Clinical trials: Mechanisms of Analgesia
Healthy
Pain Inhibitory Effects of a Single Painful Mechanical Stimulus Compared to Multiple and Multiple at Different Locations
The objective is to estimate the effects on pain thresholds of a single painful mechanical stimulus compared to multiple and multiple stimuli at different locations.
- Trial name
- NCT05730179
- Testing
- Mechanical Conditioning stimulus
- Where
- Spain
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Josue Fernandez Carnero
Pain Management, 3D Printing
The Effectiveness of the Three-dimensional Biochemical Activity Model of Pain
Aim: In this study, it was aimed to develop a pain biochemical activity model taken from a three-dimensional printer and fixed by applying epoxy resin and to investigate the effect of this model on nursing students' understanding…
- Conditions
- Pain Management, 3D Printing, Education Nursing
- Trial name
- NCT07389382
- Testing
- 3D printed pain biochemical activity training model, PowerPoint Presentations
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Zonguldak Bulent Ecevit University
ITCH
Mechanisms Underlying the Placebo Effect in Both Histaminergic and Non-histaminergic Itch
The study consists of one experimental session of approximately 1½ hours. The participant will fill in a series of questionnaires about how you perceive itch and pain, and about some traits of your personality, such as…
- Trial name
- NCT07247695
- Testing
- Histamine, Cowhage
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Arthritis, Arthritis, Juvenile Idiopathic
Pain in Inflammatory Joint Diseases
Our primary objective is to better understand the etiology and consequences of chronic paint by using an explorative approach to identify phenotypes and endotypes of patients with inflammatory joint diseases, with a special focus…
- Conditions
- Arthritis, Arthritis, Juvenile Idiopathic, Arthritis,Rheumatoid, Arthritis, Reactive
- Trial name
- Nor-Pain (NCT06718569)
- Testing
- Biological or targeted synthetic DMARD
- Where
- Norway
- Volunteers
- 350 people
- Sponsor
- Diakonhjemmet Hospital
Mechanisms and Modulators of Placebo Analgesia in Healthy Volunteers
The Effect of Oxytocin on Placebo Analgesia: an Experimental Study in Healthy Volunteers
Placebo responses contribute to medical treatment outcome. The purpose of this study is to determine whether a single intranasal application of oxytocin can increase the placebo response in an experimental model of placebo…
- Trial name
- NCT01886014
- Testing
- Oxytocin
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
ITCH
Mechanisms Underlying the Nocibo Effect of Contagious Itch. in Both Histaminergic and Nonhistaminergic Itch
The study consists of one experimental session of approximately 1½ hours. The participant will fill in a series of questionnaires about how you perceive itch and pain, and about some traits of your personality, such as…
- Trial name
- NCT07255092
- Testing
- Histamine, Cowhage (Mucuna Pruriens)
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Percutaneous Electrolysis, Pain
Analgesic Mechanisms of Percutaneous Electrolysis
Percutaneous electrolysis is based on the application of a galvanic current through an acupuncture needle. The underlying mechanisms that explain the efficacy of this technique are not completely well understood.
- Conditions
- Percutaneous Electrolysis, Pain, Analgesia, Pain Modulation
- Trial name
- NCT05097937
- Testing
- Low intensity percutaneous electrolysis, High intensity percutaneous electrolysis
- Where
- Spain
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
Fibromyalgia
Effectiveness of Acupuncture in Relieving Pain Due to Fibromyalgia
This study will determine the effectiveness of acupuncture versus a placebo in altering brain activity and relieving pain due to fibromyalgia.
- Trial name
- NCT00142597
- Testing
- Acupuncture
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Michigan
Advanced Cancer
Pain Management Support Study for Patients With Advanced Cancer
Chronic pain is one of the most feared symptoms in people with cancer. Insufficient relief from pharmacological treatments and the fear of side effects are important reasons for the growing use of complementary pain management…
- Trial name
- NCT03432247
- Testing
- Interactive Music Therapy, Verbal support
- Where
- 3 sites in United States
- Volunteers
- 103 people
- Sponsor
- Drexel University
Healthy
To Study the Mechanisms of Acupuncture Through Functional Magnetic Resonance Imaging and Peripheral Neurosensory Testing
Acupuncture may affect nerve functions. This study assesses the effect of acupuncture on both the peripheral and the central nerve systems
- Trial name
- NCT00521547
- Testing
- Electroacupuncture
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Pain, Chronic, Facet Joint Pain
Offset Mechanisms in Evaluation of Lumbar Medial Branch Blocks
This study examines the relationship between central nervous system (CNS) mechanisms of pain inhibition and the pain relief that occurs following a lumbar medial branch block (MBB).
