Clinical trials: Mean Arterial Pressure, active
Hypotension During Surgery
Comparison Bewteen Intraoperative HPI vs. High Mean Arterial Pressure Threshold
Intraoperative hypotension (IOH) is a common and serious complication during surgery, closely associated with poor postoperative outcomes.
- Trial name
- NCT06631482
- Testing
- Maintain HPI < 85, Maintain MAP>=73
- Where
- 2 sites in Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Pulmonary Hypertension, Elevated Mean Pulmonary Arterial Pressure
Non-contrast Enhanced Cardiac Magnetic Resonance Imaging in the Diagnosis and Classification of Pulmonary Hypertension
Pulmonary hypertension (PH) is a life-threatening cardiovascular disease characterized by pathological elevation of mean pulmonary arterial pressure (mPAP) >/= 25 mmHg at rest.
- Conditions
- Pulmonary Hypertension, Elevated Mean Pulmonary Arterial Pressure, Normal Mean Pulmonary Arterial Pressure
- Trial name
- CMR-PH (NCT01725763)
- Testing
- Cardiac MRI
- Where
- Austria
- Volunteers
- 150 people
- Sponsor
- Medical University of Graz
Intraoperative Hypotension, Hepatectomy
Remimazolam Versus Propofol for Maintenance of Anaesthesia During Major Hepatectomy Under Low Central Venous Pressure
The goal of this clinical trial is to learn whether remimazolam helps prevent low blood pressure better than propofol during major liver surgery in adults.
- Trial name
- NCT07789275
- Testing
- Remimazolam, Propofol
- Where
- China
- Volunteers
- 224 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Delirium - Postoperative, Postoperative Cognitive Dysfunction (POCD)
Value of the Time-Weighted Average (TWA) of Mean Arterial Pressure (MAP) and Cerebral Oximetry (rSO₂) as Predictors of Postoperative Tissue Perfusion Impairment in Patients Undergoing Cardiac Surgery
Neurological problems after heart surgery are common and include confusion, memory loss, and difficulty thinking clearly. These issues may appear hours or days after surgery and can negatively affect recovery.
- Conditions
- Delirium - Postoperative, Postoperative Cognitive Dysfunction (POCD), Postoperative Acute Kidney Injury, Postoperative Morbidity
- Trial name
- NCT07510711
- Testing
- Continuous intraoperative monitoring of MAP and rSO₂; observational study with no therapeutic intervention.
- Volunteers
- 120 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Cardiac Arrest, Out-of-hospital Cardiac Arrest (OHCA)
Mean Arterial Pressure After Out-of-hospital Cardiac Arrest
Out-of-hospital cardiac arrest is a public health problem for which overall survival is below 10%. Post-cardiac arrest syndrome is the principal cause of death in intensive care units (ICU), due to refractory shock or brain…
- Trial name
- METAPHORE (NCT05486884)
- Testing
- Maintain MAP ≥ 90 mmHg, Maintain MAP ≥ 65 mmHg
- Where
- 31 sites in France
- Volunteers
- 1,380 people
- Sponsor
- Centre Hospitalier le Mans
Acute Kidney Injury, Intra-Abdominal Hypertension
Cumulative Intra-Abdominal Pressure Burden and Acute Kidney Injury After Emergency Abdominal Surgery
The goal of this observational study is to learn whether increased pressure inside the abdomen over time is associated with acute kidney injury in adults receiving intensive care after emergency abdominal surgery.
- Trial name
- IAP-AKI (NCT07891026)
- Testing
- Serial Intra-Abdominal Pressure Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Ugur Duman
Heart; Surgery, Heart, Functional Disturbance as Result
Trial to Compare Different Strategies of Mean Arterial Pressure Management During Cardiopulmonary By-pass
Background: One of the main goals of the Cardiopulmonary By-Pass (CPB) is targeting an adequate Mean Arterial Pressure (MAP), in order to maintain appropriate perfusion pressures in all end-organs during heart surgery.
