Clinical trials: Mechanical Thrombectomy
Stroke, Acute, Cerebral Infarction
Endovascular Therapy Following Imaging Evaluation for Ischemic Stroke 3
This is a study to evaluate the hypothesis that FDA cleared thrombectomy devices plus medical management leads to superior clinical outcomes in acute ischemic stroke patients at 90 days when compared to medical management alone…
- Trial name
- DEFUSE 3 (NCT02586415)
- Testing
- Endovascular Thrombectomy, Trevo Retriever, Solitaire™ FR Revascularization Device
- Where
- 40 sites in United States
- Volunteers
- 182 people
- Sponsor
- Gregory W Albers
Acute Ischemic Stroke, Neutrophil Extracellular Traps Formation
Sodium Sivelestat With Mechanical Thrombectomy for Acute Stroke: A Pilot Study
Stroke remains a major global health burden, with acute ischemic stroke (AIS) accounting for more than 65% of all cases. Endovascular thrombectomy (EVT) has been established as the standard treatment for large vessel occlusion…
- Conditions
- Acute Ischemic Stroke, Neutrophil Extracellular Traps Formation, Large Vessel Occlusion, Thrombectomy
- Trial name
- NCT07196605
- Testing
- Sodium Sivelestat
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Xuanwu Hospital, Beijing
Peripheral Arterial Occlusion or Emboli
Case Review of the Penumbra and Indigo Systems for Mechanical Thrombectomy in the Periphery
The primary objective of this retrospective case review study is to determine the safety and effectiveness of the Penumbra and Indigo Systems for mechanical thrombectomy in a cohort of patients with confirmed peripheral or…
- Trial name
- PRISM (NCT02085551)
- Testing
- Mechanical Thrombectomy by the Indigo System
- Where
- 5 sites in United States
- Volunteers
- 85 people
- Sponsor
- Penumbra Inc.
Cerebral Artery Occlusion
Neurothrombectomy France
The Ischemic Brain Vascular Accident (CVA) is a major public health issue. An Early and appropriate charging anyone with stroke is essential to reduce mortality, reduce dependency and promote recovery of autonomy.
- Trial name
- NTF (NCT02880579)
- Where
- France
- Volunteers
- 230 people
- Sponsor
- Nantes University Hospital
Acute Stroke, Surgical Procedure
Emergent Microsurgical Intervention in Acute Stroke Patients After Mechanical Thrombectomy Failure Trial
With all of the gains that have been achieved with endovascular mechanical thrombectomy revascularization and intravenous thrombolysis logistics, there is still a subgroup of patients with salvageable brain tissue for whom…
- Trial name
- EMIAS (NCT05153642)
- Testing
- Microsurgical intervention
- Where
- 2 sites in Czechia
- Volunteers
- 50 people
- Sponsor
- University Hospital Ostrava
Acute Ischemic Stroke
FRench Acute Cerebral Multimodal Imaging to Select Patient for MEchanical Thrombectomy
FRench Acute cerebral multimodal imaging to select patient for MEchanical thrombectomy is a prospective multi-center study to determine if multimodal imaging could identify patients who may and those who may not benefit from an…
- Trial name
- FRAME (NCT03045146)
- Testing
- Multimodal brain imaging
- Where
- 2 sites in France
- Volunteers
- 220 people
- Sponsor
- University Hospital, Toulouse
Acute Ischaemic Stroke
Endovascular Therapy in Acute Ischaemic Stroke Due to Large Vessel Occlusion
Aim of Study: 1. To develop a standardized patient selection criteria and imaging protocol for endovascular therapy in acute ischaemic stroke (AIS) 2.
- Trial name
- NCT03328403
- Testing
- Aspiration First, Stent retriever first
- Where
- Hong Kong
- Volunteers
- 58 people
- Sponsor
- The University of Hong Kong
Ischemic Stroke
A Pivotal Study Evaluating Safety and Effectiveness of Adaptative Tip Catheter in Patients With Acute Ischemic Stroke
The purpose of this study is to assess the safety and the effectiveness of the Adaptive Tip Catheter (ATC) used as a first line direct aspiration thrombectomy technique for patients suffering of an acute ischemic stroke.
- Trial name
- PHAST (NCT07367100)
- Testing
- Adaptive Tip Catheter
- Where
- 10 sites in Belgium, France and 1 more
- Volunteers
- 74 people
- Sponsor
- Neuravi Limited
Stroke, Large Vessel Occlusion
Mechanical Thrombectomy Blood Flow Reversal
The goal of this study is to reduce the chance of complications during mechanical thrombectomy, which is a procedure to remove blockages from the brain.
- Trial name
- NCT06721338
- Testing
- Mechanical thrombectomy via blood flow reversal using BOBBY balloon guide catheter
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- MediSys Health Network
Cerebrovascular Disorders, Acute Cerebrovascular Disease
Inhaled Nitric Oxide in Acute Ischemic Stroke Patients Undergoing Mechanical Thrombectomy
The purpose of this study is to determine the safety and feasibility of using inhaled nitric oxide (iNO) in patients undergoing intra-arterial mechanical thrombectomy (blood clot extraction or IAMT) for treatment of acute…
- Trial name
- iNO (NCT05871606)
- Testing
- iNO
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Wake Forest University Health Sciences
Thrombosis, Venous
Acute and Subacute Iliofemoral and/or Caval Deep Vein Thrombosis: Evaluation of Mechanical Thrombectomy Systems
This is a physician-initiated, observational, monocentric, retrospective and prospective Study. The study is intended to assess the feasibility of mechanical thrombectomy of caval and iliofemoral veins according to normal…
- Trial name
- ASTER (NCT06288906)
- Testing
- mechanical thrombectomy of caval and iliofemoral veins
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS San Raffaele
Ischemic Stroke, Thrombotic Stroke
Autonomic Neuromodulation by Transcutaneous Nerve Stimulation in Acute Ischaemic Stroke.
