Clinical trials: Mechanical Ventilator Weaning
Critical Illness, Respiratory Failure
Early Versus Deferred De-escalation From Controlled Ventilation After a 48-Hour Landmark of Physiological Stability
This retrospective target trial emulation evaluates the optimal timing of de-escalation from controlled to assisted mechanical ventilation in critically ill adults.
- Conditions
- Critical Illness, Respiratory Failure, Mechanical Ventilation
- Trial name
- NCT07804992
- Testing
- Ventilatory Support De-escalation Strategy
- Where
- China
- Volunteers
- 12,736 people
- Sponsor
- Ruijin Hospital
Airway Extubation, Ventilator Weaning
Mechanical Ventilation Reconnection for One Hour After Spontaneous Breathing Trial
The aim of this study is to evaluate the feasibility to perform a future larger clinical trial to analyze whether the mechanical ventilation reconnection for 1 hour after a successful spontaneous breathing trial reduces the risk…
- Trial name
- NCT05999526
- Testing
- Reconnection to mechanical ventilation for 1 hour, Direct extubation
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Centro Hospitalar Unimed de Joinville
Mechanical Ventilator Weaning, Acute Brain Injury
Brain-injured Patients Extubation Readiness Study
The BIPER study is a stepped wedge cluster randomised clinical trial aiming to decrease extubation failure in critically-ill brain-injured patients with residual impaired consciousness using a simple clinical score.
- Conditions
- Mechanical Ventilator Weaning, Acute Brain Injury, Altered Level of Consciousness, Mechanical Ventilation
- Trial name
- Biper (NCT04080440)
- Testing
- Extubation readiness clinical score, Usual Care
- Where
- 21 sites in France
- Volunteers
- 660 people
- Sponsor
- University Hospital, Clermont-Ferrand
Ventilator-induced Diaphragm Dysfunction, VIDD
Evaluation of heepSync, a Novel Algorithm for Transcutaneous Electrical Stimulation of Respiratory Muscles in Mechanically Ventilated Patients.
Up to 76% of ICU patients on mechanical ventilation develop significant respiratory muscle atrophy within the first 24 hours, contributing to prolonged ventilation, increased morbidity, and higher healthcare costs.
- Conditions
- Ventilator-induced Diaphragm Dysfunction, VIDD, Weaning Failure
- Trial name
- NCT07363902
- Testing
- Heecap
- Where
- 3 sites in Spain
- Volunteers
- 20 people
- Sponsor
- Tesai Care SL
Ventilators, Mechanical, Intensive Care Units
Postoperative INTELLiVENT-ASV Ventilation
The aim of this study is to investigate whether postoperative ventilation with INTELLiVENT-ASV(adaptive support ventilation) in high risk patients, after cardiothoracic surgery, is as effective, more user-friendly and as safe as…
- Conditions
- Ventilators, Mechanical, Intensive Care Units, Postoperative Care
- Trial name
- POSITiVE (NCT03180203)
- Testing
- INTELLiVENT-ASV, Conventional modes
- Where
- Netherlands
- Volunteers
- 220 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Respiratory Failure
Chronic Obstructive Pulmonary Disease and Weaning From Mechanical Ventilation in Difficult to Wean Patients
To evaluate and compare two methods of weaning from mechanical ventilation in patients with chronic obstructive pulmonary disease (COPD) where the extubation failed.
- Trial name
- NCT00355732
- Testing
- Weaning from mechanical ventilation
- Where
- 2 sites in Croatia
- Sponsor
- Dr. Josip Benčević General Hospital
Complication
Is Positive Pressure Extubation a Safe Procedure?
Laboratory studies suggest extubation with positive pressure because it reduces the volume of secretions filtered into the distal airway.
- Trial name
- NCT03174509
- Testing
- Positive pressure extubation, Traditional during extubation
- Where
- Argentina
- Volunteers
- 198 people
- Sponsor
- Hospital Donación Francisco Santojanni
Cardiogenic Shock, Weaning Failure
Ultrasound Study of the Diaphragm Evolution Under ECMO
Evaluate the evolution of diaphragmatic muscle effort in cardiogenic shock in ECMO patient with ultrasounds during the first weaning attempt in intensive care patients.
- Trial name
- DIAG-ECMO (NCT03736239)
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Association Pro-arte
Ventilator Lung, Acute Brain Injury
Weaning From Mechanical Ventilation in Patients With Acute Brain Injury
Acute brain injury (ABI) patients frequently necessate intubation and invasive mechanical ventilation (IMV). While some ABI patients are capable of breathing spontaneously, which is one of the main criteria of extubation and…
- Trial name
- NCT06542107
- Where
- China
- Volunteers
- 605 people
- Sponsor
- Southeast University, China
Mechanical Ventilator Weaning, Predictive Value of Tests
ICU Predictive Score of WEaning Success in Patients At Risk of Extubation Failure
Observational study in two medical-surgical intensive care units of the Clermont-Ferrand University Hospital to develop a composite score for prediction of 72h-extubation failure in patients at risk of extubation failure.
- Conditions
- Mechanical Ventilator Weaning, Predictive Value of Tests, Ventilator Weaning, Airway Extubation
- Trial name
- I-SWEAR (NCT05114551)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Clermont-Ferrand
Prolonged Mechanical Ventilation, Ventilator Weaning
Standardized Tracheostomy Weaning Protocol for Prolonged Mechanical Ventilation
This study evaluated the feasibility and clinical outcomes of a standardized weaning protocol for tracheostomized patients requiring prolonged mechanical ventilation.
- Conditions
- Prolonged Mechanical Ventilation, Ventilator Weaning, Tracheostomy
- Trial name
- NCT06642714
- Testing
- Standardized Stepwise Weaning Protocol
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Capital Medical University
COPD, COPD Exacerbation
Study of Sleep Quality in the Intensive Care Unit and Association with Weaning from Invasive Ventilation in Patients with Chronic Obstructive Bronchopneumopathy.
Patients admitted in ICU may require invasive mechanical ventilation, using a mechanical ventilator and an endotracheal tube. In ICU, a prolonged duration of invasive mechanical ventilation may be responsible for…
- Conditions
- COPD, COPD Exacerbation, Ventilated Patients, Ventilator-Associated Pneumonia (VAP)
- Trial name
- SLEECOP (NCT06653933)
- Where
- France
- Volunteers
- 42 people
- Sponsor
- University Hospital, Grenoble
Chronic Obstructive Pulmonary Disease (COPD), Mechanical Ventilator Weaning
D-RSBI Versus RSBI for Predicting Weaning Success in COPD Patients
This prospective observational cohort study aims to compare the predictive accuracy of diaphragmatic rapid shallow breathing index (D-RSBI) versus traditional rapid shallow breathing index (RSBI) for predicting weaning success…
- Trial name
- NCT07590362
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Pneumonia
Effect of Rib Mobilization on Weaning Parameters From Mechanical Ventilator in Patients With Pneumonia
this study will be conducted to distinguish between effect of rib mobilization and routine chest physiotherapy on weaning parameters from mechanical ventilator in patients with pneumonia • HYPOTHESES: It will be hypothesized that…
- Trial name
- NCT06835842
- Testing
- rib mobilization technique, routine chest physiotherapy
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Ventilator Weaning, Sarcopenia
Comparison of Sarcopenia Index, Diaphragm Ultrasonography, and Traditional Weaning Parameters in Predicting Successful Weaning From Mechanical Ventilation
This study investigates whether the Sarcopenia Index (SI = serum creatinine/cystatin C × 100), a simple biomarker derived from routine blood tests, can predict weaning success in critically ill patients undergoing invasive…
- Conditions
- Ventilator Weaning, Sarcopenia, Diaphragm Ultrasonography
- Trial name
- NCT07844421
- Testing
- sarcopenia index, diaphragma ultrasound, parameters of mechanical ventilation (MV)
- Volunteers
- 80 people
- Sponsor
- Kocaeli City Hospital
Intra-Abdominal Hypertension, Respiratory Mechanics
Intra-Abdominal Pressure, Respiratory Mechanics, and Ventilator Liberation After Emergency Major Laparotomy
This prospective observational cohort study aims to investigate the relationship between intra-abdominal pressure (IAP), respiratory system mechanics, and successful liberation from invasive mechanical ventilation in adult…
- Conditions
- Intra-Abdominal Hypertension, Respiratory Mechanics, Mechanical Ventilation
- Trial name
- IAP-VENT (NCT07889609)
- Testing
- Serial Intra-Abdominal Pressure and Respiratory Mechanics Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Electric Stimulation, Respiration, Artificial
Breath Synchronized Abdominal Muscle Stimulation to Facilitate Ventilator Weaning: a Pilot Study
The primary objective of this study is to determine whether neuromuscular electrical stimulation applied to the abdominal wall muscles in synchrony with exhalation can increase the strength of the respiratory muscles in prolonged…
- Conditions
- Electric Stimulation, Respiration, Artificial, Ventilator Weaning
- Trial name
- NCT03019107
- Testing
- Breath synchronized abdominal NMES
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Liberate Medical
Ventilator Induced Diaphragm Dysfunction
A Protocol Comparing Temporary Transvenous Diaphragm Pacing to Standard of Care for Weaning From Mechanical Ventilation
This clinical investigation is an open-label, multi-center RCT to demonstrate the safety and effective performance of the Lungpacer DPTS (plus standard of care) as compared to Control (standard of care only) in patients aged 18…
- Trial name
- RESCUE 3 (NCT03783884)
- Testing
- Lungpacer Diaphragm Pacing Therapy
- Where
- 33 sites in United States, France and 1 more
- Volunteers
- 223 people
- Sponsor
- Lungpacer Medical Inc.
Ventilator Weaning
Switching Between Invasive and Noninvasive Ventilation to Facilitate Weaning in Difficult-weaning Patients
The aim of this study is to facilitate weaning by switching between invasive and noninvasive ventilation in difficult-weaning patients.
- Trial name
- NCT02921347
- Testing
- switching between invasive and noninvasive ventilation
- Where
- China
- Volunteers
- 83 people
- Sponsor
- Chongqing Medical University
Weaning Failure
Comparison of Two Different Types of Mechanical Ventilation Weaning in Patients in the ICU
Mechanical ventilation is widely used for ICU patients as a lifesaving procedure. However, it is associated with several complications, such as ventilator-associated pneumonia and the increase of hospital morbidity and mortality.
- Trial name
- NCT02122016
- Testing
- SmartCare, Conventional weaning protocol
- Where
- 2 sites in Brazil
- Volunteers
- 70 people
- Sponsor
- Hospital Israelita Albert Einstein