- Conditions
- Pain, Chronic, Facet Joint Pain, Pain, Procedural, Analgesia
- Trial name
- OMEGA (NCT05961800)
- Testing
- Cutaneous Probe, Quantitative Sensory Testing, Computer Tasks
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Pittsburgh
Healthy
Pain Inhibitory Effects of Other Pain Induced by Mechanical Pressure at Different Intensities
The objective is to estimate the effects on pain thresholds of a painful mechanical stimulus on the upper trapezius at moderate intensity compared to mild intensity or non-painful.
- Trial name
- NCT05730166
- Testing
- Mechanical Conditioning stimulus
- Where
- Spain
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Josue Fernandez Carnero
Pregnancy
PIEB vs CEI for Labor Analgesia: An MLAC Study
Utilizing a 'minimal local analgesic concentration (MLAC) study' design to first determine the relative potency of Programmed Intermittent Epidural Bolus (PIEB) compared to Continuous Epidural Infusion (CEI) and secondly to…
- Trial name
- NCT02573597
- Testing
- Bupivacaine, Sufentanil
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Stanford University
Post Operative Pain, Mechanisms of Analgesia
Pericapsular Nerve Group Block: An Imaging Study for Determination of the Spread of the Injectate Using 3-D CT Scan
Over the last 20 years, different interventional regional analgesia techniques have been proposed to treat pain after hip surgeries.
- Trial name
- NCT06062134
- Testing
- Pericapsular nerve group block, 18 mL ropivacaine 0.5% + 2 mL radiopaque contrast
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Philippe Gauthier
Acute Pain, Pediatric ALL
VR-PAT and fNIRS to Identify CNS Biomarkers of Pain
This study aims to use functional near-infrared spectroscopy (fNIRS) to identify and quantify pain biomarkers during burn dressing changes and pain relief induced by virtual reality (VR).
- Conditions
- Acute Pain, Pediatric ALL, Procedural Pain, Burns
- Trial name
- NCT06303687
- Testing
- VR-PAT
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Nationwide Children's Hospital
Sickle Cell Disease
Assessing Molecular Mechanisms and Effects of Music Therapy in Youth With Sickle Cell Disease Using Single-cell RNA-sequencing
The goal of this clinical trial is to evaluate whether a 4-week music therapy (MT) intervention can reduce chronic pain and improve psychosocial outcomes in youth with sickle cell disease (SCD).
- Trial name
- NCT07562451
- Testing
- Music Therapy, Standard of Care
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Emory University
Healthy
Pain Inhibitory Effects of Other Pain Induced by Mechanical Pressure Compared to Electrical Stimulation and Cold Water.
The objective is to estimate the effects on pain thresholds of a painful mechanical stimulus on the upper trapezius compared to a painful electrical stimulus and a diffuse noxious stimulus using the cold water hand immersion test.
- Trial name
- NCT05730127
- Testing
- Conditioning stimulus
- Where
- Spain
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Josue Fernandez Carnero
Acute Pain, Experimental Pain in Healthy Human Participants
Healthy Children and Virtual Reality Mediation of Simulated Pain
The objective of this study is to develop central nervous system (CNS) biomarkers of pain experienced during medical procedures and pain relief induced by Virtual Reality Pain Alleviation Therapy (VR-PAT).
- Conditions
- Acute Pain, Experimental Pain in Healthy Human Participants, Children, Adolescents
- Trial name
- NCT06854991
- Testing
- Active VR-PAT, Passive VR-PAT, iPad
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital
Lumbar Disc Herniation
Brain Effect Mechanism of Spinal Manipulative Therapy on LDH Analgesia Based on Multimodal MRI
The clinical symptoms of Lumbar Disc Herniation (LDH) can be effectively ameliorated through Spinal Manipulative Therapy (SMT), which is closely linked to the brain's pain-regulating mechanisms.
- Trial name
- NCT06277739
- Testing
- Spinal Manipulative Therapy
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Zhou Xingchen
Pain
In Vitro Studies on Pharmacological Regulation and Genetic Risk Factors of Peripheral Human Nociceptors
This protocol is for a number of in vitro studies using human surgical biopsies and evaluating the pharmacology and genetics of human nociceptors ("pain detecting") neurons
- Trial name
- NCT00223366
- Where
- United States
- Volunteers
- 2,007 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio