Clinical trials: Mechanical Thrombolysis
Ischemic Stroke
Adjunctive Intra-arterial Tenecteplase Following Mechanical Thrombectomy Pilot Trial
Prospective, single center, non-randomized, pilot study to assess the feasibility of IA TNK following standard of care mechanical thrombectomy (MT) in patients with AIS.
- Trial name
- ALLY (NCT05172934)
- Testing
- intra-arterial tenecteplase
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- ProMedica Health System
Stroke
Clinical Prognosis After Stroke in Nonagenarian Patients Treated With Thrombolysis or Mechanical Thrombectomy
Stroke is a significant cause of death and disability in France and internationally. The incidence of stroke increases with age, equal for both sexes. Of all strokes, 50% of cases occur in patients over 75 years of age.
- Trial name
- PCAT (NCT04553237)
- Where
- France
- Volunteers
- 111 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Cerebrovascular Accident (CVA)
Strokecopilot: A Precision Medicine Tool in the Stroke Emergency
Ischemic stroke or cerebral infarction (CI) is an immediate emergency affecting approximately 100,000 - 150,000 patients each year in France and is managed in the neurovascular intensive care unit (NICU).
- Trial name
- Strokecopilot (NCT05534295)
- Where
- France
- Volunteers
- 10,000 people
- Sponsor
- University Hospital, Strasbourg, France
Stroke, Ischemic, Stroke, Acute
Randomization to Endovascular Treatment Alone or Preceded by Systemic Thrombolysis With Tenecteplase in Ischemic Stroke
A phase III randomized, multi-center, double-blinded, placebo-controlled clinical trial that will examine two strategies for the treatment of acute ischemic stroke associated with a large vessel anterior occlusion within 4.5…
- Trial name
- DIRECT-TNK (NCT05199194)
- Testing
- Tenecteplase
- Where
- 13 sites in Brazil
- Volunteers
- 398 people
- Sponsor
- Hospital Moinhos de Vento
Ischemic Stroke, Covid19
Acute Revascularization Treatment in Ischemic Stroke Patients With COVID-19
Case-series and cohort studies have shown the feasibility of reperfusion therapies in patients with ischemic stroke and COVID-19, but due to the absence of a contemporary control group of non-COVID-19 patients, small sample size…
- Trial name
- NCT04895462
- Where
- Switzerland
- Volunteers
- 15,128 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Stroke, Ischemia Stroke
Minocycline in Stroke Study at Maimonides
The goal of this study is to determine if Minocycline, when added to standard care, can improve survival and functional outcomes in patients with moderate acute stroke (ischemic or hemorrhagic) aged 18 years and older.
- Conditions
- Stroke, Ischemia Stroke, Hemorrhagic Strokes, Mortality
- Trial name
- NCT07237048
- Testing
- Minocycline 200mg
- Where
- United States
- Volunteers
- 1,164 people
- Sponsor
- Joyce Chen
Thrombolytic Therapy, Thrombolysis
Submassive Pulmonary Embolism Experience With EKOS
This single site study evaluates the efficacy of ultrasound accelerated thrombolysis using EKOS Endovascular Device with a standard infusion of thrombolytics for treatment of PE
- Conditions
- Thrombolytic Therapy, Thrombolysis, Mechanical Thrombolysis, Pulmonary Embolism
- Trial name
- SPEEK (NCT02926742)
- Testing
- EkoSonic Endovascular System
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Krishna Mannava, MD, FACS, RPVI
Stroke, Acute Ischemic, Large Vessel Occlusion
INtra-arterial AltEplase folloWing successfuL reperfusIoN After mEchanical Thrombectomy
The NEWLINE trial is a multicenter, randomized, open-label, blinded endpoint (PROBE) trial evaluating whether adjunctive low-dose intra-arterial alteplase administered immediately after successful endovascular thrombectomy…
- Conditions
- Stroke, Acute Ischemic, Large Vessel Occlusion, Thrombectomy
