Clinical trials: Mechanism
Spasticity as Sequela of Stroke
Cryoneurolysis for Spasticity Treatment: Long-term Clinical Outcomes and Mechanisms in the Central Nervous System
Spasticity can make regular daily activities difficult or impossible. Cryoneurolysis is a new technique to treat spasticity that is currently being tested.
- Trial name
- NCT06958289
- Testing
- Cryoneurolysis
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Sue Peters
Burn Injury, Chronic Pain
Immune Mechanisms of Vitamin D to Reduce Chronic Pain After Burn
The goal of this pilot clinical trial is to learn whether vitamin D is able to prevent chronic pain following burn injury and to determine what biological mechanisms are engaged by Vitamin D following burn injury.
- Trial name
- NCT05619289
- Testing
- Ergocalciferol
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of North Carolina, Chapel Hill
Major Depressive Disorder, Minor Depressive Disorder
Evaluation of a Stepped Care Approach to Manage Depression in Diabetes
The study examines the efficacy of a stepped care approach for depressed diabetes patients (first study objective). 256 patients with diabetes and comorbid subthreshold or clinical depression will be randomly assigned to either a…
- Conditions
- Major Depressive Disorder, Minor Depressive Disorder, Sub-Threshold Depression, Diabetes Mellitus
- Trial name
- Ecce_homo (NCT01812291)
- Testing
- Step 1: Diabetes-Specific CBT (5 group sessions), Step 2: Depression-Specific CBT (6 single sessions), Step 3: Referral to Psychotherapist and/or Psychiatrist
- Where
- Germany
- Volunteers
- 260 people
- Sponsor
- Forschungsinstitut der Diabetes Akademie Mergentheim
Sleep Disorder, Stage IA Breast Cancer
Brief Behavioral Therapy in Improving Sleep Disorders in Patients With Stage I-III Breast Cancer Undergoing Chemotherapy
This randomized phase II trial studies how well brief behavioral therapy works in improving sleep disorders in patients with stage I-III breast cancer undergoing chemotherapy.
- Conditions
- Sleep Disorder, Stage IA Breast Cancer, Stage IB Breast Cancer, Stage II Breast Cancer
- Trial name
- NCT02002533
- Testing
- Brief Behavioral Therapy, Telephone-Based Intervention, Educational Intervention
- Where
- 6 sites in United States
- Volunteers
- 71 people
- Sponsor
- Gary Morrow
Depressive Disorder, Anxiety Disorders
Measurement-Based Care (MBC) Implementation, Effectiveness, and Mechanisms of Change
Although measurement-based care (MBC) is an evidence-based practice with known benefits, it is not always systematically implemented with fidelity. Questions remain regarding MBC's unique added value compared to usual care.
- Trial name
- MBC (NCT06671158)
- Testing
- Psychotherapy
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Carilion Clinic
Impaired Glucose Tolerance
Mechanisms of Exercise Resistance in Metabolic Disease
This project will determine exercise capacity and molecular markers of the response to acute exercise in human subjects with impaired or normal glucose tolerance.
- Trial name
- NCT03945435
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Joslin Diabetes Center
Major Depressive Disorder (MDD), Rumination
Neurobiological Mechanisms of Pathological Rumination and Effects of Aripiprazole
This randomized, single-blind (assessor-blind) controlled trial aims to investigate the efficacy of aripiprazole as an augmentation strategy for treating pathological rumination in patients with major depressive disorder (MDD).
- Trial name
- NCT06937476
- Testing
- Escitalopram, Aripiprazole 5mg
- Where
- China
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Central South University
Hypertension, Behavior and Behavior Mechanisms
Written Behavioural Persuasion Technique Intervention for Hypertension Management
This study aims to examine the feasibility and effectiveness of written behavioural persuasion techniques intervention to encourage treatment initiation and follow-up for hypertension management among the untreated hypertension…
- Trial name
- NCT05966597
- Testing
- Written persuasive leaflet, Standard referral leaflet
- Where
- Malaysia
- Volunteers
- 893 people
- Sponsor
- Monash University Malaysia
Major Depressive Diorder, Early Life Trauma
Neurocircuitry Mechanisms and Efficacy of Lumateperone as Adjunctive Therapy for Major Depressive Disorder and History of Early Life Abuse
The purpose of this clinical research study is to understand how effective and safe an investigational study drug called lumateperone is and whether it works to reduce the severity of depressive symptoms in adults with Major…
- Trial name
- ITI-ELA-MDD (NCT07369115)
- Testing
- Lumateperone 42 mg
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Texas at Austin
Peripheral Artery Disease (PAD)
Walking Effect of Long Term Ticagrelor in Subjects With PAD Who Have Undergone EVR
To compare the effect of ticagrelor versus aspirin on the change in peak walking time, evaluated on the graded treadmill test, from one to 26 weeks post-revascularization in patients with peripheral artery disease who have…
- Trial name
- TI-PAD EVR (NCT02227368)
- Testing
- Ticagrelor, Comparator
- Where
- 10 sites in United States
- Volunteers
- 40 people
- Sponsor
- AstraZeneca
Tourette Syndrome
MRI Study of Tic Remission in Tourette Syndrome
Doctors provide a ray of hope to children and their parents with the knowledge that, for most patients, symptoms of Tourette syndrome improve by the time they are young adults.
