Clinical trials: Mediastinal Diseases
B Acute Lymphoblastic Leukemia With t(v;11q23.3); KMT2A Rearranged, Recurrent B Acute Lymphoblastic Leukemia
CD19-Specific T Cells Post AlloSCT
This phase I trial investigates the side effects and best dose of CD19 positive (+) specific CAR-T cells in treating patients with CD19+ lymphoid malignancies, such as acute lymphoblastic leukemia, non-Hodgkin lymphoma, small…
- Conditions
- B Acute Lymphoblastic Leukemia With t(v;11q23.3); KMT2A Rearranged, Recurrent B Acute Lymphoblastic Leukemia, Recurrent Chronic Lymphocytic Leukemia, Recurrent Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
- Trial name
- NCT03579888
- Testing
- Autologous CD19-CD8-CD28-CD3zeta-CAR-mbIL15-HER1t T Cells, Cyclophosphamide, Fludarabine
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Cardiovascular Disease, Healthcare Associated Infectious Disease
Optimizing Prevention of Healthcare-Acquired Infections After Cardiac Surgery (HAI)_2
The investigators will conduct qualitative interviews of hospital personnel regarding HAI prevention practices, and use coded data from these interviews to assist in developing standardized practices.
- Conditions
- Cardiovascular Disease, Healthcare Associated Infectious Disease, Sternal Superficial Wound Infection, Deep Sternal Infection
- Trial name
- NCT02073760
- Testing
- There is no intervention. The investigators are interviewing cardiac surgery staff with knowledge of infection prevention.
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Pancreatic Neoplasm
Core Biopsy Endo Sonography Study Evaluation of the Significance of the Pro-core® Needle
The study is designed to evaluate the diagnostic accuracy of a new designed endoscopic ultrasonography (EUS) Core biopsy aspiration needle in comparison to a conventional EUS aspiration needle in GI-tumors.
- Trial name
- COS (NCT02181140)
- Testing
- EUS guided FNA and fine needle punction
- Where
- Germany
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Heart Failure, Cardiomyopathy
123-I mIBG (AdreView) Heart-to-Mediastinal (H/M) Ratio and SPECT Imaging on a Small Field of View-High Efficiency Cardiac SPECT System
The purpose of this study is to demonstrate correlation of the H/M ratio of AdreView when derived from a large field of view Anger SPECT system and from a small field of view high sensitivity (CZT) SPECT system.
- Trial name
- NCT01868841
- Testing
- AdreView, Single Photon Emission Computed Tomography
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Timothy M. Bateman
Lung Neoplasms, Neoplasm Metastasis
Mediastinal Lymph Node Dissection in Conjunction With Pulmonary Metastasectomy From Colorectal Cancer
To study whether or not total mediastinal lymph node dissection in conjunction with pulmonary metastasectomy from colorectal cancer is associated with improved survival compared to pulmonary metastasectomy only.
- Conditions
- Lung Neoplasms, Neoplasm Metastasis, Colorectal Cancer
- Trial name
- NCT03113318
- Testing
- Total mediastinal lymph node dissection and pulmonary metastasectomy, Only pulmonary metastasectomy
- Where
- Denmark
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Bronchiectasis Adult, Mediastinal Lymphadenopathy
Lidocaine Administration During Flexible Bronchoscopy and Endobronchial Ultrasound
The purpose of this study is to assess if there is decrease in cough during flexible bronchoscopy and endobronchial ultrasound when different modes of lidocaine administration are used.
- Conditions
- Bronchiectasis Adult, Mediastinal Lymphadenopathy, Pneumonia, Chest--Diseases
- Trial name
- NCT03829618
- Testing
- Topical lidocaine, Nebuliser solution, Nebuliser Suspension
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Severe Combined Immunodeficiency
Study Through Imaging of Visceral Lymphoid Organs in Patients With SCID Who Have Recieved Bone Marrow Allograft
To investigate the presence of seconday of lymphoid organs in patients who underwent allogenic hematopoietic stem cell transplantation 15 to 45 years ago.
