Clinical trials: Medication to Treat Opioid Use Disorder
Opioid-use Disorder, Addiction
Competitive Revision for CLARO: Collaboration Leading to Addiction Treatment and Recovery From Other Stresses
The purpose of this study is to develop and then test an enhanced version of the parent study's collaborative care intervention for co-occurring disorders (CC-COD) to reduce the risk of suicide and overdose among individuals with…
- Conditions
- Opioid-use Disorder, Addiction, Depression, Post Traumatic Stress Disorder
- Trial name
- NCT04634279
- Testing
- Collaborative care Plus
- Where
- 12 sites in United States
- Volunteers
- 68 people
- Sponsor
- RAND
Opioid Use Disorder
Evaluation of a Peer Recovery Support Program Adapted to Target Retention in Clinic-based Medication for Opioid Use Disorder Treatment
The goal of this clinical trial is to learn if receiving peer recovery support (support services provided by trained "peers" with lived experience of addiction and recovery) improves retention in medication treatment among people…
- Trial name
- PEERS (NCT07197801)
- Testing
- Peer recovery support to enhance patient engagement in medication for opioid use disorder treatment
- Where
- United States
- Volunteers
- 218 people
- Sponsor
- Geisinger Clinic
Stimulant Use Disorder
Mirtazapine for the Treatment of Methamphetamine Use in Opioid Use Disorder Patients Receiving Medication Assisted Treatment
This project will evaluate the ability of Mirtazapine (MZP), a pharmacologically unique medication with a growing body of evidence to support its efficacy and safety for the treatment of methamphetamine (MA) use among medication…
- Trial name
- MIRROM (NCT06323837)
- Testing
- Mirtazapine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Washington State University
Substance Use Disorder
OPAL: "Opiates and PhArmacoLogy"
The aim of this study is to determine the current prevalence of co-addictions, including problem/pathological gambling, in patients receiving Opiate Substitution Treatment (OST), and to then compare patients receiving OST with or…
- Trial name
- OPAL (NCT01847729)
- Where
- 7 sites in France
- Volunteers
- 263 people
- Sponsor
- Nantes University Hospital
Opioid Use, Constipation Drug Induced
Study on Quality of Life in Advanced Cancer Patients With Opioid-induced Constipation Treated With Naloxegol
Opioid-Induced Constipation (OIC) is often associated with a compromised quality of life of patients in palliative care (PC) setting.
- Conditions
- Opioid Use, Constipation Drug Induced, Cancer
- Trial name
- NCT04294550
- Testing
- Naloxegol
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- Fondazione ANT Franco Pannuti ETS
Opioid-use Disorder, Pain
Enhancing Exercise and Psychotherapy to Treat Pain and Addiction in Opioid Use Disorders ("EXPO" Pilot Trial)
The purpose of this pilot trial is to determine the feasibility of integrating exercise and psychotherapy that is specifically targeted to reducing and managing pain into residential drug treatment programs.
- Trial name
- NCT04736550
- Testing
- Exercise, Psychotherapy for Pain (I-STOP)
- Where
- 2 sites in United States
- Volunteers
- 63 people
- Sponsor
- Case Western Reserve University
Opioid Use Disorder
Reward-based Technology to Improve OUD Treatment
Millions of people in the US misuse opioids each year. Medication assisted treatment (MAT) for opioid use disorder (OUD) is highly efficacious, but only a fraction of OUD persons access MAT, and treatment non-adherence is common…
- Trial name
- OARSCM (NCT05180669)
- Testing
- OARSCM Software Application, MyMAT Software Application
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Q2i, LLC
Opioid-use Disorder
Mindful Body Awareness With Medication Treatment for Opioid Use Disorder
The national opioid epidemic requires development of real-world evidence-based treatments for opioid use disorder, including adjuncts to Medication for Opioid Use Disorder (MOUD).
- Trial name
- NCT04082637
- Testing
- Mindful Awareness in Body-oriented Therapy
- Where
- 5 sites in United States
- Volunteers
- 303 people
- Sponsor
- University of Washington
Pain, Drug Overdose
Primary Care Intervention to Reduce Prescription Opioid Overdoses
The high rate of adverse events, including overdose, resulting from opioid pain medication use threatens the quality and safety of pain care in the Veterans Health Administration (VHA) and elsewhere and is a critical public…
- Conditions
- Pain, Drug Overdose, Opioid Use Disorders
- Trial name
- POST (NCT02464410)
- Testing
- Motivational intervention, Psycho-educational control, Long-term opioid therapy informed consent
- Where
- United States
- Volunteers
- 299 people
- Sponsor
- VA Office of Research and Development
Substance Use Disorders
Addiction-focused EMDR in Inpatients Who Use Non-opioid Drugs: a Multiple Baseline Study
Rationale: It is well established that Substance Use Disorders (SUD) have severe health consequences. Despite behavioral and pharmacological treatment options, relapse rates remain high.
