Clinical trials: Mechanical Hypersensitivity
Childhood Asthma, Allergy
AsthmaVent - Effect of Mechanical Ventilation on Asthma Control in Children
AsthmaVent is a multi-center study, investigating the association between indoor air quality and childhood asthma. In Denmark, we spend more and more time indoors.
- Trial name
- AsthmaVent (NCT02068573)
- Testing
- Ventilation
- Where
- 7 sites in Denmark
- Volunteers
- 46 people
- Sponsor
- University of Aarhus
Asthma, Pollution; Exposure
Residential Ventilation Systems and Filtration for Asthma Control in Adults
The goal of this study was to investigate the effectiveness of three common approaches to upgrading residential mechanical ventilation systems in existing homes for improving asthma-related health outcomes, reducing indoor…
- Trial name
- NCT06098287
- Testing
- Residential mechanical ventilation system (Exhaust), Residential mechanical ventilation system (CFIS) and air filtration upgrades, Residential mechanical ventilation system (ERV) and air filtration upgrades
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Illinois Institute of Technology
Mechanical Ventilator Weaning, Predictive Value of Tests
ICU Predictive Score of WEaning Success in Patients At Risk of Extubation Failure
Observational study in two medical-surgical intensive care units of the Clermont-Ferrand University Hospital to develop a composite score for prediction of 72h-extubation failure in patients at risk of extubation failure.
- Conditions
- Mechanical Ventilator Weaning, Predictive Value of Tests, Ventilator Weaning, Airway Extubation
- Trial name
- I-SWEAR (NCT05114551)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Clermont-Ferrand
Allergic Rhinitis
Effect of Bacterial Lysate on Nasal Carriage of Staphylococcus Aureus
This study assesses the effectiveness of Polyvalent Mechanical Bacterial Lysate (PMBL-Ismigen) in reducing nasal methicillin-resistant Staphylococcus aureus (MRSA) colony growth in children with pollen allergic rhinitis (AR) aged…
- Trial name
- NCT04637425
- Testing
- Ismigen
- Where
- Poland
- Volunteers
- 70 people
- Sponsor
- Medical University of Lublin
Osteoarthritis, Pain
Efficacy of Etoricoxib 60 mg in Modifying Pain Hypersensitivity in People With Knee Osteoarthritis
This study aims to better understand the way in which painful osteoarthritis affects different people and whether an anti-inflammatory medication such as Arcoxia (etoricoxib) can help to modify this pain.
- Trial name
- NCT00927004
- Testing
- Etoricoxib (Arcoxia), Sugar pill
- Where
- Australia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Curtin University
Asthma
Modulation Of Airway Reactivity With Chronic Mechanical Strain
The purpose of this study is to see if the use of a machine called CPAP will help children with asthma breathe better. CPAP is a machine that produces airflow to help people with breathing problems.
- Trial name
- NCT02396849
- Testing
- Continuous Positive Airway Pressure (CPAP)
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Indiana University
Orthostatic Intolerance
Blood Pressure and Brain Blood Flow Regulation After Midodrine Administration in Those With Spinal Cord Injury
This project aims to evaluate the physiological effects of Midodrine administration during orthostatic challenge in those with high level spinal cord injury.
- Trial name
- NCT01498809
- Testing
- Midodrine
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- University of British Columbia
Acute Rhinitis, Nasal Obstruction
Performance and Safety Assessment of the Mechanical Decongestant Seawater Spray Enriched With Essential Oils From Laboratoires Gilbert in Patient With Acute Rhinitis Associated With Nasal Obstruction
The purpose of this post-market clinical investigation is to assess the performance and the safety of the mechanical decongestant seawater spray enriched with essential oils from Laboratoires Gilbert.
- Conditions
- Acute Rhinitis, Nasal Obstruction, Rhinosinusitis, Rhinopharyngitis
- Trial name
- DEMECA (NCT06580210)
- Where
- 3 sites in France
- Volunteers
- 114 people
- Sponsor
- Laboratoires Gilbert
Ventilator-Induced Diaphragmatic Dysfunction
Therapeutically Alternatives In Ventilator-Induced Diaphragm Dysfunction Critically Ill Patients
The study is a prospective experimental study on adult patients admitted to the Critical Care Department in Qasr Al-Ainy. This study is conducted prospectively to assess the efficiency of trigger sensitivity adjustment on…
- Trial name
- NCT06515600
- Testing
- Practice flow trigger sensitivity adjustment on mechanical ventilation for 1 week twice daily in addition to their plan of treatment.
