Clinical trials: Mean Arterial Pressure
Cardiac Output, High
Mean Systemic Filling Pressure and Heart Performance Predicting Fluid Responsiveness
Determining fluid responsiveness in critically ill patients by measuring mean systemic filling pressure on the intensive care unit.
- Trial name
- NCT02060942
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Major Abdominal Surgery, Duodenohemipancreatectomy
Intraoperative Haemodynamic Optimization Comparing Flow and Pressure Parameters
The purpose of the study is to confirm the hypothesis that flow treatment algorithm based on cardiac index trending by transesophageal Dopplerometry would result in reduced complications and reduced length of hospital stay in…
- Conditions
- Major Abdominal Surgery, Duodenohemipancreatectomy, Rectal Resection, Extensive Bowel Surgery
- Trial name
- Flow-press (NCT02104687)
- Testing
- Flow group, Press group
- Where
- Czechia
- Volunteers
- 140 people
- Sponsor
- University Hospital Ostrava
Anesthesia, Obstetric Anesthesia Problems
Effect of Subarachnoid Hyperbaric Bupivacaine in Obese Pregnant Patients Undergoing Cesarean Section
Evaluates the effect of hyperbaric subarachnoid bupivacaine at doses of 5 mg vs 10 mg on mean arterial pressure in obese pregnant patients undergoing cesarean section
- Trial name
- NCT06060015
- Testing
- 5mg bupivacaine, 10mg bupivacaine
- Where
- Mexico
- Volunteers
- 106 people
- Sponsor
- Hospital Civil de Guadalajara
Hemodynamic Instability, Tracheal Intubation
Attenuation Of Hemodynamic Response To Laryngoscopy. Role Of Dexmedetomidine. A Dose Finding Study
Two doses of Dexmedetomidine (0.5 µ/kg and 0.75 µ/kg) will be used to attenuate the stress response to laryngoscopy in American Society of Anesthesiology, physical class I patients which will be compared with the…
- Conditions
- Hemodynamic Instability, Tracheal Intubation, Dexmedetomidine
- Trial name
- NCT05909215
- Testing
- Normal saline, Dexmedetomidine 0.5 microgram/kg, Dexmedetomidine 0.75 microgram/kg
- Where
- Pakistan
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Sindh Institute of Urology and Transplantation
Acute Kidney Injury, Cirrhosis
Droxidopa to Increase Mean Arterial Pressure in Decompensated Cirrhosis Patients With Acute Kidney Injury
This study tests whether a medication called droxidopa can help improve blood flow to the kidneys in people with liver cirrhosis who develop kidney problems while in the hospital.
- Conditions
- Acute Kidney Injury, Cirrhosis, Decompensated Cirrhosis of Liver
- Trial name
- DROP-AKI (NCT06937307)
- Testing
- Droxidopa capsules
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Giuseppe Cullaro, MD
Dexmedetomidine, Craniotomy
Dexmedetomidine as an Adjuvant to Bupivacaine in Scalp Block vs Bupivacaine Alone for Hemodynamics Stability in Craniotomy
The investigator tested the effect of dexmedetomidine as an adjuvant to bupivacaine compared to bupivacaine alone in mean arterial pressure stability in adult patients undergoing craniotomy
- Conditions
- Dexmedetomidine, Craniotomy, Regional Anesthesia, Mean Arterial Pressure Stability
- Trial name
- NCT06951256
- Testing
- Scalp block with bupivacaine alone, Scalp block by adding dexmedetomidine as an adjuvant to bupivacaine
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Controlled Hypotension for Nasal Surgeries
Effects of Different MAP Targets on Ocular Perfusion and Optic Nerve Microvasculature During Rhinoplasty
This randomized controlled trial aims to evaluate the effects of two different mean arterial pressure (MAP) targets during controlled hypotension on ocular perfusion and optic nerve head microvasculature in patients undergoing…
- Trial name
- NCT07832305
- Testing
- Lower MAP Target Strategy (50-60 mmHg), Higher MAP Target Strategy (60-70 mmHg)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Hitit University
Cardiac Arrest
Characterizing the cerebrovAscular Physiology of Optimal Mean Arterial Pressure Targeted Resuscitation
Hypoxic ischemic brain injury is a devastating illness that occurs after cardiac arrest (the heart stopping) and can yield irreversible brain damage, often leading to death.
- Trial name
- CAMPHIBIII (NCT03609333)
- Testing
- Multimodal Neuromonitoring
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of British Columbia
Hepatorenal Syndrome
The Effect of Terlipressin in the Prevention of Type 2 Hepatorenal Syndrome by Improving Mean Arterial Pressure
Appreciation of the central role for arterial vasodilatation in the pathogenesis of hepatorenal syndrome (HRS) has led to routine use of vasoconstrictors in combination with albumin as a medical therapy for HRS.
- Trial name
- NCT02489864
- Testing
- Terlipressin
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Sun Yat-sen University
Pulmonary Hypertension
Does Oral Sildenafil (Viagra) Decrease Mean Pulmonary Artery Pressure After Cardiac Surgery?
Post-operative pulmonary hypertension is a risk factor for right ventricular failure and an increasing cause of morbidity and mortality in patients undergoing high-risk cardiac surgery.