- Trial name
- NCT05923697
- Testing
- AF-EMDR
- Where
- Netherlands
- Volunteers
- 9 people
- Sponsor
- IrisZorg
Hepatitis C, Opioid-Related Disorders
The Kentucky Viral Hepatitis Treatment Study
The overarching goal of the Kentucky Viral Hepatitis Treatment Project (KeY Treat) is to increase hepatitis C virus (HCV) treatment access and delivery in a rural Appalachian community, which is in the midst of the…
- Conditions
- Hepatitis C, Opioid-Related Disorders, Injection Drug Use
- Trial name
- KeY Treat (NCT03949764)
- Testing
- Sofosbuvir/velpatasvir (Epclusa®)
- Where
- United States
- Volunteers
- 380 people
- Sponsor
- Jennifer Havens
Opioid Use Disorder, Opioid Use Disorder, Severe
Buprenorphine Implementation at Syringe Service Programs to Reduce Overdoses
This study is testing whether offering buprenorphine treatment directly at syringe service programs (SSPs) helps more people start and stay in treatment for opioid use disorder (OUD) than referring them to community buprenorphine…
- Conditions
- Opioid Use Disorder, Opioid Use Disorder, Severe, Opioid Use Disorder, Moderate
- Trial name
- BISTRO (NCT07631598)
- Testing
- Standard of Care Referral, Low Threshold Buprenorphine
- Where
- 8 sites in United States
- Volunteers
- 512 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Opioid-use Disorder
Mobile Medication Adherence Platform for Buprenorphine-Naloxone During Treatment of Opioid Use Disorder: Phase I Study
The investigators will conduct a phase I study involving 41 participants selected randomly among patients prescribed buprenorphine-naloxone for opioid misuse as a feasibility trial of the study of the Pillsy device.
- Trial name
- MAP4BUP (NCT04656899)
- Testing
- Reminders messages to improve adherence.
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Washington State University
Opioid-use Disorder
Mindfulness-Based Relapse Prevention to Improve Medication Assisted Treatment Adherence and Drug-use Outcomes for Opioid Use Disorder
This proposal aims to determine whether an adjunctive Mindfulness-Based Relapse Prevention (MBRP) treatment program improves Medication Assisted Treatment (MAT) adherence and reduces drug-use among opioid use disorder (OUD)…
- Trial name
- NCT05042388
- Testing
- Mindfulness-Based Relapse Prevention - Rolling Admission (MBRP-RA), Treatment-As-Usual
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- West Chester University of Pennsylvania
Polysubstance Addiction, Opioid Medication Assisted Treatment
Peer Recovery to Improve Polysubstance Use and Mobile Telemedicine Retention
The purpose of this study is to evaluate the feasibility and effectiveness of a peer-led, brief, behavioral intervention to improve adherence to medication for opioid use disorder (MOUD) and reduce polysubstance use among…
- Conditions
- Polysubstance Addiction, Opioid Medication Assisted Treatment, Treatment Adherence, Retention in Care
- Trial name
- PRISM (NCT05973838)
- Testing
- Peer-Delivered Behavioral Activation ("Peer Activate")
- Where
- 4 sites in United States
- Volunteers
- 160 people
- Sponsor
- University of Maryland, College Park
Substance Use Disorders, Treatment Adherence and Compliance
Kentucky Access to Recovery Evaluation
Evaluate the long-term effectiveness of implementing vouchers as a linkage strategy in a population requiring recovery support services (RSS) when no other funding sources are available.
- Trial name
- NCT05889702
- Testing
- KATR Linkage Strategy
- Where
- 2 sites in United States
- Volunteers
- 458 people
- Sponsor
- Terry Bunn
Opioid Use
FOREward Together: Training Peer Recovery Coaches to Promote Retention and Adherence to MOUD
This project aims to implement a peer-led intervention to support retention and adherence to medications for opioid use disorder among low-income adults in Detroit, as well as a training manual for peer recovery coaches serving…
- Trial name
- NCT05098795
- Testing
- Behavioral Activation (BA)
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Henry Ford Health System
Opioid Use
Long Acting Buprenorphine Injection Compared to Sublingual Buprenorphine/Naloxone Films
While substance use disorders have been found to have relapse rates on part with other chronic illnesses such as hypertension and asthma long term abstinence remains elusive for many.
- Trial name
- NCT03744663
- Testing
- Suboxone® SL, Sublocade®
- Sponsor
- Wake Forest University Health Sciences
Family Planning Services, Substance-Related Disorders
Increasing Linkage to Family Planning Care for Individuals With Substance Use Disorder
This study will utilize mixed methods to develop and assess the feasibility and acceptability of a health educator intervention designed to connect patients in recovery from substance use disorder to reproductive health education…
- Conditions
- Family Planning Services, Substance-Related Disorders, Opiate Substitution Treatment, Sexual Health
- Trial name
- NCT04162184
- Testing
- Sexual Health Initiative for Navigation and Education (SHINE) Health Educator Intervention
- Where
- United States
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- Denver Health and Hospital Authority
Opioid Dependence, Injection Drug Use
Pilot Test of a Community-based Buprenorphine Treatment Intervention
The main goal of this study is to pilot test the community-based buprenorphine treatment (CBBT) intervention, examining buprenorphine treatment initiation, opioid use, and HIV risk behaviors.
- Trial name
- NCT01761110
- Testing
- Community-based buprenorphine treatment (CBBT) intervention
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Albert Einstein College of Medicine