Clinical trials: Medication Management, open to volunteers
Intrathecal Drug Delivery, Refractory Cancer Pain
Intrathecal Therapy Versus Standard Care for Severe Cancer Pain
Approximately 66% of patients with advanced cancer experience pain, which is often inadequately controlled and associated with a decline in health-related quality of life (HRQoL).
- Conditions
- Intrathecal Drug Delivery, Refractory Cancer Pain, Conventional Medical Management
- Trial name
- CAREGIVER (NCT07691840)
- Testing
- Intrathecal Drug Delivery, Comprehensive Medical Management
- Where
- Belgium
- Volunteers
- 72 people
- Sponsor
- Universitair Ziekenhuis Brussel
Hypertension, High Blood Pressure
Blood Pressure Care for Advancing Real-World Evidence (BPCARE)
The goal of this randomized clinical trial is to determine whether a community health worker-delivered, multi-component behavioral intervention can improve antihypertensive medication adherence and blood pressure control among…
- Trial name
- BPCARE (NCT07398391)
- Testing
- BPCARE Intervention
- Where
- 2 sites in United States
- Volunteers
- 250 people
- Sponsor
- University of California, San Diego
Hypertension
IMB-Guided Health Education Intervention for Medication Adherence and Blood Pressure Control in Non-adherent Hypertensive Patients
This study will evaluate the effectiveness of an Information-Motivation-Behavioral Skills (IMB) Model-guided health literacy intervention among adults with hypertension who are non-adherent to prescribed antihypertensive…
- Trial name
- NCT07894068
- Testing
- IMB Model-Guided Health Education Intervention, Usual Care
- Where
- 8 sites in Ethiopia
- Volunteers
- 230 people
- Sponsor
- Bahir Dar University
Complicated Staphylococcus Aureus (S. Aureus) Infections (CSAI)
Target Attainment of Continuous Infusion Flucloxacillin and Cefazolin Coupled With TDM vs. Standard of Care Treatment in Patients With Complicated S. Aureus Infection
This prospective randomized, controlled interventional pilot trial, aims to compare the achievement of the optimal target concentration with continuously administered flucloxacillin (FLU) or cefazolin (CZO) coupled with TDM and…
- Trial name
- TARGET III (NCT05655091)
- Testing
- FLU or CZO as continuous infusion, standard FLU or CZO intermittent bolus administration
- Where
- Switzerland
- Volunteers
- 36 people
- Sponsor
- University Hospital, Basel, Switzerland
Preeclampsia Severe, Toxemia Of Pregnancy
LDA and LMWH vs LDA Alone in High-risk Patients for Preeclampsia Prevention
Preeclampsia is a major cause of maternal and perinatal morbidity and mortality worldwide. Low-dose aspirin started in the first trimester reduces the risk of preeclampsia in high-risk women.
- Conditions
- Preeclampsia Severe, Toxemia Of Pregnancy, Preeclampsia, Pregnancy Complications
- Trial name
- preGO (NCT07361679)
- Testing
- Aspirin, Tinzaparin
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Alexandra Hospital, Athens, Greece
Asthma
Therapeutic Relevance of Abnormal Airway Morphology in Asthma
Most individuals with asthma can effectively manage their symptoms and maintain normal lung function using inhaled medications, unfortunately, there is a subset of asthma sufferers whose symptoms, lung function, and risk of…
- Trial name
- AirPATH (NCT06970080)
- Testing
- Inhaled corticosteroid (ICS), Oral Corticosteroid (OCS)
- Where
- 2 sites in Canada
- Volunteers
- 242 people
- Sponsor
- McMaster University
Opioid Use Disorder
Brief Digitally-Enhanced Intervention for Reducing Alcohol Use During MOUD
The goal of this clinical trial is to reduce heavy drinking and enhance medication for opioid use disorder (MOUD) outcomes in individuals receiving MOUD.
- Trial name
- NCT06718491
- Testing
- Managing Physical Reactions to Overwhelming Emotions (IMPROVE), Health Education Training (HET)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Ohio State University
Type 2 Diabetes
Effectiveness of the Diabetes Homeless Medication Support (D-HOMES) Program on Diabetes Management
The goal of this clinical trial is to learn if the Diabetes Homelessness Medication Support (D-HOMES) wellness coaching model is effective for adults who speak English or Spanish, have Type 2 diabetes with an HbA1c at or above…
- Trial name
- D-HOMES R01 (NCT07091487)
- Testing
- Diabetes Homeless Medication Support, Enhanced Usual Care/ Education
- Where
- United States
- Volunteers
- 256 people
- Sponsor
- Katherine Vickery
Acute Kidney Injury
Post-Cardiac Surgery Acute Kidney Injury Prevention by Administration of Proton Pump Inhibitor (P2 Trial)
The central hypothesis of this research study is that perioperative administration of the proton pump inhibitor (PPI) pantoprazole could reduce the development of acute kidney injury (AKI) following cardiac surgery by activation…
- Trial name
- P2 AKI PPI (NCT06706258)
- Testing
- Protonix (Pantoprazole) 40 mg q 12 hrs for 3 days, Pepcid (Famotidine) 20 mg q 12 hrs for 3 days
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- The University of Texas Health Science Center, Houston
Obesity, Overweight
A Study to Learn About Study Medicine Called Berobenatide in Adults With Knee Pain and Overweight or Obesity (VESPER-OA 1)
The purpose of this clinical study is to learn about the safety and effects of berobenatide (PF-08653944) for the treatment of knee osteoarthritis in adults with overweight or obesity.