- Trial name
- NCT00334490
- Testing
- Sildenafil
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Unity Health Toronto
Pregnancy, Cesarean Delivery
Comparison of Non-Invasive Mean Arterial Blood Pressure Measurements at the Arm and Ankle During Elective Cesarean Delivery.
This observational study aims to compare mean arterial pressure measurements obtained using an ankle blood pressure cuff with those obtained using a standard upper-arm cuff in pregnant individuals undergoing elective cesarean…
- Conditions
- Pregnancy, Cesarean Delivery, Blood Pressure Measurement in Pregnancy, Skin to Skin Contact
- Trial name
- NCT07422766
- Testing
- Mean arterial pressure
- Where
- Canada
- Volunteers
- 110 people
- Sponsor
- St. Justine's Hospital
Septic Shock
The Effect of Increasing the Mean Arterial Pressure on the Microcirculation and the Prognosis of Patients With Septic Shock
Background： The mean arterial pressure（ MAP） is a key pressure index to improve tissue perfusion. At present, there are no surprising results of large-scale clinical studies on sublingual microcirculation.
- Trial name
- NCT04136080
- Testing
- vasopressors
- Volunteers
- 752 people
- Sponsor
- Fujian Provincial Hospital
Pain
Pharmacodynamic Differences Between Branded and Unbranded Remifentanil Molecules
Unbranded drug molecules are produced after the patent of a given drug has expired. Unbranded molecules of Remifentanil have been marketed in Colombia, and several reports by anesthesiologist indicate that there are differences…
- Trial name
- NCT02048293
- Testing
- Remifentanyl, Ultiva®, Remifentanil Laboratorios Chalver de Colombia S.A., Fada Remifentanilo
- Where
- Colombia
- Volunteers
- 90 people
- Sponsor
- Fundación Universitaria de Ciencias de la Salud
Colorectal Cancer, Intraoperative Hemodynamic Management
MAP- Versus Cardiac Index-Guided Hemodynamic Management in Colorectal Surgery
This prospective randomized trial aims to compare the effects of two intraoperative hemodynamic management strategies on early postoperative renal function in patients undergoing colorectal surgery.
- Trial name
- NCT07609680
- Testing
- Mean Arterial Pressure-Guided Hemodynamic Management, Cardiac Index-Guided Hemodynamic Management
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara Etlik City Hospital
Tachycardia, Hypertension
Comparison of IV Lignocain and IV Dexmedetomidine for Attenuation of Laryngoscopic Stress Response to Direct Laryngoscopy
Hemodymanic stress response to direct laryngoscopy and endotracheal intubation is a known phenomenon that occur in almost every patient undergoing general anesthesia before surgical procedure.
- Conditions
- Tachycardia, Hypertension, Mean Arterial Pressure
- Trial name
- NCT07385040
- Testing
- Intravenous Dexmedetomidine infusion, Intravenous Lignocain
- Where
- Pakistan
- Volunteers
- 62 people
- Sponsor
- Shaheed Mohtarma Benazir Bhutto Institue of Trauma
Cerebrovascular Circulation
Quantification of Dynamic and Static Cerebral Autoregulation (CA) Under Anaesthesia
Cerebral autoregulation (CA) is the mechanism by which the brain vasculature maintains constancy of cerebral blood flow (CBF). Reliable direct measurements of CBF at different blood pressure levels are difficult because they are…
- Trial name
- SAMBA (NCT03816072)
- Testing
- Phenylephrine infusion, Mechanical ventilation, Propofol
- Where
- Netherlands
- Volunteers
- 66 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Hypertension
Isometric and Dynamic Handgrip Training Effects on Hypertension
Essential hypertension accounts for 13 percent of total deaths worldwide, accounting for one of the major risk factors. Hypertension (high blood pressure) is when the pressure in your blood vessels is too high (140/90 mmHg or…
- Trial name
- NCT06601738
- Testing
- Isomeric Hand Grip Exercises, Dynamic Hand Grip Exercises
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Riphah International University
Acute Kidney Injury, Intra-Abdominal Hypertension
Cumulative Intra-Abdominal Pressure Burden and Acute Kidney Injury After Emergency Abdominal Surgery
The goal of this observational study is to learn whether increased pressure inside the abdomen over time is associated with acute kidney injury in adults receiving intensive care after emergency abdominal surgery.
- Trial name
- IAP-AKI (NCT07891026)
- Testing
- Serial Intra-Abdominal Pressure Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Ugur Duman
Cardiac Surgery
Controling Mean Arterial Pressure Using a Closed-Loop System for Vasopressor Titration
The investigators have developed an automated vasopressor controller to improve the titration of vasopressor in order to maintain mean arterial pressure (MAP) within a narrow range and have recently shown the controller was…
- Trial name
- COMAP (NCT04586218)
- Testing
- Computer guided vasopressor infusion, Manual control of vasopressor infusion
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Clinique de la Sauvegarde
Stroke Volume, Mean Arterial Pressure
Validation of Stroke Volume Measurement by a New Noninvasive Hemodynamic Monitoring System (NexFin)in Comparison to Different Invasive Procedures as Picco2, FloTrac and TEE
Main hypothesis: there is no difference between stroke volume measurements recorded by a new noninvasive finger cuff system (NexFin) and invasive hemodynamic monitoring systems as Picco2-system, FloTrac and transesophageal…
- Trial name
- VaSNex (NCT01263990)
- Testing
- NexFin
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Charite University, Berlin, Germany