Autonomic modulation by transcutaneous vagal nerve stimulation in acute ischaemic stroke requiring mechanical thrombectomy: a phase IIa, sham controlled randomised trial.
- Conditions
- Ischemic Stroke, Thrombotic Stroke, Autonomic Dysfunction, Autonomic Imbalance
- Trial name
- VANS (NCT05417009)
- Testing
- trans-cutaneous auricular sensory stimulation
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- Queen Mary University of London
Deep Vein Thrombosis
Comparison Of Different Mechanical Thrombectomy Devices in Endovascular Treatment of Acute Iliofemoral Venous Thrombosis
A head-to-head comparison of two different types of percutaneous mechanical thrombectomy (PMT) - ClotTriever System versus aspiration thrombectomy (including rheolytic thrombectomy) - in patients with acute iliofemoral deep vein…
- Trial name
- NCT07622212
- Testing
- Percutaneous mechanical thrombectomy by ClotTriever System, Percutaneous mechanical thrombectomy by aspiration or rheolytic thrombectomy
- Where
- China
- Volunteers
- 180 people
- Sponsor
- RenJi Hospital
Deep Venous Thrombosis
Outcome of Percutaneous Mechanical Thrombectomy to Treat Acute Deep Venous Thrombosis
The purpose of this study was to compare the efficacy of Percutaneous mechanical thrombectomy (PMT) followed by standard anticoagulant therapy, with anticoagulation therapy alone, for the treatment of acute proximal lower…
- Trial name
- NCT02959801
- Testing
- Percutaneous mechanical thrombectomy
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Stroke, Acute, Blood Pressure
Clevidipine Infusion for Blood Pressure Management After Successful Revascularization in Acute Ischemic Stroke
The CLEVER Study is a prospective, 2-arm, randomized, single-center pilot study to assess the safety and efficacy of intensive blood pressure control using Clevidipine (on-label use) in AIS patients undergoing standard of care…
- Conditions
- Stroke, Acute, Blood Pressure, Mechanical Thrombectomy
- Trial name
- CLEVER (NCT05175547)
- Testing
- Clevidipine
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- ProMedica Health System
Brain Stroke, Stenting Treatment
Emergent Large Vessel Occlusion Endovascular Rescue Therapy With Underlying Intracranial Stenosis
The study objective is to establish the safety and efficacy of endovascular adjunct stenting for patients undergoing mechanical thrombectomy (MT) that are found to have residual stenosis (70-99%) following attempted clot…
- Conditions
- Brain Stroke, Stenting Treatment, Acute Ischemic Stroke
- Trial name
- EVEREST (NCT07356284)
- Testing
- Mechanical Thrombectomy plus adjunct stenting, Mechanical Thrombectomy
- Where
- United States
- Volunteers
- 342 people
- Sponsor
- ProMedica Health System
Acute Ischemic Stroke
Intensive Control of Blood Pressure in Acute Ischemic Stroke After Endovascular Therapy on Clinical Outcome (CRISIS I)
CRISIS I is a prospective, multicenter, randomized controlled trial, to asses the impact of intensive blood pressure control on clinical outcome of acute ischemic stroke patients with successful recanalization after endovascular…
- Trial name
- NCT04775147
- Testing
- Intensive BP lowering
- Where
- China
- Volunteers
- 205 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Stroke, Stroke Acute
Mechanical Thrombectomy in the Middle East and North Africa: Interim Results from the MEMENTO Registry
The MEMENTO (MEchanical thrMobectomy NETwork for MENA TOgether) Registry is a multicenter, prospective observational study aiming to evaluate the effectiveness, safety, and cost-effectiveness of mechanical thrombectomy (MT) in…
- Conditions
- Stroke, Stroke Acute, Endovascular Procedures, Large Vessel Occlusion
- Trial name
- MEMENTO Regist (NCT06702787)
- Where
- Egypt
- Volunteers
- 1,500 people
- Sponsor
- Middle East North Africa Stroke and Interventional Neurotherapies Organization
Deep Vein Thrombosis
Mechanical Thrombectomy and Catheter Directed Thrombolysis Utilization in Patients With Deep Vein Thrombosis
The goal of this observational study is to assess the utilization of mechanical thrombectomy and catheter-directed thrombolysis in patients with deep vein thrombosis in tertiary care. The main questions it aims to answer are: 1.
- Trial name
- NCT06468150
- Where
- Russia
- Volunteers
- 2,427 people
- Sponsor
- Pirogov Russian National Research Medical University
Stroke, Ischemic
A Study of the Use of the Q Aspiration Catheter to Remove Clot in Stroke Patients
The purpose of this study is to collect real-world safety and performance data on the MIVI Neuroscience, Inc. Q Aspiration Catheter for use in the removal of fresh, soft emboli and thrombi in the neurovascular system during acute…
- Trial name
- TAPAS (NCT04089917)
- Testing
- Q Aspiration Catheter
- Where
- 4 sites in Spain
- Volunteers
- 45 people
- Sponsor
- MIVI Neuroscience, Inc.