- Trial name
- NCT01405859
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Utah
Psychosis
Immune Mechanisms of Antipsychotic Treatment Response
The aim of this study is to investigate the role of the immune system in psychotic symptoms and their response to treatment. The investigators will collect blood and cerebrospinal fluid samples from participants with psychosis…
- Trial name
- IMAT (NCT06687694)
- Where
- United Kingdom
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- King's College London
Primary Biliary Cholangitis (PBC)
RELIEF: Multimodal Prehabilitation to Treat Fatigue in Patients With Primary Biliary Cholangitis
The implementation of a non-pharmacological multimodal intervention program-including physical exercise, nutritional counseling, and psychological support-is expected to improve fatigue in patients with primary biliary…
- Trial name
- RELIEF (NCT07161245)
- Testing
- Multimodal prehabilitation, standard of care
- Where
- Spain
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
Chronic Neck Pain
Specific and Shared Mechanisms Associated With Treatment for Chronic Neck Pain
It is expected that different physical therapy treatments influence outcomes in many different ways. Each treatment is assumed to have a "specific" treatment mechanism, which explains how that specific treatment works.
- Trial name
- SS-MECH (NCT05940012)
- Testing
- Manual Therapy
- Where
- United States
- Volunteers
- 122 people
- Sponsor
- Duke University
Valvular Heart Disease
Mechanism and Effect of Novel Metabolites on Valvular Heart Disease
Valvular heart disease (VHD) is a leading cause of loss of physical function, reduced quality of life and increased longevity.The epidemiology of VHD varies widely across the globe, with functional and degenerative diseases…
- Trial name
- Hestia (NCT07065500)
- Where
- China
- Volunteers
- 4,000 people
- Sponsor
- Sun Yat-sen University
Migraine
Effectiveness and Neural Mechanism of Naoan Dripping Pills for Migraine
This is a randomized, double-blind, placebo-controlled clinical trial. Its main purpose is to investigate the effects and neural mechanism of Naoan dripping pills on migraine patients by utilizing fMRI and DTI method, as well as…
- Trial name
- ENMNM (NCT03175900)
- Testing
- Naoan dripping pills
- Where
- China
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Dongzhimen Hospital, Beijing
Low Back Pain
Study on the Sociopsychoemotional Mechanism of Dysfunction in Patients With Acute and Chronic Low Back Pain
Low back pain is defined as pain that extends from the 12th rib to the iliac bone, and its increasing incidence makes it one of the major causes of decreased productivity worldwide.
- Trial name
- NCT06684665
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Hospital Mortality, Malaria
Evaluation of Local Mechanisms for Staff Motivation to Reduce Hospital Mortality
We observed in a randomised intervention trial in Bissau that mortality due to malaria could be reduced by half by adding a small monetary incentive to the staff and strict follow-up of a standard protocol for available drugs.
- Trial name
- NCT00673166
- Testing
- Staff incentive & supervision, Staff motivation
- Where
- Guinea-Bissau
- Volunteers
- 900 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Tinnitus, Subjective
Mechanism Research of Tinnitus Based on Electroencephalogram and Acoustic Therapy Intervention
This project aims to systematically and deeply study the central mechanism of tinnitus using electroencephalogram, and further study the treatment mechanism of tinnitus in combination with sound treatment strategies, so as to…
- Trial name
- EEG-RCT (NCT04449237)
- Testing
- music therapy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Eye & ENT Hospital of Fudan University
HIV Infections
Mechanisms of Lipodystrophy in HIV-Infected Pateints
The metabolic and molecular basis of lipodystrophy syndrome in HIV-infected patients is not known. Whether besides protease inhibitors, other antiretroviral drugs, HIV infection and reduction in viral load contribute to the…
- Trial name
- NCT00457665
- Testing
- Nelfinavir, Efavirenz
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- University of Texas Southwestern Medical Center