- Trial name
- NEWLINE (NCT07727395)
- Testing
- Alteplase, Endovascular thrombectomy
- Where
- 11 sites in Vietnam
- Volunteers
- 416 people
- Sponsor
- 115 People's Hospital
Stroke, Inflammation
Combinating Fingolimod With Alteplase Bridging With Mechanical Thrombectomy in Acute Ischemic Stroke
Proof-of concept clinical trials have indicated that the sphingosine-1-phosphate receptor modulator fingolimod may be efficacious in attenuating brain inflammation and improving clinical outcomes in patients with AIS as a single…
- Trial name
- FAMTAIS (NCT02956200)
- Testing
- Fingolimod
- Where
- China
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Malfunction; Catheter, Thrombosis
Prolonged Hemodialysis Catheter Survival With Copolymer Coating and Rt-PA
Surface thrombogenicity of standard double lumen catheters (stDLC) and surface modified film-coated domain structured double lumen catheters (fcDLC) consisting of a novel reactive polyurethane copolymer coating showed that in…
- Conditions
- Malfunction; Catheter, Thrombosis, Mechanical Complication of Hemodialysis Catheter
- Trial name
- PROCOPrt-PA (NCT01670474)
- Testing
- rt-PA (2mg/2mL) actilysis, rt-PA
- Where
- Switzerland
- Volunteers
- 240 people
- Sponsor
- Centre Hospitalier du Centre du Valais
Angiographically Confirmed Acute Massive Pulmonary Embolism Treated With Endovascular Mechanical Fragmentation and Thrombolytic Therapy
Pradaxa or Warfarin for Prevention of Recurrent VTE in Patients With Angiographically Confirmed Acute Massive Pulmonary Embolism undergoIng Endovascular Mechanical Fragmentation and Thrombolytic Therapy
A prospective randomised controlled study to evaluate outcomes of the treatment with pradaxa or warfarin for prevention of recurrent DVT in patients with angiographically confirmed acute massive pulmonary embolism undergoIng…
- Trial name
- Re-Spire (NCT02979561)
- Testing
- Dabigatran Etexilate, Warfarin
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Ischemic Stroke
Assess the Penumbra System in the Treatment of Acute Stroke
The purpose of this trial is to assess the safety and effectiveness of the Penumbra System as an adjunctive treatment to intravenous (IV) recombinant human tissue plasminogen activator (rtPA)in patients with acute ischemic stroke…
- Trial name
- THERAPY (NCT01429350)
- Testing
- intravenous (IV) recombinant human tissue plasminogen activator (rtPA), Penumbra System
- Where
- 4 sites in United States
- Volunteers
- 108 people
- Sponsor
- Penumbra Inc.
Acute Ischemic Stroke
Safety and Efficacy of J147 in Acute Ischemic Stroke
The goal of this clinical trial is to find out if the drug J147 improves outcomes for persons who have had an ischemic stroke. It also will learn about the safety of J147 when given by injection to stroke patients.
- Trial name
- JUMPSTART (NCT07430917)
- Testing
- J147 Emulsion for Injection
- Where
- 5 sites in United States
- Volunteers
- 196 people
- Sponsor
- Abrexa Pharmaceuticals, Inc.
Acute Ischemic Stroke
Efficacy and Safety of Butylphthalide for Acute Ischemic Stroke Patients Receiving Intravenous Thrombolysis or Endovascular Treatment
Butylphthalide, as a well-known neuroprotective medication, is a family of compounds initially isolated from the seeds of Apium graveolens Linn, of which active ingredient is dl-3-N-butylphthalide (dl-NBP).
- Trial name
- BAST (NCT03539445)
- Testing
- Butylphthalide
- Where
- China
- Volunteers
- 1,216 people
- Sponsor
- Beijing Tiantan Hospital
Stroke, Acute
Acute Stroke: Prehospital Versus In-HospitAL Initiation of Recanalization Therapy- ASPHALT
ASPHALT is an academic-driven open-label randomized controlled trial of Mobile Stroke Unit (MSU) deployment versus standard care in France, with blinded assessment of efficacy endpoints.
