Clinical trials: Mechanical Hypersensitivity
Mechanical Ventilation
Decreasing Trigger Sensitivity Could Assist PEEP to Further Improve Regional Ventilation Distribution
In mechanically ventilated patients during supine position, alveolar collapse usually distributes in dependent lung region.Decrease of flow trigger sensitivity might improve homogeneous of tidal volume distribution.
- Trial name
- NCT03241654
- Testing
- flow trigger
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Capital Medical University
Dyspnea
Patient Dyspnea Under Veno-arterial Extracorporeal Circulation
Rationale: Patients with severe heart failure increasingly benefit from extracorporeal circulatory assistance (Extracorporeal Membrane Oxygenation - ECMO) that completely replaces the function of the heart and is in addition to…
- Trial name
- DYSCO2 (NCT04815330)
- Testing
- increment sweep gas flow, non-invasive ventilation
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil
Acute Respiratory Failure, Mechanically Ventilated Patients
Concurrent Trigger Sensitivity Adjustment And Diaphragmatic Facilitation On Weaning From Mechanical Ventilation
As Acute respiratory failure (ARF) is a challenging serious condition especially when it necessitates intubation to deliver mechanical ventilation which is a fundamental strategy for supporting the respiratory function when the…
- Trial name
- NCT05387720
- Testing
- Manual diaphragmatic facilitation (PNF) technique, Trigger sensitivity adjustment on mechanical ventilation, concurrent trigger sensitivity adjustment and manual diaphragmatic facilitation (PNF) technique
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Cairo University
Migraine
Migraine is Associated With Altered Mechanical Pain Sensitivity. This Study Investigates Mechanical Pain Sensitivity, Headache Burden, and Quality of Life in Episodic and Chronic Migraine, Comparing Pressure Algometry and Algopeg® and Assessing Mechanosensitivity of Peripheral Nerves.
Migraine is one of the most prevalent neurological disorders and is associated with a substantial individual and societal burden.
- Trial name
- MechSens_Migra (NCT07559565)
- Testing
- pressure pain algometry
- Where
- Austria
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Bernhard Taxer
Neck Pain
Effects of Pain, Disability and Cervicokinesthesia After Cervical Manipulation
Cervical spine manipulation has been found to be effective in patients with mechanical neck pain. Discrepancies exist on the side of manipulation and the placebo effect of this manual intervention.
- Trial name
- NCT02645630
- Testing
- Right Cervical Manipulation, Left Cervical Manipulation
- Where
- Spain
- Volunteers
- 55 people
- Sponsor
- Universidad Rey Juan Carlos
Respiratory Failure, Mechanical Ventilation Complication
Ventilator-based Inspiratory Muscle Training for Patients With Respiratory Failure
This study will be conducted to compare the effectiveness of progressive inspiratory flow trigger sensitivity rising versus stepwise pressure support reduction as ventilator-based inspiratory muscle training methods on weaning…
- Trial name
- NCT07353814
- Testing
- adjustment of parameters on mechanical ventilation device, routine plan of weaning and Conventional Chest Physiotherapy
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Asthma
Mechanical Heat Recovery Ventilation on House Dust Mite Sensitive Asthma
Asthma has become increasingly common in the UK, demanding our consideration of the cause. Many patients with asthma are allergic to house dust mites, which thrive in modern housing.
- Trial name
- NCT00148096
- Testing
- Mechanical Heat Recovery Ventilation
- Where
- United Kingdom
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Asthma, Cough
Bronchodilating and Bronchoprotective Effects of Deep Inspirations
The objectives of this research are to compare (i) the bronchodilating and (ii) the bronchoprotective effects of deep inspirations (DIs) in individuals with: (a) asthma, (b) CVA, (c) methacholine-induced cough but normal airway…
- Trial name
- NCT01659476
- Testing
- Methacholine(MCh) Challenge Testing
- Where
- Canada
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Queen's University
Neuropathic Pain, Mechanical Hypersensitivity
AZD2066 Neuropathic Pain - Mechanical Hypersensitivity
The purpose of this study is to investigate if 28 days of treatment with AZD2066 compared to placebo can relieve the pain arising from the nervous system when the patients are touched by something that should not cause pain or…
- Trial name
- NP-MH (NCT00939094)
- Testing
- AZD2066
- Where
- 38 sites in United States
- Volunteers
- 87 people
- Sponsor
- AstraZeneca
Ventilator Associated Pneumonia
Common Canister Protocol for Inhaler Administration in Mechanically Ventilated Patients
Many hospitals employ a common canister inhaler protocol in patients that do not require mechanical ventilator support. Common canister refers to a single inhaler paired with standardized cleaning methods for use on more than one…
- Trial name
- NCT01935388
- Testing
- Common canister
- Where
- United States
- Volunteers
- 354 people
- Sponsor
- Barnes-Jewish Hospital
COPD, Asthma
Influence of Mechanical Ventilation Modes on the Efficacy of Nebulized Bronchodilator
Aerosol therapy is widely used in intensive care in critically ill patients that use mechanical ventilation (MV). However, there is a lack of standardization about aerosol performance in this group of patients.