- Trial name
- LymphImaging (NCT04246840)
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Association Pour l'Aide a la Recherche en Immunologie Pediatrique
Mediastinal Neoplasms, Thoracic Neoplasm
Pain and Quality of Life After Mediastinal Tumor Resection by Subxiphoid and Intercostal VATS
Thoracoscopic assisted mediastinal thymectomy is currently one of the most commonly used surgical methods, but there are some deficiencies.Minimally invasive surgery through the subxiphoid approach can achieve a good surgical…
- Conditions
- Mediastinal Neoplasms, Thoracic Neoplasm, Thoracic Surgery
- Trial name
- NCT03521986
- Testing
- Subxiphoid uniportal VATS, Intercostal uniportal VATS
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Lei Jiang
Multiple Myeloma, Non-Hodgkin Lymphoma
Ph I Trial of NAM NK Cells and IL-2 for Adult Pts With MM and NHL
This is a phase I trial with pilot expansion of HLA-haploidentical or HLA-mismatched related donor nicotinamide expanded-natural killer (NAM-NK) cell based therapy for patients with relapsed or refractory multiple myeloma (MM) or…
- Conditions
- Multiple Myeloma, Non-Hodgkin Lymphoma, Diffuse Large B Cell Lymphoma, Mantle-Cell Lymphoma
- Trial name
- NCT03019666
- Testing
- Nicotinamide Expanded Haploidentical or Mismatched Related Donor Natural Killer Cells
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Masonic Cancer Center, University of Minnesota
Infection, Mediastinitis
Prognostic Factors for Descending Necrotizing Mediastinitis Development in Deep Space Neck Infections
Descending necrotizing mediastinitis (DNM) is the most serious complication of deep neck infections (DNI) with high mortality. The objective of this retrospective study was to evaluate possible prognostic factors for DNM…
- Conditions
- Infection, Mediastinitis, Neck Abscess, Inflammation
- Trial name
- NCT04865003
- Testing
- treatment of infection
- Volunteers
- 289 people, healthy volunteers welcome
- Sponsor
- Clinical Center of Vojvodina
Mediastinal Tumor
Totally no Tube (TNT) Uniportal Video-assisted Thoracoscopic Surgery (VATS) VS Traditional Uniportal VATS for Mediastinal Tumor
TNT surgery is a new area of exploration and evolution in thoracic minimal invasive surgery. TNT Uniportal Video-assisted Thoracoscopic Surgery (VATS) has become popular during mediastinal tumors resection.
- Trial name
- NCT03537430
- Testing
- TNT uniportal VATS mediastinal tumor resection, Traditional uniportal VATS mediastinal tumor resection
- Where
- China
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Xueying Yang
Heart Failure, Coronary Artery Disease
123I-mIBG SPECT Imaging
This study is being done with a radioisotope, 123I-mIBG (Adreview), to develop a nuclear diagnostic imaging test for patients with decreased heart function which can be used to predict the progression of the heart disease and…
- Trial name
- NCT02043522
- Testing
- Radioisotope
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ottawa Heart Institute Research Corporation
Hyperpigmentation
Pilot Study of LED for PIE and PIH
The aim of this study is to explore the effect of medical LEDs (830 nm and 590 nm) in the prevention and treatment of PIE and PIH.
- Trial name
- NCT06349447
- Testing
- LED, without any LED exposition
- Where
- China
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Yanjun Dan
Mediastinal Disease
Validation of an AI-Assisted Mediastinal EUS System for Training Improvement: a Prospective, Multi-Center, Randomized Trial
The goal of this clinical trial is to verify the auxiliary role of the artificial intelligence (AI) system in mediastinal endoscopic ultrasound (EUS) scans. The main questions it aims to answer are as follows: 1.
- Trial name
- NCT06790108
- Testing
- Artificial intelligence device
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The Third Xiangya Hospital of Central South University
Pleural Effusion, Malignant, Pleural Mesothelioma
A Comparative Study Between Regional Anesthesia in Thoracoscopes and the Conventional General Anesthesia
Video-assisted thoracic surgery (VATS) is usually performed with general anesthesia and single lung ventilation. However, performing thoracic surgery under awake regional anesthesia has several potential advantages including…
- Conditions
- Pleural Effusion, Malignant, Pleural Mesothelioma, Pleural Empyema, Pulmonary Diseases or Conditions
- Trial name
- VATS (NCT05077111)
- Testing
- Thoracic Epidural Anesthesia, General Anesthesia with One Lung Ventilation
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mohamed Reda Ashour
Mediastinum Disease
Clinical Research on a Novel Deep-learning Based System in Mediastinal Endoscopic Ultrasound Scanning
The goal of this clinical trial is to develop and verify the auxiliary role of the artificial intelligence system in mediastinal ultrasound endoscopic scanning.
- Trial name
- NCT05792280
- Testing
- AI system
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- The Third Xiangya Hospital of Central South University