Clinical trials: Mediastinal Lymphadenopathy
Lymphadenopathy, Lung Cancer
Prevalence and Malignant Involvement of Calcified Intrathoracic Lymph Nodes in Patients Undergoing Endosonography
The presence of calcifications, which is a relatively common feature in intrathoracic lymph nodes, typically contributes to confer them a heterogeneous aspect during endosonographic B-mode examination, but their prevalence and a…
- Conditions
- Lymphadenopathy, Lung Cancer, Sarcoidosis, Tuberculosis
- Trial name
- NCT04743583
- Testing
- Endosonography B-mode examination
- Where
- Italy
- Volunteers
- 362 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Mediastinal and Hilar Lymphadenopathy
Study of Procedural Efficiency in EBUS With Dual Versus Single NEEDLEs: Evaluating the Value of a Second Needle in EBUS as it Pertains to Economic and Environmental Impact
Currently, the EBUS bronchoscopy procedure uses either one or two needles to perform the biopsy of the lymph node based on physician preference.
- Trial name
- SPEED NEEDLE (NCT07218042)
- Testing
- We randomized patients to the two arms above; there was no specific intervention performed other than randomizing patients to one or two needles.
- Where
- 3 sites in United States
- Volunteers
- 126 people
- Sponsor
- Christopher Kapp
Mediastinal Lymphadenopathy
Dx Mediastinal Malignant LAP:Compare PET and EBUS-TBNA
Lung cancer is the leading cause of death in Taiwan. The outcomes of the disease vary depending on early detection, histologic types and staging.
- Trial name
- NCT01367366
- Testing
- PET and EBUS-TBNA
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
Mediastinal Lymphadenopathy, Lung Neoplasms
Evaluation of the Utility of Rapid On-site Cytology Performed by an Interventional Pulmonologist During EBUS-TBNA.
This study is a single-centre, prospective observational analysis conducted at the Alessandria Hospital, aimed to evaluating the role of Rapid On-Site Evaluation (ROSE) performed directly by the interventional pulmonologist…
- Trial name
- ROSE (NCT07590947)
- Testing
- data collection
- Where
- Italy
- Volunteers
- 189 people
- Sponsor
- Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria
Lung Malignancies, Mediastinal Lymphadenopathy
Accuracy of Convex Probe EBUS-TBNA Versus FDG-PET/CT Imaging in Diagnosis and Staging of Lung Malignancies
Lung cancer is a prevalent cause of cancer-related mortality on a global scale. Appropriate staging of lung cancer is of paramount importance, as it customizes treatment and predicts prognosis.
- Trial name
- NCT06479798
- Testing
- Endo bronchial ultrasound transbronchial needle aspiration(EBUS-TBNA)
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Mediastinal Lymphadenopathy, Tuberculous Mediastinal Lymphadenopathy
Diagnosis of Mediastinal Tuberculous Lymphadenopathy by Endobronchial Ultrasound-guided Transbronchial Needle Aspiration (EBUS-TBNA)
Although mediastinal tuberculous lymphadenopathy is not rare in adults of such an abnormality. Isolated mediastinal without a parenchymal lung lesion in adults is unusual with the incidence of 0.25%-5.8%.
- Trial name
- NCT01121432
- Testing
- endobronchial ultrasound-guided transbronchial needle aspiration
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
Lymphadenopathy, Lung Cancer
EBUS-TBNA vs Flex 19G EBUS-TBNA
Endobronchial ultrasound (EBUS) guided transbronchial needle aspiration (EBUS-TBNA) is an excellent tool for sampling enlarged mediastinal and hilar lymph nodes, but only provides needle aspirate samples which are often adequate…
- Conditions
- Lymphadenopathy, Lung Cancer, Sarcoidosis, Lymphoma
- Trial name
- NCT02592837
- Testing
- Flexible 19G EBUS-TBNA needle, 21G EBUS-TBNA needle
- Where
- United Kingdom
- Volunteers
- 250 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Mediastinal Lymphadenopathy, Lung Malignancies
Endobronchial Ultrasound Transbronchial Needle Aspiration Using Needle Suction Versus No Suction
Cytological diagnostic accuracy between endobronchial ultrasonography endobronchial ultrasound transbronchial needle aspiration (EBUS-TBNA) samples using suction versus samples when no suction is applied.