- Trial name
- NCT03271905
- Testing
- salbutamol sulfate and ipratropium bromide, Mesh nebulization
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Universidade Federal do Rio Grande do Norte
Asthma, Cough
Sensory-Mechanical Responses to Eucapneic Voluntary Hyperventilation and Mannitol
The objectives of this study are to determine the sensory-mechanical responses to Eucapneic Voluntary Hyperventilation (EVH) and Mannitol in individuals with cough variant asthma (CVA) and methacholine-induced cough with normal…
- Conditions
- Asthma, Cough, Cough Variant Asthma
- Trial name
- NCT03105843
- Testing
- Methacholine (MCh) Challenge Testing, Eucapneic Voluntary Hyperventilation (EVH), Mannitol Inhalation Kit
- Where
- Canada
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Dr. Diane Lougheed
COPD, Congestive Heart Failure
Enhancing Utilization of Non-Invasive Positive Pressure Ventilation in Critical Care
Non-invasive positive pressure ventilation (NIV) refers to the provision of mechanical ventilation without an artificial airway (for example, an endotracheal tube).
- Conditions
- COPD, Congestive Heart Failure, Asthma, Respiratory Distress Syndrome, Adult
- Trial name
- NCT00458926
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- Tufts Medical Center
Healthy
Effect of Spinal Ketorolac After Acute Opioid Exposure
This research study is being done because pain is a significant problem for patients with a variety of medical problems and following surgery or traumatic injury.
- Trial name
- NCT00693160
- Testing
- ketorolac, remifentanil, Capsaicin
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Wake Forest University
Cervical Radiculopathy
Soft Tissue Mobilization Versus Therapeutic Ultrasound for Subjects With Neck and Arm Pain
The purpose of this study is to investigate effects of soft tissue mobilization versus therapeutic ultrasound in subjects with neck and arm pain who demonstrate neural mechanical sensitivity.
- Trial name
- NCT02081456
- Testing
- Soft Tissue Mobilization, Therapeutic Ultrasound
- Volunteers
- 23 people
- Sponsor
- Emilio J Puentedura, PT, DPT, PhD
Allergic Rhinitis
Efficacy Of Bacterial Lysate In Children With Allergic Rhinitis
This study evaluate the efficacy of Polyvalent Mechanical Bacterial Lysate (PMBL - Ismigen) to improve the clinical course of grass pollen-induced allergic rhinitis (using: TNSS, TOSS, VAS, PNIF) in children aged 5 to 17.
- Trial name
- NCT04270552
- Testing
- Ismigen
- Where
- Poland
- Volunteers
- 76 people
- Sponsor
- Medical University of Lublin
Respiratory Failure
Threshold Inspiratory Trainer Versus Trigger Sensitivity Adjustment on Weaning From Mechanical Ventilation
Ninety adult patients from both gender, with acute respiratory failure, intubated and mechanically ventilated. Their ages ranged from 50 to 70 years.
- Trial name
- NCT05846945
- Testing
- Threshold inspiratory muscle trainer device, Adjusting mechanical ventilator trigger sensitivity, Chest physiotherapy
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Cairo University
Diabetes Mellitus, Type 2, Insulin Resistance
Bone Properties Following Exercise Induced Changes in Insulin Sensitivity in People With Type 2 Diabetes
Diabetes mellitus type 2 is associated with low bone turnover and increased risk of bone fractures. Bone mineral density, however, is increased and cannot explain the increased fracture risk per se.
- Conditions
- Diabetes Mellitus, Type 2, Insulin Resistance, Bone Diseases, Metabolic, Osteoporosis, Osteopenia
- Trial name
- NCT06668090
- Testing
- Moderate intensity bike exercise
- Where
- Denmark
- Volunteers
- 42 people
- Sponsor
- Aarhus University Hospital
Allergic Rhinitis Due to Grass Pollen
The Influence of Nonspecific Immunostimulation on Changes in the Concentration of iNKT Cells
The aim of the study is to assess the effect of polyvalent mechanical bacterial lysate (PMBL, Ismigen) on the clinical course of grass pollen-induced allergic rhinitis (using: total nasal symptom score, visual analogue scale…
- Trial name
- NCT04802616
- Testing
- Ismigen
- Where
- Poland
- Volunteers
- 80 people
- Sponsor
- Medical University of Lublin
Quality of Life
Health-related Quality of Life and Nursing-sensitive Outcomes in Mechanically Ventilated Patients
This study will allow us to determine the perceived Health-Related Quality of Life (HRQL) a year after ICU discharge, and compare it with HRQL measured earlier on in the process, as well as analyse the negative experiences they…
- Trial name
- NCT02636660
- Volunteers
- 184 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute