Clinical trials: Mechanically Ventilated Patients, open to volunteers
Mechanical Ventilation
The Geniohyoid Muscle in Critical Illness
Many patients lose muscle due to being unwell in an intensive care unit. This muscle loss can lead to weakness of the arms and legs when they leave the unit, and when they go home.
- Trial name
- NCT07606690
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Warrington Hospital
Palliative Care, Withdrawal of Life Support
End-of-life Care in Mechanically Ventilated Patients: Impact of a Comprehensive Palliative Care Protocol in the Intensive Care Setting
The ARREVE-3 trial will evaluate whether a structured palliative care protocol can improve end-of-life management for mechanically ventilated ICU patients in whom a decision to withdraw life-sustaining therapies has been made.
- Conditions
- Palliative Care, Withdrawal of Life Support, Intensive Care Medicine, Sedation
- Trial name
- ARREVE-3 (NCT07368010)
- Testing
- Protocol for palliative care and life-support withdrawal
- Where
- France
- Volunteers
- 720 people
- Sponsor
- Nantes University Hospital
Remimazolam Besylate, Mechanically Ventilated ICU Patients
Effect of Remimazolam Sedation on Outcomes of Mechanically Ventilated Patients in the ICU
The goal of this clinical trial is to evaluate the effect of remimazolam sedation on outcomes of mechanically ventilated ICU patients through a single-center, prospective, randomized controlled, pilot study.
- Conditions
- Remimazolam Besylate, Mechanically Ventilated ICU Patients, Sedation
- Trial name
- NCT07596589
- Testing
- Remimazolam, propofol
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Southeast University, China
Weaning Invasive Mechanical Ventilation
Multidimensional Correlation Analysis of Heart Rate Variability and Weaning Assessment Parameters in Critically Mechanically Ventilated Patients
Background： Conventional weaning assessments are widely used but often affected by factors such as poor patient cooperation, neuromuscular issues, or unstable consciousness, leading to uncertainty in extubation timing.
- Trial name
- NCT07455214
- Testing
- BEATINFO ECG Sensor
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Fu Jen Catholic University Hospital
Prevalence of Airway Closure, in Adults in Intensive Care
Abbreviated Title: Airway Opening Pressure in Mechanically VENTilated Patients
Context: Mechanical ventilation is an essential treatment for patients admitted to intensive care. It is estimated that approximately 50% of adult patients admitted to intensive care require invasive mechanical ventilation.
- Conditions
- Prevalence of Airway Closure, in Adults in Intensive Care, Mechanical Ventilation in Controlled Mode
- Trial name
- AOP-VENT (NCT07512713)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Clermont-Ferrand
ARDS (Moderate or Severe)
Combining Electrical Impedance Tomography and Thoracic Ultrasound Toinvestigate Dynamic Changes
1. To evaluate the dynamic changes of lung ultrasound during electrical impedance tomography (EIT) PEEP titration and across the first week of ARDS. 2.
- Trial name
- NCT06958770
- Testing
- Electrical impedance tomography
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
Critically Ill, Mechanical Ventilation
The TEAM Long-Term Cohort Study (A Sub-study of TEAM(III))
This study is a prospective cohort study to evaluate the long-term effects of early activity and mobilisation compared to standard care on disability, function and health status for patients at 1, 2 and 5 years after recruitment…
- Conditions
- Critically Ill, Mechanical Ventilation, Long Term Outcome
- Trial name
- NCT05298982
- Testing
- Early activity and Mobilisation Intervention
- Where
- 16 sites in Australia
- Volunteers
- 250 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Ventilation Acquired Pneumonia
The Effect of Continuous Management of Suction Cuff Pressure and Subglottic Irrigation Suction on Preventing VALRI Study
Assessing the effectiveness of continuous cuff pressure management combined with subglottic suction irrigation in reducing ventilator-associated lower respiratory tract infections (VALRTI) in mechanically ventilated patients at…
- Trial name
- SCOPE (NCT06867237)
- Testing
- Suction cuff pressure
- Volunteers
- 90 people
- Sponsor
- Shanghai Zhongshan Hospital
Mechanical Ventilation Weaning, Chronic Disease
Phenotype-Guided Weaning in Mechanically Ventilated Patients With Chronic Comorbidities
The goal of this clinical trial is to learn whether a phenotype-guided weaning strategy can help adults with chronic comorbidities be liberated from invasive mechanical ventilation earlier.
- Trial name
- NCT07594418
- Testing
- Phenotype-Guided Weaning Strategy, Standard Care
- Volunteers
- 1,380 people
- Sponsor
- Southeast University, China
Respiratory Support
The ACCESSIT Study
The study is designed to characterize and monitor the structure, degree of activation and function of the different respiratory muscles during mechanical ventilation after spine trauma and spinal cord injury.
- Trial name
- ACCESSIT (NCT05207046)
- Testing
- Mechanical Ventilation
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Unity Health Toronto
Ventilator Induced Diaphragm Dysfunction, Respiratory Muscle Weakness
Standardization of IMT Dosage (UTIT) in Mechanical Ventilation.
Respiratory muscle weakness prolongs mechanical ventilation (MV) and delays weaning. Currently, there is no standardized dosage for Inspiratory Muscle Training (IMT) in the ICU.
- Conditions
- Ventilator Induced Diaphragm Dysfunction, Respiratory Muscle Weakness, Mechanical Ventilation Weaning
- Trial name
- UTIT-IMT (NCT07761468)
- Testing
- Inspiratory Muscle Training (IMT)
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Hospital H+ Queretaro
Ventilator Dependent
Short Effects of SIMT and EM in Prolonged Mechanically Ventilated Patients
Using mechanical ventilation for more than 18 hours can affect respiratory muscle and postural muscle control, making it difficult to wean off the ventilator and reducing mobility. The aim of this study is to: 1.
- Trial name
- NCT06368089
- Testing
- Inspiratory muscle training (IMT) group, Early mobilization (EM) group
- Where
- Thailand
- Volunteers
- 46 people
- Sponsor
- Prince of Songkla University
Eye Care, Nursing Care
Effects of Two Different Eye Care Practices on Eye Complications in Mechanically Ventilated Intensive Care Patients
This study was designed as a prospective, randomized controlled experimental study aiming to compare different approaches to eye care in intensive care patients receiving mechanical ventilation.
- Conditions
- Eye Care, Nursing Care, Intensive Care Unit
- Trial name
- NCT07070843
- Testing
- Control Group: Standard Eye Care Group, Intervention Group 1: Eye Care Using an Eye Care Kit, Intervention Group 2: Eye Care According to an Eye Care Protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 156 people
- Sponsor
- Istanbul Saglik Bilimleri University
Hemodynamic Instability, Hypovolemia
Comparison of PPV and LVOT VTI During Passive Leg Raising to Predict Fluid Responsiveness
Hemodynamic instability remains one of the leading causes of morbidity and mortality among critically ill patients in intensive care units. One major contributor to this instability is intravascular fluid deficit.
- Conditions
- Hemodynamic Instability, Hypovolemia, Critical Illness, Pulse Pressure Variation
- Trial name
- NCT07304661
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Izmir Katip Celebi University
Mechanically Ventilated Patients With Shock
The Impact of Different Sedation Regimens on Hemodynamics in Patients Undergoing Mechanical Ventilation With Shock
Mechanical ventilation is a common therapeutic intervention in the intensive care unit (ICU). However, patients undergoing mechanical ventilation often experience agitation, unplanned extubation, patient-ventilator asynchrony…
- Trial name
- NCT07037615
- Volunteers
- 50 people
- Sponsor
- Peking University People's Hospital
Anesthesia, Intravenous Fluid
Lung Recruitment Maneuver as a Potential Predictor of Fluid Responsiveness in Mechanically Ventilated Pediatric Patients
In this research study we want to learn more about using non-invasive tools as a way to predict whether or not a child under general anesthesia will require and respond to fluid administration.
- Conditions
- Anesthesia, Intravenous Fluid, Blood Pressure
- Trial name
- NCT03431064
- Testing
- Lung Recruitment Maneuver, Fluid Administration
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Boston Children's Hospital
ARDS, Human
Extracorporeal Carbon Dioxide Removal Using PrismaLung in Reducing Ventilator Induced Lung Injury
Lung protective ventilation with low tidal volumes and low driving pressure are known to reduce mortality in mechanically ventilated patients with acute respiratory failure.
- Trial name
- NCT06321497
- Testing
- Extracorporeal carbon dioxide removal
- Where
- Australia
- Volunteers
- 15 people
- Sponsor
- Peninsula Health
Difficult to Wean, Mechanically Ventilated Patients With a Tracheostomy
Identifying the Optimal IMT Dose in ICU
200,000 adults are admitted to intensive care in the UK each year. Many of these patients need help with their breathing and are put on a machine called a ventilator.
- Trial name
- NCT07256821
- Testing
- Inspiratory Muscle Training
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Ankle Contracture, Critically Ill Intensive Care Unit Patients
Continuous Passive Motion to Prevent Ankle Contracture and Muscle Atrophy in Ventilated Patients
This clinical trial aims to evaluate whether continuous passive motion (CPM) can prevent ankle joint contracture and muscle atrophy in critically ill patients receiving mechanical ventilation in the ICU.
- Conditions
- Ankle Contracture, Critically Ill Intensive Care Unit Patients, Muscle Atrophy
- Trial name
- CPM-ICU (NCT07032051)
- Testing
- Continuous Passive Motion
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
Mechanically Ventilated Patients, Lung Compliance
Effects of Ventilator Hyperinflation Versus Vibrocompression in Mechanically Ventilated Patients
The aim of the current study is to compare the effects of ventilator hyperinflation and vibrocompression on lung compliance in mechanically ventilated patients.
- Conditions
- Mechanically Ventilated Patients, Lung Compliance, Airway Clearance Impairment
- Trial name
- NCT06791798
- Testing
- Ventilator Hyperinflation, Vibrocompression, Traditional Chest Physical Therapy Program
- Where
- Egypt
- Volunteers
- 81 people
- Sponsor
- Cairo University