- Trial name
- MAP (NCT05740397)
- Testing
- Management of mean arterial pressure during cardiopulmonary by-pass in cardiac surgery interventions. The MAP will be mantained in the range of values of each study arm
- Where
- Italy
- Volunteers
- 900 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Acute Kidney Failure, Renal Replacement Therapy for Acute Kidney Injury in ICU
Effects of Sedation, TEmperature and Pressure After Cardiac Arrest and REsuscitation on Major Adverse Kidney Events (STEPCARE-MAKE)
The STEPCARE-MAKE study is a predefined sub-study of the large Sedation, TEmperature and Pressure after Cardiac Arrest and REsuscitation (STEPCARE) trial, which evaluates the effects of three interventions in comatose adult…
- Conditions
- Acute Kidney Failure, Renal Replacement Therapy for Acute Kidney Injury in ICU, Sedation in Intensive Care Unit Patients, Sedation in the ICU
- Trial name
- STEPCARE-MAKE (NCT07579390)
- Testing
- Feedback-controlled temperature device, High MAP, Deep sedation
- Where
- 52 sites in Australia, Belgium and 12 more
- Volunteers
- 3,500 people
- Sponsor
- Helsinki University Central Hospital
Postoperative Delirium (POD), Intraoperative Hypotension
Maintaining Intraoperative Mean Arterial Pressure at 85 mmHg or Higher to Reduce Postoperative Delirium in Older Patients With Arterial Hypertension Having Non-cardiac Surgery
In older patients having surgery, postoperative delirium (an acute disturbance in awareness, attention, or cognition) is common and associated with short-term and long-term morbidity and mortality.
- Trial name
- ASPIRE-85 (NCT07713121)
- Testing
- MAP at 85 mmHg or higher (intervention group), MAP at 65 mmHg or higher (control group)
- Where
- Germany
- Volunteers
- 3,432 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Hypertension, Hypertension, Systolic
Treatment of Hypertension During Sleep
On the basis of new evidence on the relationship between achieved office blood pressure (BP) measurements (OBPM) and the risk of cardiovascular disease (CVD) morbidity and mortality documented in the SPRINT trial, the recent 2017…
- Trial name
- THADEUS (NCT03457168)
- Testing
- Treatment of elevated asleep SBP mean
- Where
- 9 sites in Spain
- Volunteers
- 5,320 people
- Sponsor
- University of Vigo
Colorectal Cancer, Intraoperative Hemodynamic Management
MAP- Versus Cardiac Index-Guided Hemodynamic Management in Colorectal Surgery
This prospective randomized trial aims to compare the effects of two intraoperative hemodynamic management strategies on early postoperative renal function in patients undergoing colorectal surgery.
- Trial name
- NCT07609680
- Testing
- Mean Arterial Pressure-Guided Hemodynamic Management, Cardiac Index-Guided Hemodynamic Management
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara Etlik City Hospital
AKI - Acute Kidney Injury, CABG
Perfusion Related Evaluation of Systemic and Renal Vulnerability to Events in CABG
The goal of this observational study is to learn whether high abdominal pressure or low blood flow pressure to the kidneys is linked to kidney injury after heart surgery.
- Trial name
- PRESERVE-CABG (NCT07085286)
- Testing
- Continous IAP measurement
- Volunteers
- 45 people
- Sponsor
- Medical University of Lublin
Pregnancy, Cesarean Delivery
Comparison of Non-Invasive Mean Arterial Blood Pressure Measurements at the Arm and Ankle During Elective Cesarean Delivery.
