Clinical trials: Medically Refractory Epilepsy
Epilepsy
Efficacy of Omega-3 as Adjunctive Therapy for Medically Intractable Epilepsy: A Prospective Open-label Pilot Study
The purpose of this study is to determine whether omega-3 is effective in the treatment of medically intractable epilepsy as adjunctive therapy.
- Trial name
- NCT02899741
- Testing
- Omega-3
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Seoul National University Hospital
Epilepsy, Unspecified, Refractory (Medically)
The Use of Medicinal Cannabinoids as Adjunctive Treatment for Medically Refractory Epilepsy
Many families of children with medically refractory epilepsy are choosing to use medicinal cannabinoids (MCBD) as an adjunctive alternative treatment option. The safety, tolerability and efficacy of these products are not known.
- Trial name
- NCT02523183
- Testing
- Medical Cannabis
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Colorado, Denver
Epilepsy
P-glycoprotein Inhibition as Adjunct Treatment for Medically Refractory Epilepsy.
In up to 1 out of 3 patients with epilepsy, seizures continue to occur despite the use of one or more antiepileptic medications.
- Trial name
- NCT00524134
- Testing
- Carvedilol-CR
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Columbia University
Epilepsy
Clinical Trial of Light Therapy for Epilepsy
This study is designed to investigate whether light therapy may be an effective treatment for some people with epilepsy. Light treatment is already an established treatment for depression.
- Trial name
- NCT01028456
- Testing
- Light Therapy, 100 lux
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University College, London
Epilepsy, Seizure
Medium Chain Triglycerides as an Adjunct to the Modified Atkins Diet for Women With Catamenial Epilepsy
The modified Atkins diet (MAD) has been shown to be effective in treating intractable epilepsy. Approximately 55% of the patients started on the diet are women of childbearing age and women with epilepsy often have a pattern of…
- Conditions
- Epilepsy, Seizure, Catamenial Epilepsy, Medically Resistant Epilepsy
- Trial name
- NCT02426047
- Testing
- betaquik®
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- Johns Hopkins University
Epilepsy
Pilot Study to Evaluate MR-guided Laser Ablation of Focal Lesions in Patients With Medically Refractory Partial Epilepsy
To investigate whether MR-guided laser induced thermal therapy in patients diagnosed with focal lesional epilepsy using the Visualase Thermal Therapy System is both a feasible and safe minimally invasive technique for control of…
- Trial name
- NCT01703143
- Testing
- Laser ablation
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- Mayo Clinic
Epilepsy
Controlled Randomized Stimulation Versus Resection (CoRaStiR)
Patients will be prospectively randomized to 3 different treatment arms: Treatment group 1: patients who undergo medial temporal lobe resection Treatment group 2: patients who receive immediate hippocampal neurostimulation…
- Trial name
- NCT00431457
- Testing
- Implantation of an intracranial electrode, amygddohyppocampertomy
- Where
- 3 sites in Belgium, Germany
- Volunteers
- 12 people
- Sponsor
- University Hospital, Ghent
Epilepsy, Idiopathic Generalized Epilepsy
RNS System NAUTILUS Study
To demonstrate that the RNS System for thalamic stimulation is safe and effective as an adjunctive therapy for the reduction of primary generalized seizures in individuals 12 years of age or older who have drug-resistant…
- Conditions
- Epilepsy, Idiopathic Generalized Epilepsy, Generalized Tonic Clonic Seizure
- Trial name
- NAUTILUS (NCT05147571)
- Testing
- Responsive stimulation
- Where
- 23 sites in United States
- Volunteers
- 100 people
- Sponsor
- NeuroPace
Epilepsy
Brain Infusion of Muscimol to Treat Epilepsy
This study will examine the safety and effectiveness of infusing a chemical called muscimol into the brain to control seizures in patients with intractable epilepsy (frequent seizures that persist despite therapy).
- Trial name
- NCT00005925
- Testing
- Muscimol
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Epilepsy, Lennox Gastaut Syndrome
RNS System LGS Feasibility Study
To generate preliminary safety and effectiveness data for brain-responsive neurostimulation of thalamocortical networks as an adjunctive therapy in reducing the frequency of generalized seizures in individuals 12 years of age or…
- Conditions
- Epilepsy, Lennox Gastaut Syndrome, Lennox-Gastaut Syndrome, Intractable, Seizures
- Trial name
- NCT05339126
- Testing
- RNS System
- Where
- 6 sites in United States
- Volunteers
- 24 people
- Sponsor
- NeuroPace
Drug Resistant Epilepsy, Medically Refractory Epilepsy
The Efficacy of a Subanesthetic Doses of IV Ketamine in the Treatment Drug Resistant Epilepsy
Ketamine is a medication that came into clinical practice in the 1960's. Ketamine is used as an anesthetic and to provide pain relief. Recently, Ketamine was approved to treat drug resistant depression using subanesthetic doses.
- Conditions
- Drug Resistant Epilepsy, Medically Refractory Epilepsy, Refractory Epilepsy
- Trial name
- NCT05019885
- Testing
- Ketamine Hydrochloride
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Madeline Fields
Idiopathic Generalized Epilepsy
High-Intensity Focused Ultrasonic Ablation of the Centromedian Thalamic Nucleus for Treatment of Medically Refractory Generalized Epilepsy in Patients Ages 18 Years to 89 Years
The purpose of this study is to find out if magnetic resonance (MRI)-guided high-intensity focused ultrasound (HIFU) is safe and effective for treating medically refractory generalized epilepsy.
- Trial name
- HIFU for MRGE (NCT07803692)
- Testing
- Intervention 1, Intervention 2
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Oregon Health and Science University
Epilepsy, Epilepsy, Temporal Lobe
Surgery as a Treatment for Medically Intractable Epilepsy
Background: Drug resistant epilepsy is the term used to describe epilepsy that cannot be controlled by medication. Many people whose seizures do not respond to medication will respond to surgical treatment, relieving seizures…
- Conditions
- Epilepsy, Epilepsy, Temporal Lobe, Partial Epilepsy
- Trial name
- NCT01273129
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Focal Epilepsy, Temporal Lobe Epilepsy
Spatial Scene Recognition Memory in Epilepsy Surgery
This study investigates the anatomical and physiological basis of spatial scene recognition memory in patients with temporal lobe epilepsy and temporal lobe lesions.
- Conditions
- Focal Epilepsy, Temporal Lobe Epilepsy, Medically Refractory Epilepsy, Memory Disorders
- Trial name
- NCT07580183
- Testing
- Virtual Tour Recognition Memory Task, Intracranial EEG Recording with Research Electrodes (Aim III only), MRI Neuroimaging and Neuropsychological Assessment (Aim I)
- Where
- 2 sites in United States
- Volunteers
- 620 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Epilepsy
Non-Invasive Seizure Localization in Patients With Medically Refractory Localization Related Epilepsy: Synchronized MEG-EEG Recordings
This study will evaluate the magnetoencephalography (MEG) alone and together with electroencephalography (EEG) in non-invasive presurgical evaluation.
- Trial name
- NCT00071305
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Epilepsy
Cannabidiol (CBD) to 27 Patients (Aged 2 Years - 19 Years) With Drug Resistant Epilepsy
Part A: To evaluate the safety and tolerability of multiple ascending doses of GWP42003-P compared with placebo with respect to: Incidence, type and severity of adverse events (AEs) Effect on vital signs, including weight Effect…
- Trial name
- NCT02286986
- Testing
- Cannabidiol
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Utah
Epilepsy
Controlled Randomized Vagus Nerve Stimulation (VNS) Therapy Versus Resection (CoRaVNStiR)
Background: There are a variety of treatment options for medically refractory medial temporal lobe epilepsy. Evidence from randomized trials indicates vagus nerve stimulation therapy can be used as a proven therapy for medically…
- Trial name
- CoRaVNStiR (NCT02089243)
- Testing
- Vagus nerve stimulation therapy, Resective surgery
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Xijing Hospital
Epilepsy, Seizure
Modified Atkins Diet Plus KetoCal for Adult Epilepsy
The modified Atkins diet (MAD) has been shown to be effective in treating children and adults with medically resistant seizures.
- Conditions
- Epilepsy, Seizure, Medically Resistant Epilepsy, Medically Resistant Seizures
- Trial name
- NCT01834482
- Testing
- Modified Atkins diet, KetoCal
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Johns Hopkins University
Refractory Epilepsy, Deep Brain Stimulation
Optimization of Deep Brain Stimulation Parameters in Patients With Medically Refractory Epilepsy
Deep brain stimulation (DBS) is used to treat epilepsy in cases where patients are medically refractory and are not candidates for surgical resection.
- Trial name
- NCT05493722
- Testing
- Physician-Selected Settings Stimulation, Optimized Settings Stimulation, DBS Setting Optimization
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Refractory Epilepsy
Evaluation of Onfi Conversion Therapy Replacing Clonazepam in Patients With Medically Refractory Epilepsy
The purpose of the study is to examine the clinical safety, tolerability, and efficacy of clobazam (Onfi) when it replaces the pre-existing clonazepam therapy in patients with refractory epilepsy.
- Trial name
- NCT01932502
- Testing
- clobazam (Onfi), Initial conversion and titration, Conversion schedule - Week 1
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix