Clinical trials: Mechanisms of Analgesia
Pain Management
Acute Effects of Transcutaneous Electrical Nerve Stimulation at Acupoints on Nociceptive Transmission
The goal of this clinical trial is to learn if transcutaneous electrical nerve stimulation (TENS) applied to acupoints can modulate pain transmission and cortical processing in healthy adult volunteers.
- Trial name
- NCT07267052
- Testing
- transcutaneous electrical nerve stimulation (TENS), EEG machine
- Where
- Taiwan
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Pain
Effects of Anticipation of Pain Relief on Brain Mechanisms
This study will use brain imaging technology to examine chemical systems in the brain that suppress pain and stress when an individual has an expectation of pain relief.
- Trial name
- NCT00200876
- Testing
- Hypertonic saline, Isotonic saline
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Pain
Attenuation of Pain in Men and Women
The purpose of this study is to examine opioid and endocannabinoid mechanisms of exercise-induced analgesia in men and women.
- Trial name
- NCT01220414
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Analgesia
The Analgesic Effect of Auditory Inputs and Its Relation to Psychological and Neurobiological Mechanisms
The study investigates the analgesic effect of different auditory inputs. Employing a within-subject design, the study includes healthy participants that are exposed to thermal stimuli while listening to three different auditory…
- Trial name
- NCT03410563
- Testing
- Auditory inputs
- Where
- Denmark
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Pain, Chronic Pain
The Effects and Mechanisms of Brief Mindfulness Meditation and Hypnosis for Pain
The aim of this study is to determine the effects and mechanisms of 1 x 20-min training in mindfulness meditation and self-hypnosis relative to an inert control. Participants will be randomly assigned to condition.
- Trial name
- NCT05323383
- Testing
- Mindfulness Meditation, Self-hypnosis, Attention Control
- Where
- Australia
- Volunteers
- 300 people
- Sponsor
- The University of Queensland
Pain, Shoulder, Post Operative Pain
The Role of Neurofeedback Training and Pain Management in Post-operative Shoulder Rehabilitation
The primary aim is to compare the efficacy of neurofeedback training (NFT) and pain management protocol (PMP) in pain reduction, restoration of shoulder function, and improved cognitive performance as the post-operative…
- Trial name
- NCT05948007
- Testing
- Neurofeedback training, Pain management protocol
- Sponsor
- Chang Gung Memorial Hospital
Lumbar Disc Herniation
Brain Connectomic Mechanisms of Spinal Manipulative Therapy on LDH Analgesia Based on Multimodal MRI
Low back and leg pain caused by lumbar disc herniation (LDH) is common. Lever positioning manipulation (LPM) is a spinal manual therapy used to relieve this pain, but how it affects the brain is unclear.
- Trial name
- NCT07728149
- Testing
- Active Lever Positioning Manipulation
- Where
- China
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- The Third Affiliated hospital of Zhejiang Chinese Medical University
Pain Management, Capsaicin-Induced Pain
TaVNS for Capsaicin-Induced Pain
Effective pain management remains a major clinical challenge. Transcutaneous auricular vagus nerve stimulation (taVNS) has emerged as a promising, non-invasive neuromodulation technique due to its safety, ease of administration…
- Conditions
- Pain Management, Capsaicin-Induced Pain, Transcranial Magnetic Stimulation Repetitive, Electroencephalography
- Trial name
- NCT07719868
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Chronic Pain, Central Sensitisation
Mechanisms Of Change in Adolescent Pain Self-management
The MOCAS Study aims to describe the mechanisms through which sleep deficiency affects youth responses to an online pain self-management intervention over a 6-month period.
- Conditions
- Chronic Pain, Central Sensitisation, Headache
- Trial name
- MOCAS (NCT04043962)
- Testing
- Web-based CBT (Web-MAP)
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Seattle Children's Hospital
Analgesia
RM1 Project 1 - tAN Naloxone
This two-visit, randomized, double-blind, sham-controlled trial, uses a novel naloxone blockade model in 136 individuals to determine whether the analgesic effects of a 30-minute transcutaneous auricular neurostimulation (tAN)…
- Trial name
- NCT05490134
- Testing
- Naloxone, Saline
- Where
- United States
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Pain
Brain Response to Pain Control in People With Chronic Pain
Background: Researchers want to look at how the brain responds to painful stimulations. They also want to see if these responses are different in people with and without chronic pain.
- Trial name
- NCT01878019
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Irritable Bowel Syndrome
Brain Imaging and Pain in Irritable Bowel Syndrome
This study examines the mechanisms, including brain imaging of placebo analgesia
- Trial name
- NCT00065754
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Florida
Musculoskeletal Pain, Fibromyalgia
Neural Mechanisms of Light Driven Analgesia
The goal of this study will be to understand the biological mechanisms that are responsible to light-driven analgesia. Light presented to the retina has been shown to have pain relieving properties in pre-clinical and clinical…
- Conditions
- Musculoskeletal Pain, Fibromyalgia, Healthy Controls Group - Age and Sex-matched
- Trial name
- NCT07245303
- Testing
- S-cone modulating visual stimulus, Equal Energy White Visual Stimulus, Green light visual stimulus (S-OFF)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Fentanyl Analgesia
Analgesic Effect and Plasma Concentration of Epidural Versus Intravenous Fentanyl
CONTEXT AND OBJECTIVE: Controversies exist regarding the site of action of Fentanyl after epidural injection. The objective of this investigation was to compare the analgesic effect of epidural and intravenous Fentanyl for lower…
- Trial name
- FTN (NCT00635986)
- Testing
- Fentanyl
- Volunteers
- 30 people
- Sponsor
- Federal University of São Paulo
Experimental Dental Pain
Mechanisms of Acupuncture Analgesia on Experimental Dental Pain - A Psychophysical Study (Phase1)
The investigators will assess the effects of manual acupuncture on experimental dental pain in 36 healthy subjects by means of subjective pain intensity ratings and pain-specific autonomic nervous system (ANS) reactions.
- Trial name
- MAC-DENT1 (NCT02589418)
- Testing
- Acupuncture, No Acupuncture
- Where
- 2 sites in Switzerland
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Lumbar Disc Herniation, Multimodal Brain Function
Brain Effect Mechanism of Lever Positioning Manipulation on LDH Analgesia Based on Multimodal MRI
In order to further investigate the key brain targets and central response mechanism characteristics of analgesia, the dominant disease of LDH was taken as the object of this study, which was divided into operation group, comfort…
- Conditions
- Lumbar Disc Herniation, Multimodal Brain Function, Analgesia Mechanism, Lever Positioning Manipulation
- Trial name
- NCT05613179
- Testing
- Group1 (lever positioning manipulation)
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- The Third Affiliated hospital of Zhejiang Chinese Medical University