This observational study aims to compare mean arterial pressure measurements obtained using an ankle blood pressure cuff with those obtained using a standard upper-arm cuff in pregnant individuals undergoing elective cesarean…
- Conditions
- Pregnancy, Cesarean Delivery, Blood Pressure Measurement in Pregnancy, Skin to Skin Contact
- Trial name
- NCT07422766
- Testing
- Mean arterial pressure
- Where
- Canada
- Volunteers
- 110 people
- Sponsor
- St. Justine's Hospital
Resistant Hypertension, Hemodynamic Instability
Effect of Electrical Stimulation and Exercise on Blood Flow in Patients With Resistant High Blood Pressure
The goal of this clinical trial is to learn if the combination between transcutaneous electrical nerve stimulation (TENS) and isometric exercise (IE) can improve blood pressure in men and women between 50 to 60 years old suffered…
- Conditions
- Resistant Hypertension, Hemodynamic Instability, Essential (Primary) Hypertension, Abdominal Obesity
- Trial name
- NCT07383220
- Testing
- Transcutaneous Electrical Nerve Stimulation, Isometric Exercise, Aerobic, Dynamic Resistance, stretch and Breathing Exercises and Lifestyle Modification Advices
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Mohamed Mohamed Ali Morgan
Cardiogenic Shock
Personalisation of Mean Arterial Pressure in Adult Patients With Cardiogenic Shock
Cardiogenic shock is a life-threatening condition characterized by inadequate cardiac output, leading to organ hypoperfusion and high mortality.
- Trial name
- CARDIOPAM (NCT07345559)
- Testing
- Personalized MAP, Standard MAP
- Where
- 11 sites in France
- Volunteers
- 406 people
- Sponsor
- CMC Ambroise Paré
Sepsis
Perfusion Efficiency-Guided MAP De-escalation in Elderly Septic Shock
This is a single-center, prospective, randomized crossover physiological trial conducted in elderly patients (≥65 years) with septic shock in the intensive care unit (ICU).
- Trial name
- NCT07887854
- Testing
- Ascending MAP titration sequence, Descending MAP titration sequence
- Volunteers
- 24 people
- Sponsor
- Peking Union Medical College Hospital
Coronary Artery Disease, Postoperative Complications
Intraoperative Targeted Versus Liberal Blood Pressure Management in Patients Undergoing Off-pump Coronary Artery Bypass Grafting
The goal of this clinical trial is to learn whether two approaches to anesthesia and blood pressure management can improve care for adults having off-pump coronary artery bypass grafting (OPCAB).
- Trial name
- NCT07787364
- Testing
- Targeted Blood Pressure Management, Liberal Blood Pressure Management, Remimazolam
- Volunteers
- 416 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Shock
Effects of Increasing Mean Arterial Pressure on Renal Function in Patients With Shock and With Elevated Central Venous Pressure
The purpose of this study is to assess the effect of a higher mean arterial pressure on renal function for patients with shock and elevated central venous pressure.
- Trial name
- MAPAKI (NCT05655065)
- Testing
- increase of mean arterial pressure at 65-70 mmHg, increase of mean arterial pressure at 80-85 mmHg
- Where
- 2 sites in France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Angers
Controlled Hypotension for Nasal Surgeries
Effects of Different MAP Targets on Ocular Perfusion and Optic Nerve Microvasculature During Rhinoplasty
This randomized controlled trial aims to evaluate the effects of two different mean arterial pressure (MAP) targets during controlled hypotension on ocular perfusion and optic nerve head microvasculature in patients undergoing…
- Trial name
- NCT07832305
- Testing
- Lower MAP Target Strategy (50-60 mmHg), Higher MAP Target Strategy (60-70 mmHg)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Hitit University
Acute Kidney Injury, Cirrhosis
Droxidopa to Increase Mean Arterial Pressure in Decompensated Cirrhosis Patients With Acute Kidney Injury
This study tests whether a medication called droxidopa can help improve blood flow to the kidneys in people with liver cirrhosis who develop kidney problems while in the hospital.
- Conditions
- Acute Kidney Injury, Cirrhosis, Decompensated Cirrhosis of Liver
- Trial name
- DROP-AKI (NCT06937307)
- Testing
- Droxidopa capsules
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Giuseppe Cullaro, MD