Clinical trials: Mechanical Ventilation Complication
Mechanical Ventilation Complication
Specific Small RNA in Plasma for Predicting Diaphragm Dysfunction in Mechanically Ventilated Patients
Through the literature screening of MyomiRX 7, the detection of mechanical ventilation group, difficult withdrawal unit and healthy adult plasma levels of MyomiRX in the evaluation of function and skeletal muscle thickness of the…
- Trial name
- NCT03172169
- Testing
- no Intervention
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Southeast University, China
Respiratory Failure, Critical Illness
The Efficacy of P0.1-guided Sedation Protocol in Critically Ill Patients Receiving Invasive Mechanical Ventilation: A Randomized Controlled Trial
This clinical trial aims to assess the efficacy of sedation protocol targeting optimal respiratory drive using P0.1 and arousal level compared with conventional sedation strategy (targeting arousal level alone) in patients…
- Conditions
- Respiratory Failure, Critical Illness, Respiratory Distress Syndrome, Adult, Lung Injury
- Trial name
- NCT06203405
- Testing
- Titrating sedation targeting both optimal P0.1 and appropriate arousal level, Fentanyl, Midazolam
- Where
- Thailand
- Volunteers
- 214 people
- Sponsor
- Siriraj Hospital
Cirrhosis, Mechanical Ventilation Complication
Extubation Failure in Critically Ill Cirrhotic Patients.
Although a life-saving intervention, invasive mechanical ventilation (MV) prone to complications and side effects. Cirrhotic patients with a need of prolonged MV have a poor prognosis in ICU compared to general population of…
- Conditions
- Cirrhosis, Mechanical Ventilation Complication, Critical Illness
- Trial name
- FREELIVER (NCT05244005)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier
Mucus Retention, Mechanical Ventilation Complication
Efficacity and Safety of Mechanical Insufflation-exsufflation on ICU
Critically ill and intubated patients on mechanical ventilation (IMV) often present retention of respiratory secretions, increasing the risk of respiratory infections and associated morbidity.
- Conditions
- Mucus Retention, Mechanical Ventilation Complication, Mucus; Plug, Tracheobronchial
- Trial name
- NCT03316079
- Testing
- Chest physiotherapy techniques, Mechanical insufflation-exsufflation
- Where
- 3 sites in France
- Volunteers
- 26 people
- Sponsor
- University Hospital, Bordeaux
Injury of Diaphragm, Mechanical Ventilation Complication
Using Ultrasound to Study Respiratory Muscle Function in Critically Ill Patients
Mechanical ventilation can be life saving strategy for patients with respiratory failure due to a variety of reasons. Once the underlying illness has resolved, intensive care doctors have to take a decision on when the patient is…
- Conditions
- Injury of Diaphragm, Mechanical Ventilation Complication, Critical Illness
- Trial name
- NCT03139695
- Testing
- Ultrasound
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Severe Burns, Acute Kidney Injury
Association of Continuous Renal Replacement Therapy With Mortality and Length of Stay in Critically Burned Patients
This retrospective observational study aims to investigate the clinical outcomes of critically ill burn patients who underwent continuous renal replacement therapy (CRRT).
- Conditions
- Severe Burns, Acute Kidney Injury, Critical Illness
- Trial name
- CRRT-BURN (NCT07195565)
- Where
- Turkey (Türkiye)
- Volunteers
- 238 people
- Sponsor
- Pinar Timur Tasci
Obese
Mechanical Ventilation in Obese Surgical Patients
The purpose of this study is to evaluate whether an intraoperative positive end-expiratory pressures (PEEP) setting strategy aimed at minimizing the mechanical power delivered to the lungs via transpulmonary pressure improves…
- Trial name
- NCT07774065
- Testing
- Standard PEEP (8 cmH₂O)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Electrical Impedance Tomography (EIT), Postoperative Pulmonary Complications (PPCs)
EIT-guided PEEP Titration Versus Standard Ventilation in Bariatric Surgery
This study is a prospective, single-center, single-blind, randomized controlled clinical trial. Patients scheduled for laparoscopic bariatric surgery will be selected and randomly assigned to either the EIT-guided individualized…
- Conditions
- Electrical Impedance Tomography (EIT), Postoperative Pulmonary Complications (PPCs), Recruitment, Mechanical Ventilation Complication
- Trial name
- EIT (NCT07207772)
- Testing
- Group P-eit, Group P-8
- Where
- China
- Volunteers
- 118 people
- Sponsor
- Jianbo Wu
Effect of Drug, Adverse Drug Event
Efficacy and Safety of Remimazolam Besylate for Sedation in Post-Non-Cardiac Surgery Patients Requiring Mechanical Ventilation
A multi-center, prospective, randomized, double-blind, active-controlled, no-inferiority clinical trial conducted across 5 tertiary medical centers in China.
- Conditions
- Effect of Drug, Adverse Drug Event, Mechanical Ventilation Complication, Critical Illness
- Trial name
- NCT06575530
- Testing
- Remimazolam Besylate, Dexmedetomidine Hydrochloride
- Where
- China
- Volunteers
- 306 people
- Sponsor
- Beijing Shijitan Hospital, Capital Medical University
Mechanical Ventilation Complication, Pediatric Respiratory Diseases
Tracheal Suctioning With or Without Expiratory Pause Maneuver in Children
The purpose of this study is to evaluate the efficacy of tracheal suctioning associate with expiratory pause maneuver in children on invasive mechanical ventilation.
