Clinical trials: Medically Unexplained Symptoms
Post COVID-19 Condition, Somatic Symptom Disorder
MR-spectroscopy in Post-covid Condition Prior to and Following a Yoga Breathing Intervention
From a clinical perspective, we find that many patients with Post COVID condition suffer from severe and debilitating shortness of breath, while routine pulmonary investigations fail to find the cause of the problems experienced.
- Trial name
- SpeCY (NCT05946512)
- Testing
- yoga, social contact
- Where
- Austria
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Chronic Somatoform Disorders in Adolescents
Non-Medication Methods to Relieve Adolescents with Somatoform Disorders
This research aims to investigate the effects of Tai Chi and relaxation techniques on adolescents (12-19 years old) with chronic somatoform disorders.
- Trial name
- Tai Chi Ados (NCT06865833)
- Testing
- Tai Chi and Relaxation Intervention
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Severe Health Anxiety, Hypochondriasis
Outcome of Cognitive Behavioral Therapy for Patients With Severe Health Anxiety Treated in Group Only. A RCT.
Background: The prevalence of severe health anxiety is reported to be 1-2% in Western communities. This functional disorder is difficult for medical doctors to treat, the course of the disorder is often chronic, and that is…
- Conditions
- Severe Health Anxiety, Hypochondriasis, Illness Anxiety Disorder, Somatic Symptom Disorder
- Trial name
- CHAG (NCT02131883)
- Testing
- Group-Cognitive Behavioral Therapy, Wait-List with treatment as usual
- Where
- Denmark
- Volunteers
- 84 people
- Sponsor
- Psychiatric Research Unit, Region Zealand, Denmark
Anxiety
Grow With Grit: A School Nurse-Led SBIRT Pilot for Early Anxiety Detection
All enrolled students and their parents or guardians will complete baseline anxiety questionnaires. Students with a positive baseline screen will receive a brief school nurse-delivered coping skill, referral support when…
- Trial name
- GwG (NCT07766785)
- Testing
- Grow with Grit
- Where
- 4 sites in United States
- Volunteers
- 60 people
- Sponsor
- McLaughlin Research Institute for Biomedical Sciences, Inc.
Medically Unexplained Symptoms, Sense of Coherence
Sense of Coherence and Empowerment at Patients With MUPS
This is a study on Metacognitive therapy in general practice in Norway. The intervention is a small pilot study to examine whether Metacognitive therapy is feasible in an ordinary general practice.
- Trial name
- NCT05121922
- Testing
- Metacognitive Therapy
- Where
- Norway
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Somatic Symptom Disorder
Alexithymia and Attachment Style in Patients With Somatic Symptoms
To evaluate whether emotional awareness, attachment style and the ability to abstract and symbolize (IQ) influence the appearance of somatic symptoms.
- Trial name
- NCT05666921
- Testing
- psychological assessment
- Where
- 2 sites in Italy
- Volunteers
- 300 people
- Sponsor
- Meyer Children's Hospital IRCCS
Somatic Disorders, Psychologic
Somatic Symptoms and Depression in Undergraduate Physiotherapy Students: A Community-Based Cross-Sectional Study
This cross-sectional, community-based study aimed to investigate the association between depression and somatic symptoms among physical therapy students in Egypt.
- Conditions
- Somatic Disorders, Psychologic, Public Health
- Trial name
- NCT07066787
- Testing
- psychological group, somatic
- Where
- Egypt
- Volunteers
- 106 people
- Sponsor
- Cairo University
Anxiety Disorders, Depression
Study Evaluating Venlafaxine Extended-Release in Depressed and Anxious Patients
To examine the efficacy and safety of venlafaxine XR in the treatment of physical and emotional symptoms in patients with an operationally-defined diagnosis of multisomatoform disorder (MSD).
- Trial name
- NCT00546923
- Testing
- Venlafaxine XR
- Volunteers
- 210 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Psychiatric Disorder, Somatic Symptom
National Investigation in College and High School Among Adolescents on Health and Substances at the FSEF
For the clinical component: Describe the young people hospitalised in residential care at the FSEF, in particular through vulnerability factors and their psychosocial repercussions (school level, repetition, intensity of…
- Conditions
- Psychiatric Disorder, Somatic Symptom, Traumatic Injury
- Trial name
- EnCLASS-FSEF (NCT05225441)
- Where
- France
- Volunteers
- 598 people
- Sponsor
- Fondation Santé des Étudiants de France
Autism Spectrum Disorder, Somatic Symptom Disorder
Somatic Symptoms in Autism Spectrum Disorder: Data Integration
Autistic patients have higher rates of co-morbid somatic symptoms. Thus, compared to the general population, they experience more health-related concerns, such as autoimmune disease, gastrointestinal disease, cardiovascular…
- Trial name
- NCT05886361
- Testing
- No intervention involved
- Where
- Taiwan
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Functional Disorder
Patient Education and Duloxetine, Alone and in Combination, for Patients With Multisystem Functional Somatic Disorder
The goal of this clinical trial is to test if patient education or duloxetine can be used to treat multisystem functional somatic disorder (FSD).