- Trial name
- ASPHALT (NCT05649670)
- Testing
- Mobile Stroke Unit deployment
- Where
- 11 sites in France
- Volunteers
- 450 people
- Sponsor
- Centre Hospitalier St Anne
Ischemic Stroke
Bridging Thrombolysis Versus Direct Mechanical Thrombectomy in Acute Ischemic Stroke
Intravenous thrombolysis with recombinant tissue-type plasminogen activator (IV t-PA) has been the only proven therapy for acute ischemic stroke (AIS) for almost 20 years.
- Trial name
- SWIFT DIRECT (NCT03192332)
- Testing
- Stent-retriever thrombectomy with revascularization device of the Solitaire™ type, Intravenous thrombolysis with recombinant tissue-type plasminogen activator (IV t-PA)
- Where
- 48 sites in Austria, Canada and 6 more
- Volunteers
- 410 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Acute Pulmonary Embolism
Percutaneous Mechanical Thrombectomy With or Without Low-Dose Catheter-Directed Thrombolysis in Acute Intermediate-High Risk Pulmonary Embolism
Acute pulmonary embolism (PE) is the third most common cardiovascular cause of death. In patients with intermediate-high risk acute PE, percutaneous mechanical thrombectomy (PMT) using large-bore catheters achieves rapid…
- Trial name
- PMT-LDCDT-PE (NCT07865572)
- Testing
- PMT alone (percutaneous mechanical thrombectomy only), PMT plus low-dose catheter-directed thrombolysis (PMT+LDCDT)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Qiu Jipeng
Ischemic Stroke, Acute
Intra-arterial Recombinant Human TNK Tissue-type Plasminogen Activator (rhTNK-tPA) Thrombolysis for Acute Large Vascular Occlusion After Successful Mechanical Thrombectomy Recanalization
The goal of this clinical trial is to evaluate whether intra-arterial (IA) rhTNK-tPA thrombolysis can improve neurological outcomes in acute large vessel occlusion patients after successful mechanical thrombectomy (MT)…
- Trial name
- ANGEL-TNK (NCT05624190)
- Testing
- Recombinant Human tenecteplase Tissue-type Plasminogen Activator (rhTNK-tPA), Best Medical Management
- Where
- China
- Volunteers
- 256 people
- Sponsor
- Beijing Tiantan Hospital
Iliofemoral Venous Thrombosis
Pharmaco Mechanical Thrombolysis Associated With Anticoagulation Compared With Anticoagulation in the Acute Phase of Very Symptomatic Proximal Venous Thrombosis of the Lower Limbs.
Iliofemoral DVTs (IF DVTs) are vascular disorders associated with high morbidity and mortality, which can be complicated by long-term post-thrombotic syndrome (PTS).
- Trial name
- PMT-DVT (NCT06472518)
- Testing
- pharmaco mechanical thrombolysis
- Where
- France
- Volunteers
- 228 people
- Sponsor
- Nantes University Hospital
Acute Ischemic Stroke, Arterial Thrombosis
Intra-arterial Thrombolysis After Successful Thrombectomy for Acute Ischemic Stroke in the Posterior Circulation (IAT-TOP)
The CHOICE study suggested that the use of adjunct intra-arterial alteplase after successful endovascular reperfusion in large vessel occlusion acute ischemic strokes may result in a greater likelihood of excellent neurological…
- Conditions
- Acute Ischemic Stroke, Arterial Thrombosis, Posterior Circulation Brain Infarction
- Trial name
- NCT05897554
- Testing
- intra-arterial alteplase
- Where
- China
- Volunteers
- 247 people
- Sponsor
- Xuanwu Hospital, Beijing