- Conditions
- Obesity, Overweight, Osteoarthritis of the Knee
- Trial name
- NCT07919678
- Testing
- Berobenatide
- Where
- 40 sites in United States, Canada
- Volunteers
- 656 people
- Sponsor
- Pfizer
Anesthesia, Surgery
Veterans Enhanced Recovery Using Integrative Treatments Around Surgery
The study aims to assess the implementation and effectiveness of Integrative Treatments - Music Medicine, Aromatherapy, and Battlefield Acupuncture - in the management of perioperative pain and anxiety, and in the reduction of…
- Conditions
- Anesthesia, Surgery, Knee Arthropathy
- Trial name
- VERITAS (NCT06333938)
- Testing
- Nonpharmacologic Treatment, Standard Care
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Durham VA Medical Center
Acute Respiratory Failure
Examination of Personalized SpO2 Targets
Mechanical ventilation involves titrating the fraction of inspired oxygen to maintain arterial oxygen saturation (SpO2). The SpO2 target that results in the best outcomes for critically ill adults has historically been unknown.
- Trial name
- EXPRESS (NCT07536984)
- Testing
- Personalized SpO2 Target, Usual Care
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- Vanderbilt University Medical Center
Chronic Condition, Adverse Event
PAUSE: Sick Day Medication Management Mobile App Study
Diabetes, heart disease and kidney disease have high morbidity and costs of care. Medications used to treat these conditions are effective.
- Trial name
- PAUSE (NCT06433414)
- Testing
- PAUSE App
- Volunteers
- 320 people
- Sponsor
- University of Alberta
Post-Traumatic Stress Disorder, Violence-Related Symptom
A Case Management Algorithm for Women Victims of Violence
A considerable body of research has demonstrated that women who are victims of interpersonal violence are at substantially elevated risk for the development of post-traumatic stress disorder (PTSD).
- Trial name
- VIGITRAUMA (NCT04953273)
- Testing
- Vigitrauma
- Where
- 8 sites in France
- Volunteers
- 756 people
- Sponsor
- University Hospital, Lille
Obesity, Overweight
A Study to Learn About the Study Medicine Called PF-08653944 Taken Once-Weekly Compared to Placebo in Chinese Adults With Overweight or Obesity
Overweight and obesity are long-term health conditions that can increase the risk of serious health problems, including heart disease, type 2 diabetes, and other medical conditions.
- Trial name
- NCT07792954
- Testing
- Berobenatide
- Where
- 34 sites in China
- Volunteers
- 300 people
- Sponsor
- Pfizer
Brain Activity Related to Opioid Administration, Brain Activity Related to Drug Liking
Characterizing the EEG Signature of Fentanyl and Its Association With Drug Liking
The goal of this study is to characterize an electroencephalogram (EEG) biomarker for fentanyl and understand where this signal is coming from in the brain.
- Trial name
- NCT06699953
- Testing
- Observational study in patients receiving fentanyl for surgery
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Stanford University
Alzheimer's Disease, Healthy Participants
A Study to Evaluate the Drug Levels, Absolute Bioavailability, Safety, Tolerability, and Immunogenicity of Single-Dose of BMS-986446 in Healthy Adults After Single-dose Administration, and Participants With Early Alzheimer's Disease After Multiple Dose Administration
The purpose of this study is to evaluate the drug levels, absolute bioavailability, safety, tolerability, and immunogenicity of single-Dose of BMS-986446 in healthy adults after single-dose administration, and participants with…
- Trial name
- NCT07780383
- Testing
- BMS-986446
- Where
- 6 sites in United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Malignant Solid Tumors, Moderate to High Emetogenic Chemotherapy (MEC/HEC) Drugs
Nanocrystalline Megestrol for Managing Chemotherapy-Induced Nausea and Vomiting
The goal of this clinical trial is to learn if medroxyprogesterone acetate oral suspension (Meishiya®) works to prevent nausea and vomiting caused by single-day moderate to high emetogenic chemotherapy (MEC/HEC) in the…
- Trial name
- NCT07124195
- Testing
- Medroxyprogesterone acetate oral suspension, high antiemetic regimen, moderate antiemetic regimen
- Where
- China
- Volunteers
- 126 people
- Sponsor
- The First Affiliated Hospital of Xinxiang Medical College
Diabetes Type 2
Dulce Digital 2.0 - Innovative Diabetes Self-Management in the Digital Age
The proposed research, "Dulce Digital 2.0," will evaluate two mHealth adaptions of Project Dulce that are designed to improve digital health literacy, increase underserved individuals' capacity to access and engage with vital…
- Trial name
- Dulce Digital (NCT05416060)
- Testing
- Dulce Digital Text-Based Education, Project Dulce Telehealth, Project Dulce Live
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Scripps Whittier Diabetes Institute
Asthma in Children, Intellectual Disabilities (F70-F79)
Smart Inhaler and Remote Asthma Management in Adolescents With Intellectual and Developmental Disabilities
Correct use of daily medications containing inhaled corticosteroids is key for asthma control, yet children with intellectual and developmental disabilities (IDD) face additional barriers to proper inhaler use.
- Conditions
- Asthma in Children, Intellectual Disabilities (F70-F79), Developmental Disability, Autism Spectrum Disorder
- Trial name
- IDD (NCT07746921)
- Testing
- Use of active remote smart inhaler in the home setting, Use of passive remote smart inhaler in the home setting
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Children's Hospital Los Angeles