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- South Valley University
Post Endodontic Pain, Mechanical Detection Threshold
The Effects of Preemptive Multimodal Analgesic on Endodontic Pain Following Root Canal Therapy.
A clinical trial comparing preemptive multimodal analgesics with placebo in the management of immediate and chronic post-endodontic pain.
- Conditions
- Post Endodontic Pain, Mechanical Detection Threshold, Mechanical Pain Threshold, Mechanical Pain Sensitivity
- Trial name
- NCT07400471
- Testing
- Pregabalin- Acetaminophen, Duloxetine- Acetaminophen
- Where
- Bangladesh
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Chattogram International Dental College
Hip Arthroplasty
Effect of Spinal Ketorolac on Mechanical Hypersensitivity After a Total Hip Replacement
Chronic pain in patients following total hip replacement seems to be a significant problem. Previous research has shown that more effective pain management in the early postoperative period may decrease the incidence of the…
- Trial name
- NCT00621530
- Testing
- ketorolac tromethamine opthalmic solution
- Where
- 2 sites in United States
- Volunteers
- 62 people
- Sponsor
- Wake Forest University
Asthma, Cough Variant Asthma
Physiology of Cough in Asthma: Comparison of Sensory-Mechanical Responses to Mannitol and Methacholine Challenge Tests
Cough is a common, disruptive and at times disabling symptom which often prompts patients to seek medical attention. Determining the cause(s) of chronic cough can be challenging, and costly.
- Trial name
- NCT01064245
- Testing
- high-dose methacholine challenge test, mannitol challenge test
- Where
- Canada
- Volunteers
- 29 people
- Sponsor
- Dr. Diane Lougheed
Chronic Low-back Pain
Conditioned Pain Modulation in Localized vs Widespread Chronic Low Back Pain
This study aims to compare function of the body's endogenous pain modulation system between people with localized low back pain versus widespread body pain.
- Trial name
- NCT05972395
- Testing
- Localized vs Widespread Mechanical Pain Hypersensitivity
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Ahram Canadian University
Respiratory Failure
Effect of Different Proprioceptive Neuromuscular Facilitation Techniques Versus Flow Trigger Sensitivity on Weaning Off Mechanical Ventilation
Weaning is a critical stage in respiratory care, requiring strategies to optimize breathing muscle function and reduce patient dependence on ventilatory support.
- Trial name
- PNF techniques (NCT06831201)
- Testing
- Flow trigger sensitivity group, Active proprioceptive facilitation technique ( active PNF) technique, Passive proprioceptive facilitation technique ( passive PNF) technique
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Beni-Suef University
Postoperative Cough, Cough Hypersensitivity Syndrome
Effects of Energy Versus Mechanical Surgical Devices on Postoperative Cough
Numerous current studies have indicated that transecting the pulmonary plexus nerve as a routine step in radical lung cancer surgery is an independent risk factor for cough hypersensitivity (CH).
- Trial name
- ENERGY-COUGH (NCT07524712)
- Testing
- Energy Device Vagus Nerve Transection, Mechanical Vagus Nerve Transection
- Where
- China
- Volunteers
- 248 people
- Sponsor
- Tongji Hospital
Respiratory Failure, Critical Illness
Double Triggering Asynchrony in Mechanically Ventilated Patients.
This observational study examined double triggering asynchrony in28ICU patients on mechanical ventilation. Researchers collected data on patient characteristics, health conditions, and outcomes to understand how this problem…
- Conditions
- Respiratory Failure, Critical Illness, Mechanical Ventilation
- Trial name
- NCT07380607
- Where
- Egypt
- Volunteers
- 28 people
- Sponsor
- Mansoura University
Heartburn, Dyspepsia
The Effects of Tegaserod on Mechanical Sensitivity of the Esophagus and Stomach in Patients With Heartburn and Dyspepsia.
Investigate the role of tegaserod in modulating gastric sensitivity to mechanical distention of the stomach
- Trial name
- NCT00171457
- Testing
- Tegaserod
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Novartis
Neck Pain
Thoracic Manipulation and Mobilization for Neck Pain
The purpose of this randomized clinical trial was to examine the widespread effects of thoracic spine thrust manipulation and thoracic non-thrust mobilization on pressure pain sensitivity and neck pain intensity in patients with…
- Trial name
- NCT02051478
- Testing
- Thoracic mobilization, Thoracic manipulation
- Where
- Spain
- Volunteers
- 55 people
- Sponsor
- Universidad Rey Juan Carlos