Clinical trials: Medication Abortion
Pregnancy Related, Abortion Early
Medication Abortion Via Pharmacy Dispensing
This mixed-methods study follows a prospective cohort of patients receiving Mifeprex ® (mifepristone) for medication abortion dispensed by pharmacists after undergoing standard clinical evaluation.
- Trial name
- NCT03320057
- Testing
- Mifepristone, Training on mifepristone dispensing
- Where
- 6 sites in United States
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- Daniel Grossman
Threatened Miscarriage
Chinese Herbal Medicine (New "Shoutai Wan") and/or Oral Progesterone Intervention Trial for Threatened Miscarriage
Threatened miscarriage is manifested by vaginal bleeding, with or without abdominal pain, while the cervix is closed and the fetus is viable and inside the uterine cavity.
- Trial name
- NCT02633878
- Testing
- Chinese Herbal Medicine (New "Shoutai Wan") plus Oral Progesterone
- Where
- 22 sites in China
- Volunteers
- 1,656 people
- Sponsor
- Heilongjiang University of Chinese Medicine
Abortion in First Trimester
Dextromethorphan as a Novel Non-opioid Adjunctive Agent for Pain Control in Medication Abortion
This study evaluates dextromethorphan as a non-opioid adjunctive medication for pain control during medication abortion. This is double-blinded, four-arm randomized controlled trial enrolling 156 women over a period of 9-12…
- Trial name
- DexMab (NCT03480009)
- Testing
- Dextromethorphan Hydrobromide, Avicel PH101 (Microcrystalline Cellulose NF) for Compounding, Oxycodone
- Where
- 2 sites in United States
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Study Investigator-Sponsor
Medical; Abortion, Fetus
Home Follow-up After Medication Abortion
This study aims to evaluate a home follow-up alternative after medication abortion with pregnancy testing and a completion test.
- Trial name
- NCT04304365
- Testing
- Follow-up clinic visit, Text message, Low Sensitivity Pregnancy Test (LSPT)
- Sponsor
- Boston Medical Center
Pain
Pain and Medical Abortion Among Teenaged Women Compared to Adult Women
In this two-parted study the need and sufficiency of analgesics and experienced pain is compared between teen-aged and adult women undergoing medical termination of pregnancy (MToP)in early pregnancy (under 9weeks of gestation).
- Trial name
- NCT02678897
- Testing
- Oxynorm on-demand, Oxynorm via PCA
- Where
- 2 sites in Finland
- Volunteers
- 242 people
- Sponsor
- Helsinki University Central Hospital
Complete Uterine Evacuation After Use of Study Drugs
Medical Abortion With Mifepristone + Misoprostol (13 - 22 Weeks)
A double-blind randomized controlled trial to compare a shorter interval between the administration of mifepristone and misoprostol (simultaneous administration compared to 24hours from administration of mifepristone to receipt…
- Trial name
- NCT01768299
- Testing
- Mifepristone, Misoprostol
- Where
- 3 sites in Vietnam
- Volunteers
- 504 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Undesired Pregnancy
Human Chorionic Gonadotropin (hCG) Trend After Medication Abortion
This project will be a prospective physiologic study. We will closely follow 60 medication abortion patients with serial repeat serum hCG and urine semi-quantitative hCG testing.
- Trial name
- NCT02179944
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Planned Parenthood League of Massachusetts
Recurrent Pregnancy Loss
Establishment of Special Disease Cohort for RPLand Study of Impact Mechanism of Early Embryo Development
Recurrent pregnancy loss (RPL) is a refractory disease with diverse etiologies, complex pathogenesis and limited therapeutic options. Current tests and treatments lack uniform specifications.
- Trial name
- NCT05186207
- Testing
- abnormal pre-pregnancy test results that need clinical intervention
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Abortion in First Trimester
Pharmacist Provision of Medication Abortion
This will be a pilot study among two pharmacists providing start to finish medication abortions to 10 patients utilizing a previously created toolkit.
- Trial name
- NCT04956731
- Testing
- Pharmacist Provision of Medication Abortion
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Pregnancy, Abortion Early
Assessment of Early Pregnancy MAB Completion
This is a prospective study to evaluate if successful completion of a medication abortion in patients with very early pregnancy can be detected with a urine pregnancy test at 2 weeks instead of 4 weeks.