- Trial name
- NCT05805475
- Testing
- Endotracheal suctioning with expiratory pause, Endotracheal suctioning without expiratory pause
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Mechanical Ventilation Complication, Respiratory Insufficiency
Transpulmonary Pressures in Mechanical Ventilated Patients With Morbid Obesity
The study consists in determine the transpulmonary pressure in morbidly obesity patients that require mechanical ventilation. both gender only adults Medical intensive care patients.
- Trial name
- NCT02309190
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- The University of Texas Health Science Center, Houston
Preterm Birth
Repercussions of Respiratory Physiotherapy in Preterm Infants Under Mechanical Ventilation
Respiratory diseases are a major morbidity and mortality causes of neonatal requiring mechanical ventilation, especially in newborn preterm infants (PN), thus respiratory therapy becomes increasingly necessary in order to…
- Trial name
- preterm (NCT03159039)
- Testing
- Conventional Physiotherapy, Prolonged slow exhalation technique
- Volunteers
- 43 people
- Sponsor
- Universidade Cidade de Sao Paulo
Traumatic Brain Injury, Weaning Failure
Study of Variables Related to the Discontinuation of Mechanical Ventilation in Patients With Head Injury
The purpose of this study is to evaluate physiological variables to the decision about the appropriate time to discontinuation of mechanical ventilation in patients with traumatic brain injury.
- Conditions
- Traumatic Brain Injury, Weaning Failure, Mechanical Ventilation Complication
- Trial name
- INDEXTBI (NCT01713010)
- Testing
- Predictive indexes of weaning from mechanical ventilation
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of Uberlandia
Mechanical Ventilation Complication
Effect of Three Modalities of Spontaneous Breathing Tests on Respiratory Efforts in Tracheostomized Patients
Datas are lacking concerning weaning from mechanical ventilation for tracheostomized patients. In particular, the effect of different modalities of spontaneous breathing trials on respiratory effort has not been extensively…
- Trial name
- TWEEP (NCT03856424)
- Testing
- Modality 1, Modality 2, Modality 3
- Where
- Switzerland
- Volunteers
- 18 people
- Sponsor
- Piquilloud Imboden Lise
Respiratory Complications, Pneumonia
Incidence and Complications of Post-extubation and Post-tracheostomy Dysphagia in Adult Patients in the Critical Care Unit
Acquired Swallowing Disorder in ICU (ICU-ASD), also known as postextubation dysphagia, is a multicausal problem experienced by survivors in intensive care units (ICUs) when the efficiency, safety of swallowing, or both are…
- Conditions
- Respiratory Complications, Pneumonia, Quality of Lifte, Death
- Trial name
- NCT06583824
- Volunteers
- 414 people
- Sponsor
- Complejo Hospitalario Universitario de Albacete
Infant, Newborn, Infant, Low Birth Weight
Delivery Room CPAP in Extremely Low Birth Weight Infants
This pilot study was designed to determine the feasibility of randomizing extremely low birth weight (ELBW) infants <28 weeks' gestation who required resuscitation to one of two resuscitation methods, either: (a) 100% oxygen by…
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- DR-CPAP (NCT01223274)
- Testing
- CPAP/PEEP, Standard management practices
- Where
- 6 sites in United States
- Volunteers
- 104 people
- Sponsor
- NICHD Neonatal Research Network
Mechanical Ventilation Complication
Automatic Adjustment for Asynchronies During Mechanical Ventilation
Asynchronies between the patient and the artificial ventilator are a frequent problem. They may cause altered sleep, ventilator-induced lung injury, prolong length of ICU stay, cause neuro-psycologic complications and increase…
- Trial name
- i-Sync (NCT06295237)
- Testing
- Intellisync+
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Hospital San Carlos, Madrid
Mechanical Ventilation Complication, Severe Acute Respiratory Infection
The REDEEM Pilot Study: A Feasibility RCT of Early ECMO in Severe Acute Respiratory Infection, Including COVID-19, WHO
Patients who are critically ill in intensive care with moderate to severe acute respiratory infection often require mechanical ventilation.
- Conditions
- Mechanical Ventilation Complication, Severe Acute Respiratory Infection, Covid19
- Trial name
- REDEEM (NCT04708457)
- Testing
- VV-ECMO
- Where
- 2 sites in Australia, Germany
- Volunteers
- 6 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Peripheral Vascular Diseases
General Versus Regional Anaesthesia in Peripheral Arterial Surgery: Incidence of Postoperative Pulmonary Complications.
The study will be designed as a prospective clinical trial. Patients scheduled for lower limb arterial bypass surgery will be randomly allocated for treatment with spinal anesthesia associated with spontaneous ventilation (nasal…
- Trial name
- NCT04566016
- Testing
- Regional anesthesia
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Mechanical Ventilation Complication, Acute Respiratory Failure
Protocolized Post-Extubation Respiratory Support Study
Invasive mechanical ventilation is common in the medical intensive care unit, and the period of time following extubation remains high risk as 11 to 15% of patients require reintubation after their first extubation.
- Conditions
- Mechanical Ventilation Complication, Acute Respiratory Failure, Intubation Complication
- Trial name
- PROPER (NCT03288311)
- Testing
- Protocolized post-extubation respiratory support, Usual Care
- Where
- United States
- Volunteers
- 751 people
- Sponsor
- Vanderbilt University Medical Center