- Trial name
- EDULOX (NCT06232473)
- Testing
- Patient Education, Duloxetine, Enhanced usual care
- Where
- Denmark
- Volunteers
- 424 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Post Traumatic Stress Disorder
Pranayama for Posttraumatic Stress Disorder
This study aims to investigate the effect of pranayama (yoga-breathing techniques) on post-traumatic symptom severity in patients with post-traumatic stress disorder undergoing standard, out-patient, trauma-focused psychotherapy.
- Trial name
- PRANAPTSD (NCT05645588)
- Testing
- Pranayama assisted trauma-focused standard psychotherapy (TF-SPT), Trauma-focused standard psychotherapy (TF-SPT)
- Sponsor
- Universität Duisburg-Essen
Refractory Constipation, Somatic Symptom Disorder (DSM-5)
Evaluation of Fluoxetine for Refractory Constipation With Somatic Symptom Disorder Features
This single-center, randomized, double-blind, placebo-controlled trial evaluates the efficacy and safety of fluoxetine (40 mg/day) versus placebo in 194 adults with refractory chronic constipation exhibiting Somatic Symptom…
- Conditions
- Refractory Constipation, Somatic Symptom Disorder (DSM-5), Functional Constipation (FC)
- Trial name
- REFLECT (NCT06506136)
- Testing
- Fluoxetine
- Volunteers
- 194 people
- Sponsor
- Zhifeng Zhao, PhD
Persistent Physical Symptoms
PRINCE Primary: Integrated GP Care for Persistent Physical Symptoms - a Feasibility & Cluster Randomised Controlled Trial
PRINCE primary is cluster randomised waiting list controlled trial to evaluate the feasibility of an integrated approach to care in general practice for adults with persistent physical symptoms (PPS).
- Trial name
- PRINCE Primary (NCT02444520)
- Testing
- Integrated GP Care
- Where
- United Kingdom
- Volunteers
- 161 people
- Sponsor
- King's College London
Medically Unexplained Chronic Fatigue, Chronic Fatigue Syndrome
Fatigue Self-Management in Primary Care
This study will evaluate, in a primary care setting, the effectiveness of a brief self-management behavioral treatment in patients with medically unexplained chronic fatigue.
- Trial name
- NCT00997451
- Testing
- Cognitive-behavioral self-management, Symptom monitoring
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- Stony Brook University
COVID-19, Psychosocial Stress
DIgital Online SuPport for COVID-19 StrEss
The COVID-19 pandemic leads to a greatly increased risk of substantial psychological stress worldwide. We intend to evaluate an online support program aiming at reducing stress in the context of the COVID-19 pandemic.
- Conditions
- COVID-19, Psychosocial Stress, Mental Health
- Trial name
- DISPOSE (NCT04324190)
- Testing
- Guided online support program, WHO recommendations (waiting condition)
- Where
- Germany
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Gunther Meinlschmidt
Somatoform Disorders
Cognitive Behavior Therapy for Somatization Disorder
This study will examine the long-term effects of cognitive behavioral therapy on the physical symptoms, functioning, and health care utilization of people with multiple medically unexplained physical symptoms.
- Trial name
- NCT00276887
- Testing
- Cognitive Behavior Therapy, Psychiatric Consultation Letter
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Transition Shock, Nurses' Intention to Quit
Feasibility of Virtual Tai Chi Easy for Registered Nurses
This study will examine the feasibility of virtual Tai Chi Easy training for registered nurses and see if participation results in changes in symptoms of transition shock, healthcare-related psychological traumatic stress…
- Conditions
- Transition Shock, Nurses' Intention to Quit, Stress, Somatic Symptoms
- Trial name
- TCERN (NCT06423638)
- Testing
- Virtual Tai Chi Easy
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Generalized Anxiety Disorder, Major Depressive Disorder
Development of Online EMDR Therapy System and Its Comparative Testing With Face-to-Face EMDR Therapy for Treatment of Anxiety and Depressive Disorders in Pakistan
This study aims at developing an online system for the remote delivery of EMDR therapy in Pakistan. Moreover, this study will compare the efficacy of online EMDR therapy with face-to-face EMDR therapy.
- Conditions
- Generalized Anxiety Disorder, Major Depressive Disorder, Social Anxiety Disorder, Somatic Symptom
- Trial name
- NCT05785312
- Testing
- Online EMDR Therapy System, Face to Face Eye Movement Desensitization & Reprocessing Therapy
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Khushal Khan Khattak Univeristy, Karak, Pakistan
Mind-Body Therapies
Breathing Therapy for Patients in General Practice
Medically unexplained physical symptoms (MUPS) capture conditions characterized by symptoms without corresponding objective findings, such as asthenia, low back pain, fibromyalgia, irritable bowel syndrome, or chronic fatigue…
- Trial name
- NCT06575920
- Testing
- Breathing excercizes
- Where
- Norway
- Volunteers
- 15 people
- Sponsor
- University of Agder