04855201
- Testing
- Bocidelpar
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Astellas Pharma Global Development, Inc.
Arterial Stiffness, Maximal Oxygen Uptake
Reducing Arterial Stiffness with a Smart Ring and AI-Guided Exercise
The goal of this three-month clinical trial is to study if wearing an Oura Ring and following the exercise guidance provided by an AI-based Advisor in the Oura App works to reduce arterial stiffness.
- Trial name
- GONDOR-AS (NCT06644014)
- Testing
- Exercise, Smart Ring
- Where
- Finland
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Pauli Ohukainen
Age-related Muscle Decline
CALM-AF-AI: Counteracting Age-related Loss of Muscle With AAV-Follistatin Combined With Angiogenesis-Inducing VEGF Plasmid Gene Therapy
This Phase 1/2a, open-label, non-randomized study is designed to evaluate the safety and tolerability of intramuscular AAV9-Follistatin gene therapy administered either as monotherapy or in combination with a VEGF-encoding…
- Trial name
- CALM-AF-AI (NCT07443826)
- Testing
- AAV9-Follistatin gene therapy, VEGF Plasmid
- Where
- Honduras
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Unlimited Biotechnology LLC
Single Ventricle Heart Disease
Fontan Udenafil Exercise Longitudinal Assessment Trial
This study will evaluate the clinical efficacy and safety of udenafil, an orally administered, potent and selective inhibitor of PDE5, versus placebo for the treatment of adolescent subjects who have undergone the Fontan…
- Trial name
- FUEL (NCT02741115)
- Testing
- Udenafil
- Where
- 30 sites in United States, Canada and 1 more
- Volunteers
- 400 people
- Sponsor
- Mezzion Pharma Co. Ltd