- Trial name
- NCT01734980
- Testing
- Endobronchial Ultrasound
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northwell Health
Lymphadenopathy
Comparison of Endobronchial Ultrasound-Guided Biopsy Using Fine Needle Aspiration Versus Fine Needle Capillary Sampling
Primary objective: To estimate the degree of agreement in diagnosis of cytologic samples from mediastinal lymph nodes obtained by Endobronchial Ultrasound (EBUS)-guided Fine Needle Capillary Sampling (FNC) versus Fine Needle…
- Trial name
- NCT00886847
- Testing
- Lymph Node Needle Tissue Collections
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- M.D. Anderson Cancer Center
Lung Non-Small Cell Carcinoma
A Study of Targeted Post-Surgery Radiation Therapy for Non-Small Cell Lung Cancer With Remaining Lymph Node Cancer After Treatment
This phase II trial compares the effect of intensity-modulated post-operative radiation therapy (I²-PORT) followed by standard of care therapy (chemotherapy or immunotherapy) to standard of care therapy alone in treating patients…
- Trial name
- NCT07293247
- Testing
- Chemotherapy, Immunotherapy, Intensity-Modulated Radiation Therapy
- Where
- 111 sites in United States
- Volunteers
- 164 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Mediastinal Lymphadenopathy, Hilar Lymphadenopathy
Conventional Versus Ultrasound-guided Transbronchial Needle Aspiration for the Diagnosis of Hilar/Mediastinal Lymphadenopathies
The main purpose of the present study is to assess whether the sensitivity of Ultrasound-guided Transbronchial Needle Aspiration (EBUS-TBNA) is superior to that of conventional TBNA in the diagnosis of hilar/mediastinal…
- Conditions
- Mediastinal Lymphadenopathy, Hilar Lymphadenopathy, Lymphoma, Lung Neoplasms
- Trial name
- NCT01658280
- Testing
- EBUS-TBNA
- Where
- Italy
- Volunteers
- 253 people
- Sponsor
- Azienda Ospedaliero, Universitaria Ospedali Riuniti
Mediastinal Lymphadenopathy, Non-small Cell Lung Carcinoma
Optical Biopsy for Thoracic Lymph Nodes.
EUS-FNA is the recommended diagnostic examination of choice when patients present with suspected lower mediastinal lymph nodes on imaging.
- Conditions
- Mediastinal Lymphadenopathy, Non-small Cell Lung Carcinoma, Sarcoidosis
- Trial name
- NCT02689050
- Testing
- Needle based confocal laser endomicroscopy (nCLE)
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Sarcoidosis, Mediastinal Diseases
Endobronchial Ultrasonography in the Diagnosis of Sarcoidosis
Sarcoidosis is a benign, inflammatory condition which will typically involve the lungs and lymph glands in the chest. Diagnosis is often confirmed with bronchoscopic biopsy.
- Trial name
- NCT00373555
- Testing
- Bronchoscopy
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Calgary
Adult Nasal Type Extranodal NK/T-Cell Lymphoma, Adult T-Cell Leukemia/Lymphoma
Salvia Hispanica Seed in Reducing Risk of Disease Recurrence in Patients With Non-Hodgkin Lymphoma
This pilot clinical trial studies Salvia hispanica seed in reducing the risk of returning disease (recurrence) in patients with non-Hodgkin lymphoma.
- Conditions
- Adult Nasal Type Extranodal NK/T-Cell Lymphoma, Adult T-Cell Leukemia/Lymphoma, Anaplastic Large Cell Lymphoma, Angioimmunoblastic T-Cell Lymphoma
- Trial name
- NCT02652715
- Testing
- Laboratory Biomarker Analysis, Quality-of-Life Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Mayo Clinic
Lymphadenopathy, Lung Cancer
EBUS-TBNA vs Flex 19G EBUS-TBNA
This is a prospective randomised diagnostic clinical study to determine whether the use of a new flexible sampling needle can improve the yield of endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA).
- Conditions
- Lymphadenopathy, Lung Cancer, Sarcoidosis, Lymphoma
- Trial name
- NCT02916459
- Testing
- 21G EBUS-TBNA needle, Flexible 19G EBUS-TBNA needle
- Where
- Germany
- Volunteers
- 250 people
- Sponsor
- Heidelberg University
Lung Cancer Metastatic, Nodes, Lung
Neck Ultrasound by Respiratory Physicians in Patients With Lung Cancer
This is a study of routine neck ultrasound performed by respiratory physicians in patients with mediastinal lymphadenopathy and suspected lung cancer
- Trial name
- NCT03970564
- Testing
- Neck ultrasound guide lymph node sampling
- Where
- Ireland
- Volunteers
- 30 people
- Sponsor
- University College Hospital Galway
Hypermetabolic Lymphadenopathy Mediastinum Lower, Posterior and Middle, Detected by PET-CT With 18F-FDG (PET)
Feasibility Study on the Contribution of Guided Puncture With Echoendoscopy
Impact of screening nodes mediastinal by PET, at different times of the management of cancer disease, remain unclear. Benefits of combined PET and puncture with echoendoscopy for the diagnosis subsequent therapeutic management…
- Trial name
- APOGEE (NCT01892501)
- Testing
- Guided punction of mediastinal lymphadenopathy by echoendoscopy, PET scan
- Where
- France
- Volunteers
- 75 people
- Sponsor
- Institut Bergonié