- Trial name
- NCT06893484
- Testing
- Weekly high-sensitivity urine pregnancy tests
- Where
- 3 sites in United States
- Volunteers
- 400 people
- Sponsor
- University of Washington
Threatened Miscarriage
Non-interventional Study of Therapy for Threatened Miscarriage
Study the efficacy and safety of therapy for threatened miscarriage with medicinal products Utrogestan (micronized progesterone), 200 mg capsules (Besins Healthcare SA, Belgium), and Duphaston (Dydrogesterone), 10 mg coated…
- Trial name
- NCT03309735
- Testing
- Micronized progesterone, Dydrogesterone
- Where
- 17 sites in Russia
- Volunteers
- 1,241 people
- Sponsor
- Besins Healthcare
Sexually Transmitted Disease (STD), Gonorrhea
Assessing Acceptability and Feasibiity of STI Self-swab Testing, to be Offered at the Time of Telemed Medication Abortion Provision
The goal of this interventional study is to provide more access to STI testing for patients who seek abortion care through telemedicine, particularly for those whose access to STI testing is otherwise limited.
- Conditions
- Sexually Transmitted Disease (STD), Gonorrhea, Chlamydia, Trichomonas Infection
- Trial name
- STAMP (NCT06951438)
- Testing
- Self-swab collection PCR test for chlamydia, gonorrhea, trichomonas
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Queen's Medical Center
Abortion in First Trimester, Abortion Early
Research on Equity in Abortion Care by TeleHealth
This study will examine the ways in which telehealth for reproductive healthcare affects timing, costs, and follow-up care; whether telehealth reaches people in areas with greater health inequities; and the attributes of…
- Conditions
- Abortion in First Trimester, Abortion Early, Abortion; Attempted
- Trial name
- REACH (NCT06787274)
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Abortion Early
MA-ASAP at Independent Abortion Clinics: A Demonstration Project
In this study, the investigators propose to conduct a parallel study to MA-ASAP (ClinicalTrials.gov Identifier: NCT05278780) at an independent clinic.
- Trial name
- NCT05781061
- Testing
- Screening for Eligibility
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Abortion, Medical
The Misoprostol-Only Regimen Evidence Study
The goal of this study is to evaluate the effectiveness, non-inferiority, and side-effect profile of an updated misoprostol-only regimen, as compared to the combined mifepristone-misoprostol regimen, among people seeking…
- Trial name
- MORE (NCT07174856)
- Testing
- Misoprostol-only medication abortion regimen, Combined regimen
- Where
- United States
- Volunteers
- 1,900 people
- Sponsor
- Ibis Reproductive Health
Misoprostol, Drug-induced Abortion
Compare the Different Routes of Administration of Misoprostol During Medicinal Abortion Between 7 and 9 Weeks of Amenorrhoea (SA)
In France, drug-induced abortion is allowed up to 9SA, after which the surgical route is preferred. Mifepristone 600mg is used 36-48 hours before the introduction of Misoprostol. This is recommended orally at a dose of 400 μg.
- Trial name
- Misoprostol (NCT03140384)
- Testing
- Assess the efficacy and side effects of Misoprostol according to the route of administration
- Where
- France
- Sponsor
- Centre Hospitalier Universitaire, Amiens
HIV Infections
Anti-HIV Activity and Safety of 3 Different Doses of Mifepristone in HIV Infected People
The purpose of this study is to determine the anti-HIV activity and safety of 3 different doses of mifepristone (also known as VGX-410 and RU486) in HIV infected people.
- Trial name
- NCT00099645
- Testing
- Mifepristone
- Where
- 10 sites in United States
- Volunteers
- 48 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Abortion, Drug-Induced, Pharmacies
Evaluating an Intervention to Increase Use of Call Centre Support for Self-managed Medical Abortion
Self-management of medical abortion (MA) pills purchased from pharmacies is considered to be one of the reasons behind falling morbidity and mortality from unsafe abortion in recent years.
- Trial name
- NCT03248050
- Testing
- Pharmacy encouraged to promote call centre use to clients
- Volunteers
- 1,359 people, healthy volunteers welcome
- Sponsor
- Marie Stopes International
Medical Abortion, Complete or Unspecified, Without Complication
Randomized Study of Letrozole and Trilostane for Medical Abortion
In menstruation an effective shedding of the endometrial lining occurs. Both progesterone and estrogen levels fall sharply at this time.
- Trial name
- NCT01615211
- Testing
- Letrozole, Trilostane
- Where
- Sweden
- Volunteers
- 36 people
- Sponsor
- Kristina Gemzell Danielsson
Early Abortion
Advance Provision of Medication Abortion
This mixed-methods study follows a prospective cohort of participants receiving Mifeprex® (mifepristone) by a clinician in advance of a potential unintended pregnancy.
- Trial name
- NCT03829696
- Testing
- Mifeprex® (Mifepristone 200 mg), Misoprostol 800 mcg, ella® (ulipristal acetate emergency contraception 30 mg)
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Francisco