Clinical trials: Mechanical Ventilation Weaning
Patient Ventilator Interactions, Spontaneous Breathing Trial
Entropy Analysis and Complex Patient-ventilator Interactions During Mechanical Ventilation
Complex patterns of patient-ventilator interactions could be miscalculated by visual observation of mechanical ventilator screens or current algorithms based on physiologic waveforms to detect patient-ventilator asynchronies.
- Trial name
- ENTROPY-ICU (NCT04128124)
- Testing
- processing signals of airway pressure and airway flow to calculate entropy
- Where
- Spain
- Volunteers
- 107 people
- Sponsor
- Corporacion Parc Tauli
Mechanical Ventilation, Weaning Failure
Ventilatory Settings and Monitoring Variables Associated With Weaning Failure in Critically Ill Patients
Mechanical ventilation (MV) is essential in managing acute respiratory failure. Its duration is a crucial aspect since both, unnecessary prolongation and premature withdrawal have deleterious effects on patient outcomes in the…
- Conditions
- Mechanical Ventilation, Weaning Failure, Weaning Failure of Mechanical Ventilation, Intensive Care Unit ICU
- Trial name
- WEAN-FAIL (NCT06683781)
- Where
- Argentina
- Volunteers
- 1,077 people
- Sponsor
- Hospital Italiano de Buenos Aires
Mechanical Ventilation Pressure High, Weaning Failure
Extremes of Respiratory Effort in Weaning Failure From Mechanical Ventilation: a Prospective Observational Study
The presence of high levels of respiratory effort in patients under mechanical ventilation may worsen the adjacent lung injury even after adapting protective ventilation.
- Trial name
- NCT06464224
- Testing
- low respiratory effort, high respiratory effort
- Where
- Brazil
- Volunteers
- 1 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Mechanical Ventilation, Autonomic Nervous System Diseases
Variability Analysis as a Predictor of Liberation From Mechanical Ventilation
The purpose of this study is to evaluate if the variability of biological signals, such as heart rate and temperature, can predict weaning from mechanical ventilation in patients with failure to wean.
- Trial name
- NCT01140750
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The Cleveland Clinic
Weaning Failure
Can High Intensity Inspiratory Muscle Training Improve Inspiratory Muscle Strength and Accelerate Weaning in Medical Patients With Difficulty on Weaning?
Introduction: It has been described that invasive mechanical ventilation leads to diaphragm weakness. The inspiratory muscle weakness is related with a difficult and prolonged weaning as well as longer duration of mechanical…
- Trial name
- NCT04347317
- Testing
- Low Intensity IMT, High Intensity IMT
- Where
- 2 sites in Spain
- Volunteers
- 40 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Respiratory Insufficiency Requiring Mechanical Ventilation
Evaluation on the Effect of Acupuncture and Neuromuscular Electrical Stimulation on Mechanical Ventilation Patients
Acupuncture is a treatment intervention used globally for a wide variety of disorders. Its efficacy has been established over the course of 3000 years, originating in Asia and diversifying worldwide.The scientific basis for…
- Trial name
- NCT05221710
- Testing
- electroacupuncture
- Where
- China
- Volunteers
- 120 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Traumatic Brain Injury, Weaning Failure
Study of Variables Related to the Discontinuation of Mechanical Ventilation in Patients With Head Injury
The purpose of this study is to evaluate physiological variables to the decision about the appropriate time to discontinuation of mechanical ventilation in patients with traumatic brain injury.
- Conditions
- Traumatic Brain Injury, Weaning Failure, Mechanical Ventilation Complication
- Trial name
- INDEXTBI (NCT01713010)
- Testing
- Predictive indexes of weaning from mechanical ventilation
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of Uberlandia
Acute Respiratory Failure
NAVASET: Nava Level Titration Using Comfort Scales
Determining the optimal Neurally Adjusted Ventilatory Assist (NAVA) level remains challenging, and several methods have been suggested. However none of them seems easily utilisable.
- Trial name
- NCT02133443
- Testing
- PSV - pressure support ventilation, Neurally Adjusted Ventilatory Assist
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Caen
Cardiac Surgery
Cardiac Surgery and Diaphragm Function
Diaphragm dysfunction is common after cardiac surgery and may delay weaning from mechanical ventilation and cause respiratory distress.
- Trial name
- NCT02208479
- Testing
- Non invasive ultrasound measurement of the diaphragm thickness during breathing
- Where
- France
- Volunteers
- 66 people
- Sponsor
- University Hospital, Grenoble
Mechanical Ventilation Weaning, Spontaneous Breathing Trial
High-Flow Tracheal Oxygen During Spontaneous Breathing Trial
The purpose of this study is to find out whether high-flow tracheal oxygen (HFTO) delivered at flows greater than 60 L/min can increase end-expiratory lung volume (EELV) in intubated patients during a spontaneous breathing trial…
- Conditions
- Mechanical Ventilation Weaning, Spontaneous Breathing Trial, High Flow Oxygen Therapy
- Trial name
- HFTO-SBT (NCT07864415)
- Testing
- T-piece, HFTO 50, washout, HFTO 70, washout, PSV., T-piece, HFTO 70, washout, HFTO 50, washout, PSV.
- Volunteers
- 30 people
- Sponsor
- Argentinian Intensive Care Society
Delirium in the Intensive Care Unit, Mechanical Ventilation Complication
The Association Between the Extubation Process and Delirium in the Intensive Care Unit
There are limited studies in the literature investigating the relationship between delirium and the pre- and post-extubation periods in patients planned for extubation.
- Trial name
- NCT07196813
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people
- Sponsor
- Eskisehir Osmangazi University
Rapid Shallow Breathing
Prediction of Weaning Outcomes by Using Rate of Change of Rapid Shallow Breathing Index
This trial examines weaning outcomes using the rapid shallow breathing index rate.
- Trial name
- NCT00366197
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Atlantic Health System
Pediatric Respiratory Diseases, Ventilator Weaning
WOB and Paediatric Mechanical Ventilation
Rationale: The most common approach to weaning infants and children is gradual reduction of ventilatory support ("traditional approach").
- Conditions
- Pediatric Respiratory Diseases, Ventilator Weaning, Respiration, Artificial, Respiratory Failure
- Trial name
- PedWOB (NCT05254691)
- Testing
- Sprinting
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Mechanical Ventilation Weaning
Autonomic Modulation in Patients Undergoing Assisted Mechanical Ventilation: Comparison Between PAV+ and PSV
The aim of the study is to investigate autonomic modulation in terms of heart rate variability (i.e., HRV) in patients undergoing assisted mechanical ventilation in PSV mode, compared to patients assisted in PAV+ mode.
- Trial name
- NCT06590311
- Testing
- Heart Rate Variability
- Where
- Italy
- Volunteers
- 48 people
- Sponsor
- University of Roma La Sapienza
Weaning From Mechanical Ventilation, Tracheostomy Weaning
Physiological Effect High-flow Tracheal Oxygen on Viscosity of Airway Mucus and Respiratory Effort in Patients Weaning From Invasive Mechanical Ventilation
Rationale: Tracheostomized patients weaning from mechanical ventilation are at risk for dryness of airway mucosa and sputum accumulation during disconnection from mechanical ventilation.
- Conditions
- Weaning From Mechanical Ventilation, Tracheostomy Weaning, Respiratory Failure
- Trial name
- PIONEER (NCT06776939)
- Testing
- Oxygen therapy
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Henrik Endeman
Ventilated Patient in Intensive Care
Weighted Blanket to Improve Sedation and Comfort During Ventilator Weaning
Patients in the ICU who are being taken off of a breathing machine (ventilator weaning) commonly experience anxiety, agitation, sleep disruption, and physiologic stress.
- Trial name
- NCT07710469
- Testing
- Weighted blanket, Standard hospital linens
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Massachusetts General Hospital
Weaning Mechanical Ventilation, ICU Ill Patients
Diaphragmatic Ultrasonography in Difficult Weaning
Weaning from mechanical ventilation (MV) is a gradual process that includes several steps until the complete withdrawal of ventilatory support.
- Conditions
- Weaning Mechanical Ventilation, ICU Ill Patients, Diaphragm Dysfunction
- Trial name
- DUS-WEAN (NCT07751237)
- Testing
- Diaphragmatic ultrasound
- Where
- Brazil
- Volunteers
- 220 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Critical Illness, Diastolic Dysfunction
Diastolic dYsfunctioN AssessMent in critICally Ill Patients
The role of the left ventricular diastolic function (LVDD) in the weaning failure from mechanical ventilation in unclear. Specifically, is unclear whether the outcome of the weaning process could be affected by a pre-existing…
- Conditions
- Critical Illness, Diastolic Dysfunction, Diastolic Heart Failure, Weaning Failure
- Trial name
- DYNAMIC (NCT04584203)
- Testing
- Bedside Echocardiography, Spontaneuos breathing trial, Bedside Echocardiography_1
- Where
- 8 sites in Italy
- Volunteers
- 297 people
- Sponsor
- Humanitas Clinical and Research Center
Respiratory Insufficiency
Integrated Pulmonary Index (IPI) as a Determinate of Weaning Success and/or Failure in the Pediatric Population
Integrated pulmonary index (IPI) is a tool that monitors respiratory status. It takes into account four parameters: respiratory rate, end-tidal CO2, heart rate and O2 saturation using a pulse oximeter and specialized sidestream…
- Trial name
- IPI (NCT01795196)
- Where
- United States
- Sponsor
- Rush University Medical Center
Mechanical Ventilation Complication
Preoperative Inspiratory Muscle Training
In light of the corona virus pandemic (COVID-19), there is critical need to conserve scarce mechanical ventilation (MV) resources.
- Trial name
- NCT04423614
- Testing
- Inspiratory Muscle Training, Relaxation Breathing
- Sponsor
- University of Florida